Metabolites,
Год журнала:
2024,
Номер
14(11), С. 615 - 615
Опубликована: Ноя. 12, 2024
Background/Objectives:
Metabolic
disorders,
including
diabetes,
obesity,
and
cardiovascular
diseases,
are
significant
global
health
issues.
Nutraceuticals,
such
as
Sclerocarya
birrea
(SB),
known
for
its
high
polyphenol
content,
increasingly
explored
managing
these
conditions.
This
study
aims
to
evaluate
the
antihyperglycemic,
hypolipidemic,
antihypertensive
effects
of
SB
in
animal
models
understand
potential
a
natural
intervention
metabolic
diseases.
Methods:
A
systematic
review
meta-analysis
were
conducted
according
PRISMA
guidelines.
Searches
across
databases
like
PubMed,
Web
Science,
Embase,
Scopus
identified
studies
using
disorders.
Inclusion
criteria
with
intervention,
control
groups,
quantitative
measures
parameters.
The
was
registered
INPLASY
(INPLASY2024100031).
Results:
revealed
that
significantly
reduces
blood
glucose
levels
diabetic
models.
Acute
administration
showed
pooled
standardized
mean
difference
(SMD)
−7.13
(95%
CI:
−11.44
−2.83)
at
1
h
−9.75
−15.92
−3.59)
2–4
post-administration.
Chronic
indicated
non-significant
reduction
(SMD:
−5.69,
95%
−16.38
5.01).
Conclusions:
appears
have
reducing
may
offer
benefits
other
cardiometabolic
risk
factors,
lipid
profiles
oxidative
stress.
However,
variability
results
underscores
need
further
research,
clinical
trials,
confirm
clarify
mechanisms
by
which
impact
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 915 - 915
Опубликована: Янв. 22, 2025
Polyphenols
are
micronutrients
found
in
fruits,
vegetables,
tea,
coffee,
cocoa,
medicinal
herbs,
fish,
crustaceans,
and
algae.
They
can
also
be
synthesized
using
recombinant
microorganisms.
Interest
plant-derived
natural
compounds
has
grown
due
to
their
potential
therapeutic
effects
with
minimal
side
effects.
This
is
particularly
important
as
the
aging
population
faces
increasing
rates
of
chronic
diseases
such
cancer,
diabetes,
arthritis,
cardiovascular,
neurological
disorders.
Studies
have
highlighted
polyphenols’
capacity
reduce
risk
factors
linked
onset
illnesses.
narrative
review
discusses
polyphenol
families
metabolism,
cardioprotective
polyphenols
evidenced
from
vitro
studies,
well
vivo
on
different
animal
models
cardiac
disease.
study
explores
molecular
mechanisms
underlying
these
benefits.
Current
research
suggests
that
may
protect
against
ischemia,
hypertension,
hypertrophy,
heart
failure,
myocardial
injury
through
complex
mechanisms,
including
epigenetic
genomic
modulation.
However,
further
studies
under
nutritionally
physiologically
relevant
conditions,
untargeted
multigenomic
approaches,
needed
more
comprehensively
elucidate
firmly
prove
polyphenols.
Food & Function,
Год журнала:
2024,
Номер
15(19), С. 9632 - 9661
Опубликована: Янв. 1, 2024
Metabolic
syndrome
(MetS)
is
a
disease
condition
incorporating
the
abnormal
accumulation
of
various
metabolic
components,
including
obesity,
insulin
resistance
and
glucose
tolerance,
hypertension,
atherosclerosis,
or
dyslipidemia.
Nutrients,
Год журнала:
2024,
Номер
16(18), С. 3168 - 3168
Опубликована: Сен. 19, 2024
The
convergence
of
cardiovascular,
kidney,
and
metabolic
disorders
at
the
pathophysiological
level
has
led
to
recognition
cardiovascular-kidney-metabolic
(CKM)
syndrome,
which
represents
a
significant
global
health
challenge.
Polyphenols,
group
phytochemicals,
have
demonstrated
potential
health-promoting
effects.
This
review
highlights
impact
maternal
polyphenol
supplementation
on
CKM
offspring.
Initially,
we
summarize
interconnections
between
polyphenols
each
aspect
syndrome.
We
then
discuss
in
vivo
studies
that
investigated
use
during
pregnancy
breastfeeding,
focusing
their
role
preventing
syndrome
Additionally,
explore
common
mechanisms
underlying
protective
effects
supplementation.
Overall,
this
underscores
early-life
interventions
safeguarding
against
It
emphasizes
importance
continued
research
advance
our
understanding
facilitate
clinical
translation
these
interventions.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(8), С. 220 - 220
Опубликована: Авг. 8, 2024
Diabetes
mellitus,
characterized
by
enduring
hyperglycemia,
precipitates
oxidative
stress,
engendering
a
spectrum
of
complications,
notably
increased
bone
vulnerability.
