IP International Journal of Medical Microbiology and Tropical Diseases,
Год журнала:
2024,
Номер
10(4), С. 303 - 312
Опубликована: Дек. 12, 2024
Monkeypox
virus
(MPXV),
a
zoonotic
pathogen
related
to
smallpox,
has
gained
attention
due
its
resurgence
and
potential
for
outbreaks.
This
review
provides
comprehensive
analysis
of
MPXV’s
epidemiology,
transmission,
control
measures,
focusing
on
major
outbreaks
in
India,
including
recent
cases
2022
2023.
The
discusses
the
viral
structure,
pathogenesis,
clinical
presentations,
emphasizing
diagnostic
challenges
outbreak
management
strategies.
Key
methods
such
as
PCR,
culture,
serology
are
explored.
roles
agencies
National
Institute
Virology
(NIV)
Pune
Indian
Council
Medical
Research
(ICMR),
evaluated.
highlights
importance
early
detection,
improved
public
health
responses,
effective
prevention
strategies
mitigate
future
Recommendations
enhanced
research
directions
also
outlined.
Tropical Diseases Travel Medicine and Vaccines,
Год журнала:
2025,
Номер
11(1)
Опубликована: Янв. 14, 2025
Abstract
Monkeypox
virus
(MPXV)
is
an
enclosed,
double-stranded
DNA
from
the
Orthopoxvirus
genus,
which
also
contains
variola,
vaccinia,
and
cowpox.
MPXV,
was
once
confined
to
West
Central
Africa,
has
recently
had
a
rebound,
spreading
beyond
its
original
range
since
2017.
The
distinguished
by
unique
morphology,
includes
oval
or
brick-shaped
structure
complex
lipid
protein
makeup.
current
multi-country
outbreak
designated
public
health
emergency
in
2022,
highlighted
MPXV’s
shifting
epidemiology
ability
spread
rapidly
over
globe.
‘No
one
safe
until
everyone
safe’
slogan
we
often
heard
during
COVID-19
pandemic,
now
required
for
growing
global
regional
mpox
outbreaks.
epidemic
divided
into
two
clades:
Clade
I
II,
have
distinct
pathogenic
characteristics.
Diagnostic
approaches
developed
with
advances
molecular
techniques,
yet
problems
persist
resource-constrained
situations.
This
overview
summarizes
virus’s
history,
epidemiology,
clinical
characteristics,
offering
insights
recent
comeback
response
efforts.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 11, 2024
Monkeypox
(mpox)
is
a
zoonotic
illness
caused
by
the
monkeypox
virus
(MPXV),
with
higher
health
concerns
among
people
who
are
pregnant,
children,
and
persons
immunocompromised,
including
untreated
advanced
HIV
disease.
Significant
progress
has
been
made
in
developing
vaccines
against
mpox,
yet
critical
challenges
limitations
persist
ensuring
their
effectiveness,
safety,
accessibility.
The
pertinence
of
this
review
highlighted
World
Health
Organization's
declaration
global
emergency
on
August
14,
2024,
due
to
recent
mpox
outbreak,
underscoring
necessity
for
effective
vaccine
solutions
face
rapidly
evolving
virus.
Here,
we
comprehensively
analyze
various
platforms
utilized
prevention,
attenuated
non-replicating
vaccines,
viral
vector-based
recombinant
protein
DNA
mRNA
vaccines.
We
evaluate
advantages
each
platform,
highlighting
urgent
need
ongoing
research
innovation
enhance
efficacy
safety.
Recent
advancements,
such
as
incorporating
immunostimulatory
sequences,
improved
delivery
systems,
polyvalent
explored
potential
offer
broader
protection
diverse
orthopoxvirus
strains.
This
work
underscores
optimize
currently
available
investigate
novel
vaccination
strategies
address
future
public
emergencies
effectively.
By
focusing
these
methodologies,
aim
contribute
development
robust
adaptable
other
related
threats.
Mpox,
is
a
zoonotic
disease
caused
by
the
monkeypox
virus
and
primarily
endemic
to
Africa.
As
countries
gradually
stop
smallpox
vaccination,
resistance
declining,
increasing
risk
of
infection
with
mpox
other
viruses.
On
14
August
2024,
World
Health
Organization
announced
that
spread
constituted
public
health
emergency
international
concern.
Mpox's
transmission
routes
symptoms
are
complex
pose
new
challenges
global
health.
Several
vaccines
(such
as
ACAM2000,
JYNNEOS,
LC16m8,
genetically
engineered
vaccines)
antiviral
drugs
tecovirimat,
brincidofovir,
cidofovir,
varicella
immunoglobulin
intravenous
injection)
have
been
developed
marketed
prevent
control
this
disease.
This
review
aims
introduce
epidemic
situation,
epidemiological
characteristics,
physiological
pathological
preventive
measures
for
in
detail,
provide
scientific
basis
prevention
viruses
worldwide.
