BMC Complementary Medicine and Therapies,
Год журнала:
2024,
Номер
24(1)
Опубликована: Фев. 1, 2024
Abstract
Background
Melissa
officinalis
(MO)
is
a
well-known
medicinal
plant
species
used
in
the
treatment
of
several
diseases;
it
widely
as
vegetable,
adding
flavour
to
dishes.
This
study
was
designed
evaluate
therapeutic
effect
MO
Extract
against
hyperthyroidism
induced
by
Eltroxin
and
γ-radiation.
Methods
Hyperthyroidism
injecting
rats
with
(100
µg/kg/
day)
for
14
days
exposure
γ-radiation
(IR)
(5
Gy
single
dose).
The
hyperthyroid
were
orally
treated
extract
(75
mg/kg/day)
at
beginning
second
week
injection
continued
another
week.
levels
thyroid
hormones,
liver
enzymes
proteins
besides
impaired
hepatic
redox
status
antioxidant
parameters
measured
using
commercial
kits.
gene
expression
nuclear
factor
erythroid
2-related
2
(Nrf2)
its
inhibitor
Kelch-like
ECH-associated
protein-1(Keap-1)
addition
inflammatory
mediators
including
tumor
necrosis
factor-α
(TNF-
α),
Monocyte
chemoattractant
protein-1
(MCP-1)
fibrogenic
markers
such
transforming
growth
factor-beta1
(TGF-β1)
determined.
Results
reversed
+
IR
on
attenuated
hormones.
Moreover,
alleviated
hyperthyroidism-induced
damage
inhibiting
enzymes’
activities
well
enhancing
production
concomitant
improving
cellular
homeostasis
attenuating
deranged
balance
modulating
Nrf2/Keap-1
pathway.
Additionally,
response
suppressing
TNF-
α
MCP-1
prevented
fibrosis
via
Nrf2-mediated
inhibition
TGF-β1/Smad
Conclusion
Accordingly,
these
results
might
strengthen
hepatoprotective
rat
model
regulating
Nrf-2/
Keap-1
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 30, 2023
Oxidative
stress,
resulting
from
dysregulation
in
the
secretion
of
adrenal
hormones,
represents
a
major
concern
human
health.
The
present
review
comprehensively
examines
various
categories
endocrine
within
glands,
encompassing
glucocorticoids,
mineralocorticoids,
and
androgens.
Additionally,
comprehensive
account
hormone
disorders,
including
insufficiency,
Cushing’s
syndrome,
tumors,
is
presented,
with
particular
emphasis
on
their
intricate
association
oxidative
stress.
also
delves
into
an
examination
nutritional
antioxidants,
namely
vitamin
C,
E,
carotenoids,
selenium,
zinc,
polyphenols,
coenzyme
Q10,
probiotics,
elucidates
role
mitigating
adverse
effects
stress
arising
imbalances
levels.
In
conclusion,
harnessing
power
antioxidants
has
potential
to
help
caused
by
imbalance
hormones.
This
could
lead
new
research
therapeutic
interventions.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15246 - 15246
Опубликована: Окт. 17, 2023
Parabens
are
classified
as
endocrine-disrupting
chemicals
(EDCs)
capable
of
interfering
with
the
normal
functioning
thyroid,
affecting
proper
regulation
biosynthesis
thyroid
hormones
(THs),
which
is
controlled
by
hypothalamic-pituitary-thyroid
axis
(HPT).
Given
crucial
role
these
in
health
and
growing
evidence
diseases
related
to
dysfunction,
this
review
looks
at
effects
paraben
exposure
on
thyroid.
In
study,
we
considered
research
carried
out
vitro
vivo
epidemiological
studies
published
between
1951
2023,
demonstrated
an
association
parabens
dysfunctions
HPT
axis.
humans,
increases
thyroid-stimulating
hormone
(TSH)
levels,
while
decreases
TSH
levels
rodents.
The
THs
also
poorly
described,
well
peripheral
metabolism.
Regardless,
recent
have
shown
different
actions
subtypes
axis,
allows
us
speculate
that
mechanism
action
different.
Furthermore,
more
evident
women
than
men.
Therefore,
future
needed
clarify
their
mechanisms
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 31, 2023
In
recent
years,
there
has
been
a
significant
increase
in
the
concomitant
incidence
of
Hashimoto’s
thyroiditis
(HT)
and
polycystic
ovary
syndrome
(PCOS),
both
terms
incidence,
etiology,
clinical
consequences.
PCOS
patients
suffering
from
autoimmune
thyroid
diseases
show
insulin
resistance,
impaired
glucose
tolerance,
weight
gain,
metabolic
reproductive
complications.
Studies
have
shown
that
chronic
stress
its
consequence,
i.e.
oxidative
stress,
play
an
important
role
pathomechanism
disorders.
It
also
long-term
exposure
to
triggers
biological
mechanisms,
particular
related
regulation
inflammatory
cascade,
which
plays
key
diseases.
The
paper
is
review
literature
on
immune
processes
pathogenesis
HT
PCOS.
addition,
source
knowledge
about
treatment
these
diseases,
use
antioxidants
therapeutic
management.
World Journal of Psychiatry,
Год журнала:
2025,
Номер
15(2)
Опубликована: Янв. 14, 2025
BACKGROUND
Depression
is
a
significant
psychiatric
disorder
with
particularly
high
prevalence
among
adolescents.
