Identification of Protein Networks and Biological Pathways Driving the Progression of Atherosclerosis in Human Carotid Arteries Through Mass Spectrometry-Based Proteomics DOI Open Access
Gergő Kalló, Khadiza Zaman,

László Potor

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13665 - 13665

Published: Dec. 20, 2024

Vulnerable atherosclerotic plaques, especially hemorrhaged lesions, are the major cause of mortalities related to vascular pathologies. The early identification vulnerable plaques helps stratify patients at risk developing acute events. In this study, proteomics analyses human carotid artery samples collected from with atheromatous and complicated respectively, as well healthy controls were performed. proteins isolated analyzed by a bottom-up shotgun approach that relied on nanoflow liquid chromatography-tandem mass spectrometry (LC-MS/MS) using both data-dependent (DDA) data-independent (DIA) acquisitions. data obtained high-resolution DIA displayed stronger distinction among groups compared DDA analyses. Differentially expressed further examined Ingenuity Pathway Analysis® focus pathological molecular processes driving atherosclerosis. From more than 150 significantly regulated canonical pathways, atherosclerosis signaling neutrophil extracellular trap verified protein-targeted extraction. results our study expected facilitate better understanding disease progression's drivers provide inspiration for multiomics hypothesis-driven studies.

Language: Английский

Cadmium-induced iron dysregulation contributes to functional impairment in brain endothelial cells via the ferroptosis pathway DOI

Junkyung Gil,

Dong‐Min Kim, Sungbin Choi

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117233 - 117233

Published: Jan. 1, 2025

Language: Английский

Citations

0
Macrophage pyroptosis and its crucial role in ALI/ARDS DOI Creative Commons

Yuju Cai,

Luorui Shang,

Fangyuan Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to injury. However, the pathogenesis of ALI/ARDS remains complex issue. In recent years, role macrophage pyroptosis in injury has garnered extensive attention worldwide. This paper reviews mechanism pyroptosis, discusses its ALI/ARDS, introduces several drugs intervening measures that can regulate influence progression ALI/ARDS. By doing so, we aim enhance understanding provide novel insights for treatment.

Language: Английский

Citations

0
Disrupting the immune homeostasis: the emerging role of macrophage ferroptosis in autoimmune diseases DOI
Tian‐Fu Liu, Yichen Huang, Yizhe Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 157, P. 114745 - 114745

Published: May 3, 2025

Language: Английский

Citations

0
Inflammation unleashed: The role of pyroptosis in chronic liver diseases DOI Creative Commons
Lujian Zhu,

Hongjie Tong,

Chao Ren

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 113006 - 113006

Published: Aug. 29, 2024

Pyroptosis, a newly identified form of programmed cell death intertwined with inflammatory responses, is facilitated by the Gasdermin family's pore-forming activity, leading to lysis and release pro-inflammatory cytokines. This process double-edged sword in innate immunity, offering protection against pathogens while risking excessive inflammation tissue damage when dysregulated. Specifically, pyroptosis operates through two distinct signaling pathways, namely Caspase-1 pathway Caspase-4/5/11 pathway. In context chronic liver diseases like fibrosis cirrhosis, emerges as central contributing factor their pathogenesis. The identification characterized activation immune cells secretion cytokines such IL-1α, IL-1β, TNF-α. review explores interrelationship between inflammasome, protein complex located that recognizes danger signals initiates activation, resulting IL-1β IL-18. article delves into influence inflammasome on various disorders, specific focus molecular pathophysiological mechanisms. Additionally, potential therapeutic implications targeting for are highlighted future consideration.

Language: Английский

Citations

3
Mechanisms and treatment of atherosclerosis: focus on macrophages DOI Creative Commons
Linlin Zhang, Jiawei Li, Yanhong Kou

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 6, 2024

Macrophages are the basic mediators and coordinators of various types chronic inflammation play a crucial role in formation development atherosclerosis (AS). In complex microenvironment atherosclerotic plaques, macrophages different sources exposed to signal stimuli thus polarized into subpopulations. Various with predominantly M1 M2 phenotypes also regulatory roles initiation progression AS. Lipid-lowering drugs, mainly statins, widely used clinical practice, but adverse reactions obvious there is lack personalized treatment. Emerging targeted macrophage Traditional Chinese medicine (TCM)-related therapies can regulate cellular microenvironment, inhibit polarization macrophages, promote activation providing new ideas for prevention treatment

Language: Английский

Citations

3
Macrophages, Metabolism, Mitochondria, Circadian Rhythmicity and the Pathogen: The Multidimensional Nature of Tuberculosis DOI
Paula Guzmán-Téllez,

Miguel Angel Rivero-Silva,

María Maximina Bertha Moreno‐Altamirano

et al.

Results and problems in cell differentiation, Journal Year: 2024, Volume and Issue: unknown, P. 341 - 364

Published: Jan. 1, 2024

Language: Английский

Citations

0
Identification of Protein Networks and Biological Pathways Driving the Progression of Atherosclerosis in Human Carotid Arteries Through Mass Spectrometry-Based Proteomics DOI Open Access
Gergő Kalló, Khadiza Zaman,

László Potor

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13665 - 13665

Published: Dec. 20, 2024

Vulnerable atherosclerotic plaques, especially hemorrhaged lesions, are the major cause of mortalities related to vascular pathologies. The early identification vulnerable plaques helps stratify patients at risk developing acute events. In this study, proteomics analyses human carotid artery samples collected from with atheromatous and complicated respectively, as well healthy controls were performed. proteins isolated analyzed by a bottom-up shotgun approach that relied on nanoflow liquid chromatography-tandem mass spectrometry (LC-MS/MS) using both data-dependent (DDA) data-independent (DIA) acquisitions. data obtained high-resolution DIA displayed stronger distinction among groups compared DDA analyses. Differentially expressed further examined Ingenuity Pathway Analysis® focus pathological molecular processes driving atherosclerosis. From more than 150 significantly regulated canonical pathways, atherosclerosis signaling neutrophil extracellular trap verified protein-targeted extraction. results our study expected facilitate better understanding disease progression's drivers provide inspiration for multiomics hypothesis-driven studies.

Language: Английский

Citations

0