Nanotechnology,
Год журнала:
2024,
Номер
36(4), С. 042001 - 042001
Опубликована: Окт. 21, 2024
Abstract
The
global
health
threat
posed
by
the
Monkeypox
virus
(Mpox)
requires
swift,
simple,
and
accurate
detection
methods
for
effective
management,
emphasizing
growing
necessity
decentralized
point-of-care
(POC)
diagnostic
solutions.
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR),
initially
known
its
nucleic
acid
abilities,
presents
itself
as
an
attractive
strategy.
CRISPR
offers
exceptional
sensitivity,
single-base
specificity,
programmability.
Here,
we
reviewed
latest
developments
in
CRISPR-based
POC
devices
testing
strategies
Mpox
detection.
We
explored
crucial
role
of
genetic
sequencing
designing
crRNA
reaction
understanding
transmission
mutations.
Additionally,
showed
integration
CRISPR-Cas12
strategy
with
pre-amplification
amplification-free
methods.
Our
study
also
focused
on
significant
Cas12
proteins
effectiveness
coupled
recombinase
polymerase
amplification
(RPA)
envision
future
prospects
challenges,
positioning
CRISPR-Cas12-based
a
frontrunner
next
generation
molecular
biosensing
technologies.
Infectious Disorders - Drug Targets,
Год журнала:
2024,
Номер
24(4)
Опубликована: Янв. 21, 2024
Monkeypox
is
a
viral
disease;
its
outbreak
was
recently
declared
global
emergency
by
the
World
Health
Organization.
For
first
time,
monkeypox
virus
(MPXV)-infected
patient
found
in
India.
Various
researchers
back-to-back
tried
to
find
solution
this
health
just
after
COVID-19.
In
review,
we
discuss
current
status
of
India,
transmission,
virulence
factors,
symptoms,
treatment,
and
preventive
guidelines
generated
Indian
Ministry.
We
that
(MPXV)
disease
different
from
smallpox,
age
group
between
30-40
years
old
more
prone
MPXV
disease.
also
that,
besides
homosexuals,
gays,
bisexuals,
non-vegetarians,
it
affects
normal
straight
men
women
who
have
no
history
travel.
Close
contact
should
be
avoided
rats,
monkeys
sick
people
are
affected
monkeypox.
To
date,
there
drugs,
but
Tecovirimat
effective
than
other
drugs
used
for
diseases
like
smallpox.
Therefore,
need
develop
an
antiviral
agent
against
factor
MXPV.
Abstract
Background
Limited
data
is
available
regarding
the
severity
and
mortality
of
Mpox
in
individuals
with
immunocompromised
conditions.
Therefore,
we
performed
this
meta-analysis
to
understand
impact
HIV-
or
non-HIV-associated
immunosuppression
on
requiring
hospitalization
mortality.
Methods
A
thorough
literature
search
was
from
2022
up
January
2024.
The
results
were
presented
as
odds
ratios
(ORs).
We
only
included
patients
who
required
for
rather
than
isolation.
Results
total
34
studies
analysis.
Our
analysis
did
not
find
a
significant
difference
risk
between
HIV-positive
those
HIV-negative
(OR
=
1.03;
P
0.85;
7
studies;
CD4
count
fewer
200
cells/µL
less
0.5%
across
all
studies).
Patients
lower
an
unsuppressed
RNA
viral
load
(>
copies/ml)
had
significantly
higher
5.3,
<
0.001)
3,
0.001),
respectively.
Most
reported
deaths
HIV
counts
below
cells/µL,
some
fatal
cases
occurring
non-HIV
immunosuppressed
patients,
particularly
organ
transplant
recipients.
Based
autopsy
findings,
confirmed
multiple
organs,
digestive
tract,
lung,
testes.
Furthermore,
documented
death
that
suspected
be
related
hemophagocytic
lymphohistiocytosis
(HLH)
immune
reconstitution
inflammatory
syndrome
(IRIS).
reports
showed
concomitant
non-Mpox
infections
at
time
Conclusions
finding
shows
acts
opportunistic
pathogen
individuals.
These
should
prioritized
early
care
closely
monitored
signs
deteriorating
clinical
Clinical
manifestations
findings
strongly
suggest
dissemination
lungs.
However,
presence
complicates
assessment
attribution
death.
Caution
exercised
when
interpreting
suggesting
poorer
outcomes
immunosuppression,
current
evidence
scarce
further
research
needed.
Journal of Biomolecular Structure and Dynamics,
Год журнала:
2024,
Номер
unknown, С. 1 - 12
Опубликована: Янв. 4, 2024
Understanding
the
pathogenesis
mechanism
of
Monkeypox
virus
(MPXV)
is
essential
to
guide
therapeutic
development
against
virus.
In
current
study,
we
investigated
impact
only
two
reported
substitutions,
S30L,
D88N,
and
S30L-D88N
on
G9R
replication
complex
in
2022
with
E4R
using
structural
modeling,
simulation,
free
energy
calculation
methods.
From
molecular
docking
dissociation
constant
(K
