Novel Panel of Long Noncoding RNAs as Diagnostic Biomarkers for Amnestic Mild Cognitive Impairment in Peripheral Blood

Journal of Alzheimer s Disease, Год журнала: 2024, Номер 99(4), С. 1385 - 1396

Опубликована: Май 20, 2024

Background: Long noncoding RNAs (lncRNAs) regulate the pathogenesis of Alzheimer’s disease (AD). Objective: To identify lncRNAs in peripheral blood as potential diagnostic biomarkers for amnestic mild cognitive impairment. Methods: In discovery group, a microarray was used to screen significant differences lncRNA expression between patients with impairment (MCI) caused by AD and normal controls (NCs) ( n = 10; MCI, 5; NC, 5). Furthermore, two analytic groups were assessed (analytic group 1: MCI (aMCI), 2: 30; AD, aMCI, 10) finalized validation 150; 50; 50). groups, real-time quantitative reverse-transcription polymerase chain reaction differentially expressed aMCI NC groups. Results: We identified 67 upregulated 220 downregulated among profiles. The panel T324988, NR_024049, ENST00000567919, ENST00000549762 displayed highest discrimination ability NCs. area under receiver operating characteristic curve this combined model 0.941, sensitivity 92.00% specificity 84.00%. Conclusions: This study reports on four promising diagnose aMCIs.

Язык: Английский

LncRNA 51A: A promising diagnostic biomarker for assessing cognitive decline in occupationally exposed aluminum workers

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 111, С. 104548 - 104548

Опубликована: Авг. 31, 2024

Язык: Английский