Changes and Long-Term Effects of the Immune System after COVID-19 Infection

Theoretical and Natural Science, Год журнала: 2025, Номер 69(1), С. 78 - 84

Опубликована: Янв. 15, 2025

Following the pandemic in 2020, physical health has generally declined. All of this is brought on by modifications to body's immune system and consequences sequelae. The current research gap caused neglect COVID-19's after effects. In paper, relationship between changes, complications their conditions was studied, preliminary results harm prevention sequelae were obtained. system's alterations during epidemic infection its are main topics article, including cytokine storms, inflammatory responses, changes cells. At same time, article explores underlying conditions, such as chronic diseases autoimmune diseases, they cause. Through observation analysis later stages epidemic, reasons for general decline people's fitness system. future, it hoped that there will be improvements disease measures diseases.

Язык: Английский

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High-Grade Infection after Branched Endovascular Aortic Repair in Patient with Recent COVID-19 Hospitalization

Diagnostics, Год журнала: 2024, Номер 14(2), С. 205 - 205

Опубликована: Янв. 18, 2024

In the context of COVID-19 pandemic, global healthcare landscape has undergone significant transformations, particularly impacting management complex medical conditions such as aortic aneurysms. This study focuses on a 76-year-old female patient with history extensive cardiovascular surgeries, including valve replacement, Bentall operation, and Frozen Elephant Trunk procedure, who presented type II thoracoabdominal aneurysm post-COVID-19 recovery. A comprehensive frailty assessment using Modified Frailty Index two-phase endovascular approach for treatment, considering patient’s was performed. Upon successful management, postoperative course complicated by reinfection Enterococcus faecalis superinfection, highlighting increased risk bacterial superinfections challenges posed antimicrobial resistance in patients. The underscores necessity vigilant surveillance multidisciplinary managing cases, importance personalized care strategies, integrating infectious disease adapting practices to unique pandemic. case contributes evolution knowledge aneurysms era, advocating patient-centric treatment approaches continuous research into long-term outcomes.

Язык: Английский

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A Bioinformatics and Systems Biology Approach to Identifying the Influence of COVID-19 on Patients with Osteoarthritis

The Open Bioinformatics Journal, Год журнала: 2025, Номер 18(1)

Опубликована: Апрель 7, 2025

Background Clinical findings show that the incidence of osteoarthritis (OA) is significantly increased in late stage coronavirus disease 2019 southwest China. However, there continues to be a lack substantial evidence elucidating potential molecular mechanism underlying OA and COVID-19. Objective The objective this study clarify genetic interaction between COVID-19 explore therapeutic targets for COVID-19-infected patients with OA. Methods Two differentially expressed gene (DEG) sets extracted from GSE171110 GSE55235 datasets were intersected generate common DEGs, which used functional enrichment, hub pathway identification, candidate drug-gene disease–gene prediction. Associations genes immune cell infiltration also generated increase clinical relevance. Results A total 127 DEGs screened datasets. Functional enrichment analysis demonstrated pathways activated both diseases mainly concentrated circadian rhythm, cellular response chemical stimulus, B signaling pathway, organic substances. TF miRNA analyses identified 14 TFs 2 (CDK1 TOP2A) as final genes. Furthermore, 28 possible drugs targeting these 9 relevant tumor predicted treatment CDK1 TOP2A successfully can serve novel We out valuable after infection. Conclusion markers targeted therapy Additionally, 1 (resting mast cells), diseases,

Язык: Английский

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Identification of Common Dysregulated Genes in COVID-19 and Hypersensitivity Pneumonitis: A Systems Biology and Machine Learning Approach

OMICS A Journal of Integrative Biology, Год журнала: 2023, Номер 27(5), С. 205 - 214

