Effects of the DailyColors™ Polyphenol Supplement on Serum Proteome, Cognitive Function, and Health in Older Adults at Risk of Cognitive and Functional Decline. DOI Creative Commons
Mary F. O’Leary, Joanna L. Bowtell, Megan Richards

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Abstract The Mediterranean diet is associated with reduced mortality and cognitive decline, largely due to its polyphenol content. However, Western populations often do not meet recommended fruit vegetable intakes. Polyphenols exert anti-inflammatory effects may influence extracellular vesicle (EV) dynamics. DailyColors™ a polyphenol-rich blend inspired by the Diet, containing extracts from 16 fruits, vegetables, herbs. This 60-day, double-blind, placebo-controlled, randomised trial involved 150 UK adults aged 50+ BMI ≥ 25, recruited complete physical fitness assessments via PROTECT-UK online platform. Participants received either medium (750mg) or high (2000mg) dose of (∼300mg ∼750mg polyphenols, respectively) placebo. A sub-group (n=15 per group) underwent additional assessments, including blood pressure measurements, characterisation circulating EVs tandem-mass-tagged serum proteomics. Significant benefits were observed, improvements in reaction time for high-dose group accuracy both active supplement groups. also showed significant gains on Timed Stand Test (P<0.001). All groups improved Chair Test. Proteomic analysis significantly protein expression immune pre-β1-HDL pathways, suggesting effects. Pre-β1-HDL proteins are typically elevated obesity; their reduction suggests reversal this obesity-related effect. No changes noted EV concentration size. supplementation, enhance function, fitness, systemic health older, overweight adults, potentially mimicking diet. These findings warrant investigation larger trials.

Language: Английский

Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials DOI Creative Commons
Gofarana Wilar, Cecep Suhandi, Kohji Fukunaga

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 213, P. 107641 - 107641

Published: Feb. 1, 2025

Language: Английский

Citations

2
The effects of curcumin supplementation on biomarkers of inflammation, oxidative stress, and endothelial function: A meta-analysis of meta-analyses DOI

Zeynab Kavyani,

Kianoosh Najafi,

Navid Naghsh

et al.

Prostaglandins & Other Lipid Mediators, Journal Year: 2024, Volume and Issue: 174, P. 106867 - 106867

Published: June 28, 2024

Language: Английский

Citations

10
The PI3K/Akt pathway: a target for curcumin’s therapeutic effects DOI
Mahdieh Aliyari,

Sahar Ghoflchi,

Seyed Isaac Hashemy

et al.

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 17, 2025

Language: Английский

Citations

1
Plant Polyphenols as Heart’s Best Friends: From Health Properties, to Cellular Effects, to Molecular Mechanisms of Action DOI Open Access
Sanja Stanković, Slavica Mutavdžin, Dragan Djurić

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 915 - 915

Published: Jan. 22, 2025

Polyphenols are micronutrients found in fruits, vegetables, tea, coffee, cocoa, medicinal herbs, fish, crustaceans, and algae. They can also be synthesized using recombinant microorganisms. Interest plant-derived natural compounds has grown due to their potential therapeutic effects with minimal side effects. This is particularly important as the aging population faces increasing rates of chronic diseases such cancer, diabetes, arthritis, cardiovascular, neurological disorders. Studies have highlighted polyphenols’ capacity reduce risk factors linked onset illnesses. narrative review discusses polyphenol families metabolism, cardioprotective polyphenols evidenced from vitro studies, well vivo on different animal models cardiac disease. study explores molecular mechanisms underlying these benefits. Current research suggests that may protect against ischemia, hypertension, hypertrophy, heart failure, myocardial injury through complex mechanisms, including epigenetic genomic modulation. However, further studies under nutritionally physiologically relevant conditions, untargeted multigenomic approaches, needed more comprehensively elucidate firmly prove polyphenols.

Language: Английский

Citations

1
The therapeutic effect and possible mechanisms of alginate oligosaccharide on metabolic syndrome by regulating gut microbiota DOI
Jingyi Wang, Zixuan Zhang, Tong Dai

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(19), P. 9632 - 9661

Published: Jan. 1, 2024

Metabolic syndrome (MetS) is a disease condition incorporating the abnormal accumulation of various metabolic components, including obesity, insulin resistance and glucose tolerance, hypertension, atherosclerosis, or dyslipidemia.

Language: Английский

Citations

7
Maternal Polyphenols and Offspring Cardiovascular–Kidney–Metabolic Health DOI Open Access
You‐Lin Tain, Chien‐Ning Hsu

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3168 - 3168

Published: Sept. 19, 2024

The convergence of cardiovascular, kidney, and metabolic disorders at the pathophysiological level has led to recognition cardiovascular-kidney-metabolic (CKM) syndrome, which represents a significant global health challenge. Polyphenols, group phytochemicals, have demonstrated potential health-promoting effects. This review highlights impact maternal polyphenol supplementation on CKM offspring. Initially, we summarize interconnections between polyphenols each aspect syndrome. We then discuss in vivo studies that investigated use during pregnancy breastfeeding, focusing their role preventing syndrome Additionally, explore common mechanisms underlying protective effects supplementation. Overall, this underscores early-life interventions safeguarding against It emphasizes importance continued research advance our understanding facilitate clinical translation these interventions.

