Macrophage pyroptosis and its crucial role in ALI/ARDS
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 14, 2025
Acute
lung
injury(ALI)/acute
respiratory
distress
syndrome(ARDS)
is
a
severe
clinical
syndrome
characterized
by
high
morbidity
and
mortality,
primarily
due
to
injury.
However,
the
pathogenesis
of
ALI/ARDS
remains
complex
issue.
In
recent
years,
role
macrophage
pyroptosis
in
injury
has
garnered
extensive
attention
worldwide.
This
paper
reviews
mechanism
pyroptosis,
discusses
its
ALI/ARDS,
introduces
several
drugs
intervening
measures
that
can
regulate
influence
progression
ALI/ARDS.
By
doing
so,
we
aim
enhance
understanding
provide
novel
insights
for
treatment.
Язык: Английский
Inflammation unleashed: The role of pyroptosis in chronic liver diseases
International Immunopharmacology,
Год журнала:
2024,
Номер
141, С. 113006 - 113006
Опубликована: Авг. 29, 2024
Pyroptosis,
a
newly
identified
form
of
programmed
cell
death
intertwined
with
inflammatory
responses,
is
facilitated
by
the
Gasdermin
family's
pore-forming
activity,
leading
to
lysis
and
release
pro-inflammatory
cytokines.
This
process
double-edged
sword
in
innate
immunity,
offering
protection
against
pathogens
while
risking
excessive
inflammation
tissue
damage
when
dysregulated.
Specifically,
pyroptosis
operates
through
two
distinct
signaling
pathways,
namely
Caspase-1
pathway
Caspase-4/5/11
pathway.
In
context
chronic
liver
diseases
like
fibrosis
cirrhosis,
emerges
as
central
contributing
factor
their
pathogenesis.
The
identification
characterized
activation
immune
cells
secretion
cytokines
such
IL-1α,
IL-1β,
TNF-α.
review
explores
interrelationship
between
inflammasome,
protein
complex
located
that
recognizes
danger
signals
initiates
activation,
resulting
IL-1β
IL-18.
article
delves
into
influence
inflammasome
on
various
disorders,
specific
focus
molecular
pathophysiological
mechanisms.
Additionally,
potential
therapeutic
implications
targeting
for
are
highlighted
future
consideration.
Язык: Английский
Mechanisms and treatment of atherosclerosis: focus on macrophages
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 6, 2024
Macrophages
are
the
basic
mediators
and
coordinators
of
various
types
chronic
inflammation
play
a
crucial
role
in
formation
development
atherosclerosis
(AS).
In
complex
microenvironment
atherosclerotic
plaques,
macrophages
different
sources
exposed
to
signal
stimuli
thus
polarized
into
subpopulations.
Various
with
predominantly
M1
M2
phenotypes
also
regulatory
roles
initiation
progression
AS.
Lipid-lowering
drugs,
mainly
statins,
widely
used
clinical
practice,
but
adverse
reactions
obvious
there
is
lack
personalized
treatment.
Emerging
targeted
macrophage
Traditional
Chinese
medicine
(TCM)-related
therapies
can
regulate
cellular
microenvironment,
inhibit
polarization
macrophages,
promote
activation
providing
new
ideas
for
prevention
treatment
Язык: Английский
Cadmium-induced iron dysregulation contributes to functional impairment in brain endothelial cells via the ferroptosis pathway
Toxicology and Applied Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 117233 - 117233
Опубликована: Янв. 1, 2025
Язык: Английский
Disrupting the immune homeostasis: the emerging role of macrophage ferroptosis in autoimmune diseases
International Immunopharmacology,
Год журнала:
2025,
Номер
157, С. 114745 - 114745
Опубликована: Май 3, 2025
Язык: Английский
Low butyrate concentrations exert anti-inflammatory and high concentrations exert pro-inflammatory effects on macrophages
The Journal of Nutritional Biochemistry,
Год журнала:
2025,
Номер
unknown, С. 109962 - 109962
Опубликована: Май 1, 2025
Язык: Английский
Macrophages, Metabolism, Mitochondria, Circadian Rhythmicity and the Pathogen: The Multidimensional Nature of Tuberculosis
Results and problems in cell differentiation,
Год журнала:
2024,
Номер
unknown, С. 341 - 364
Опубликована: Янв. 1, 2024
Язык: Английский
Identification of Protein Networks and Biological Pathways Driving the Progression of Atherosclerosis in Human Carotid Arteries Through Mass Spectrometry-Based Proteomics
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13665 - 13665
Опубликована: Дек. 20, 2024
Vulnerable
atherosclerotic
plaques,
especially
hemorrhaged
lesions,
are
the
major
cause
of
mortalities
related
to
vascular
pathologies.
The
early
identification
vulnerable
plaques
helps
stratify
patients
at
risk
developing
acute
events.
In
this
study,
proteomics
analyses
human
carotid
artery
samples
collected
from
with
atheromatous
and
complicated
respectively,
as
well
healthy
controls
were
performed.
proteins
isolated
analyzed
by
a
bottom-up
shotgun
approach
that
relied
on
nanoflow
liquid
chromatography-tandem
mass
spectrometry
(LC-MS/MS)
using
both
data-dependent
(DDA)
data-independent
(DIA)
acquisitions.
data
obtained
high-resolution
DIA
displayed
stronger
distinction
among
groups
compared
DDA
analyses.
Differentially
expressed
further
examined
Ingenuity
Pathway
Analysis®
focus
pathological
molecular
processes
driving
atherosclerosis.
From
more
than
150
significantly
regulated
canonical
pathways,
atherosclerosis
signaling
neutrophil
extracellular
trap
verified
protein-targeted
extraction.
results
our
study
expected
facilitate
better
understanding
disease
progression's
drivers
provide
inspiration
for
multiomics
hypothesis-driven
studies.
Язык: Английский