Опубликована: Апрель 17, 2023

A comprehensive knowledge on systems biology of severe acute respiratory syndrome coronavirus 2 is crucial for differential diagnosis COVID-19. Interestingly, the radiological and pathological features COVID-19 mimic that hypersensitivity pneumonitis (HP), another pulmonary fibrotic phenotype. This motivated us to explore overlapping pathophysiology HP, if any, using a approach. Two datasets were obtained from Gene Expression Omnibus database (GSE147507 GSE150910) common differentially expressed genes (DEGs) both diseases identified. Fourteen DEGs, significantly altered in diseases, found be implicated complement activation growth factor activity. total five microRNAs (hsa-miR-1-3p, hsa-miR-20a-5p, hsa-miR-107, hsa-miR-16-5p, hsa-miR-34b-5p) transcription factors (KLF6, ZBTB7A, ELF1, NFIL3, ZBT33) exhibited highest interaction with these genes. Next, C3, CFB, MMP-9, IL1A identified as hub HP. Finally, top-ranked (hub genes) evaluated random forest classifier discriminate between disease control group (coronavirus 2019 [COVID-19] vs. controls, HP controls). supervised machine learning approach demonstrated 100% 87.6% accuracy differentiating respectively. These findings provide new molecular leads inform diagnostics therapeutics research innovation.

Язык: Английский

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Single-Cell Transcriptomics Reveals Evidence of Endothelial Dysfunction in the Brains of COVID-19 Patients with Implications for Glioblastoma Progression

Brain Sciences, Год журнала: 2023, Номер 13(5), С. 762 - 762

Опубликована: Май 5, 2023

Endothelial dysfunction is implicated in various inflammatory diseases such as ischemic stroke, heart attack, organ failure, and COVID-19. Recent studies have shown that endothelial the brain attributed to excessive responses caused by SARS-CoV-2 infection, leading increased permeability of blood-brain barrier consequently neurological damage. Here, we aim examine single-cell transcriptomic landscape COVID-19 its implications for glioblastoma (GBM) progression.Single-cell transcriptome data GSE131928 GSE159812 were obtained from gene expression omnibus (GEO) analyze profiles key players innate immunity inflammation between GBM analysis patients revealed cells had undergone significant changes, with several genes involved immune upregulated. Moreover, transcription factors observed modulate this inflammation, including interferon-regulated genes.The results indicate a overlap context dysfunction, suggesting there may be an link connecting severe infection progression.

Язык: Английский

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Bioinformatics and system biology approach to identify the influences among COVID-19, ARDS and sepsis

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Май 16, 2023

Background Severe coronavirus disease 2019 (COVID -19) has led to severe pneumonia or acute respiratory distress syndrome (ARDS) worldwide. we have noted that many critically ill patients with COVID-19 present typical sepsis-related clinical manifestations, including multiple organ dysfunction syndrome, coagulopathy, and septic shock. The molecular mechanisms underlie COVID-19, ARDS sepsis are not well understood. objectives of this study were analyze potential identify drugs for the treatment using bioinformatics a systems biology approach. Methods Three RNA-seq datasets (GSE171110, GSE76293 GSE137342) from Gene Expression Omnibus (GEO) employed detect mutual differentially expressed genes (DEGs) functional enrichment, pathway analysis, candidate analysis. Results We obtained 110 common DEGs among sepsis. ARG1, FCGR1A, MPO, TLR5 most influential hub genes. infection immune-related pathways functions main these three diseases. FOXC1, YY1, GATA2, FOXL, STAT1 STAT3 important TFs COVID-19. mir-335-5p, miR-335-5p hsa-mir-26a-5p associated Finally, retrieved DSigDB database indicate drug molecules drug-targets interaction. Conclusion performed analysis under ontology terms found some associations Transcription factors–genes interaction, protein–drug interactions, DEGs-miRNAs coregulatory network also identified on datasets. believe in may contribute effective

Язык: Английский

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The influence of COVID-19 on colorectal cancer was investigated using bioinformatics and systems biology techniques

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Июнь 30, 2023

Introduction Coronavirus disease 2019 (COVID-19) is a global pandemic and highly contagious, posing serious threat to human health. Colorectal cancer (CRC) risk factor for COVID-19 infection. Therefore, it vital investigate the intrinsic link between these two diseases. Methods In this work, bioinformatics systems biology techniques were used detect mutual pathways, molecular biomarkers, potential drugs CRC. Results A total of 161 common differentially expressed genes (DEGs) identified based on RNA sequencing datasets Functional analysis was performed using ontology keywords, pathway also performed. The DEGs further utilized create protein-protein interaction (PPI) network identify hub key modules. revealed transcription factors-gene interactions, co-regulatory networks with DEGs-miRNAs DEGs, predicted possible as well. ten include troglitazone, estradiol, progesterone, calcitriol, genistein, dexamethasone, lucanthone, resveratrol, retinoic acid, phorbol 12-myristate 13-acetate, some which have been investigated CRC therapies. Discussion By clarifying relationship CRC, we hope provide novel clues promising therapeutic treat illnesses.

