Non-coding RNAs and neuroinflammation: implications for neurological disorders DOI Creative Commons
Yvonne Chen,

Julia Mateski,

Linda Gerace

и другие.

Experimental Biology and Medicine, Год журнала: 2024, Номер 249

Опубликована: Фев. 28, 2024

Neuroinflammation is considered a balanced inflammatory response important in the intrinsic repair process after injury or infection. Under chronic states of disease, injury, infection, persistent neuroinflammation results heightened presence cytokines, chemokines, and reactive oxygen species that result tissue damage. In CNS, surrounding microglia normally contain macrophages other innate immune cells perform active surveillance. The resulting cytokines produced by these affect growth, development, responsiveness present both white gray matter regions CNS. Controlling levels ultimately improves neurocognitive function lesions associated with neurologic disease. MicroRNAs (miRNAs) are master regulators genome subsequently control activity responses crucial sustaining robust acute immunological towards an infection while dampening pathways chemokines neuroinflammation. Numerous reports have directly implicated miRNAs controlling abundance interleukins, TGF-B, NF-kB, toll-like receptor-signaling intrinsically linked development neurological disorders such as Parkinson’s, ALS, epilepsy, Alzheimer’s, neuromuscular degeneration. This review focused on discussing role play regulating initiating states, many which maintain level and/or neuron-specific secondary messengers. Dysregulated microglia, astrocytes, oligodendrocytes, epididymal cells, contribute to overall glial-specific niche impacts neuronal conductivity, signaling action potentials, neurotransmitter robustness, neuron-neuron specific communication, neuron-muscular connections. Understanding regulate microglial activation step forward developing non-coding RNA-based therapeutics treat potentially correct behavioral cognitive deficits typically found patients suffering from

Язык: Английский

Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy DOI Creative Commons

Saixian Shi,

Ye Chen,

Zhijian Luo

и другие.

Cell Communication and Signaling, Год журнала: 2023, Номер 21(1)

Опубликована: Март 14, 2023

Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, alone or in combination variety of cancers, while it has been found to cause serious cardiac side effects clinical application. More more researchers are trying explore the molecular mechanisms DOX-induced cardiomyopathy (DIC), which oxidative stress inflammation considered play significant role. This review summarizes signaling pathways related DIC compounds that exert cardioprotective by acting on relevant pathways, including role Nrf2/Keap1/ARE, Sirt1/p66Shc, Sirt1/PPAR/PGC-1α NOS, NOX, Fe2+ stress, as well NLRP3/caspase-1/GSDMD, HMGB1/TLR4/MAPKs/NF-κB, mTOR/TFEB/NF-κB inflammation. Hence, we attempt explain terms inflammation, provide theoretical basis new idea for further drug research reducing DIC. Video Abstract.

Язык: Английский

Процитировано

116
The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets DOI Creative Commons

Alhamdu Adamu,

Shuo Li,

Fankai Gao

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Апрель 12, 2024

Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) certain stimuli such as trauma, infection, and neurodegenerative diseases. This is cellular immune response whereby glial cells are activated, inflammatory mediators liberated reactive oxygen nitrogen species synthesized. key process that helps protect brain from pathogens, but inappropriate, or protracted inflammation yields pathological states Parkinson’s disease, Alzheimer’s, Multiple Sclerosis, other disorders showcase various pathways neurodegeneration distributed in parts CNS. review reveals major neuroinflammatory signaling associated with neurodegeneration. Additionally, it explores promising therapeutic avenues, stem cell therapy, genetic intervention, nanoparticles, aiming regulate neuroinflammation potentially impede decelerate advancement these conditions. A comprehensive understanding intricate connection between diseases pivotal for development future treatment strategies can alleviate burden imposed by devastating disorders.

Язык: Английский

Процитировано

112
Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective Treatment DOI Creative Commons
Shane Whelan, Brigid Lucey, Karen Finn

и другие.

Microorganisms, Год журнала: 2023, Номер 11(9), С. 2169 - 2169

Опубликована: Авг. 28, 2023

Urinary tract infections (UTIs) are among the most common bacterial infections, especially women and older adults, leading to a significant global healthcare cost burden. Uropathogenic

Язык: Английский

Процитировано

68
Acute lung injury caused by sepsis: how does it happen? DOI Creative Commons
Baisheng Sun, M. Lei, Jiaqi Zhang

и другие.

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Ноя. 21, 2023

Sepsis is a systemic inflammatory disease caused by severe infections that involves multiple organs, among which the lung most susceptible, leaving patients highly vulnerable to acute injury (ALI). Refractory hypoxemia and respiratory distress are classic clinical symptoms of ALI sepsis, has mortality rate 40%. Despite extensive research on mechanisms exact pathological process not fully understood. This article reviews advances in pathogenesis sepsis focusing treatment regimens adopted practice for corresponding molecular mechanisms. review can only contribute theories but also recommend new strategies related injuries.

