Unraveling role of ubiquitination in drug resistance of gynecological cancer DOI Open Access
Yu Li

American Journal of Cancer Research, Год журнала: 2024, Номер 14(5), С. 2523 - 2537

Опубликована: Янв. 1, 2024

Chemotherapy is the principal treatment for advanced cancer patients.However, chemotherapeutic resistance, an important hallmark of cancer, considered as a key impediment to effective therapy in patients.Multiple signaling pathways and factors have been underscored participate governing drug resistance.Posttranslational modifications, including ubiquitination, glycosylation, acetylation phosphorylation, emerged players modulating resistance gynecological tumors, such ovarian cervical endometrial cancer.In this review article, we summarize role ubiquitination sensitivity cancers.Moreover, describe numerous compounds that target cancers reverse resistance.In addition, provide future perspectives fully elucidate mechanisms by which controls contributing restoring sensitivity.This highlights complex interplay between providing novel insights into potential therapeutic targets personalized strategies overcome bottleneck resistance.

Язык: Английский

Long noncoding RNAs regulate intrauterine adhesion and cervical cancer development and progression DOI
Xuemei Wang, Yu Gu,

Leichao Zhang

и другие.

Seminars in Cell and Developmental Biology, Год журнала: 2023, Номер 154, С. 221 - 226

Опубликована: Фев. 24, 2023

Язык: Английский

Процитировано

7
A combination of cuproptosis and lncRNAs predicts the prognosis and tumor immune microenvironment in cervical cancer DOI Creative Commons
Yitong Huang,

Chenxiang Pan,

Suni Wu

и другие.

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Апрель 12, 2024

Abstract Background Cuproptosis induces proteotoxic stress and eventually leads to cell death. However, the relationship between cuproptosis lncRNAs in cervical cancer has not been fully elucidated. Therefore, we aim explore association among lncRNAs, clinical features cancer. Methods RNA sequencing, genetic mutations, data of CESC patients were obtained from TCGA. Cuproptosis-associated genes gathered. WGCNA was used cluster important modules, KEGG, GO, GSEA GSVA functional pathway enrichment. The immune microenvironment cuproptosis-related performed by using cibersort algorithm other platforms, including XCELL, TIMER, QUANTISEQ, MCPCOUNTER EPIC. Fluorescence quantitative PCR employed detect expression LINC01833 LINC02321, CCK-8 scratch assays assess proliferation migration capabilities after LINCRNA interference. Results 202 upregulated 45 downregulated selected. survival analysis showed that there a statistically significant difference rates high-risk low-risk groups. prognosis tumour mutation burden degree infiltration differed noticeably BHG712, TL-2-105, FR-180204, Masitinib, TAK-715, ODI-027, JW-7-24-2, OSI-930 had substantially higher IC50 values group. Notably, found AL360178.1 associated with RNF44 E3 ubiquitin ligase expression. In lines, LINC02321 displayed upregulation. Efficient siRNA transfection led decreased LINC02321. This knockdown significantly hindered both cells compared negative control. Conclusion conclusion, constructed five cuprotosis-related lncRNA prognostic models, which may be new tumor therapeutic targets for prevention treatment

Язык: Английский

Процитировано

2
Single-cell RNA sequencing reveals the communications between tumor microenvironment components and tumor metastasis in osteosarcoma DOI Creative Commons
Jiatong Li,

Yang Bai,

He Zhang

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 11, 2024

Osteosarcoma is a common type of bone cancer characterized by poor prognosis due to its metastatic nature. The tumor microenvironment (TME) plays critical role in metastasis and therapy response. Therefore, our study aims explore the mechanism osteosarcoma, potentially opening new avenues for treatment.

Язык: Английский

Процитировано

2
The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy DOI Creative Commons
Xuemei Wang, Ying Zhang, Yao Wu

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Май 5, 2023

Bladder cancer is one of the common malignant urothelial tumors. Post-translational modification (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation, have been revealed to participate in bladder initiation progression. Ubiquitination PTM, which conducted by E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase. ubiquitin ligases play a key role oncogenesis progression drug resistance cancer. Therefore, this review, we summarize current knowledge regarding functions development. Moreover, provide evidence regulation immunotherapy Furthermore, mention multiple compounds that target improve therapy efficacy We hope our review can stimulate researchers clinicians investigate whether how targeting acts novel strategy for therapy.

Язык: Английский

Процитировано

6
Programmed Death Ligand 1 Regulatory Crosstalk with Ubiquitination and Deubiquitination: Implications in Cancer Immunotherapy DOI Open Access

Soon-Bin Kim,

Soonjae Hwang, Ji-Young Cha

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2939 - 2939

Опубликована: Март 3, 2024

Programmed death ligand 1 (PD-L1) plays a pivotal role in cancer immune evasion and is critical target for immunotherapy. This review focuses on the regulation of PD-L1 through dynamic processes ubiquitination deubiquitination, which are crucial its stability function. Here, we explored intricate mechanisms involving various E3 ubiquitin ligases deubiquitinating enzymes (DUBs) that modulate expression cells. Specific discussed detail, highlighting their roles tagging degradation. Furthermore, discuss actions DUBs stabilize by removing chains. The interplay these not only dictates levels but also influences progression patient response to immunotherapies. therapeutic implications targeting regulatory pathways propose novel strategies enhance efficacy PD-L1/PD-1-based therapies. Our underscores complexity significant impact tumor microenvironment immunotherapy outcomes.

