Using metabolomics to investigate the relationship between the metabolomic profile of the intestinal microbiota derivatives and mental disorders in inflammatory bowel diseases: a narrative review DOI Creative Commons

Parvin Zarei,

Peyman Adibi, Ahmad Vaez

et al.

Research in Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 20(1), P. 1 - 24

Published: Jan. 1, 2025

Individuals with inflammatory bowel disease (IBD) are at a higher risk of developing mental disorders, such as anxiety and depression. The imbalance between the intestinal microbiota its host, known dysbiosis, is one factors, disrupting balance metabolite production their signaling pathways, leading to progression. A metabolomics approach can help identify role gut in disorders associated IBD by evaluating metabolites comprehensively. This narrative review focuses on studies that have comprehensively elucidated altered microbial pathways underlying patients. information was compiled searching PubMed, Web Science, Scopus, Google Scholar from 2005 2023. findings indicated dysbiosis patients leads depression through disturbances metabolism carbohydrates, sphingolipids, bile acids, neurotransmitters, neuroprotective, amino acids. Furthermore, reduction neuroprotective factors increase inflammation observed these also contribute worsening psychological symptoms. Analyzing profile comparing it healthy individuals using advanced technologies like metabolomics, aids early diagnosis prevention disorders. allows for more precise identification microbes responsible production, enabling development tailored dietary pharmaceutical interventions or targeted manipulation microbiota.

Language: Английский

Regulation of colonic neuropeptide Y expression by the gut microbiome in patients with ulcerative colitis and its association with anxiety- and depression-like behavior in mice DOI Creative Commons
Min-Kyung Joo, Jae Wook Lee, Jeong‐Hwa Woo

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 25, 2024

Patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC), show an increased incidence of anxiety and depression; however, the association between UC-associated psychiatric disorders gut microbiota is unclear. This study aimed to examine whether from patients UC can alter colonic gene expression, leading anxiety- depression-like behavior in mice receiving fecal transplantation (FMT). RNA sequencing transcriptome analyses revealed a difference expression FMT (UC-FMT mice) those healthy controls (HC-FMT mice). Gene ontology analysis downregulation neuropeptide signaling pathways, Y (NPY) colons UC-FMT mice. The protein levels NPY also decreased colon plasma compared HC-FMT oral administration

Language: Английский

Citations

8
The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients DOI Open Access

Oana Belei,

Diana-Georgiana Basaca,

Laura Olariu

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(5), P. 1361 - 1361

Published: Feb. 27, 2024

Inflammatory bowel diseases (IBDs) have seen an exponential increase in incidence, particularly among pediatric patients. Psychological stress is a significant risk factor influencing the disease course. This review assesses interaction between and progression, focusing on articles that quantified inflammatory markers IBD patients exposed to varying degrees of psychological stress.

Language: Английский

Citations

8
Psychological impairment in inflammatory bowel diseases: the key role of coping and defense mechanisms DOI Creative Commons
Gabriella Martino, Anna Viola, Carmelo M. Vicario

et al.

Research in Psychotherapy Psychopathology Process and Outcome, Journal Year: 2024, Volume and Issue: 26(3)

Published: Jan. 15, 2024

A comprehensive investigation of psychological features in chronic patients is very important for tailoring effective treatments. In this study we tested anxiety, depression, health related quality life (HR-QoL), alexithymia, coping styles, and defense mechanisms, eighty-four with Crohn disease (CD) ulcerative colitis (UC). Participants reported low to moderate HRQoL apart from alexithymia. Women experienced lower QoL higher levels anxiety depressive symptoms. Coping strategies were distress symptoms QoL. Positive attitude principalization, showed negative associations alexithymia also found be associated mental health. CD used significantly more turning against objects (p=0.02) projections (p=0.01) UC reversal (p=0.04). Elderly women perceived Multiple regression analysis revealed depression independently Significant differences emerged styles among UC. participants maladaptive which distress, together level Findings suggest that aspects play a key role suffering inflammatory bowel diseases. multi-integrated clinical strategy including psychotherapeutic interventions should considered treating

Language: Английский

Citations

7
Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia’s Gut Feeling DOI Creative Commons
Gohar Fakhfouri, Nataša R. Mijailović, Reza Rahimian

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 177 - 177

Published: Jan. 17, 2024

Inflammatory bowel disease (IBD), a common term for Crohn’s and ulcerative colitis, is chronic, relapse-remitting condition of the gastrointestinal tract that increasing worldwide. Psychiatric comorbidities, including depression anxiety, are more prevalent in IBD patients than healthy individuals. Evidence suggests varying levels neuroinflammation might underlie these states patients. Within this context, microglia crucial non-neural cells brain responsible innate immune responses following inflammatory insults. Alterations microglia’s functions, such as secretory profile, phagocytic activity, synaptic pruning, play significant roles mediating psychiatric manifestations IBD. In review, we discuss role played by IBD-associated comorbidities.

