Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Март 10, 2023
Abstract
Mild
cognitive
impairment
(MCI)
generally
signifies
a
transitional
clinical
stage
prior
to
dementia.
Cognitive
working
is
dynamic
process
where
both
functional
decline
and
improvement
are
mutual.
Patients
with
amnestic
MCI
have
high
risk
progress
toward
Alzheimer’s
disease.
Both
mild
sporadic
disease
multifactorial
disorders
consequential
from
multifaceted
cross-talk
among
molecular
biological
processes.
Non-coding
RNAs
play
an
important
role
in
the
regulation
of
gene
expression,
mainly
long
non-coding
(lncRNAs),
that
regulate
other
RNA
transcripts
through
binding
microRNAs.
Cross-talk
between
RNAs,
including
coding
produces
significant
regulatory
network
all
transcriptome.
The
relationship
genes
non-codingRNAscould
improve
knowledge
genetic
factors
contributing
predisposition
pathophysiology
MCI.
objective
this
study
was
identify
expression
patterns
relevant
lncRNA-associated
miRNA
axes
blood
patients,
which
includes
lncRNA-
HAR1A,
HAR1B,
lncRNA-MEG9,
lncRNA-ST7-AS1,
lncRNA-TUNAR.
Microarray
investigations
demonstrated
modifications
(lncRNA)
patients
compared
control
samples.
This
first
explore
lncRNA
profiles
Impairment
blood.
Our
proposals
targets
involved
pathways
connected
pathogenesis
Journal of Neuroinflammation,
Год журнала:
2022,
Номер
19(1)
Опубликована: Ноя. 19, 2022
Abstract
Zinc
finger
E-box
binding
homeobox
1
(ZEB1)
is
a
master
modulator
of
the
epithelial–mesenchymal
transition
(EMT),
process
whereby
epithelial
cells
undergo
series
molecular
changes
and
express
certain
characteristics
mesenchymal
cells.
ZEB1,
in
association
with
other
EMT
transcription
factors,
promotes
neuroinflammation
through
production
inflammatory
mediators,
morphology
function
immune
cells,
multiple
signaling
pathways
that
mediate
response.
The
ZEB1–neuroinflammation
axis
plays
pivotal
role
pathogenesis
different
CNS
disorders,
such
as
brain
tumors,
sclerosis,
cerebrovascular
diseases,
neuropathic
pain,
by
promoting
tumor
cell
proliferation
invasiveness,
formation
hostile
micromilieu
surrounding
neuronal
tissues,
dysfunction
microglia
astrocytes,
impairment
angiogenesis,
blood–brain
barrier.
Future
studies
are
needed
to
elucidate
whether
could
serve
diagnostic,
prognostic,
and/or
therapeutic
target
for
disorders.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Март 30, 2022
Energy
metabolism
reprogramming
is
the
characteristic
feature
of
tumors.
The
tumorigenesis,
metastasis,
and
drug
resistance
ovarian
cancer
(OC)
dependent
on
energy
metabolism.
Even
under
adequate
oxygen
conditions,
OC
cells
tend
to
convert
glucose
lactate,
glycolysis
can
rapidly
produce
ATP
meet
their
metabolic
needs.
Non-coding
RNAs
(ncRNAs)
interact
directly
with
DNA,
RNA,
proteins
function
as
an
essential
regulatory
in
gene
expression
tumor
pathology.
Studies
have
shown
that
ncRNAs
regulate
process
by
interacting
predominant
enzyme
cellular
signaling
pathway,
participating
tumorigenesis
progression.
This
review
summarizes
mechanism
regulation
investigates
potential
therapeutic
targets.
Neurobiology of Disease,
Год журнала:
2023,
Номер
178, С. 106032 - 106032
Опубликована: Фев. 6, 2023
The
runt-related
transcription
factor-1
(RUNX1)
gene
with
its
lncRNA
RUNXOR
are
recently
becoming
a
research
focus
in
various
diseases,
specifically
immune-related
diseases
as
they
implicated
multiple
pathways.
Interestingly,
their
role
sclerosis
(MS)
remains
unstudied.
present
study
explored
the
of
RUNXOR/RUNX1
development
and
progression
MS
investigated
possible
mechanism
action.
We
measured
serum
expression
levels
RUNXOR,
well
RUNX1,
microtubule
associated
protein
2
(MAP2),
nerve
growth
factor
(NGF)
brain-derived
neurotrophic
(BDNF)
mRNAs
30
healthy
controls
120
patients
subdivided
into
4
groups:
clinically
isolated
syndrome
patients,
relapsing-remitting
(RRMS)
relapse,
RRMS
remission
secondary
progressive
patients.
Additionally,
we
MAP2,
NGF,
BDNF
interleukin-10
(IL-10).
All
RNA
were
markedly
downregulated
and,
consequently,
IL-10
significantly
decreased
compared
to
controls.
Moreover,
parameters
varied
within
groups.
According
receiver-operating-characteristic
(ROC)
curve
logistic
regression
analyses,
RUNX1
mRNA
predictors
disease
progression,
addition
exhibiting
diagnostic
potential.
Altogether,
this
suggests
implication
RUNXOR-RUNX1
axis
development,
increased
MS-related
disability,
highlights
potential
utility
studied
promising
diagnostic/prognostic
biomarkers
for
MS.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8751 - 8751
Опубликована: Авг. 11, 2024
Primary
progressive
multiple
sclerosis
(PPMS),
the
least
frequent
type
of
(MS),
is
characterized
by
a
specific
course
and
clinical
symptoms,
it
associated
with
poor
prognosis.
