Long-Term Implicit Epigenetic Stress Information in the Enteric Nervous System and its Contribution to Developing and Perpetuating IBS DOI Creative Commons
Noémi Császár-Nagy, Petr Bob, István Bókkon

и другие.

Current Neuropharmacology, Год журнала: 2024, Номер 22(13), С. 2100 - 2112

Опубликована: Май 10, 2024

: Psychiatric and mood disorders may play an important role in the development persistence of irritable bowel syndrome (IBS). Previously, we hypothesized that stress-induced implicit memories persist throughout life via epigenetic processes enteric nervous system (ENS), independent central (CNS). These ENS contribute to developing perpetuating IBS. Here, further elaborate on our earlier hypothesis. That is, during pregnancy, maternal prenatal stresses perturb HPA axis increase circulating cortisol levels, which can affect gut microbiota. Maternal cross placental barrier cortisol-circulating levels fetus. This leads dysregulation axis, affecting microbiota, microbial metabolites, intestinal permeability Microbial such as short-chain fatty acids (which also regulate fetal ENS), modulate a range diseases by inducing changes. mentioned suggest stress-related, implicit, long-term be programmed into pregnancy. Subsequently, this stress information from could conveyed CNS through bidirectional microbiota-gut-brain (MGBA), leading perturbed functional connectivity among various brain networks affective pain processes.

Язык: Английский

Rapid shift of gut microbiome and enrichment of beneficial microbes during arhatic yoga meditation retreat in a single-arm pilot study DOI Creative Commons
Sanjay Swarup, Abhishek Gupta, Mei Chung

и другие.

BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 13, 2025

The human microbiome plays a vital role in health, mediated by the gut–brain axis, with large diversity of functions and physiological benefits. dynamics mechanisms meditations on oral gut modulations are not well understood. This study investigates short-term during an Arhatic Yoga meditation retreat as improving well-being through possible gut-brain axis. A single-arm pilot clinical trial was conducted controlled environment 9-day intensive practices vegetarian diet. Oral fecal samples 24 practitioners were collected at start (Day0: T1), middle (Day3: T2), end (Day9:T3) retreat. Targeted 16S rRNA gene amplicon sequencing performed for both samples. Functional pathway predictions identified using phylogenetic investigation communities reconstruction unobserved states (PICRUSt2). DESeq2 used to identify differential abundant taxa. Various statistical analyses assess significant changes data. Our findings revealed that together diet led profiles within profile showed (p < 0.05) difference species richness evenness study, while non-metric multidimensional scaling (NMDS) confirmed shift T2 timepoint, which further supported PERMANOVA analysis 0.05). Health-benefiting microbes known improve gastrointestinal gut-barrier functions, immune modulation, axis enriched. Gut beginner advanced similar trends convergence study. implies strong selection pressure beneficial microbiome. demonstrates combined short resulted enrichment health-promoting microbes. Such microbial consortia may be developed potential health benefits probiotics systems, Study submitted https://clinicaltrials.gov/on28-02-2024 . Retrospective registered.

Язык: Английский

Процитировано

2
Fecal microbiota transplantation for the management of autoimmune diseases: Potential mechanisms and challenges DOI
Xiaomin Liu, Mei Liu, Ming Zhao

и другие.

Journal of Autoimmunity, Год журнала: 2023, Номер 141, С. 103109 - 103109

Опубликована: Сен. 10, 2023

Язык: Английский

Процитировано

21
Regulation of colonic neuropeptide Y expression by the gut microbiome in patients with ulcerative colitis and its association with anxiety- and depression-like behavior in mice DOI Creative Commons
Min-Kyung Joo, Jae Wook Lee, Jeong‐Hwa Woo

и другие.

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 25, 2024

Patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC), show an increased incidence of anxiety and depression; however, the association between UC-associated psychiatric disorders gut microbiota is unclear. This study aimed to examine whether from patients UC can alter colonic gene expression, leading anxiety- depression-like behavior in mice receiving fecal transplantation (FMT). RNA sequencing transcriptome analyses revealed a difference expression FMT (UC-FMT mice) those healthy controls (HC-FMT mice). Gene ontology analysis downregulation neuropeptide signaling pathways, Y (NPY) colons UC-FMT mice. The protein levels NPY also decreased colon plasma compared HC-FMT oral administration

Язык: Английский

Процитировано

9
The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients DOI Open Access

Oana Belei,

Diana-Georgiana Basaca,

Laura Olariu

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(5), С. 1361 - 1361

Опубликована: Фев. 27, 2024

Inflammatory bowel diseases (IBDs) have seen an exponential increase in incidence, particularly among pediatric patients. Psychological stress is a significant risk factor influencing the disease course. This review assesses interaction between and progression, focusing on articles that quantified inflammatory markers IBD patients exposed to varying degrees of psychological stress.

