Medicina,
Год журнала:
2024,
Номер
60(12), С. 2091 - 2091
Опубликована: Дек. 21, 2024
Background
and
Objectives:
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
an
important
chronic
with
major
health
risks,
especially
in
the
presence
of
T2DM,
but
pathophysiology
this
condition
not
fully
understood.
This
study
aimed
to
investigate
platelet
hematometric
indices
patients
T2DM
MASLD.
Materials
Methods:
Demographic
medical
(including
anthropometric)
data
were
collected
from
271
participants,
whom
blood
samples
also
drawn
fasting
conditions
for
complete
count,
metabolic
panel,
ferritin,
haptoglobin,
creatinine,
fibrosis
markers.
The
correlations
main
parameters
clinical
laboratory
investigated
by
bivariate
multiple
regression
analyses.
Results:
median
platelets
number
was
235·103/μL,
thus,
population
divided
into
two
subgroups:
higher
lower
numbers
(group
1
(mean):
286.38
±
43.29·103/μL
group
2
188.12
39.77·103/μL).
Despite
similar
BMIs,
had
fatty
index
(FLI)
(84.44
18.04
vs.
79.85
17.98;
p
=
0.0088)
insulin
resistance
(HOMA-IR:
3.16
1.50
2.63
1.31;
0.0008),
direct
bilirubin,
transaminases,
uric
acid,
ferritin
concentrations.
Higher
percentages
males
subjects
HOMA-IR
values
>2.5
accounted
group.
In
analyses,
count
plateletcrit
(PTC)
correlated
independently
sex,
leucocyte
HOMA-IR,
bilirubin
concentrations
(p
<
0.0001).
distribution
width
(PDW)
positively
separate
analyses
(β
0.060;
0.0004,
β
0.052;
0.0025),
GGT,
while
mean
volume
presented
a
weak
significant
positive
association
FLI.
Patients
PDW
PTC.
Conclusions:
Male
MASLD
PTC
larger
PDW.
associated
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
common
as
well
leading
causes
mortality
worldwide,
and
sorafenib
first-line
treatment
in
HCC
patients.
Unfortunately,
drug
resistance
to
often
develops.
However,
underlying
mechanism
remains
unclear.
Here,
we
reveal
important
role
macrophage
extracellular
traps
(METs)-mediated
crosstalk
between
macrophages
tumor
cells
resistance.
Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2264 - 2264
Опубликована: Окт. 4, 2024
Observational
studies
have
highlighted
the
pivotal
role
of
inflammatory
cytokines
in
cirrhosis
progression.
However,
existence
a
causal
link
between
and
remains
uncertain.
In
this
study,
we
conducted
bidirectional
Mendelian
randomization
(MR)
analysis
at
summarized
level
to
illuminate
potential
relationship
two
variables.
European Journal of Gastroenterology & Hepatology,
Год журнала:
2024,
Номер
37(1), С. 10 - 14
Опубликована: Окт. 28, 2024
Metabolic-associated
steatotic
liver
disease
(MASLD)
is
the
most
common
cause
of
chronic
in
Western
countries,
with
rapidly
increasing
prevalence
worldwide,
estimated
at
around
40%
due
to
modernization
and
urbanization.
MASLD
defined
as
hepatic
steatosis
identified
through
histology,
imaging,
blood
markers,
absence
other
secondary
causes
fat
accumulation,
such
significant
alcohol
consumption,
use
steatogenic
medication,
or
hereditary
disorders.
The
current
management
strategies
addressing
involve
lifestyle
modifications
treating
coexisting
conditions
obesity,
hyperlipidemia,
insulin
resistance,
type
2
diabetes.
Several
studies
demonstrate
that
antiplatelet
drugs,
including
acetylsalicylic
acid,
have
beneficial
effects
on
hepatocytes
by
decreasing
inflammation,
oxidative
stress,
resistance
may
prevent
fibrosis
progression
MASLD.
This
review
article
discusses
impact
aspirin
triglyceride
accumulation
hepatocytes.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 10, 2024
AbstractBackground:
Diabetic
retinopathy
(DR),
a
prevalent
complication
in
patients
with
type
2
diabetes,
has
attracted
increasing
attention.
Recent
studies
have
explored
plausible
association
between
and
significant
liver
fibrosis.
The
aim
of
this
investigation
was
to
develop
sophisticated
machine
learning
(ML)
model,
leveraging
comprehensive
clinical
datasets,
forecast
the
likelihood
fibrosis
interpret
ML
model
by
applying
SHapley
Additive
exPlanations
(SHAP)
method.
Methods:
This
inquiry
based
on
data
from
National
Health
Nutrition
Examination
Survey
2005-2008
cohort.
Utilizing
Fibrosis-4
index(FIB-4),
stratified
across
spectrum
grades
(F0-F4).
severity
determined
using
retinal
imaging
segmented
into
four
discrete
gradations.
A
ten-fold
cross-validation
approach
used
gauge
propensity
towards
Eight
methodologies
were
used:
Extreme
Gradient
Boosting
(XGBoost),
Random
Forest,
multilayer
perceptron,
Support
Vector
Machines,
Logistic
Regression,
Plain
Bayes,
Decision
Tree,
k-nearest
neighbors.
efficacy
these
models
gauged
metrics,
such
as
area
under
curve
(AUC).
SHAP
method
deployed
unravel
intricacies
feature
importance
explicate
inner
workings
model.