Язык: Английский

Процитировано

48
HIV–Host Cell Interactions DOI Creative Commons
Sepiso K. Masenga, Bislom C. Mweene, Emmanuel Luwaya

и другие.

Cells, Год журнала: 2023, Номер 12(10), С. 1351 - 1351

Опубликована: Май 9, 2023

The development of antiretroviral drugs (ARVs) was a great milestone in the management HIV infection. ARVs suppress viral activity host cell, thus minimizing injury to cells and prolonging life. However, an effective treatment has remained elusive for four decades due successful immune evasion mechanisms virus. A thorough understanding molecular interaction with cell is essential both preventive curative therapies This review highlights several inherent that promote its survival propagation, such as targeting CD4+ lymphocytes, downregulation MHC class I II, antigenic variation envelope complex minimizes antibody access, how they collaboratively render system unable mount response.

Язык: Английский

Процитировано

46
Molecular Mechanisms for the Vicious Cycle between Insulin Resistance and the Inflammatory Response in Obesity DOI Open Access
Dariusz Szukiewicz

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 9818 - 9818

Опубликована: Июнь 6, 2023

The comprehensive anabolic effects of insulin throughout the body, in addition to control glycemia, include ensuring lipid homeostasis and anti-inflammatory modulation, especially adipose tissue (AT). prevalence obesity, defined as a body mass index (BMI) ≥ 30 kg/m2, has been increasing worldwide on pandemic scale with accompanying syndemic health problems, including glucose intolerance, resistance (IR), diabetes. Impaired sensitivity or IR paradoxically leads diseases an inflammatory component despite hyperinsulinemia. Therefore, excess visceral AT obesity initiates chronic low-grade conditions that interfere signaling via receptors (INSRs). Moreover, response IR, hyperglycemia itself stimulates primarily defensive associated subsequent release numerous cytokines real threat organ function deterioration. In this review, all components vicious cycle are characterized particular emphasis interplay between both innate adaptive immune responses related obesity. Increased accumulation should be considered main environmental factor responsible for disruption epigenetic regulatory mechanisms system, resulting autoimmunity inflammation.

Язык: Английский

Процитировано

44
Inflammasomes in neurological disorders — mechanisms and therapeutic potential DOI
Kishore Aravind Ravichandran, Michael T. Heneka

Nature Reviews Neurology, Год журнала: 2024, Номер 20(2), С. 67 - 83

Опубликована: Янв. 9, 2024

Язык: Английский

Процитировано

40
Macrophage plasticity: signaling pathways, tissue repair, and regeneration DOI Creative Commons
Lingfeng Yan, Jue Wang,

Xin Cai

и другие.

MedComm, Год журнала: 2024, Номер 5(8)

Опубликована: Авг. 1, 2024

Abstract Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) alternatively (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay signaling pathways, transcriptional regulators, epigenetic modifications orchestrates polarization, allowing respond stimuli dynamically. Here, we provide comprehensive overview the cascades governing focusing on roles Toll‐like receptors, signal transducer activator transcription proteins, nuclear microRNAs. We also discuss emerging concepts metabolic reprogramming trained immunity, contributing their functional adaptability. Macrophage plasticity plays pivotal role in repair regeneration, macrophages coordinating inflammation, angiogenesis, matrix remodeling restore homeostasis. By harnessing potential novel therapeutic strategies targeting polarization could be developed for diseases, including chronic wounds, fibrotic disorders, inflammatory conditions. Ultimately, deeper understanding molecular mechanisms underpinning will pave way innovative regenerative medicine engineering approaches.

Язык: Английский

Процитировано

38
Inflammatory response of nanoparticles: Mechanisms, consequences, and strategies for mitigation DOI
Muhammad Summer,

Rimsha Ashraf,

Shaukat Ali

и другие.

Chemosphere, Год журнала: 2024, Номер 363, С. 142826 - 142826

Опубликована: Июль 11, 2024

Язык: Английский

Процитировано

35
Altered X-chromosome inactivation predisposes to autoimmunity DOI Creative Commons
Christophe Huret, Léa Ferrayé,

Antoine David

и другие.

Science Advances, Год журнала: 2024, Номер 10(18)

Опубликована: Май 3, 2024

In mammals, males and females show marked differences in immune responses. Males are globally more sensitive to infectious diseases, while susceptible systemic autoimmunity. X-chromosome inactivation (XCI), the epigenetic mechanism ensuring silencing of one X females, may participate these sex biases. We perturbed expression trigger XCI, noncoding RNA Xist , female mice. This resulted reactivation genes on inactive X, including members Toll-like receptor 7 (TLR7) signaling pathway, monocyte/macrophages dendritic B cells. Consequently, mice spontaneously developed inflammatory signs typical lupus, anti–nucleic acid autoantibodies, increased frequencies age-associated germinal center cells, expansion Mechanistically, TLR7 is dysregulated macrophages, leading sustained target upon stimulation. These findings provide a direct link between maintenance XCI female-biased autoimmune manifestations highlight altered as cause

Язык: Английский

Процитировано

30