Язык: Английский

Процитировано

8
Stressing Out Cancer: Chronic Stress Induces Dysbiosis and Enhances Colon Cancer Growth DOI
Shannon E. McCollum, Yatrik M. Shah

Cancer Research, Год журнала: 2024, Номер 84(5), С. 645 - 647

Опубликована: Март 4, 2024

Abstract Psychologic stress significantly impacts colorectal cancer, and chronic is known to decrease treatment efficacy survival rates in patients with cancer. Previous studies have linked psychologic changes the gut microbiota, role of microbiota cancer progression well characterized. Despite this, mechanistic link between remains unclear. In this issue Cancer Research, Cao colleagues reveal that exacerbates by reducing presence Lactobacillus johnsonii (L. johnsonii) its metabolite protocatechuic acid (PCA). The authors demonstrate an increase β-catenin expression as major mechanism which potentiates stemness pathogenesis. Administration L. or PCA stressed mice decreased activity progression. This study defines a precise underlying progression, emphasizing relevance well-being outcome. addition, demonstrates potential supplementation promising therapeutics for treatment. See related article et al., p. 771

Язык: Английский

Процитировано

8
Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia’s Gut Feeling DOI Creative Commons
Gohar Fakhfouri, Nataša R. Mijailović, Reza Rahimian

и другие.

Cells, Год журнала: 2024, Номер 13(2), С. 177 - 177

Опубликована: Янв. 17, 2024

Inflammatory bowel disease (IBD), a common term for Crohn’s and ulcerative colitis, is chronic, relapse-remitting condition of the gastrointestinal tract that increasing worldwide. Psychiatric comorbidities, including depression anxiety, are more prevalent in IBD patients than healthy individuals. Evidence suggests varying levels neuroinflammation might underlie these states patients. Within this context, microglia crucial non-neural cells brain responsible innate immune responses following inflammatory insults. Alterations microglia’s functions, such as secretory profile, phagocytic activity, synaptic pruning, play significant roles mediating psychiatric manifestations IBD. In review, we discuss role played by IBD-associated comorbidities.

Язык: Английский

Процитировано

7
Role of the gut microbiome in psychological symptoms associated with inflammatory bowel diseases DOI Creative Commons
Konstantina Atanasova,

Laura-Louise Knödler,

Wolfgang Reindl

и другие.

Seminars in Immunopathology, Год журнала: 2025, Номер 47(1)

Опубликована: Янв. 27, 2025

Abstract The brain-gut axis constitutes the basis for bidirectional communication between central nervous system and gastrointestinal tract driven by neural, hormonal, metabolic, immunological, microbial signals. Alterations in gut microbiome composition as observed inflammatory bowel diseases can modulate brain function emerging empirical evidence has indicated that interactions among microbiome-axis seem to play a significant role pathogenesis of both psychiatric disorders their comorbidity. Yet, immunological molecular mechanisms underlying co-occurrence psychological symptoms are still poorly understood. aim this narrative review is highlight contemporary findings supporting pivotal pathophysiology highly prevalent neuropsychiatric such fatigue, depression, anxiety. Finally, we focus on modulation potential treatment option comorbid immune-mediated especially diseases. High-quality clinical trials required clarify how through dietary interventions or probiotic, prebiotic synbiotic be used clinically improve mental health thus quality life patients with

Язык: Английский

Процитировано

1
Interactions Between Antidepressants and Intestinal Microbiota DOI Creative Commons

Feiyu Xu,

Qinglian Xie,

Weihong Kuang

и другие.

Neurotherapeutics, Год журнала: 2023, Номер 20(2), С. 359 - 371

Опубликована: Март 1, 2023

Язык: Английский

Процитировано

16
Allostatic load increases the incidence and risk of adverse prognosis in inflammatory bowel disease DOI Creative Commons
Jianhui Zhao, Erxu Xue,

Siyun Zhou

и другие.

Alimentary Pharmacology & Therapeutics, Год журнала: 2024, Номер 60(8), С. 1062 - 1074

Опубликована: Авг. 21, 2024

Elevated allostatic load (AL) has been associated with the risk and poor prognosis of many chronic diseases. The association between AL inflammatory bowel disease (IBD) is unknown.

Язык: Английский

Процитировано

6
Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood DOI Creative Commons
Andreea Sălcudean, Andreea Georgiana Nan,

Cristina Raluca Bodo

и другие.

Diagnostics, Год журнала: 2023, Номер 13(11), С. 1868 - 1868

Опубликована: Май 26, 2023

Inflammatory bowel disease (IBD), which includes Crohn’s disease, ulcerative colitis, and unspecified inflammatory is a chronic, unpredictable immune-mediated condition of the gastrointestinal tract. In pediatric populations, diagnosis chronic debilitating pathology significantly reduces quality life. Children diagnosed with IBD may cope physical symptoms such as abdominal pain or fatigue, but mental emotional well-being are also important for preventing reducing risk developing psychiatric conditions. Short stature, growth delay delayed puberty can contribute to poor body image low self-esteem. Furthermore, treatment per se alter psycho-social functioning due side effects medication surgical procedures colostomy. It essential acknowledge treat early signs distress in order prevent development serious disorders adult The literature underlines importance incorporating psychological health services part management disease. Diagnosing problems patients improve their adherence course and, consequently, reduce long-term morbidity mortality.

Язык: Английский

Процитировано

13