The
genesis
reactive
oxygen
species
(ROS),
byproduct
metabolism,
instigates
detriment
and
impairs
metabolism
in
diabetic
conditions.
This
review
delves
into
the
mechanisms
ROS
generation
its
impact
on
homeostasis
within
context
diabetes.
Furthermore,
summarizes
cutting-edge
progress
development
ROS-neutralizing
biomaterials
tailored
for
amelioration
osteopathy.
These
are
engineered
to
modulate
dynamics,
thereby
mitigating
inflammatory
responses
facilitating
repair.
Additionally,
challenges
therapeutic
prospects
ROS-targeted
clinical
application
disease
treatment
is
addressed.
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1728 - 1728
Опубликована: Май 31, 2024
This
review
aimed
to
examine
the
effects
of
curcumin
on
chronic
inflammatory
metabolic
disease
by
extensively
evaluating
meta-analyses
randomized
controlled
trials
(RCTs).
We
performed
a
literature
search
RCTs
published
in
English
PubMed®/MEDLINE
up
31
July
2023.
identified
54
for
inflammation,
antioxidant,
glucose
control,
lipids,
anthropometric
parameters,
blood
pressure,
endothelial
function,
depression,
and
cognitive
function.
A
reduction
C-reactive
protein
(CRP)
levels
was
observed
seven
ten
RCTs.
In
five
eight
meta-analyses,
intake
significantly
lowered
interleukin
6
(IL-6)
levels.
six
nine
tumor
necrosis
factor
α
(TNF-α)
malondialdehyde
(MDA)
14
15
reduced
fasting
(FBG)
12
homeostasis
model
assessment
insulin
resistance
(HOMA-IR).
glycated
hemoglobin
(HbA1c)
19
total
cholesterol
(TC)
Curcumin
plays
protective
effect
disease,
possibly
via
improved
homeostasis,
MDA,
TC,
inflammation
(CRP,
IL-6,
TNF-α,
adiponectin).
The
safety
efficacy
as
natural
product
support
potential
prevention
treatment
diseases.
Antioxidants,
Год журнала:
2024,
Номер
13(8), С. 983 - 983
Опубликована: Авг. 14, 2024
Chronic
kidney
disease
(CKD)
increases
the
risk
of
cardiovascular
and
cognitive
impairment.
Curcumin
is
a
polyphenol
that
improves
vascular
function
in
older
adults;
however,
its
effects
on
patients
with
CKD
are
unknown.
We
hypothesized
curcumin
supplementation
would
improve
CKD.
Eighty-eight
adults
diagnosed
stage
3b
or
4
(aged
66
±
8
years,
75%
male)
participated
12-month,
randomized,
double-blind,
placebo-controlled
study
to
test
(Longvida
Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 31, 2024
ABSTRACT
The
aim
of
this
meta‐analysis
was
to
determine
the
effect
curcumin
on
a
range
health
outcomes.
PubMed,
EMBASE,
Scopus,
and
Web
Science
were
searched
from
inception
until
September
2023.
Randomized
clinical
trials
(RCTs)
that
compared
Curcuma
longa
L.
with
placebo
considered
eligible.
risk
bias
overall
certainty
evidence
assessed
using
Newcastle‐Ottawa
Scale
Grading
Recommendations
Assessment,
Development,
Evaluation
(GRADE),
respectively.
We
meta‐analyzed
sizes
across
eligible
studies
random‐effects
model.
In
total,
103
RCTs
42
outcomes
included,
incorporating
total
population
7216
participants.
Overall,
23
out
(55%)
reported
statistically
significant
sizes.
credibility
rated
as
high
for
fasting
blood
sugar
(FBS),
C‐reactive
protein
(CRP),
high‐density
lipoprotein
(HDL),
weight.
remaining
presented
moderate
(waist
circumference
[WC],
hip
[HC],
body
mass
index
[BMI],
insulin,
Homeostatic
Model
Assessment
Insulin
Resistance
[HOMA‐IR],
quantitative
insulin‐sensitivity
check
[QUICKI],
leptin,
gamma‐glutamyl
transferase
[GGT],
glutathione
[GSH],
superoxide
dismutase
[SOD]),
low
(14
outcomes),
or
very
outcomes)
evidence.
conclusion,
supplementation
can
modify
FBS
some
glycemic
indices,
lipid
parameters,
well
inflammatory
oxidative
parameters.
This
updated
summary
accumulated
may
help
inform
clinicians
future
guidelines
regarding
medical
scientific
interest
in
curcumin.
However,
due
limitations
methodological
quality
included
studies,
well‐designed
long‐term
large
sample
are
needed.
Trial
registration:
PROSPERO:
CRD42021251969