It
requires
extensive
differential
diagnosis
often
long-term
follow-up
before
its
correct
recognition.
Despite
recent
progress
in
research
into
treatment
for
MS,
management
this
disease
still
poses
challenge.
Considering
modern
concept
progression
“smoldering”
throughout
all
stages
disease,
thorough
exploration
PPMS
may
provide
better
insight
mechanisms
potential
implications.
The
goal
study
was
to
review
current
evidence
from
investigations
PPMS,
including
background,
characteristics,
biomarkers
therapeutic
opportunities.
Processes
underlying
CNS
damage
are
discussed,
chronic
immune-mediated
inflammation,
neurodegeneration,
remyelination
failure.
A
clinical,
biochemical
radiological
presented,
which
useful
monitoring
predicting
PPMS.
Therapeutic
options
summarized,
approved
therapies,
ongoing
trials
future
directions
investigations.
implications
findings
would
be
reliable
assessments
outcomes,
improvements
individualized
approaches
and,
hopefully,
novel
targets,
relevant
progression.
Frontiers in Genetics,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 26, 2022
Long
non-coding
RNAs
(lncRNAs)
have
been
demonstrated
to
in
the
pathophysiology
of
multiple
sclerosis
(MS).
In
order
appraise
role
T
cell-related
lncRNAs
this
disorder,
we
assessed
expressions
NEST,
RMRP,
TH2-LCR,
MAFTRR
and
FLICR
MS
patients
healthy
individuals.
We
detected
significant
difference
expression
RMRP
between
cases
controls.
There
were
substantial
correlations
among
patients,
but
not
The
strongest
found
with
correlation
coefficients
0.69
0.59,
respectively.
ROC
curve
analysis
revealed
appropriate
power
differentiating
controls
(AUC
value
=
0.84).
Expression
NEST
lncRNA
was
positively
correlated
disease
duration
negatively
age
at
onset.
brief,
reported
dysregulation
two
proposed
as
a
putative
marker
for
disorder.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 6, 2023
Idiopathic
inflammatory
myopathies
(IIMs)
are
common
autoimmune
diseases
that
affect
skeletal
muscle
quality
and
function.
The
lack
of
an
early
diagnosis
treatment
can
lead
to
irreversible
damage.
Non-coding
RNAs
(ncRNAs)
play
important
role
in
transfer,
regeneration,
differentiation,
regulation
specific
antibody
levels
pain
IIMs.
ncRNAs
be
detected
blood
hair;
therefore,
detection
has
great
potential
for
diagnosing,
preventing,
treating
IIMs
conjunction
with
other
methods.
However,
the
roles
mechanisms
underlying
their
subtypes
remain
unclear.
Here,
we
review
by
which
micro
long
non-coding
RNA-messenger
RNA
networks
regulate
provide
a
basis
use
as
diagnostic
tools
therapeutic
targets
Biomedicines,
Год журнала:
2023,
Номер
11(11), С. 2963 - 2963
Опубликована: Ноя. 2, 2023
Mild
cognitive
impairment
(MCI)
is
a
transitional
clinical
stage
prior
to
dementia.
Patients
with
amnestic
MCI
have
high
risk
of
progression
toward
Alzheimer's
disease.
Both
mild
and
sporadic
disease
are
multifactorial
disorders
consequential
from
multifaceted
cross-talk
among
molecular
biological
processes.
Non-coding
RNAs
play
an
important
role
in
the
regulation
gene
expression,
mainly
long
non-coding
(lncRNAs),
that
regulate
other
RNA
transcripts
through
binding
microRNAs.
Cross-talk
between
RNAs,
including
coding
produces
significant
regulatory
network
all
transcriptome.
The
relationship
genes
could
improve
knowledge
genetic
factors
contributing
predisposition
pathophysiology
MCI.
objective
this
study
was
identify
expression
patterns
relevant
lncRNA-associated
miRNA
axes
blood
patients,
which
includes
lncRNA-SNHG16,
lncRNA-H19,
lncRNA-NEAT1.
Microarray
investigations
demonstrated
modifications
(lncRNA)
patients
compared
control
samples.
This
first
explore
lncRNA
profiles
blood.
Our
proposes
targets
involved
pathways
connected
pathogenesis
Journal of Neurochemistry,
Год журнала:
2024,
Номер
169(1)
Опубликована: Авг. 28, 2024
Abstract
The
α4β2
nAChRs
are
crucial
ion
channels
that
control
neurotransmitter
release
and
play
a
role
in
various
physiologic
pathologic
processes.
CHRNA4
encodes
the
α4‐nAChRs,
while
CHRNB2
β2‐nAChRs.
Recent
studies
have
found
different
variants
of
α4β2‐nAChRs
individuals
with
conditions
such
as
AD,
ADHD,
ALS,
PD,
brain
abnormalities.
We
conducted
scoping
review
following
six‐stage
methodology
structure
adhering
to
PRISMA
guidelines.
systematically
reviewed
articles
using
relevant
keywords
up
October
2,
2023.
In
this
summary,
we
cover
clinical
symptoms
reported,
genes
protein
CHRNB2,
mutations
these
genes,
inheritance
patterns,
functional
impact
polymorphisms
epidemiology
diseases.
research
indicates
may
significant
neurodegenerative
disorders,
possibly
impacting
neuronal
function
through
yet
undiscovered
regulatory
pathways.
Studying
how
interact
disease‐related
aggregates
lead
new
treatment
options
for
disorders.
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