A Systematic Review on Advances in Management of Oxidative Stress-Associated Cardiovascular Diseases

Antioxidants, Год журнала: 2024, Номер 13(8), С. 923 - 923

Опубликована: Июль 29, 2024

Oxidative stress plays a significant role in the pathogenesis of cardiovascular diseases, such as myocardial ischemia/reperfusion injury, atherosclerosis, heart failure, and hypertension. This systematic review aims to integrate most relevant studies on oxidative management diseases. We searched literatures PubMed database using specific keywords. put emphasis those manuscripts that were published more recently higher impact journals. reviewed total 200 articles. examined current managements including supplements like resveratrol, vitamins C E, omega-3 fatty acids, flavonoids, coenzyme-10, which have shown antioxidative properties potential benefits. In addition, we pharmacological treatments newly discovered antioxidants nanoparticles show effects targeting pathways. Lastly, biomarkers, soluble transferrin receptor, transthyretin, cystatin evaluating antioxidant status identifying risk. By addressing mechanisms, this paper emphasizes importance maintaining balance between oxidants progression is registered with International Platform Registered Systematic Review Meta-analysis Protocols (INPLASY), registration # INPLASY202470064.

Язык: Английский

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Gastrodin prevents myocardial injury in sleep-deprived mice by suppressing ferroptosis through SIRT6

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(11), С. 9111 - 9121

Опубликована: Июнь 19, 2024

Язык: Английский

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Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 23, 2025

Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.

Язык: Английский

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Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 298, С. 118269 - 118269

Опубликована: Май 10, 2025

Язык: Английский

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Decreased serum and local GPX4 and SLC7A11 expression correlates with disease severity in non-traumatic osteonecrosis of the femoral head

Journal of Orthopaedic Surgery and Research, Год журнала: 2025, Номер 20(1)

Опубликована: Май 17, 2025

Ferroptosis is implicated in various musculoskeletal conditions, including non-traumatic osteonecrosis of the femoral head (NT-ONFH). The objective this study was to explore levels two crucial proteins associated with ferroptosis, namely Glutathione peroxidase 4 (GPX4) and Solute Carrier Family 7 Member 11 (SLC7A11), both serum samples, correlate their expression clinical severity NT-ONFH. included 136 NT-ONFH patients an equal number healthy controls. In addition, 68 subjects suffering from neck fractures (FNF) were study. concentrations GPX4 SLC7A11 quantified using enzyme-linked immunosorbent assay. among tissue samples identified through immunohistochemical staining, western blot analysis, quantitative real-time polymerase chain reaction (qRT-PCR). radiographic condition evaluated utilizing Association Research Circulation Osseous (ARCO) classification system, while symptomatic assessed Visual Analogue Scale (VAS) alongside Harris Hip Score (HHS). Patients diagnosed had considerably reduced comparison individuals control group. Negative correlations ARCO stages observed. A total 73 ONFH FNF underwent hip replacement. mRNA protein lower necrotic areas compared non-necrotic tissues. Subsequent Receiver operating characteristic (ROC) curve analysis suggested that decreased local could serve as potential biomarkers for progression ONFH. Furthermore, found be negatively linked VAS score but positively related HHS score. SLC7A11, at site, inversely correlated Targeting ferroptosis its therapeutic interventions a viable strategy mitigate

Язык: Английский

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Advances in Manganese-based nanomaterials for cancer therapy via regulating Non-Ferrous ferroptosis

International Journal of Pharmaceutics, Год журнала: 2024, Номер 669, С. 125101 - 125101

Опубликована: Дек. 19, 2024

Язык: Английский

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