Marine Drugs,
Год журнала:
2024,
Номер
22(7), С. 304 - 304
Опубликована: Июнь 28, 2024
From
sea
shores
to
the
abysses
of
deep
ocean,
marine
ecosystems
have
provided
humanity
with
valuable
medicinal
resources.
The
use
organisms
is
discussed
in
ancient
pharmacopoeias
different
times
and
geographic
regions
still
deeply
rooted
traditional
medicine.
Thanks
present-day,
large-scale
bioprospecting
rigorous
screening
for
bioactive
metabolites,
ocean
coming
back
as
an
untapped
resource
natural
compounds
therapeutic
potential.
This
renewed
interest
drugs
propelled
by
a
burgeoning
research
field
investigating
molecular
mechanisms
which
newly
identified
intervene
pathophysiology
human
diseases.
Of
great
clinical
relevance
are
molecules
endowed
anti-inflammatory
immunomodulatory
properties
emerging
applications
management
chronic
inflammatory
disorders,
autoimmune
diseases,
cancer.
Here,
we
review
historical
development
pharmacology
Eastern
Western
worlds
describe
status
drug
discovery.
Finally,
discuss
importance
conducting
sustainable
exploitation
resources
through
biotechnology.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Июнь 6, 2024
Ginger
(
Zingiber
officinale
)
is
a
rhizome
that
has
been
used
as
healthy
herbal
plant
for
years.
Ginger’s
chemical
components
are
recognized
to
provide
beneficial
health
effects,
namely
antioxidants
and
anti-inflammatory
agents
with
the
potential
operate
immunomodulators.
This
literature
review
covers
numerous
publications
concerning
ginger’s
immunomodulatory
potential,
associated
antioxidant
effects
in
modifying
body’s
immune
system.
Pathophysiology
of
oxidative
stress
inflammation
were
introduced
before
diving
deep
down
into
plants
an
immunomodulator.
properties
provided
by
gingerol,
shogaols,
paradol,
zingerone.
mechanism
linked
Nrf2
signaling
pathway
activation.
Its
Akt
inhibition
NF-KB
activation,
triggering
release
cytokines
while
reducing
proinflammatory
cytokines.
consumption
food
drink
was
also
explored.
Overall,
ginger
its
active
have
shown
strong
reduce
inflammation.
Challenges
future
prospects
elaborated
development.
Future
collaborations
between
researchers
from
various
fields,
including
chemists,
biologists,
clinicians,
pharmacists,
industry,
required
further
investigate
effect
on
human
immunity.
Collaboration
industry
can
help
accelerate
advancement
applications.
Intelligent Pharmacy,
Год журнала:
2024,
Номер
2(3), С. 312 - 328
Опубликована: Фев. 15, 2024
Extracellular
vesicles
(EVs)
are
nanometric
size,
a
cell-derived
drug
delivery
carrier
composed
of
membrane-bound
structures,
release
into
the
cellular
medium
and
found
in
body
fluids.
EVs
serve
dual
purpose,
acting
as
means
disposing
redundant
material
method
communication
between
cells.
Their
natural
origin,
biocompatibility,
protein,
nucleic
acid
composition
boosts
superior
targeting
capabilities.
While
strong
safety
profile,
intrinsic
pleiotropic
therapeutic
effects,
ability
to
accommodate
both
lipophilic
hydrophilic
agents,
pass
through
blood–brain
barrier
makes
them
exceptional
nanocarrier.
Several
synthetic
methods
have
been
fabricated
introduced
market
throughout
previous
few
decades.
However,
their
inefficiency,
cytotoxicity,
and/or
immunogenicity
hinder
applications.
Evidence
demonstrates
that
play
critical
role
major
physiological
pathological
processes,
such
homeostasis,
infection
propagation,
cancer
progression,
cardiovascular
diseases.
Moreover,
offer
range
advantages
over
traditional
carriers,
thus
paving
way
for
innovative
approaches.
Although
applications
is
limited
due
lack
scalable
isolation
techniques
efficient
loading,
great
potential
nanocarriers.
The
review
summarizes
discuss
recent
progress
challenges
associated
with
development
Archives of Gerontology and Geriatrics Plus,
Год журнала:
2023,
Номер
1(1), С. 100003 - 100003
Опубликована: Дек. 25, 2023
Aging
is
a
complex
journey
shaped
by
interactions
among
mechanisms,
biochemistry,
physiology,
and
social
habits.
This
review
explores
aging's
core
facets
uncovering
the
mechanisms
driving
cellular
senescence,
oxidative
stress,
telomere
shortening,
mitochondrial
dysfunction.
