Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 228, P. 116174 - 116174
Published: March 27, 2024
Language: Английский
Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: March 14, 2023
Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, alone or in combination variety of cancers, while it has been found to cause serious cardiac side effects clinical application. More more researchers are trying explore the molecular mechanisms DOX-induced cardiomyopathy (DIC), which oxidative stress inflammation considered play significant role. This review summarizes signaling pathways related DIC compounds that exert cardioprotective by acting on relevant pathways, including role Nrf2/Keap1/ARE, Sirt1/p66Shc, Sirt1/PPAR/PGC-1α NOS, NOX, Fe2+ stress, as well NLRP3/caspase-1/GSDMD, HMGB1/TLR4/MAPKs/NF-κB, mTOR/TFEB/NF-κB inflammation. Hence, we attempt explain terms inflammation, provide theoretical basis new idea for further drug research reducing DIC. Video Abstract.
Language: Английский
Citations
112
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: April 12, 2024
Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) certain stimuli such as trauma, infection, and neurodegenerative diseases. This is cellular immune response whereby glial cells are activated, inflammatory mediators liberated reactive oxygen nitrogen species synthesized. key process that helps protect brain from pathogens, but inappropriate, or protracted inflammation yields pathological states Parkinson’s disease, Alzheimer’s, Multiple Sclerosis, other disorders showcase various pathways neurodegeneration distributed in parts CNS. review reveals major neuroinflammatory signaling associated with neurodegeneration. Additionally, it explores promising therapeutic avenues, stem cell therapy, genetic intervention, nanoparticles, aiming regulate neuroinflammation potentially impede decelerate advancement these conditions. A comprehensive understanding intricate connection between diseases pivotal for development future treatment strategies can alleviate burden imposed by devastating disorders.
Language: Английский
Citations
101
Microorganisms, Journal Year: 2023, Volume and Issue: 11(9), P. 2169 - 2169
Published: Aug. 28, 2023
Urinary tract infections (UTIs) are among the most common bacterial infections, especially women and older adults, leading to a significant global healthcare cost burden. Uropathogenic
Language: Английский
Citations
63
Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1849 - 1849
Published: July 21, 2023
The gut microbiome plays a critical role in maintaining overall health and immune function. However, dysbiosis, an imbalance composition, can have profound effects on various aspects of human health, including susceptibility to viral infections. Despite numerous studies investigating the influence infections microbiome, impact dysbiosis infection pathogenesis remains relatively understudied. clinical variability observed SARS-CoV-2 seasonal influenza infections, presence natural HIV suppressors, suggests that host-intrinsic factors, may contribute pathogenesis. has been shown host system by regulating intestinal homeostasis through interactions with cells. This review aims enhance our understanding how perturb mucosal cells, affecting response Specifically, we focus exploring between gamma delta (γδ) T cells microbes context inflammatory examine highlighting disease outcomes. Furthermore, discuss emerging evidence potential future directions for modulation therapy
Language: Английский
Citations
43
Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(2), P. 67 - 83
Published: Jan. 9, 2024
Language: Английский
Citations
37
Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142826 - 142826
Published: July 11, 2024
Language: Английский
Citations
32
MedComm, Journal Year: 2024, Volume and Issue: 5(8)
Published: Aug. 1, 2024
Abstract Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) alternatively (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay signaling pathways, transcriptional regulators, epigenetic modifications orchestrates polarization, allowing respond stimuli dynamically. Here, we provide comprehensive overview the cascades governing focusing on roles Toll‐like receptors, signal transducer activator transcription proteins, nuclear microRNAs. We also discuss emerging concepts metabolic reprogramming trained immunity, contributing their functional adaptability. Macrophage plasticity plays pivotal role in repair regeneration, macrophages coordinating inflammation, angiogenesis, matrix remodeling restore homeostasis. By harnessing potential novel therapeutic strategies targeting polarization could be developed for diseases, including chronic wounds, fibrotic disorders, inflammatory conditions. Ultimately, deeper understanding molecular mechanisms underpinning will pave way innovative regenerative medicine engineering approaches.
Language: Английский
Citations
31
Science Advances, Journal Year: 2024, Volume and Issue: 10(18)
Published: May 3, 2024
In mammals, males and females show marked differences in immune responses. Males are globally more sensitive to infectious diseases, while susceptible systemic autoimmunity. X-chromosome inactivation (XCI), the epigenetic mechanism ensuring silencing of one X females, may participate these sex biases. We perturbed expression trigger XCI, noncoding RNA Xist , female mice. This resulted reactivation genes on inactive X, including members Toll-like receptor 7 (TLR7) signaling pathway, monocyte/macrophages dendritic B cells. Consequently, mice spontaneously developed inflammatory signs typical lupus, anti–nucleic acid autoantibodies, increased frequencies age-associated germinal center cells, expansion Mechanistically, TLR7 is dysregulated macrophages, leading sustained target upon stimulation. These findings provide a direct link between maintenance XCI female-biased autoimmune manifestations highlight altered as cause
Language: Английский
Citations
28
Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(4), P. 628 - 644
Published: March 21, 2024
Language: Английский
Citations
21
Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1051 - 1051
Published: May 9, 2024
Transient left ventricular dysfunction (TLVD), a temporary condition marked by reversible impairment of function, remains an underdiagnosed yet significant contributor to morbidity and mortality in clinical practice. Unlike the well-explored atherosclerotic disease epicardial coronary arteries, diverse etiologies TLVD require greater attention for proper diagnosis management. The spectrum disorders associated with includes stress-induced cardiomyopathy, central nervous system injuries, histaminergic syndromes, various inflammatory diseases, pregnancy-related conditions, genetically determined syndromes. Furthermore, myocardial infarction non-obstructive arteries (MINOCA) origins such as artery spasm, thromboembolism, spontaneous dissection (SCAD) may also manifest TLVD, eventually showing recovery. This review highlights range ischemic non-ischemic situations that lead gathering conditions like Tako-Tsubo Syndrome (TTS), Kounis syndrome (KS), Myocarditis, Peripartum Cardiomyopathy (PPCM), Tachycardia-induced cardiomyopathy (TIC). Differentiation amongst these causes is crucial, they involve distinct clinical, instrumental, genetic predictors bode different outcomes recovery potential function. purpose this improve everyday approaches treating diseases providing extensive survey linked elements impacting prognosis outcomes.
Language: Английский
Citations
21