Non-Coding RNA,
Год журнала:
2025,
Номер
11(1), С. 7 - 7
Опубликована: Янв. 17, 2025
Psoriasis
is
a
chronic
immune-mediated
disease
with
complex
pathogenesis.
The
altered
proliferation
and
differentiation
of
keratinocytes,
together
the
activity
dendritic
cells
T
cells,
are
crucial
drivers
psoriasis
progression.
Long
non-coding
RNAs
(lncRNAs)
composed
over
200
nucleotides
exert
large
variety
functions,
including
regulation
gene
expression.
Under
pathological
conditions,
expression
lncRNAs
frequently
dysregulated.
Recent
studies
demonstrated
that
significantly
affect
major
cellular
processes,
their
aberrant
likely
involved
in
pathogenesis
various
disorders.
In
this
review,
we
will
discuss
role
pathophysiology
psoriasis.
We
summarize
recent
investigated
relationships
between
keratinocyte
pro-inflammatory
responses.
Journal of Orthopaedic Translation,
Год журнала:
2023,
Номер
41, С. 20 - 32
Опубликована: Июль 1, 2023
Synovial
mesenchymal
stem
cell
(SMSC)
exerts
chondroprotective
effects
in
osteoarthritis
(OA)
clinical
models.
However,
the
regulatory
potentials
of
SMSC-derived
exosomes
(SMSC-Exo)
OA
still
need
to
be
discovered,
which
attracted
our
attention.
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 283 - 299
Опубликована: Янв. 1, 2025
Lichen
sclerosus
(LS)
is
a
chronic
inflammatory
disease
affecting
skin
and
mucosal
tissues,
particularly
external
genitalia,
with
risk
of
cancer.
Its
etiology
unknown,
possibly
involving
immune
dysregulation
inflammation.
Study
used
DNA
methylation
(DNAme)
single-cell
RNA
sequencing
(scRNA-seq)
to
compare
LS
normal
skin.
A
detailed
DNAme
profile
was
created,
analyzing
differentially
methylated
probes
(DMPs)
cell
type-specific
DMPs.
EpiSCORE
deconvolution
infiltration
analyses
identified
altered
types
in
LS.
Immunohistochemistry
confirmed
cellular
changes.
Enrichment
analysis
significantly
pathways,
communication
described
interactions
among
patterns
generally
distinguished
from
skin,
few
exceptions.
Data
showed
that
T
cells
increased
fibroblasts
decreased
Immunohistochemical
staining
the
changes
cells.
DMPs
indicated
significant
impacts
on
fibroblast-related
processes
key
pathways.
The
COLLAGEN
signal
most
prominent
communication.
CD99-CD99
interaction
strongest
between
fibroblasts.
Combining
scRNA-seq
data
revealed
composition
pathways
LS,
enhancing
understanding
its
pathogenesis
highlighting
potential
therapeutic
targets
diagnostic
markers.
Journal of Complementary and Integrative Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Abstract
Fisetin,
a
flavonol
belonging
to
the
flavonoid
subclass,
is
ubiquitous
dietary
present
in
fruits
and
vegetables,
including
fruit
peels,
has
proven
potential
for
anticancer
activity,
especially
lung
cancer
–
leading
cause
of
cancer-related
deaths
globally.
The
current
paper
provides
most
detailed
elaborate
list
various
roles
fisetin
experimentally
induced
cells,
these
include
promotion
apoptosis,
inhibition
cell
proliferation,
migration,
invasion,
as
well
regulation
autophagy.
Among
molecular
targets,
some
identified
pathways,
such
PI3K/Akt,
MAPK,
NF-κB,
that
affects
are
crucial
tumor
formation,
so
it
can
be
considered
chemopreventive
agent.
Moreover,
improves
effectiveness
conventional
treatments
chemo-
radiosensitizer
minimizes
side
effects.
However,
overall
utility
clinical
use
now
somewhat
restricted
by
its
poor
solubility
short
half-life.
It
predicted
future
development
nanotechnologies
drug
delivery,
nanoparticle
encapsulation,
might
help
solve
difficulties.
Further
Preclinical
investigations
required
uniformly
determine
safety,
efficacy,
standard
dosage
consumption
therapy.
The
role
of
programmed
death-ligand
1
(PD-L1),
an
essential
immune
checkpoint
protein,
has
garnered
considerable
interest
in
recent
years
due
to
its
influence
on
responses,
particularly
inhibiting
immature
Th
cells
into
Th17
cells.
This
study
aims
examine
the
effect
PD-L1
psoriasis
progress,
which
is
condition
characterized
by
response
dominated
We
constructed
knockout
(PD-L1KO)
and
overexpression
(PD-L1OE)
mice
through
CRISPR/Cas9
technology
assess
impact
imiquimod
(IMQ)-induced
psoriasis-like
mouse
model.
In
comparison
IMQ,
ear
thickness
exhibited
a
reduction,
PASI
score
decreased,
HE
sections
revealed
thinning
epidermal
spines
PD-L1OE
mice.
PD-L1KO
mice,
however,
showed
opposite
results.
Moreover,
immunohistochemical
assessments
skin
lesion
tissues
demonstrated
heightened
proliferation
inflammatory
infiltration
group,
accompanied
elevated
tissue
expression
proliferating
cell
nuclear
antigen
(PCNA),
Nuclear
factor
kappa-light-chain-enhancer
activated
B
(NF-κB)
p50,
F4/80
IMQ-treated
WT
absence
IMQ-induced
was
found
intensify
response,
as
evidenced
phosphorylated
signal
transducers
activators
transcription
3
(pSTAT3)
CD3
affected
compared
both
According
our
findings,
plays
important
roles
inflammation,
proliferation,
regulating
responses.
Targeting
may
present
promising
therapeutic
strategy
for
management
psoriasis.