Results:
The
analysis
included
5363
participants,
whom
2116
(39.45%)
exhibited
notable
Following
random
allocation,
3754
individuals
assigned
training
set
1610
allocated
validation
Twelve
variables
curated
for
integration
Among
eight
scrutinized,
XGBoost
attained
zenith
both
AUC
(0.977,
95%
CI:
0.974-0.981)
F1
score
(0.896,
0.885-0.907).
In
internal
validation,
sustained
its
superiority,
an
0.969
0.885,
surpassing
all
other
models.
methodology
unveils
six
foremost
factors
through
ranking.
Conclusion:
Sophisticated
crafted
discern
intervene
early.
Journal of Clinical and Experimental Hematopathology,
Год журнала:
2024,
Номер
64(3), С. 166 - 176
Опубликована: Янв. 1, 2024
The
interaction
between
cancer
cells
and
stromal
contributes
to
the
pathogenesis
of
various
types
tumors
in
tumor
microenvironment
(TME).
Macrophages
(Mφs),
a
type
cell,
are
transformed
into
tumor-associated
Mφs
(TAMs)
after
integrating
within
solid
tumors.
TAMs
known
interact
with
induce
progression.
Thus,
construct
an
organ-specific
TME,
which
is
advantageous
for
survival
TME.
density
be
involved
prognosis
patients
lymphomas.
A
higher
increases
lymphoma
cells,
promoting
This
review
focuses
on
lymphoid
tissues,
such
as
TAMs,
fibroblastic
reticular
(FRCs),
follicular
dendritic
(FDCs).
also
signal
transduction
caused
by
via
factors
cytokines.
IL-10
other
cytokines
secreted
activate
JAK/STAT
pathway
lymphoma,
classic
Hodgkin
diffuse
large
B-cell
lymphoma.
FRCs
play
roles
promotion
Cytokines/chemokines
FDCs
essential
cell
survival,
proliferation,
invasion,
migration
In
conclusion,
FRCs,
crucial
TME
Furthermore,
histological
spatial
analysis
revealing
positional
relationship
each
could
highlight
lymphoma-stromal
interactions.
BMC Medical Informatics and Decision Making,
Год журнала:
2024,
Номер
24(1)
Опубликована: Ноя. 11, 2024
Diabetic
retinopathy
(DR),
a
prevalent
complication
in
patients
with
type
2
diabetes,
has
attracted
increasing
attention.
Recent
studies
have
explored
plausible
association
between
and
significant
liver
fibrosis.
The
aim
of
this
investigation
was
to
develop
sophisticated
machine
learning
(ML)
model,
leveraging
comprehensive
clinical
datasets,
forecast
the
likelihood
fibrosis
interpret
ML
model
by
applying
SHapley
Additive
exPlanations
(SHAP)
method.
Platelets
are
important
players
in
hemostasis.
Alterations
platelet
number
and/or
function
lead
to
life-threatening
conditions
like
thrombosis,
myocardial
infarction
and
stroke.
During
aging,
changes
at
the
cellular,
organ
systemic
level
occur
that
affect
counts,
functionality,
expression
of
surface
receptors,
clearance
markers
as
well
their
interactions
with
immune
cells.
Understanding
how
these
influence
platelets
can
help
prevent
alterations
hemostasis
thrombosis
we
observe
elderly.
In
this
review,
highlight
respective
sites
life
cycle:
bone
marrow,
liver
spleen,
but
also
show
immunity
contribute.
We
point
out
necessity
for
further
research
on
age-related
systems
interplay
better
understand
complex
processes
cause
cycle
during
aging.
Medicina,
Год журнала:
2024,
Номер
60(12), С. 2091 - 2091
Опубликована: Дек. 21, 2024
Background
and
Objectives:
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
an
important
chronic
with
major
health
risks,
especially
in
the
presence
of
T2DM,
but
pathophysiology
this
condition
not
fully
understood.
This
study
aimed
to
investigate
platelet
hematometric
indices
patients
T2DM
MASLD.
Materials
Methods:
Demographic
medical
(including
anthropometric)
data
were
collected
from
271
participants,
whom
blood
samples
also
drawn
fasting
conditions
for
complete
count,
metabolic
panel,
ferritin,
haptoglobin,
creatinine,
fibrosis
markers.
The
correlations
main
parameters
clinical
laboratory
investigated
by
bivariate
multiple
regression
analyses.
Results:
median
platelets
number
was
235·103/μL,
thus,
population
divided
into
two
subgroups:
higher
lower
numbers
(group
1
(mean):
286.38
±
43.29·103/μL
group
2
188.12
39.77·103/μL).
Despite
similar
BMIs,
had
fatty
index
(FLI)
(84.44
18.04
vs.
79.85
17.98;
p
=
0.0088)
insulin
resistance
(HOMA-IR:
3.16
1.50
2.63
1.31;
0.0008),
direct
bilirubin,
transaminases,
uric
acid,
ferritin
concentrations.
Higher
percentages
males
subjects
HOMA-IR
values
>2.5
accounted
group.
In
analyses,
count
plateletcrit
(PTC)
correlated
independently
sex,
leucocyte
HOMA-IR,
bilirubin
concentrations
(p
<
0.0001).
distribution
width
(PDW)
positively
separate
analyses
(β
0.060;
0.0004,
β
0.052;
0.0025),
GGT,
while
mean
volume
presented
a
weak
significant
positive
association
FLI.
Patients
PDW
PTC.
Conclusions:
Male
MASLD
PTC
larger
PDW.
associated
