International Journal of Biological Macromolecules, Год журнала: 2024, Номер 283, С. 137543 - 137543
Опубликована: Ноя. 13, 2024
Язык: Английский
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 7547 - 7566
Опубликована: Июль 1, 2024
Abstract: Cancer poses a significant threat to human life and health. Chemotherapy is currently one of the effective cancer treatments, but many chemotherapy drugs have cell toxicity, low solubility, poor stability, narrow therapeutic window, unfavorable pharmacokinetic properties. To solve above problems, target drug delivery tumor cells, reduce side effects drugs, an anti-tumor system based on microenvironment has become focus research in recent years. The construction reduction-sensitive nanomedicine disulfide bonds attracted much attention. Disulfide good reductive responsiveness can effectively high glutathione (GSH) levels environment, enabling precise delivery. further enhance targeting accelerate release, are often combined with pH-responsive nanocarriers highly expressed ligands cells construct systems. connect molecules polymer system, as well between different carrier molecules. This article summarized systems (DDS) that researchers constructed years bond microenvironment, cleavage-triggering conditions, various loading strategies, design. In this review, we also discuss controlled release mechanisms these DDS clinical applicability challenges faced translation. Keywords: bond, systems, GSH/ROS
Язык: Английский
Процитировано
18
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3414 - 3414
Опубликована: Март 18, 2024
The association between cancer and inflammation is well established. Chronic represents a fundamental step in the development progression of some types cancer. Tumors are composed heterogeneous population infiltrating cells including macrophages, fibroblasts, lymphocytes, granulocytes, mast cells, which respond to signals from microenvironment and, turn, produce cytokines, chemokines, transcription factors, receptors, miRNAs. Recent data demonstrate that, addition classical (M1) alternative (M2) macrophage subtypes, there many intermediate subtypes that potentially play different roles response environmental stimuli. infiltrated by macrophages called TAMs mainly display an M2-like phenotype tumor growth-permissive activities. There bidirectional interaction tumor-infiltrating determines polarization ultimately or regression. These complex interactions still unclear but understanding them for new therapeutic strategies. Re-educating tumor-permissive into anti-tumor focus research. This review aims analyze most recent articles investigating interplay tumors, TAMs, strategies re-educating macrophages.
Язык: Английский
Процитировано
6
Molecular Therapy — Methods & Clinical Development, Год журнала: 2025, Номер 33(1), С. 101427 - 101427
Опубликована: Фев. 5, 2025
The liver, which plays pivotal roles in metabolism and immunity, often confers tolerance, suppressing immune responses to pathogens. Adjuvanted, lipid nanoparticle-encapsulated mRNA vaccines (mRNA-LNPs) offer a promising approach overcome tolerance. In this study, the immunostimulatory activity of well-documented adjuvants, i.e., 2'3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), resiquimod (R848), polyinosinic:polycytidylic acid (Poly I:C), on non-parenchymal liver cells was determined. When co-applied with mRNA-loaded LNPs, these adjuvants enhanced at variable extents. Moreover, efficiency translation presence cGAMP comparable non-adjuvanted control. Repetitive co-application mRNA-LNPs showed improvement cellular when R848 or R848/cGAMP treatments were used. These findings emphasize need delineate delicate balance between immunomodulatory properties selecting for mRNA-LNP insights how enhance immunity infectious diseases cancers that affect liver.