Язык: Английский

Процитировано

2
CDC20 promotes radioresistance of prostate cancer by activating Twist1 expression DOI

Chuanlai Yang,

Yuegang Ge,

Yachen Zang

и другие.

APOPTOSIS, Год журнала: 2023, Номер 28(11-12), С. 1584 - 1595

Опубликована: Авг. 3, 2023

Язык: Английский

Процитировано

5
Deciphering roles of protein post-translational modifications in IgA nephropathy progression and potential therapy DOI Creative Commons
Meng‐Ying Sun,

Guojuan Shi,

Xiaohan Zhang

и другие.

Aging, Год журнала: 2024, Номер unknown

Опубликована: Янв. 3, 2024

Immunoglobulin A nephropathy (IgAN), one type of glomerulonephritis, displays the accumulation glycosylated IgA in mesangium. Studies have demonstrated that both genetics and epigenetics play a pivotal role occurrence progression IgAN. Post-translational modification (PTM) has been revealed to critically participate IgAN development because PTM dysregulation results impaired degradation proteins regulate pathogenesis. growing number studies identify PTMs, including sialylation, o-glycosylation, galactosylation, phosphorylation, ubiquitination deubiquitination, modulate initiation Hence, this review, we discuss functions mechanisms PTMs regulation Moreover, outline numerous compounds govern attenuate progression. Targeting might be useful strategy ameliorate

Язык: Английский

Процитировано

1
Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma DOI Creative Commons
Xinyu Zhou,

Sirui Hang,

Qingqing Wang

и другие.

Biomolecules, Год журнала: 2024, Номер 14(8), С. 908 - 908

Опубликована: Июль 25, 2024

Post-translational modifications (PTMs) influence protein functionality by modulating stability, localization, and interactions with other molecules, thereby controlling various cellular processes. Common PTMs include phosphorylation, acetylation, ubiquitination, glycosylation, SUMOylation, methylation, sulfation, nitrosylation. Among these modifications, O-GlcNAcylation has been shown to play a critical role in cancer development progression, especially hepatocellular carcinoma (HCC). This review outlines the of progression HCC. Moreover, we delve into underlying mechanisms HCC highlight compounds that target O-GlcNAc transferase (OGT) O-GlcNAcase (OGA) improve treatment outcomes. Understanding will offer insights potential therapeutic strategies targeting OGT OGA, which could for patients

Язык: Английский

Процитировано

1
Role of UFMylation in tumorigenesis and cancer immunotherapy DOI Creative Commons
Lijuan Ding, Xin Jiang, Te Li

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 23, 2024

Protein post-translational modifications (PTMs) represent a crucial aspect of cellular regulation, occurring after protein synthesis from mRNA. These modifications, which include phosphorylation, ubiquitination, acetylation, methylation, glycosylation, Sumoylation, and palmitoylation, play pivotal roles in modulating function. PTMs influence localization, stability, interactions, thereby orchestrating variety processes response to internal external stimuli. Dysregulation is linked spectrum diseases, such as cancer, inflammatory neurodegenerative disorders. UFMylation, type PTMs, has recently gained prominence for its regulatory role numerous processes, including stress, key signaling pathways influencing functions. This review highlights the function UFMylation development progression tumors, underscoring potential therapeutic target. Moreover, we discuss tumorigenesis malignant progression, explore impact on cancer immunotherapy. The article aims provide comprehensive overview biological functions propose how targeting could enhance effectiveness immunotherapy strategies.

Язык: Английский

Процитировано

1
Ubiquitination-related biomarkers in metastatic melanoma patients and their roles in tumor microenvironment DOI Creative Commons
Zhang Li, Zhehao Shi, Fan Zhang

и другие.

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Май 19, 2023

Skin cutaneous melanoma (SKCM) is the deadliest type of malignancy. Ubiquitination a process protein sorting and degradation that exhibits multiple functions in progression various tumors. This study aimed to characterize set genes for ubiquitination SKCM.The expression patterns ubiquitin-associated (URGs) corresponding clinical information SKCM tissues were comprehensively analyzed based on The Cancer Genome Atlas (TCGA) database. We performed univariate multivariate Cox proportional regression models risk scores identify four critical related prognostic (HCLS1, CORO1A, NCF1 CCRL2), which used construct signatures. also studied effects HCLS1, CORO1A CCRL2 tumor metastasis-related indicators at cellular level through vitro experiments.SKCM patients low-risk group showing longer survival than those high-risk group. Characteristic correlated with several clinicopathological variables reflected infiltration immune cells. In addition, knockdown CLS1, affected malignant biological behavior EMT signaling pathway.This provides novel prospective strategy improve patients.

Язык: Английский

Процитировано

3