Unraveling Epigenetic Interplay between Inflammation, Thrombosis, and Immune-Related Disorders through a Network Meta-analysis DOI Creative Commons
Shankar Chanchal, Swati Sharma,

Syed Mohd

и другие.

TH Open, Год журнала: 2023, Номер 08(01), С. e81 - e92

Опубликована: Дек. 5, 2023

Abstract Inflammation and thrombosis are two distinct yet interdependent physiological processes. The inflammation results in the activation of coagulation system that directs immune its activation, resulting initiation pathophysiology thrombosis, a process termed immune-thrombosis. Still, shared underlying molecular mechanism related to has not been explored extensively. Inspired answer this, we carried out comprehensive gene expression meta-analysis using publicly available datasets four diseases, including venous systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease. A total 609 differentially expressed genes (DEGs) by all were identified based on combined effect size approach. pathway enrichment analysis DEGs showed various epigenetic pathways such as histone-modifying enzymes, posttranslational protein modification, chromatin organization, chromatin-modifying HATs acetylate proteins. Network-based protein–protein interaction enzyme coding dominating among top hub genes. miRNA-interacting partner 10 was determined. predomination epitranscriptomics regulation opens layout for miRNA same diseases. We 30 DEmiRs these There 9 common selected from list partners significant microRNAs dataset acquisition. These found regulate involved modulation indicate promising aspect needs be future studies context immunothrombosis

Язык: Английский

T cell dysregulation in SLE DOI
Klaus Tenbrock, Thomas Rauen

Clinical Immunology, Год журнала: 2022, Номер 239, С. 109031 - 109031

Опубликована: Май 6, 2022

Язык: Английский

Процитировано

40
The circRNA–miRNA–mRNA regulatory network in plasma and peripheral blood mononuclear cells and the potential associations with the pathogenesis of systemic lupus erythematosus DOI
Fengping Zheng, Lishan Tan, Fan Zhang

и другие.

Clinical Rheumatology, Год журнала: 2023, Номер 42(7), С. 1885 - 1896

Опубликована: Март 2, 2023

Язык: Английский

Процитировано

12
The critical importance of epigenetics in autoimmune-related skin diseases DOI

Lingyu Gao,

Qianjin Lu

Frontiers of Medicine, Год журнала: 2023, Номер 17(1), С. 43 - 57

Опубликована: Фев. 1, 2023

Язык: Английский

Процитировано

11
Circulatory microRNAs and proinflammatory cytokines as predictors of lupus nephritis DOI Creative Commons
Dalia Saad ElFeky,

Noha Mohamed Omar,

Olfat Shaker

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 11, 2024

Introduction Lupus nephritis (LN) is one of the most prevalent severe organ manifestations systemic lupus erythematosus (SLE), impacting 70% SLE patients. MicroRNAs (miRNAs), are small non-coding RNA molecules which influence expression approximately one-third human genes after process transcription. Dysregulation miRNAs was documented in numerous disorders, including and LN. Cytokines orchestrators immune response autoimmune diseases. Our study aims to explore variation levels circulating proinflammatory cytokines as potential diagnostic biomarkers among LN patients without comparison controls. Methods The involved 20 patients, LN, 10 healthy Serum IL-12 IL-21 addition miR-124, miR-146a, miR-199a, miR-21 were assessed using enzyme-linked immunosorbent assay (ELISA) for quantitative real-time PCR miRNAs. Results A significant downregulation miR-124 (p<0.001) a overexpression miR-146a (p=0.005) found In control group, miR-21, significantly upregulated (p=<0.001) with high values these discriminating from according Receiver operating curve (ROC) analysis. Logistic regression analysis revealed that only miR-199a an independent predictor (OR 1.69; 95% CI: 1.1-2.6). reduced but increased However, there no statistically difference either scenario. both controls, exhibited highest serum IL-21, difference. Regression associated creatinine SLEDAI score (p= 0.009 0.03, respectively), while hemoglobin level (p=0.03). Conclusion MiR-199a might be used biomarker this disease. MiR-146a play important role pathophysiology.

Язык: Английский

Процитировано

2
Clinical Research Progress of Small Molecule Compounds Targeting Nrf2 for Treating Inflammation-Related Diseases DOI Creative Commons
Zhenzhen Zhai, Yanxin Huang,

Yawei Zhang

и другие.

Antioxidants, Год журнала: 2022, Номер 11(8), С. 1564 - 1564

Опубликована: Авг. 12, 2022

Studies have found that inflammation is a symptom of various diseases, such as coronavirus disease 2019 (COVID-19) and rheumatoid arthritis (RA); it also the source other Alzheimer's (AD), Parkinson's (PD), lupus erythematosus (LE), liver damage. Nrf2 (nuclear factor erythroid 2-related 2) an important multifunctional transcription in cells plays central regulatory role cellular defense mechanisms. In recent years, several studies strong association between activation fight against inflammation-related diseases. A number small molecule compounds targeting entered clinical research. This article reviews research status are trials for treatment COVID-19, arthritis, disease, erythematosus, injury.

