Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(12)
Опубликована: Дек. 5, 2024
Psoriasis
is
a
chronic
and
incurable
skin
inflammation
driven
by
an
abnormal
immune
response.
Our
study
aims
to
investigate
the
potential
of
interferon-γ
(IFN-γ)
primed
mesenchymal
stem
cells
(IMSCs)
in
targeting
T
attenuate
psoriasis-like
inflammation,
elucidate
underlying
molecular
mechanism
involved.
Mesenchymal
(MSCs)
were
isolated
from
umbilical
cord
identified
based
on
their
surface
markers.
models
established
then
treated
with
IMSCs.
Flow
cytometry
analysis
was
used
examine
cell
markers
percentages.
Indoleamine-2,3-dioxygenase
(IDO)
knocked
down
small
interfering
RNA
(siRNA)
examined
western
blot
assay.
The
proliferative
capacity
assessed
using
water-soluble
tetrazolium
salt-1(WST-1).
Additionally,
immunohistochemical
assay
determine
epidermal
thickness.
psoriasis
area
severity
index
(PASI)
scores
also
assessed.
We
observed
significant
therapeutic
efficacy
IMSCs
against
mice.
Treatment
resulted
notable
reduction
infiltration
within
psoriatic
lesions.
Furthermore,
we
demonstrated
that
mediated
upregulation
IDO
through
IFN-γ
stimulation.
In
vitro,
inhibited
proliferation,
vivo,
eliminated
when
MSCs
transfected
siRNA.
can
treat
suppressing
suppression
IDO.
Cells,
Год журнала:
2023,
Номер
12(1), С. 184 - 184
Опубликована: Янв. 2, 2023
Immune
cells
and
commensal
microbes
in
the
human
intestine
constantly
communicate
with
react
to
each
other
a
stable
environment
order
maintain
healthy
immune
activities.
system-microbiota
cross-talk
relies
on
complex
network
of
pathways
that
sustain
balance
between
tolerance
immunogenicity.
Probiotic
bacteria
can
interact
stimulate
intestinal
microflora
modulate
specific
functions
homeostasis.
Growing
evidence
shows
probiotic
present
important
health-promoting
immunomodulatory
properties.
Thus,
use
probiotics
might
represent
promising
approach
for
improving
system
So
far,
few
studies
have
been
reported
beneficial
modulatory
effect
probiotics.
However,
many
others,
which
are
mainly
focused
their
metabolic/nutritional
properties,
published.
Therefore,
mechanisms
behind
interaction
host
only
partially
described.
The
review
aims
collect
summarize
most
recent
scientific
results
resulting
implications
how
improve
functions.
Hence,
description
currently
known
is
provided.
JDDG Journal der Deutschen Dermatologischen Gesellschaft,
Год журнала:
2023,
Номер
21(4), С. 363 - 372
Опубликована: Апрель 1, 2023
Summary
The
study
of
psoriasis
has
yielded
fundamental
new
insights
into
immunologic
regulation
and
innovative
therapies
in
a
way
that
few
other
diseases
have.
In
this
review,
we
summarize
the
main
features
current
research
with
emphasis
on
pathophysiological
processes
milestones
approval
various
biologics
small
molecule
drugs.
Thus,
through
research,
are
gaining
better
understanding
interplay
between
components
innate
adaptive
immune
systems.
New
therapeutics
interfere
crucial
regulatory
networks.
Based
knowledge,
outline
what
believe
to
be
some
most
important
future
directions
therapeutic
clinical
developments
psoriasis.
These
span
multiple
areas,
ranging
from
genetic,
epigenetic,
cellular,
immunological
mechanisms
studies
particular
forms
psoriasis,
individual
systemic
effects
disease
its
treatment,
incorporation
large
connected
data
sets
artificial
intelligence.
goal
is
understand
holistically,
molecular
organismic
societal
levels,
order
develop
individualized
prevention
treatment
strategies.
Despite
impressive
progress,
must
continue
evolve
at
both
smallest
largest
scales
comprehensively
address
needs
physicians
patients.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Авг. 7, 2024
Psoriasis
is
one
of
the
most
common
autoimmune
skin
diseases.
Increasing
evidence
shows
that
alterations
in
diversity
and
function
microbiota
can
participate
pathogenesis
psoriasis
through
various
pathways
mechanisms.
Journal of Applied Microbiology,
Год журнала:
2025,
Номер
136(5)
Опубликована: Май 1, 2025
Abstract
The
skin
microbiome
is
an
essential
component
on
our
and
critical
for
the
maintenance
of
health.
It
consists
a
diverse
ecosystem
bacteria,
fungi,
viruses.
Different
body
sites
in
humans
exhibit
vastly
different
levels
sebum,
temperature,
pH,
therefore
microbes
that
colonize
these
areas
have
adapted
to
create
niche
colonization.
Healthy
microbial
diversity
important
normal
function
skin,
imbalances
been
found
correlate
with
several
diseases,
such
as
atopic
dermatitis,
acne
vulgaris,
psoriasis,
chronic
wound
infections.
These
microorganisms,
especially
commensal
produce
various
metabolites
short-chain
fatty
acids,
antimicrobial
peptides,
siderophores,
tryptophan-derived
metabolites.
can
interact
aid
host
processes,
healing
colonization
resistance.
Metabolites
produced
by
commensals
promising
therapeutical
potential
drug-resistant
bacterial
infections
place
conventional
antibiotics
combat
widespread
antibiotic
In
this
review,
we
will
discuss
composition
microbiota
classes
its
members,
well
how
changes
impact
certain
disease
conditions.
