Rosacea, microbiome and probiotics: the gut-skin axis

Frontiers in Microbiology, Год журнала: 2024, Номер 14

Опубликована: Янв. 8, 2024

Rosacea is an inflammatory skin disease involving diverse symptoms with a variable clinical progress which can severely impact the patient’s quality of life as well their mental health. The pathophysiological model rosacea involves unbalanced immune system predisposed to excessive inflammation, in addition vascular and nervous alterations, being certain cutaneous microorganisms’ triggers onset. gut-skin axis explains bidirectional interaction between gut microbiota some diseases such atopic dermatitis, psoriasis, or rosacea. introduction consolidation next-generation sequencing recent years has provided unprecedented information about microbiome. However, characterization patients been little explored, contrast other dermatitis psoriasis. Furthermore, evolution not always adequate it common for them present sustained symptomatology frequent flare-ups. In this context, probiotic supplementation could improve these happens pathologies. Through review we aim establish compile basics directions current knowledge understand mechanisms by microbiome influences pathogenesis rosacea, how modulation benefit patients.

Язык: Английский

---

Bifidobacterium animalis BD400 protects from collagen-induced arthritis through histidine metabolism

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 22, 2025

Background Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease. Numerous clinical studies have indicated correlation between alterations in gut microbiota the onset progression of RA. This research aims to restore intestinal healthy state through oral administration Bifidobacterium early stages with goal delaying Methods Collagen-induced (CIA) rat model was constructed assess development RA using scores, paw thickness, pathological analysis knee joint. The immune response evaluated by determinating specific antibodies cytokines serum synovial fluid. expression barrier protein analyzed qPCR evaluate function. Alterations metabolites were assessed 16S rDNA non-targeted metabolomics. Results findings reveal that administering animalis BD400 orally led significant reduction scores swelling thickness CIA rats. Additionally, there decrease osteo-facial fusion calcified cartilage thickening Furthermore, B. resulted down-regulation inflammatory factors TNF-α collagenase MMP-13 Levels (anti-CII IgG, anti-CII IgG1, IgG2a) cytokine IL-17A serum, as well (TNF-α IL-1β) fluid BD400-treated rats, significantly reduced ( p < 0.05). gene levels proteins (occludin-1, MUC-2, ZO-1) showed increase 0.05) altered composition microorganisms rats at phylum genus levels, particularly affecting HT002. alleviates down-regulating 1-methyl-L-histidine urocanate histidine metabolism, laying foundation for prevention. Conclusion By HT002 metabolism restored permeability, inhibited response, ultimately slowed down

Язык: Английский

---

Preventing Bacterial Translocation in Patients with Leaky Gut Syndrome: Nutrition and Pharmacological Treatment Options

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(6), С. 3204 - 3204

Опубликована: Март 16, 2022

Leaky gut syndrome is a medical condition characterized by intestinal hyperpermeability. Since the barrier one of essential components maintaining homeostasis along gastrointestinal tract, loss its integrity due to changes in bacterial composition, decreased expression levels tight junction proteins, and increased concentration pro-inflammatory cytokines may lead hyperpermeability followed development non-gastrointestinal diseases. Translocation microorganisms their toxic metabolites beyond tract fallouts leaky syndrome. The presence bacteria sterile tissues distant organs cause damage chronic inflammation progression disorders, including inflammatory bowel diseases, liver cirrhosis, acute pancreatitis. Currently, there are no guidelines for treatment or prevention translocation patients with syndrome; however, several studies suggest that dietary intervention can improve function restrict invasion. This review contains current literature data concerning influence diet, supplements, probiotics, drugs on permeability translocation.

Язык: Английский

---

Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation

Nutrients, Год журнала: 2022, Номер 14(9), С. 1918 - 1918

Опубликована: Май 3, 2022

Increasing evidence on the significance of nutrition in reproduction is emerging from both animal and human studies, suggesting a mutual association between female fertility. Different “fertile” dietary patterns have been studied; however, humans, conflicting results or weak correlations are often reported, probably because individual variations genome, proteome, metabolome, microbiome extent exposure to different environmental conditions. In this scenario, “precision nutrition”, namely personalized based deep phenotyping metabolomics, microbiome, nutrigenetics each case, might be more efficient for infertile patients than applying generic nutritional approach. review, we report new insights into management patients, discussing main nutrigenetic, nutrigenomic, microbiomic aspects that should investigated achieve effective interventions. Specifically, will focus low-grade chronic inflammation, which associated with several infertility-related diseases.

Язык: Английский

---

Limosilactobacillus reuteri SLZX19-12 Protects the Colon from Infection by Enhancing Stability of the Gut Microbiota and Barrier Integrity and Reducing Inflammation

Microbiology Spectrum, Год журнала: 2022, Номер 10(3)

Опубликована: Июнь 6, 2022

The use of antibiotics to treat bacterial infections leads a series side effects. As an alternative method, the biocontrol strategy, which uses probiotics suppress pathogens, is considered potential way deal with in gut.

