Integration of Electrospun Scaffolds and Biological Polymers for Enhancing the Delivery and Efficacy of Mesenchymal Stem/Stromal Cell Therapies

Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(6)

Опубликована: Июнь 24, 2024

Mesenchymal stem/stromal cells (MSCs) have emerged as a promising therapeutic approach for variety of diseases due to their immunomodulatory and tissue regeneration capabilities. Despite potential, the clinical application MSC therapies is hindered by limited cell retention engraftment at target sites. Electrospun scaffolds, with high surface area-to-volume ratio tunable physicochemical properties, can be used platforms delivery. However, synthetic polymers often lack bioactive cues necessary optimal cell-scaffold interactions. Integrating electrospun scaffolds biological polymers, such polysaccharides, proteins, composites, combines mechanical integrity materials bioactivity natural represents strategic enhance The molecular interactions between MSCs blended or functionalized been examined in recent studies, it has shown that integration adhesion, proliferation, paracrine secretion through activation multiple signaling pathways, FAK/Src, MAPK, PI3K/Akt, Wnt/β-catenin, YAP/TAZ. Preclinical studies on small animals also reveal enhancing delivery efficacy context regenerating bone, cartilage, muscle, cardiac, vascular, nervous tissues. Future research should concentrate identifying distinct characteristics niche, investigating processes involved MSC-scaffold interactions, applying new technologies stem treatment biofabrication scaffold design. Research large animal models collaboration among scientists, engineers, physicians are crucial translating these advancements into use.

Язык: Английский

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Emerging Trends in Bioprinting for Cartilage Regeneration: Materials, Techniques and Challenges

Pakistan BioMedical Journal, Год журнала: 2025, Номер unknown, С. 02 - 10

Опубликована: Янв. 31, 2025

Cartilage repair is a major clinical problem because of the poor intrinsic healing capacity cartilage coupled with limitations conventional therapies and synthetic substitutes. These challenges have been pursued by bioprinting, which technique that can generate scaffolds mimic native cartilage. This review aims to discuss current future development bioprinting for tissue regeneration focus on most common biomaterials such as alginate, gelatin, collagen, along emerging materials smart hydrogels, nanomaterials, bioactive molecules. The also outlines other technologies like high resolution, 4D, hybrid, microfluidic assisted are believed improve mechanical properties, biological integration vascularization constructs produced through bioprinting. Some problems still unresolved those scale up, biocompatibility immune response hinders application bioprinted further concludes owing some regulatory issues lack an ideal practice in persists. prospects highlighted include use patient derived cells, artificial intelligence process optimization adaptive biomaterials. Mitigating these challenged integrated advanced will enable translation develop personalized, functional, durable constructs.

Язык: Английский

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Comparative analysis of non-fermented and Saccharomyces boulardii-fermented whey: Peptidomic profiling, in silico bioactive peptide analysis, and in vivo evaluation of serum proteins and immune response

International Dairy Journal, Год журнала: 2025, Номер unknown, С. 106222 - 106222

Опубликована: Фев. 1, 2025

Язык: Английский

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Distinct impacts of aging on the immune responses to extracellular matrix-based vs. synthetic biomaterials

Biomaterials, Год журнала: 2025, Номер unknown, С. 123204 - 123204

Опубликована: Фев. 1, 2025

Язык: Английский

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Applications and prospects of biomaterials in diabetes management

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Март 7, 2025

Diabetes is a widespread metabolic disorder that presents considerable challenges in its management. Recent advancements biomaterial research have shed light on innovative approaches for the treatment of diabetes. This review examines role biomaterials diabetes diagnosis and treatment, as well their application managing diabetic wounds. By evaluating recent developments alongside future obstacles, highlights promising potential care, underscoring importance enhancing patient outcomes refining methodologies.

Язык: Английский

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Recent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny-diameter artificial arteries

Deleted Journal, Год журнала: 2025, Номер 7(1)

Опубликована: Март 24, 2025

Abstract Despite advances in synthetic vascular grafts, replicating the dynamic biological functions of native microvasculature remains a critical challenge cardiovascular tissue engineering. While polymer-based conduits offer scalability and dimensional versatility, inherent bioinert nature leads to high failure rates < 6 mm diameter applications due thrombotic complications mechanical mismatch with host tissue. Decellularized matrices (dECM) scaffolds emerge as biologically strategic alternative, preserving crucial basement membrane components biomechanical cues through collagen/elastin retention. The present review systematically elaborates research advancements, determinants, practical challenges utilizing dECM for tiny-diameter artificial vessels (inner 3 mm), while proposing three forward-looking solutions address clinical translation barriers: (1) matrix optimization strategies diameter-specific compliance matching elastin reconstitution; (2) sterilization preservation protocols structural integrity controlled immunogenicity; (3) immunomodulatory engineering via macrophage polarization regulation. proposed methodologies establish innovative avenues transplantation vessels. Graphical abstract

Язык: Английский

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Advances in bioink-based 3D printed scaffolds: optimizing biocompatibility and mechanical properties for bone regeneration

Biomaterials Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The development of bioink-based 3D-printed scaffolds has revolutionized bone tissue engineering (BTE) by enabling patient-specific and biomimetic constructs for regeneration.

Язык: Английский

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Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Май 9, 2024

Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, autonomic function. There is currently no effective treatment for SCI. SCI occurs within three temporal periods: acute, subacute, chronic. In each period there are different alterations in the cells, inflammatory factors, signaling spinal cord. Many biomaterials have been investigated of SCI, including hydrogels fiber scaffolds, some progress has made using multiple materials. However, limitations when individual treatment, these can be significantly improved by combining treatments with stem cells. order to better understand investigate new strategies its several combination therapies that include materials combined drugs, cytokines, etc. summarized current review.

Язык: Английский

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Challenges and Pitfalls of Research Designs involving Magnesium-Based Biomaterials: An Overview

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6242 - 6242

Опубликована: Июнь 5, 2024

Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial development these implants. To achieve implant success, an understanding cellular responses post-implantation, proper model selection, good study design are crucial. There several challenges reaching a safe effective translation laboratory findings into practice. The utilization Mg-based biomedical devices eliminates need biomaterial removal surgery post-healing mitigates adverse effects associated with permanent implantation. high corrosion rate implants poses unexpected degradation, structural failure, hydrogen evolution, alkalization, cytotoxicity. biocompatibility degradability materials based on magnesium have been studied by many researchers in vitro; however, evaluations addressing impact material vivo still be improved. Several animal models, including rats, rabbits, dogs, pigs, explored assess potential magnesium-based Moreover, strategies alloying coating identified enhance degradation transform opportunities. This review aims explore Mg across applications within (in vitro) vivo) models.

Язык: Английский

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Tissue Engineering Scaffolds: The Importance of Collagen

Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Фев. 19, 2024

Tissue engineering focuses on developing replacement tissues and organs to maintain, restore, or improve their function. To achieve this goal, an optimal scaffold is required promote cell growth biomolecules release involved in the repair process. In tissues, extracellular matrix (ECM) provides spatial mechanical cues cells physical support. Therefore, creating a that mimics ECM of tissue organ interest facilitate its represents urgent need. Collagen most abundant protein essential for maintaining biological structural integrity as well providing Collagen-based scaffolds can be obtained from decellularized collagen matrix, preserving original shape structure, by extracting, purifying, polymerizing alone with other natural biosynthetic polymers ceramics, which chemically physically cross-linked, modified natural/synthetic inorganic materials, supplemented biochemical factors. The properties obtaining products intellectual property collagen-based clinical trials patents are discussed. Here, we described importance repair.

Язык: Английский

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