Язык: Английский
Процитировано
0
Cancer Medicine, Год журнала: 2025, Номер 14(3)
Опубликована: Фев. 1, 2025
ABSTRACT Background Lung cancer is among the most common and deadliest malignant tumors worldwide. It often detected at late stages, resulting in unfavorable outcomes, with tumor cell heterogeneity medication resistance. Tumor‐associated macrophages are key cells contributing to progression. They categorized into two primary phenotypes: Proinflammatory (M1) anti‐inflammatory (M2) which involved onset progression of NSCLC. The role cytokines secreted by lung described, effects various substances such as RNA or protein on differentiation polarization phenotypes highlighted characterize impact immune state therapeutic effect treatments patient prognosis. Researchers have primarily aimed investigate innovative carriers strategies based modify microenvironment. Objectives These approaches integrated other treatments, particularly immunotherapy, enhance efficacy. Methods A comprehensive review was carried out systematically synthesizing existing literature PubMed, using combination keywords “TAMs”, “NSCLC”, “Drug resistance”, “therapy”. available studies were screened for selection quality relevance. Conclusions TAMs promote invasion, growth, metastasis promoting angiogenesis EMT. In addition, they contribute development drug resistance immunosuppressive microenvironment establishment. factors TAM can weaken activity cells, inhibit their killing tumors, leading suppression hindering effectiveness treatment. Therefore, a target immunotherapy. Various being explored, including reducing recruitment influencing treat treatment systems achieve precise delivery drugs gene interfering molecules without causing side effects.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Фев. 26, 2025
Lung cancer remains a leading cause of cancer-related deaths worldwide, necessitating innovative treatments. Tumor-associated macrophages (TAMs) are primary immunosuppressive effectors that foster tumor proliferation, angiogenesis, metastasis, and resistance to therapy. They broadly categorized into proinflammatory M1 tumor-promoting M2 phenotypes, with elevated infiltration correlating poor prognosis. Strategies aimed at inhibiting TAM recruitment, depleting TAMs, or reprogramming therefore highly promising. Key signaling pathways, such as CSF-1/CSF-1R, IL-4/IL-13-STAT6, TLRs, CD47-SIRPα, regulate polarization. Additionally, macrophage-based drug delivery systems permit targeted agent transport hypoxic regions, enhancing Preclinical studies combining TAM-targeted therapies chemotherapy immune checkpoint inhibitors have yielded improved responses prolonged survival. Several clinical trials also reported benefits in previously unresponsive patients. Future work should clarify the roles macrophage-derived exosomes, cytokines, additional mediators shaping microenvironment. These insights will inform design next-generation carriers optimize combination immunotherapies within precision medicine frameworks. Elucidating phenotypes their regulatory molecules central developing novel strategies curb progression ultimately improve outcomes lung cancer. Importantly, immunomodulation may offer expanded treatment avenues.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Metastasis is the leading cause of death in patients with lung cancer. Multidisciplinary comprehensive treatments (MDT), including surgery, chemotherapy, radiotherapy, gene-targeted therapy, immunotherapy, antibody-drug conjugate (ADC), natural products, etc., have been currently used for cancer metastasis. The MDT model has shown promising efficacy against metastasis clinical practice. However, these therapies some limitations, such as unusual toxic side effects, drug resistance, limited indications, and high costs. Therefore, emerging technological platforms are imperative to overcome bottlenecks. Nanomedicine can be prepare efficient delivery systems owing its good biocompatibility, targeting, responsive release, multidrug codelivery plays an important role synergistic antimetastasis because optical, acoustic, electrical, thermal, magnetic functions. This review analyses limitations model, briefly outlines advantages nanotechnology, introduces nanodrug systems, summarizes nanostrategies based on invasion-metastasis cascade process, provides a summary prospects challenges translation nanomedicines.
Язык: Английский
Процитировано
0
European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 204, С. 114510 - 114510
Опубликована: Сен. 21, 2024
Язык: Английский
Процитировано
2
Journal of Dental Sciences, Год журнала: 2024, Номер 20(2), С. 811 - 818
Опубликована: Окт. 11, 2024
Porphyromonas gingivalis (P. gingivalis) has been shown to induce apoptosis in endothelial cells and contribute the progression of atherosclerosis. While Polyinosinic-polycytidylic acid (Poly (I:C)) is known activate innate immune response against infections, its potential interference with P. gingivalis-induced atherosclerosis remains unclear. This study aimed elucidate role underlying mechanisms Poly (I:C) mediating human umbilical vein (HUVECs) induced by gingivalis. A mice model a bacteremia were established investigate effects on aortic root, as well expression levels apoptosis-related proteins including Caspase 3, 9, Bax, Bcl-2. Subsequently, HUVECs cultured vitro compare cell these under stimulation gingivalis, both without treatment; additionally, activation status JAK/STAT signaling pathway was assessed. The administration diminished root mice, enhanced anti-apoptotic protein Bcl-2, decreased 3 9. Furthermore, exhibited similar vitro. Additionally, treatment activated pathway, while STAT inhibitor found attenuate effects. attenuated cellular apoptosis, involvement this mechanism.
Язык: Английский
Процитировано
0
Journal of Dental Sciences, Год журнала: 2024, Номер 20(2), С. 754 - 763
Опубликована: Окт. 31, 2024
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 283, С. 137543 - 137543
Опубликована: Ноя. 13, 2024
Язык: Английский
Процитировано
0