Язык: Английский

Процитировано

10
Estradiol in Systemic Lupus Erythematosus DOI

Ancuţa Constantin,

Cristian Băicuş

Acta Endocrinologica (Bucharest), Год журнала: 2023, Номер 19(2), С. 274 - 276

Опубликована: Янв. 1, 2023

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune polymorphous disease that primarily affects women of reproductive age. This gender disparity has suggested the importance investigating role hormones in pathogenesis disease. Estradiol, most potent form estrogen, plays key shaping immune system including production lymphocytes, peripheral differentiation regulatory T cells (T-regs), antibody production, and complement interferon systems, been studied systemic lupus erythematosus (SLE). It operates by binding to estrogen receptors (ERs) α β, initiating cellular responses alterations gene expression. Regulatory are instrumental preserving immunological self-tolerance moderating responses. Estradiol's serum levels correlate with expansion CD4+CD25+ FoxP3+ healthy females. However, this response reduced patients. Estradiol also interacts microRNAs (miRNAs) regulation. Hsa-miR-10b-5p, miRNA targeting SRSF1, overexpressed SLE patients its increase exposure estrogens. Other miRNAs show correlation plasma levels. The precise remains complex multifaceted topic for further research.

Язык: Английский

Процитировано

4
Epigenetic regulation of FOXP3 gene expression in relation to impaired function of regulatory T cells in systemic lupus erythematosus DOI Creative Commons
Parnian Fakour, Ata Shirizadeh,

Ahmad Tahamoli‐Roudsari

и другие.

Exploration of Immunology, Год журнала: 2024, Номер unknown, С. 640 - 657

Опубликована: Окт. 21, 2024

The impaired function of regulatory T (Treg) cells and the imbalance Treg/Th17 play a central role in developing autoimmune diseases such as systemic lupus erythematosus (SLE). Treg are crucial for maintaining immune homeostasis tolerance to self-antigens. One most important transcription factors that regulate differentiation is FOXP3 protein. Aberrant epigenetic modifications affecting gene expression consequently dysregulated have been implicated pathogenesis SLE. Therefore, understanding intricate interplay between pattern mechanisms (e.g., DNA methylation, histone non-coding RNAs microRNAs long RNAs) unravelling underlying Moreover, targeting these pathways may offer novel therapeutic strategies restoring balance ameliorating pathology. This review report aimed provide an update on controlling SLE disease.

Язык: Английский

Процитировано

1
miR-132-3p downregulates FOXO1 in CD4+ T cells and is associated with disease manifestations in patients with lupus DOI Creative Commons
Haihong Qin,

Chen Sun-yi,

Xiao Liu

и другие.

Journal of International Medical Research, Год журнала: 2024, Номер 52(10)

Опубликована: Окт. 1, 2024

Objective This study aimed to evaluate the expression status of miR-132-3p in CD4 + T cells patients with systemic lupus erythematosus (SLE) and explore its potential role SLE development. Methods The included 60 30 healthy controls. was detected by real-time quantitative reverse transcription polymerase chain. Bioinformatics analyses were employed predict target genes miR-132-3p. associations between levels Disease Activity Index (SLEDAI) score, as well laboratory characteristics, analyzed. Results significantly higher compared analysis identified FOXO1 a gene miR-132-3p, particular emphasis on FOXO signaling pathway. up-regulation associated high SLEDAI anti-double-stranded DNA levels, low C3 C4 positive anti-ribosomal P, 24-hour urinary protein SLE. Conclusions may contribute cell dysregulation during targeting could potentially be used assess disease severity.

Язык: Английский

Процитировано

1
Analysis of microRNA-199a-3p expression in CD4+ T cells of systemic lupus erythematosus DOI
Huijing Wang, Guannan Geng, Danting Zhang

и другие.

Clinical Rheumatology, Год журнала: 2023, Номер 42(6), С. 1683 - 1694

Опубликована: Фев. 10, 2023

Язык: Английский

Процитировано

3
The RNA-Binding and RNA-Melting Activities of the Multifunctional Protein Nucleobindin 1 DOI Open Access
Alisa Mikhaylina,

Arina Svoeglazova,

Elena Stolboushkina

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6193 - 6193

Опубликована: Март 24, 2023

Nucleobindin 1 (NUCB1) is a ubiquitous multidomain protein that belongs to the EF-hand Ca2+-binding superfamily. NUCB1 interacts with Galphai3 protein, cyclooxygenase, amyloid precursor and lipids. It involved in stress response human diseases. In addition, this transcription factor binds DNA E-box motif. Using surface plasmon resonance molecular beacon approaches, we first showed RNA binding melting activities of NUCB1. We suggest could induce local changes structured RNAs via GGAUAU loop sequence. Our results demonstrate importance structure for its RNA-chaperone activity vitro.

Язык: Английский

Процитировано

2