Inflammation and malnutrition in inflammatory bowel disease

˜The œLancet. Gastroenterology & hepatology, Год журнала: 2023, Номер 8(6), С. 579 - 590

Опубликована: Март 15, 2023

Язык: Английский

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The relationship between nutrition and the immune system

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Дек. 8, 2022

Nutrition plays an essential role in the regulation of optimal immunological response, by providing adequate nutrients sufficient concentrations to immune cells. There are a large number micronutrients, such as minerals, and vitamins, well some macronutrients amino acids, cholesterol fatty acids demonstrated exert very important specific impact on appropriate activity. This review aims summarize at extent amount data accrued date related modulation function certain micro emphasize their importance maintaining human health. Thus, among many, relevant case point examples brought discussed: (1) The vitamin A/all-trans-retinoic-acids (ATRA) acute promyelocytic leukemia, being this utilized efficient therapeutic agent via effective (2) involvement C fight against tumor cells increase active NK (3) stimulation apoptosis, suppression cancer cell proliferation, delayed development mediated calcitriol/vitamin D means immunity (4) use selenium cofactor reach more response COVID vaccination (5). crucial regulate function, which is be sensitive variations macronutrient concentration. Other reviewed well.

Язык: Английский

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Fermented Foods in the Management of Obesity: Mechanisms of Action and Future Challenges

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2665 - 2665

Опубликована: Янв. 31, 2023

Fermented foods are part of the staple diet in many different countries and populations contain various probiotic microorganisms non-digestible prebiotics. Fermentation is process breaking down sugars by bacteria yeast species; it not only enhances food preservation but can also increase number beneficial gut bacteria. Regular consumption fermented has been associated with a variety health benefits (although some risks exist), including improved digestion, enhanced immunity, greater weight loss, suggesting that have potential to help design effective nutritional therapeutic approaches for obesity. In this article, we provide comprehensive overview effects corresponding mechanisms action obesity obesity-related metabolic abnormalities.

Язык: Английский

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Production, characterisation, and biological properties of Tenebrio molitor-derived oligopeptides

Food Chemistry, Год журнала: 2024, Номер 450, С. 139400 - 139400

Опубликована: Апрель 16, 2024

Three protein hydrolysates from Tenebrio molitor were obtained by enzymatic hydrolysis employing two food-grade proteases (i.e. Alcalase and Flavourzyme), a complete characterisation of their composition was done. The digestion-derived products using the INFOGEST protocol. In vitro antioxidant activity anti-inflammatory activities evaluated. flour showed high ability to scavenge DPPH radical (EC50 values 0.30 0.87 mg/mL). hydrolysate with combination could decrease gene expression pro-inflammatory genes after being digested. Furthermore, peptidome fully determined for first time T. digests, 40 peptides selected based on bioactivity be evaluated in silico tools, including prediction tools molecular docking. These results provide new perspectives use edible insects as sustainable not nutritionally disadvantageous food human consumption.

Язык: Английский

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Oregano Essential Oil as a Natural Plant Additive Affects Growth Performance and Serum Antibody Levels by Regulating the Rumen Microbiota of Calves

Animals, Год журнала: 2024, Номер 14(6), С. 820 - 820

Опубликована: Март 7, 2024

This experiment aimed to investigate whether supplementation of calves with different doses oregano essential oil (OEO) could promote the development gastrointestinal tract and enhance immune ability by regulating rumen microbiota. Twenty-four 70-day-old healthy disease-free Holstein male were randomly divided into four groups, control group fed a basal diet, treatment provided 4 g, 6 8 g per day in addition diet. After 14-day pre-test, 56-day formal test was conducted. At days 0 56 standard period, weighed, average daily weight gain during period calculated, serum samples collected measure concentration immunoglobulins (IgA, IgG, IgM) serum; at fluid from calves, 16SrRNA sequenced analyze changes microbiota calves. The analyzed sequencing. results study showed that (1) OEO significantly increased end (

Язык: Английский

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Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics

Biomedicines, Год журнала: 2025, Номер 13(1), С. 179 - 179

Опубликована: Янв. 13, 2025

In the current era, malnutrition is seen as both undernutrition and overweight obesity; conditions are caused by nutrient deficiency or excess improper use imbalance in intake of macro micronutrients. Recent evidence suggests that alters intestinal microbiota, known dysbiosis. Secretory immunoglobulin A (sIgA) plays an important role maintaining increasing beneficial microbiota populations protecting against pathogenic species. Depletion bacterial throughout life also conditioned malnutrition. This review aims to synthesize establishes interrelationship between diet, malnutrition, changes flora, sIgA levels. Targeted nutritional therapies combined with prebiotic, probiotic, postbiotic administration can restore immune response intestine host’s homeostasis.

