Clinical & Translational Oncology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 26, 2024
Язык: Английский
Pain and Therapy, Год журнала: 2024, Номер 13(3), С. 409 - 433
Опубликована: Апрель 27, 2024
One of the most common musculoskeletal disorders, osteoarthritis (OA), causes worldwide disability, morbidity, and poor quality life by degenerating articular cartilage, modifying subchondral bone, inflaming synovial membranes. OA pathogenesis pathways must be understood to generate new preventative disease-modifying therapies. In recent years, it has been acknowledged that gut microbiota (GM) can significantly contribute development OA. Dysbiosis GM disrupt "symphony" between host GM, leading a immunological response activates "gut–joint" axis, ultimately worsening This narrative review summarizes research supporting "gut–joint axis" hypothesis, focusing on interactions immune system in its two main components, innate adaptive immunity. Furthermore, pathophysiological sequence events link imbalance OA-related pain is broken down further investigated. We also suggest diet prebiotics, probiotics, nutraceuticals, exercise, fecal transplantation could improve management represent potential therapeutic tool light scarce panorama drugs (DMOADs). Future needed elucidate these complex interactions, prioritizing how particular change i.e., rise or drop specific bacterial strain, correlates with certain subset pinpoint associated signaling pathway leads
Язык: Английский
Процитировано
7
Inflammopharmacology, Год журнала: 2024, Номер 32(5), С. 2781 - 2800
Опубликована: Авг. 21, 2024
Язык: Английский
Процитировано
5
Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)
Опубликована: Март 11, 2025
Язык: Английский
Процитировано
0
Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Март 26, 2025
Язык: Английский
Процитировано
0
Archives of Microbiology, Год журнала: 2024, Номер 206(3)
Опубликована: Фев. 18, 2024
Язык: Английский
Процитировано
4
Virology Journal, Год журнала: 2025, Номер 22(1)
Опубликована: Фев. 13, 2025
Mother-to-child transmission (MTCT) is one of the main routes HBV, and previous studies focused on efficacy safety nucleoside analogues (NAs) in preventing MTCT. There are limited data virologic changes chronic hepatitis B (CHB) patients after discontinuing treatment postpartum retreatment. A retrospective-prospective real-world pilot cohort study pregnant women with CHB was conducted. Biochemical virological characteristics (HBsAg, HBeAg HBV DNA) received NAs pre-pregnancy (n = 24), discontinued delivery 88) retreatment 22) were collected during follow-up. The incidences clearance, half decrease HBsAg, 0.5 lg HBsAg < 1000 IU/mL 5.7% (4/70), 10.0% (8/48), 6.3% (3/48) 1.6% (1/61), respectively. More significantly decreases DNA observed compared to pre-pregnancy. Significantly higher cumulative achieved Long-term follow-up results indicated that it safe for positive discontinue delivery. pregnancy can benefit from because unexpected which may be helpful achieve goal functional cure. Trial registration number ClinicalTrials.gov (No.ChiCTR2100054116).
Язык: Английский
Процитировано
0
Discover Oncology, Год журнала: 2025, Номер 16(1)
Опубликована: Март 22, 2025
Cancer stem cells (CSCs), are a critical subpopulation within tumours, and defined by their capacity for self-renewal, differentiation, tumour initiation. These unique traits contribute to progression, metastasis, resistance conventional treatments like chemotherapy radiotherapy, often resulting in cancer recurrence poor patient outcomes. As such, CSCs have become focal points developing advanced therapies. This review highlights progress CSC-targeted treatments, including chimeric antigen receptor T-cell (CAR-T) therapy, immunotherapy, molecular targeting, nanoparticle-based drug delivery systems. Plant-derived compounds gene-editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR), explored potential enhance precision minimize side effects. Metabolic pathways integral CSC survival, mitochondrial dynamics, mitophagy (regulated dynamin-related protein 1 [DRP1] the PINK1/Parkin pathway), one-carbon metabolism, amino acid metabolism (involving enzymes glutaminase (GLS) glutamate dehydrogenase (GDH]), lipid hypoxia-induced metabolic reprogramming mediated hypoxia-inducible factors (HIF-1α HIF-2α), examined therapeutic targets. The adaptability of through autophagy, flexibility, epigenetic regulation metabolites α-ketoglutarate, succinate, fumarate is discussed. Additionally, extracellular vesicles nicotinamide adenine dinucleotide (NAD⁺) identified pivotal redox balance, DNA repair, modifications. Addressing challenges heterogeneity, immune evasion, treatment durability requires interdisciplinary collaboration. Advancing therapies essential overcoming preventing relapse, paving way transformative treatments. underscores importance leveraging innovative technologies fostering collaboration revolutionize treatment.
Язык: Английский
Процитировано
0
Diabetic Medicine, Год журнала: 2024, Номер unknown
Опубликована: Июль 12, 2024
Abstract Background/Aims As a microvascular complication, diabetic kidney disease is the leading cause of chronic and end‐stage renal worldwide. While underlying pathophysiology driving transition to failure yet be fully understood, recent studies suggest that cellular senescence central in development progression. Consequently, understanding molecular mechanisms which initiate drive response milieu crucial developing targeted therapies halt progression disease. Methods To understand mechanistic pathways underpinning context disease, we reviewed literature using PubMed for English language articles contained key words related senescence, inflammation, fibrosis, senescence‐associated secretory phenotype (SASP), autophagy, diabetes. Results Aberrant accumulation metabolically active senescent cells notable event Through autocrine‐ paracrine‐mediated mechanisms, resident potentiate inflammation fibrosis through increased expression secretion pro‐inflammatory cytokines, chemoattractants, recruitment immune cells, myofibroblast activation, extracellular matrix remodelling. Compounds eliminate and/or target SASP – including senolytic senomorphics drugs demonstrate promising results reducing cell burden associated effect. Conclusions Here evidence link between highlight potential therapeutic targets could exploited delay improve outcomes individuals with Trials are now required translate their clinical setting.
Язык: Английский
Процитировано
3
Journal of Molecular Medicine, Год журнала: 2024, Номер 102(7), С. 899 - 912
Опубликована: Май 13, 2024
Язык: Английский
Процитировано
1
Cancer Cell International, Год журнала: 2024, Номер 24(1)
Опубликована: Сен. 13, 2024
Язык: Английский
Процитировано
1