Language: Английский

Citations

6
Biomaterials Designed to Modulate Reactive Oxygen Species for Enhanced Bone Regeneration in Diabetic Conditions DOI Creative Commons
Mingshan Li, Zhihe Zhao, Jianru Yi

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(8), P. 220 - 220

Published: Aug. 8, 2024

Diabetes mellitus, characterized by enduring hyperglycemia, precipitates oxidative stress, engendering a spectrum of complications, notably increased bone vulnerability. The genesis reactive oxygen species (ROS), byproduct metabolism, instigates detriment and impairs metabolism in diabetic conditions. This review delves into the mechanisms ROS generation its impact on homeostasis within context diabetes. Furthermore, summarizes cutting-edge progress development ROS-neutralizing biomaterials tailored for amelioration osteopathy. These are engineered to modulate dynamics, thereby mitigating inflammatory responses facilitating repair. Additionally, challenges therapeutic prospects ROS-targeted clinical application disease treatment is addressed.

Language: Английский

Citations

4
Curcumin Restrains TGF‐β2‐Induced Proliferation, Migration, Invasion and EMT in Lens Epithelial Cells by Regulating FGF7/ZEB1 Axis DOI
Jing He, Ping Xie,

Yangjun Ou

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 26, 2025

ABSTRACT Posterior capsular opacification (PCO) is the most common complication after cataract surgery characterized by hyperproliferation, migration and epithelial‐mesenchymal transition (EMT) in residual lens epithelial cells (LECs). Curcumin a polyphenol compound possessing diverse pharmacological properties. Here, we investigated functions its potential mechanisms of curcumin PCO using transforming growth factor beta2 (TGF‐β2)‐treated LECs. Cell phenotypes were analyzed MTT, 5‐thynyl‐2′‐deoxyuridine (EdU), transwell, scratch assays, respectively. Levels FGF7 (Fibroblast Growth Factor 7), ZEB1 (Zinc finger E‐box binding homeobox 1), EMT‐related proteins detected qRT‐PCR western blot analysis. The protein interaction between was validated Co‐immunoprecipitation assay. treatment weakened TGF‐β2‐induced proliferation, migration, invasion EMT progression expression boosted Functionally, deficiency suppressed LECs, could reverse suppressing action on LEC dysfunction. Mechanistically, directly interacted with ZEB1, regulate via FGF7. Moreover, overexpression abolish protective effects or LECs under TGF‐β2 stimulation. In conclusion, protected against enhancement process regulating FGF7/ZEB1 axis, suggesting new insight into application therapy.

Language: Английский

Citations

0
Impacts of Curcumin Supplementation on Cardiometabolic Risk Factors in Patients With Polycystic Ovary Syndrome: A Systematic Review and Dose−Response Meta‐Analysis DOI Creative Commons
Shooka Mohammadi, Somayeh Ziaei, Mehrnaz Morvaridi

et al.

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(3)

Published: March 1, 2025

Patients with polycystic ovary syndrome (PCOS) commonly have cardiometabolic risk factors. Oxidative stress (OS) significantly contributes to the development of diseases. Curcumin (CUR) exhibits antioxidant properties that aid in OS regulation. This systematic review and dose-response meta-analysis randomized clinical trials (RCTs) evaluated effects CUR supplementation on factors women PCOS. A search across various databases was implemented identify eligible RCTs published until January 2024. conducted employing a random-effects model. Eight were included meta-analysis. It indicated substantially reduced fasting blood sugar (FBS) (standardized mean difference [SMD]: -0.40 mg/dL, 95% confidence interval [CI]: -0.59, -0.21; p < 0.001), insulin (SMD: -0.32 µU/mL, CI: -0.49, -0.14; homeostasis model assessment resistance (HOMA-IR) -0.36, -0.54, -0.19; total cholesterol (TC) -0.34 -0.61, -0.08; = 0.01). In addition, it increased quantitative sensitivity check index (QUICKI) 0.37, 0.13, 0.61; 0.001) CUR-treated group compared control group. However, did not significant impacts body mass (BMI), weight, serum levels follicle-stimulating hormone (FSH), triglycerides (TG), dehydroepiandrosterone (DHEA), high-density lipoprotein (HDL), testosterone, low-density (LDL), luteinizing (LH). study revealed may potential enhance health by reducing hyperglycemia, resistance, TC

Language: Английский

Citations

0
Is Curcumin Intake Really Effective for Chronic Inflammatory Metabolic Disease? A Review of Meta-Analyses of Randomized Controlled Trials DOI Open Access

Young‐Min Lee,

Yoona Kim

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1728 - 1728

Published: May 31, 2024

This review aimed to examine the effects of curcumin on chronic inflammatory metabolic disease by extensively evaluating meta-analyses randomized controlled trials (RCTs). We performed a literature search RCTs published in English PubMed®/MEDLINE up 31 July 2023. identified 54 for inflammation, antioxidant, glucose control, lipids, anthropometric parameters, blood pressure, endothelial function, depression, and cognitive function. A reduction C-reactive protein (CRP) levels was observed seven ten RCTs. In five eight meta-analyses, intake significantly lowered interleukin 6 (IL-6) levels. six nine tumor necrosis factor α (TNF-α) malondialdehyde (MDA) 14 15 reduced fasting (FBG) 12 homeostasis model assessment insulin resistance (HOMA-IR). glycated hemoglobin (HbA1c) 19 total cholesterol (TC) Curcumin plays protective effect disease, possibly via improved homeostasis, MDA, TC, inflammation (CRP, IL-6, TNF-α, adiponectin). The safety efficacy as natural product support potential prevention treatment diseases.

Language: Английский

Citations

3