Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 26, 2025
Post-translational
modifications
such
as
SUMOylation
are
crucial
for
the
functionality
and
signal
transduction
of
a
diverse
array
proteins.
Analogous
to
ubiquitination,
has
garnered
significant
attention
from
researchers
been
implicated
in
pathogenesis
various
human
diseases
recent
years,
cancer,
neurological
lesions,
cardiovascular
diseases,
diabetes
mellitus,
so
on.
The
diabetes,
particularly
type
1
2
closely
associated
with
immune
dysfunction,
which
constitutes
primary
focus
this
review.
This
review
will
elucidate
process
its
impact
on
mellitus
development
complications,
focusing
regulatory
effects
microenvironment.
article
summarizes
signaling
pathways
at
both
cellular
molecular
levels
that
these
processes.
Furthermore,
it
proposes
potential
new
targets
drug
aimed
prevention
treatment
based
insights
gained
process.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9646 - 9646
Опубликована: Сен. 6, 2024
Bioinformatics
has
emerged
as
a
valuable
tool
for
screening
drugs
and
understanding
their
effects.
This
systematic
review
aimed
to
evaluate
whether
in
silico
studies
using
anti-obesity
peptides
targeting
therapeutic
pathways
obesity,
when
subsequently
evaluated
vitro
vivo,
demonstrated
effects
consistent
with
those
predicted
the
computational
analysis.
The
was
framed
by
question:
“What
or
proteins
have
been
used
treat
obesity
studies?”
structured
according
acronym
PECo.
protocol
developed
registered
PROSPERO
(CRD42022355540)
accordance
PRISMA-P,
all
stages
of
adhered
these
guidelines.
Studies
were
sourced
from
following
databases:
PubMed,
ScienceDirect,
Scopus,
Web
Science,
Virtual
Heath
Library,
EMBASE.
search
strategies
resulted
1015
articles,
which,
based
on
exclusion
inclusion
criteria,
7
included
this
review.
identified
originated
various
sources
including
bovine
alpha-lactalbumin
cocoa
seed
(Theobroma
cacao
L.),
chia
(Salvia
hispanica
rice
bran
(Oryza
sativa),
sesame
(Sesamum
indicum
sea
buckthorn
flour
(Hippophae
rhamnoides),
adzuki
beans
(Vigna
angularis).
All
articles
underwent
vivo
reassessment
molecular
docking
methodology
studies.
Among
review,
46.15%
classified
having
an
“uncertain
risk
bias”
six
thirteen
criteria
evaluated.
primary
target
investigated
pancreatic
lipase
(n
=
5),
enzyme
demonstrating
inhibition,
finding
supported
both
vivo.
Additionally,
other
PPARγ
PPARα
agonists
2).
Notably,
exhibited
different
mechanisms
action
lipid
metabolism
adipogenesis.
findings
underscore
effectiveness
simulation
tool,
providing
crucial
insights
guiding
investigations
discovery
novel
peptides.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 26, 2025
Post-translational
modifications
such
as
SUMOylation
are
crucial
for
the
functionality
and
signal
transduction
of
a
diverse
array
proteins.
Analogous
to
ubiquitination,
has
garnered
significant
attention
from
researchers
been
implicated
in
pathogenesis
various
human
diseases
recent
years,
cancer,
neurological
lesions,
cardiovascular
diseases,
diabetes
mellitus,
so
on.
The
diabetes,
particularly
type
1
2
closely
associated
with
immune
dysfunction,
which
constitutes
primary
focus
this
review.
This
review
will
elucidate
process
its
impact
on
mellitus
development
complications,
focusing
regulatory
effects
microenvironment.
article
summarizes
signaling
pathways
at
both
cellular
molecular
levels
that
these
processes.
Furthermore,
it
proposes
potential
new
targets
drug
aimed
prevention
treatment
based
insights
gained
process.