Язык: Английский

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Non-Anticoagulant Activities of Low Molecular Weight Heparins—A Review

Pharmaceuticals, Год журнала: 2023, Номер 16(9), С. 1254 - 1254

Опубликована: Сен. 5, 2023

Low molecular weight heparins (LMWHs) are derived from heparin through chemical or enzymatic cleavage with an average (Mw) of 2000–8000 Da. They exhibit more selective activities and advantages over heparin, causing fewer side effects, such as bleeding heparin-induced thrombocytopenia. Due to different preparation methods, LMWHs have diverse structures extensive biological activities. In this review, we describe the basic methods in field compare main principles these specific detail. Importantly, focus on non-anticoagulant pharmacological effects their conjugates, preventing glycocalyx shedding, anti-inflammatory, antiviral infection, anti-fibrosis, inhibiting angiogenesis, cell adhesion improving endothelial function. effective various diseases at animal level, including cancer, some viral diseases, fibrotic obstetric diseases. Finally, briefly summarize usage potential applications clinic promote development utilization LMWHs.

Язык: Английский

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A hub gene signature as a therapeutic target and biomarker for sepsis and geriatric sepsis-induced ARDS concomitant with COVID-19 infection

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Сен. 26, 2023

COVID-19 and sepsis represent formidable public health challenges, characterized by incompletely elucidated molecular mechanisms. Elucidating the interplay between sepsis, particularly in geriatric patients suffering from sepsis-induced acute respiratory distress syndrome (ARDS), is of paramount importance for identifying potential therapeutic interventions to mitigate hospitalization mortality risks. We employed bioinformatics systems biology approaches identify hub genes, shared pathways, biomarkers, candidate therapeutics managing ARDS context infection, as well co-existing or sequentially occurring infections. corroborated these genes utilizing murine sepsis-ARDS models blood samples derived afflicted ARDS. Our investigation revealed 189 differentially expressed (DEGs) among datasets. constructed a protein-protein interaction network, unearthing pivotal modules. Notably, nine displayed significant alterations correlations with critical inflammatory mediators pulmonary injury septic lungs. Simultaneously, 12 changes neutrophil-recruiting chemokine Of these, six (CD247, CD2, CD40LG, KLRB1, LCN2, RETN) showed across COVID-19, single-cell RNA sequencing analysis diverse immune cell types furnished insights into disease pathogenesis. Functional underscored interconnection sepsis/sepsis-ARDS enabling us pinpoint targets, transcription factor-gene interactions, DEG-microRNA co-regulatory networks, prospective drug chemical compound interactions involving genes. offers targets/biomarkers, sheds light on response ARDS, emphasizes association proposes alternative pathways targeted interventions.

Язык: Английский

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Exploration of the link between COVID‐19 and alcoholic hepatitis from the perspective of bioinformatics and systems biology

MedComm – Future Medicine, Год журнала: 2023, Номер 2(2)

Опубликована: Июнь 1, 2023

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been suggested to purpose threats health of mankind. Alcoholic hepatitis (AH) is a life‐threatening and chronic liver failure that takes place in sufferers who drink excessively. During the epidemic, AH an increasing incidence severe illness mortality. The intrinsic relationship molecular pathogenesis, as well common therapeutic strategies for two diseases are still poorly understood. transcriptome COVID‐19 compared obtain altered genes hub were screened out through protein–protein interaction (PPI) network analysis. Via gene ontology (GO), pathway enrichment, transcription regulator analysis, deeper appreciation interplay mechanism between established. Finally, gene‐disease gene–drug analysis displayed instruct clinical treatments. With 181 differentially expressed (DEGs) obtained, 10 captured. Follow‐up studies located these typically mediated occurrence by regulating activities immune system. Other results suggest pathways ailments enriched function cells release molecules. top drug candidates have chosen primarily, some which proved effective treating infected with COVID‐19. This study reveals pathogenesis assist discover necessary targets combat ongoing pandemic induced via SARS‐CoV‐2 infection acquire promising remedy diseases.

Язык: Английский

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