The
also
delves
into
biochemistry
physiology
of
aging,
shedding
light
on
hormonal
shifts,
genetic
influences,
immune
system
modifications
that
contribute
to
aging
process.
It
navigates
terrain
habits
linked
considering
profound
impact
dietary
choices,
physical
activity,
engagement,
stress
management.
These
elements
intricately
intertwine,
emphasizing
holistic
nature
aging.
interplay
between
underscores
need
for
comprehensive
understanding
transcends
single
disciplines.
Deciphering
these
factors
significance
personalized
approaches
healthy
Tailoring
interventions
individual
genetics,
lifestyles,
health
needs
emerges
as
critical
strategy
optimizing
well-being
in
later
life.
In
conclusion,
this
illuminates
multifaceted
urging
embrace
complexity
interdependence.
By
fostering
holistic,
approach,
individuals
can
navigate
with
grace,
vitality,
resilience.
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
4(8)
Опубликована: Май 31, 2024
Immune
dysregulation
is
a
pivotal
factor
in
the
onset
and
progression
of
various
diseases.
In
cancer,
immune
system's
inability
to
discern
eliminate
abnormal
cells
leads
uncontrolled
tumor
growth.
When
faced
with
resilient
pathogens
or
harmful
toxins,
system
encounters
challenges
clearance
neutralization.
Achieving
delicate
balance
pro‐inflammatory
anti‐inflammatory
signals
essential
managing
range
disorders
Like
other
biomedical
research
domains,
nanotechnology
has
provided
innovative
approaches
for
rebalancing
host
immunity.
Among
plethora
nanotechnology‐based
interventions,
concept
cell
membrane‐coated
nanoparticles
holds
significant
potential
immunomodulatory
applications
owing
their
biomimetic
properties
that
allow
precise
interaction
compromised
system.
This
review
thoroughly
examines
novel
nanosystems
modulation.
The
exploration
covers
crucial
elements,
including
origins
characteristics
membranes,
methods
employed
procurement
coating,
physicochemical/biological
characterization
techniques,
enhancement
therapeutic
efficacy
via
functionalization.
Subsequently,
case
studies‐based
analysis
utilizing
these
bioinspired
tackling
different
conditions
caused
by
disturbance
been
comprehensively
discussed.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 30, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
exhibits
increased
lipid
enrichment
in
hepatocytes.
The
spectrum
of
this
includes
stages
such
as
nonalcoholic
simple
(NAFL),
steatohepatitis
(NASH),
and
fibrosis.
Changes
lifestyle
behaviors
have
been
a
major
factor
contributing
to
the
cases
NAFLD
patients
globally.
Therefore,
it
is
imperative
explore
pathogenesis
NAFLD,
identify
therapeutic
targets,
develop
new
strategies
improve
clinical
management
disease.
Immunoregulation
strategy
through
which
organism
recognizes
eliminates
antigenic
foreign
bodies
maintain
physiological
homeostasis.
In
process,
multiple
factors,
including
immune
cells,
signaling
molecules,
cytokines,
play
role
governing
evolution
NAFLD.
This
review
seeks
encapsulate
advancements
research
regarding
regulation
spanning
from
underlying
mechanisms
practical
applications.
Hepatology Communications,
Год журнала:
2024,
Номер
8(6)
Опубликована: Июнь 1, 2024
Autoimmune
hepatitis
(AIH)
is
a
chronic
inflammatory
liver
disease
that
can
lead
to
cirrhosis
and
failure.
AIH
present
in
all
ages,
races,
ethnicities,
but
it
predominantly
affects
women.
As
heterogeneous
disease,
presents
variably
different
patients,
making
diagnosis
treatment
challenge.
Currently,
the
standard
for
comprises
immunosuppressants;
however,
their
long-term
use
associated
with
adverse
effects.
The
pathogenesis
of
complex,
involving
T
cells,
macrophages,
plasma
cells
invade
periportal
parenchyma
an
cascade
result
damage.
Due
complexity
pathogenesis,
targets
several
pathways.
However,
unlike
other
autoimmune
diseases
which
targeted
treatments
have
been
approved,
there
has
little
progress
made
advancing
paradigm
AIH.
Major
obstacles
include
challenges
conducting
clinical
trials,
particularly
patient
recruitment
ensuring
diverse
range
backgrounds;
poorly
defined
outcomes
assess
response
improved
quality
life;
lack
study
designs
account
stage
variations
treatment.
A
focus
on
individualized
steroid-free
approaches
needed
improve
prognosis
minimize
steroid-associated