Язык: Английский

---

Collinsella is associated with cumulative inflammatory burden in an established rheumatoid arthritis cohort

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 153, С. 113518 - 113518

Опубликована: Авг. 6, 2022

To analyze the gut microbiota of patients with rheumatoid arthritis (RA) according to disease activity. An observational cross-sectional study 110 RA and age- sex-matched controls was performed. Patients were classified activity (DAS28 ≥ 3.2 or DAS28 < 3.2). Clinical epidemiological variables included. The analyzed using 16S rRNA sequencing bioinformatics analysis based on QIIME PICRUSt. A multivariate performed identify factors associated inflammatory mean indicated remission/low in 71 (64.5 %) moderate/high 39 (35.5 during follow-up. Alpha beta diversity revealed differences between 3 groups. In RA, we observed a significant change abundance genera compared other Collinsella Bifidobacterium increased controls. metabolic profile characterized by pathways related Biosynthesis, Generation Precursor Metabolites/Energy, Degradation/Utilization/Assimilation cumulative age (OR [95 % CI], 1.065 [1.002–1.131]), obesity [95% 3.829 [1.064–8.785]), HAQ score 2.729 [1.240–5.009]), expansion genus 3.000 [1.754–9.940]). composition differed activity, Collinsella, age, obesity, physical function burden RA.

Язык: Английский

---

The brain-gut-microbiota interplay in depression: A key to design innovative therapeutic approaches

Pharmacological Research, Год журнала: 2023, Номер 192, С. 106799 - 106799

Опубликована: Май 19, 2023

Depression is the most prevalent mental disorder in world associated with huge socio-economic consequences. While depressive-related symptoms are well known, molecular mechanisms underlying disease pathophysiology and progression remain largely unknown. The gut microbiota (GM) emerging as a key regulator of central nervous system homeostasis by exerting fundamental immune metabolic functions. In turn, brain influences intestinal microbial composition through neuroendocrine signals, within so-called microbiota-brain axis. balance this bidirectional crosstalk important to ensure neurogenesis, preserve integrity blood-brain barrier avoid neuroinflammation. Conversely, dysbiosis permeability negatively affect development, behavior, cognition. Furthermore, although not fully defined yet, changes GM depressed patients reported influence pharmacokinetics common antidepressants affecting their absorption, metabolism, activity. Similarly, neuropsychiatric drugs may shape turn an impact on efficacy toxicity pharmacological intervention itself. Consequently, strategies aimed at re-establishing correct homeostatic (i.e., prebiotics, probiotics, fecal transplantation, dietary interventions) represent innovative approach improve pharmacotherapy depression. Among these, probiotics Mediterranean diet, alone or combination standard care, hold promise for clinical application. Therefore, disclosure intricate network between depression will give precious insights diagnostic therapeutic approaches towards depression, profound implications drug development practice.

Язык: Английский

---

Psoriasis: Interplay between dysbiosis and host immune system

Autoimmunity Reviews, Год журнала: 2022, Номер 21(11), С. 103169 - 103169

Опубликована: Авг. 12, 2022

Язык: Английский

---

Role of mucosal immunity and epithelial–vascular barrier in modulating gut homeostasis

Internal and Emergency Medicine, Год журнала: 2023, Номер 18(6), С. 1635 - 1646

Опубликована: Июль 4, 2023

The intestinal mucosa represents the most extensive human barrier having a defense function against microbial and food antigens. This is represented externally by mucus layer, consisting mainly of mucins, antimicrobial peptides, secretory immunoglobulin A (sIgA), which serves as first interaction with microbiota. Below placed epithelial monolayer, comprising enterocytes specialized cells, such goblet Paneth enterochromaffin others, each specific protective, endocrine, or immune function. layer interacts both luminal environment underlying lamina propria, where mucosal immunity processes primarily take place. Specifically, between microbiota an intact results in activation tolerogenic processes, mediated FOXP3+ regulatory T homeostasis. Conversely, impairment function, alteration normal composition (dysbiosis), imbalance pro- anti-inflammatory factors may result inflammation disease. Another crucial component gut-vascular barrier, formed endothelial pericytes, glial regulates passage molecules into bloodstream. aim this review to examine various components assessing their system, focus on immunological homeostasis inflammation.

Язык: Английский

---

Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management

Food Science & Nutrition, Год журнала: 2023, Номер 11(4), С. 1671 - 1704

Опубликована: Март 7, 2023

Dysfunction of gut barrier is known as "leaky gut" or increased intestinal permeability. Numerous recent scientific evidences showed the association between dysfunction and multiple gastrointestinal tract (GI) non-GI diseases. Research also demonstrated that food plays a crucial role to cause remedy related We reviewed articles from electronic databases, mainly PubMed. The data were based on animal models, cell human research in vivo vitro models. In this comprehensive review, our aim focused relationship dietary factors, permeability dysfunction, This review synthesizes currently available literature discussed three parts: (a) mechanism function, (b) supplements may promote health, medication alter (c) table organizes synthesized information by general mechanisms for diseases leaky gut/intestinal associated influences. With future research, intervention could be new target individualized disease prevention management.

Язык: Английский

---