Language: Английский

Citations

7
Allostatic load increases the incidence and risk of adverse prognosis in inflammatory bowel disease DOI Creative Commons
Jianhui Zhao, Erxu Xue,

Siyun Zhou

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(8), P. 1062 - 1074

Published: Aug. 21, 2024

Elevated allostatic load (AL) has been associated with the risk and poor prognosis of many chronic diseases. The association between AL inflammatory bowel disease (IBD) is unknown.

Language: Английский

Citations

6
Interactions Between Antidepressants and Intestinal Microbiota DOI Creative Commons

Feiyu Xu,

Qinglian Xie,

Weihong Kuang

et al.

Neurotherapeutics, Journal Year: 2023, Volume and Issue: 20(2), P. 359 - 371

Published: March 1, 2023

Language: Английский

Citations

13
Stressing Out Cancer: Chronic Stress Induces Dysbiosis and Enhances Colon Cancer Growth DOI
Shannon E. McCollum, Yatrik M. Shah

Cancer Research, Journal Year: 2024, Volume and Issue: 84(5), P. 645 - 647

Published: March 4, 2024

Abstract Psychologic stress significantly impacts colorectal cancer, and chronic is known to decrease treatment efficacy survival rates in patients with cancer. Previous studies have linked psychologic changes the gut microbiota, role of microbiota cancer progression well characterized. Despite this, mechanistic link between remains unclear. In this issue Cancer Research, Cao colleagues reveal that exacerbates by reducing presence Lactobacillus johnsonii (L. johnsonii) its metabolite protocatechuic acid (PCA). The authors demonstrate an increase β-catenin expression as major mechanism which potentiates stemness pathogenesis. Administration L. or PCA stressed mice decreased activity progression. This study defines a precise underlying progression, emphasizing relevance well-being outcome. addition, demonstrates potential supplementation promising therapeutics for treatment. See related article et al., p. 771

Language: Английский

Citations

5
Impact of Helicobacter pylori Eradication on Inflammatory Bowel Disease Onset and Disease Activity: To Eradicate or Not to Eradicate? DOI Creative Commons
Antonietta Gerarda Gravina, Raffaele Pellegrino, Veronica Iascone

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(8), P. 179 - 179

Published: Aug. 8, 2024

Helicobacter pylori infection has significant epidemiological relevance due to the carcinogenic nature of this bacterium, which is potentially associated with cancer. When detected, it should ideally be eradicated using a treatment that currently involves combination gastric acid suppressors and multiple antibiotics. However, raises questions regarding efficacy safety profiles in patients specific comorbidities, including inflammatory bowel diseases (IBD). Eradication therapy for H. includes components adverse gastrointestinal events, such as Clostridioides difficile colitis. This necessitates quantifying risk through dedicated studies determine whether antimicrobial could significantly IBD relapse or exacerbation pre-existing IBD, well lead de novo onset IBD. Although available evidence reassuring about eradication limited, there are no recommendations particular situation leading international guidelines. Therefore, need evaluate regimens both clinical trial settings real-life studies.

Language: Английский

Citations

5
Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer DOI Open Access

Abdo Jurjus,

Jad El Masri, Maya Ghazi

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1236 - 1236

Published: April 21, 2024

Inflammatory bowel disease (IBD), a continuum of chronic inflammatory diseases, is tightly associated with immune system dysregulation and dysbiosis, leading to inflammation in the gastrointestinal tract (GIT) multiple extraintestinal manifestations. The pathogenesis IBD not completely elucidated. However, it an increased risk colorectal cancer (CRC), which one most common malignancies. In both CRC, complex interplay occurs between gut microbiota (GM), alteration GM composition. Melatonin, neuroendocrine hormone, was found be involved this interplay, especially since present high amounts gut, some protective effects. Actually, melatonin enhances integrity intestinal mucosal barrier, regulates response, alleviates inflammation, attenuates oxidative stress. Thereby, authors summarize multifactorial interaction focusing on new findings related mechanisms action addition its documented positive outcomes treatment these two pathologies possible future perspectives use as adjuvant therapy.

Language: Английский

Citations

4
Anti-inflammatory and protective effects of Aripiprazole on TNBS-Induced colitis and associated depression in rats: Role of kynurenine pathway DOI

Afrooz Mohammadgholi-Beiki,

Mohammad Sheibani, Majid Jafari‐Sabet

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 133, P. 112158 - 112158

Published: April 30, 2024

Language: Английский

Citations

4