This
mental
health
condition
can
have
severe
consequences,
including
academic
failure,
social
withdrawal,
and
suicidal
behavior.
Given
the
increasing
rate
of
depression
in
this
age
group,
understanding
underlying
biological
mechanisms
essential
for
early
detection
intervention.
Recent
studies
suggested
that
immune
markers
play
role
pathophysiology
depression,
prompting
further
investigation
their
potential
association
depressive
symptoms
AIM
To
investigate
relationship
between
(monocytes,
lymphocytes,
direct
bilirubin)
incidence
severity
METHODS
cross-sectional
study
recruited
145
adolescent
patients
[male
(M)/female
(F)
=
38/107]
from
Jiangbin
Hospital
Guangxi,
Zhuang
163
healthy
controls
(M/F
77/86)
routine
check-ups.
Blood
samples
were
collected
after
an
overnight
fast.
was
measured
using
Zung
Self-Rating
Scale.
The
inclusion
criteria
12-24
years,
diagnosis
(ICD-10),
no
recent
antidepressant
use.
exclusion
included
comorbidities
serious
somatic
diseases.
Key
statistical
methods
group
comparisons
correlation
analyses.
RESULTS
There
higher
females
(P
<
0.001).
Significant
differences
observed
groups
(Z
9.43,
P
had
monocyte
3.43,
0.001)
lymphocyte
(t
2.29,
0.05)
counts,
serum
bilirubin
levels
4.72,
Monocyte
count
varied
significantly
according
to
severity,
lower
counts
mild
-2.90,
0.05).
A
negative
(ρ
-0.22,
0.01).
Logistic
regression
analysis
showed
predicted
depression.
CONCLUSION
elevated
adolescents
has
been
highlighted.
Therefore,
it
necessary
explore
relationships
these
Frontiers in Nutrition,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 16, 2025
Oxidative
stress
contributes
to
the
development
of
cardiometabolic
diseases
and
cancers.
Numerous
studies
have
highlighted
adverse
effects
high
reactive
oxygen
species
(ROS)
levels
in
progression
chronic
noncommunicable
also
during
infections.
On
other
hand,
antioxidants
play
a
crucial
role
preventing
oxidative
or
postponing
cell
damage
via
direct
scavenging
free
radicals
indirectly
Keap1/Nrf2/ARE
pathway,
among
others.
Dietary
can
be
obtained
from
various
sources,
mainly
through
plant-based
diet,
including
fruits
vegetables.
The
dietary
antioxidant
index
(DAI)
has
been
developed
assess
total
intake
diet.
This
review
delineated
performance
DAI
risk
assessment
different
diseases.
It
is
suggested
that
score
prevents
obesity-related
diseases,
diabetes
mellitus,
hyperuricemia,
dyslipidemia,
metabolic
(dysfunction)-associated
steatotic
liver
disease
(MASLD).
Additionally,
negatively
associated
with
Helicobacter
pylori
Human
papillomavirus
infection,
thus
reducing
gastric
cervical
cancer.
Also,
osteoporosis,
miscarriage,
infertility,
mental
illnesses.
However,
further
prospective
observations
clinical
trials
are
warranted
confirm
application
studied.
Nutrients,
Год журнала:
2025,
Номер
17(3), С. 594 - 594
Опубликована: Фев. 6, 2025
Houttuynia
cordata
Thunb.
holds
a
longstanding
reputation
as
traditional
folk
remedy
in
East
Asia,
where
it
has
been
employed
to
treat
variety
of
inflammatory
conditions,
nephritis,
hepatitis
and
cancer.
Despite
its
extensive
use,
there
exists
paucity
research
examining
efficacy
managing
thyroid
disorders
diabetes.
Moreover,
the
bioactive
components
responsible
for
modulating
molecular
pathways
remain
elusive.
Objectives:
This
aimed
determine
key
ethanolic
extract
H.
(HCEE)
thyroid-modifying
properties
examine
effects
on
rats
with
experimentally
induced
hypothyroidism
Methods:
Molecular
docking
was
performed
investigate
possible
mechanisms
regulation
HCEE
constituents.
Researchers
by
adding
6-propyl-2-thiouracil
their
drinking
water
period
four
weeks.
To
induce
diabetes,
received
an
intraperitoneal
injection
streptozotocin.
The
animals
were
then
given
daily
oral
doses
(500
mg/kg
b.w.),
levothyroxine
(50
or
glibenclamide
(5
b.w.)
28
days.
Following
this
treatment,
standard
methods
measure
biochemical
parameters
rats’
serum.
Results:
results
demonstrate
that
ameliorated
increasing
serum
T3
(14.38%)
T4
(125.96%)
levels
decreasing
TSH
(p
<
0.01;
−41.75%)
levels.
In
diabetic
hypothyroidism,
significantly
0.001)
increased
(149.51%)
(73.54%)
reduced
(−64.39%)
silico
analysis
demonstrated
identified
compounds
from
may
enhance
hormone
function
through
interaction
receptor
protein
TRβ1
(PDB:3GWS),
similar
conventional
pharmaceuticals
triiodothyronine
(T3).
Conclusions:
exhibits
potential
natural
alternative
synthetic
medications
prevention
treatment
dysfunctions.