Язык: Английский

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Endocrine Adverse Events in Patients Treated with Immune Checkpoint Inhibitors: A Comprehensive Analysis

Medicina, Год журнала: 2025, Номер 61(1), С. 123 - 123

Опубликована: Янв. 14, 2025

Background and Objectives: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, but their use is associated with a spectrum of immune-related adverse events (irAEs), including endocrine disorders. This study aims to investigate the incidence, timing, treatment modalities, impact ICI-related side effects in patients. Materials Methods: retrospective analyzed 139 patients treated ICIs between 2016 2022. Data regarding irAEs, hypothyroidism, hyperthyroidism, hypophysitis, diabetes mellitus, were collected. The examined timing irAE onset, management approaches, association irAEs outcomes. Results: most common was hypothyroidism (65.5%), followed by hyperthyroidism (2.3%), hypophysitis (8.6%), mellitus (0.7%). These disorders typically emerged within first six months ICI therapy. Most cases managed conservatively or hormone replacement Patients who developed exhibited higher objective response rate (ORR) clinical benefit (CBR) compared those without irAEs. Conclusions: Endocrine dysfunction significant toxicity Early recognition, prompt diagnosis, appropriate are crucial minimize on patient health quality life. highlights potential improved Further research needed elucidate underlying mechanisms identify predictive biomarkers for development.

Язык: Английский

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The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(22), С. 14195 - 14195

Опубликована: Ноя. 17, 2022

Intestinal homeostasis is maintained through the interplay of intestinal mucosa, local and systemic immune factors, microbial content gut. Iron a trace mineral in most organisms, including humans, which essential for growth, metabolism response. Paradoxically, excessive iron intake and/or high status can be detrimental to intestine lead overload ferroptosis-programmed cell death mediated by iron-dependent lipid peroxidation within membranes, contributes several diseases. In this review, we comprehensively review recent findings on impacts ferroptosis mucosal inflammation then present progress ferroptosis-targeting therapy Understanding involved mechanisms provide new understanding disease pathogenesis facilitate advanced preventive therapeutic strategies dysfunction

Язык: Английский

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Pet Wellness and Vitamin A: A Narrative Overview

Animals, Год журнала: 2024, Номер 14(7), С. 1000 - 1000

Опубликована: Март 25, 2024

The health of companion animals, particularly dogs and cats, is significantly influenced by nutrition, with vitamins playing a crucial role. Vitamin A, in particular, indispensable, diverse roles ranging from vision to immune modulation reproduction. Despite its importance, the metabolism dietary requirements vitamin A animals remain complex not fully understood. This review provides comprehensive overview historical perspective, digestion, metabolism, physiological roles, deficiency, excess, interactions other micronutrients animals. Additionally, it highlights future research directions gaps our understanding. Insights into personalized nutrition strategies based on genetic variability, longitudinal studies tracking status investigations immunomodulatory effects are for optimizing pet wellness. Furthermore, understanding stability bioavailability food formulations essential ensuring provision adequate micronutrients. Overall, this underscores importance animal need further enhance optimize recommendations well-being.

Язык: Английский

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Immunity in digestive diseases: new drugs for inflammatory bowel disease treatment—insights from Phase II and III trials

Journal of Gastroenterology, Год журнала: 2024, Номер 59(9), С. 761 - 787

Опубликована: Июль 9, 2024

Inflammatory bowel disease (IBD), encompassing Crohn's (CD) and ulcerative colitis (UC), continues to challenge treatment paradigms. Advancements in therapeutic options have been driven by Phase 2 3 clinical trials of new drug classes, particularly sphingosine-1-phosphate (S1P) modulators interleukin-23 (IL-23) inhibitors.

Язык: Английский

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