Breast cancer cells promote osteoclast differentiation in an MRTF-dependent paracrine manner DOI Open Access
Pooja A. Chawla, Ishani Sharma, David Gau

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 8, 2023

ABSTRACT Bone is a frequent site for breast cancer metastasis. The vast majority of cancer-associated metastasis osteolytic in nature, and RANKL (receptor activator nuclear factor κB)-induced differentiation bone marrow-derived macrophages (BMDMs) to osteoclasts (OCLs) key requirement metastatic growth cells. In this study, we demonstrate that Myocardin-related transcription (MRTF) cells plays an important role paracrine modulation RANKL-induced osteoclast differentiation. This partly attributed MRTF’s critical maintaining the basal cellular expression connective tissue (CTGF), findings align with strong positive correlation between CTGF MRTF-A gene signature human disease context. Luminex analyses reveal MRTF depletion has broad impact on OCL-regulatory cell-secreted factors extend beyond CTGF. Experimental studies diminishes OCL abundance colonization vivo , suggesting inhibition could be effective strategy diminish formation skeletal involvement cancer. summary, study highlights novel tumor-extrinsic function relevant SIGNIFICANCE STATEMENT MRTF, transcriptional coactivator SRF, known promote progression through its tumor-cell-intrinsic function. Whether how activity tumor modulates other types microenvironment are not clearly understood. uncovers tumor-cell-extrinsic promoting regulation, further demonstrates vivo. Our suggest

Язык: Английский

Nanomaterials for bone metastasis DOI

Xinyan Hao,

Buchan Jiang,

Junyong Wu

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 640 - 651

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

33
Cellular senescence in the tumor with a bone niche microenvironment: friend or foe? DOI Creative Commons

Sajad Alavimanesh,

Negar Nayerain Jazi,

Maedeh Choubani

и другие.

Clinical and Experimental Medicine, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 23, 2025

Cellular senescence is understood to be a biological process that defined as irreversible growth arrest and was originally recognized tumor-suppressive mechanism prevents further propagation of damaged cells. More recently, cellular has been shown have dual role in prevention tumor promotion. Senescent cells carry senescence-associated secretory phenotype (SASP), which altered by factors including pro-inflammatory cytokines, chemokines, other proteases, leading the alteration tissue microenvironment. Though would eventually halt cancerous potential cells, SASP contributes environment promoting inflammation, matrix remodeling, cell invasion. The paradox prevention/promotion particularly relevant bone niche microenvironment, where longer-lasting, chronic inflammation promotes formation. Insights into mechanistic understanding provide basis for targeted therapies, such senolytics, aim eliminate senescent or inhibitors, tumor-promoting effects senescence. These therapeutic interventions offer significant clinical implications treating cancer healthy aging.

Язык: Английский

Процитировано

2
NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance DOI Creative Commons
Shaoyan Shi, Xuehai Ou, Chao Liu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 30, 2025

Osteosarcoma, a highly aggressive malignancy with generally poor prognosis, is characterized by tumor cells’ ability to evade immune responses and resist treatment. The nuclear transcription factor NF-κB signaling pathway crucial in regulating inflammatory reactions. It occupies central position the development of osteosarcoma microenvironment. This research aimed explore how influences recruitment polarization tumor-associated macrophages myeloid-derived suppressor cells, both which contribute immunosuppression. Furthermore, facilitates surveillance evasion cells altering expression checkpoint molecules, such as PD-L1. also enhances cell resistance chemotherapy radiotherapy activating anti-apoptotic pathways exacerbating treatment-induced inflammation. Potential therapeutic approaches include using inhibitors, possibly combination overcome mechanisms reshape antitumor responses. A thorough examination NF-κB’s role expected yield novel clinical treatment strategies, significantly improve patient prognosis targeting this key pathway.

Язык: Английский

Процитировано

0
Targeting tumorous Circ-E-Cadherinencoded C-E-Cad inhibits the recruitment and function of breast cancer-associated myeloid-derived suppressor cells DOI Creative Commons

Junyi Zhou,

Hao Xu, X Li

и другие.

Pharmacological Research, Год журнала: 2024, Номер 204, С. 107204 - 107204

Опубликована: Май 2, 2024

We previously demonstrated that the C-E-cad protein encoded by circ-E-cadherin promotes self-renewal of glioma stem cells. The expression pattern in breast cancer and its potential function tumor microenvironment are unclear. was detected specimens. influence on MDSCs assessed using FACS vivo tumorigenesis experiments. synergistic effect anti-C-E-cad anti-PD-1 antibodies validated vivo. were found to be upregulated vs. normal samples. recruitment MDSCs, especially PMN-MDSCs. activates EGFR signaling cells transcription CXCL8; moreover, binds maintains glycolysis Targeting enhanced efficiency. Our data suggested is markedly overexpressed MDSC survival. increases efficacy immune checkpoint inhibitor therapy.

Язык: Английский

Процитировано

4
Osteoimmunology in bone malignancies: A symphony with evil DOI Creative Commons

Churui Song,

Tie Tong,

Biqi Dai

и другие.

Journal of the National Cancer Center, Год журнала: 2024, Номер 4(4), С. 354 - 368

Опубликована: Сен. 14, 2024

Язык: Английский

Процитировано

1
Cellular crosstalk in the bone marrow niche DOI Creative Commons

Zeqi Huang,

Zoya Iqbal,

Zhe Zhao

и другие.

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Дек. 3, 2024

The bone marrow niche is a special microenvironment that comprises elements, including hematopoietic stem cells, osteoblasts, and endothelial helps maintain their characteristic functions. Here, we elaborate on the crosstalk between various cellular components, other cells in niche. We further explain mechanism of preserving equilibrium niche, which crucial for directional regulation reconstruction repair. Additionally, elucidate intercommunication among osteocytes, osteoblast maturation activation by lymphocytes, deficiency megakaryocytes can markedly impair formation, interaction macrophages mesenchymal Finally, discussed new immunotherapies tumors BM In this review, aimed to provide candid overview highlight concepts underlying unknown mechanisms hematopoiesis reconstruction. Thus, review may more comprehensive understanding role these improving function help identify therapeutic potential different diseases future.

Язык: Английский

Процитировано

1
Targeting myeloid-derived suppressor cells in the tumor microenvironment: potential therapeutic approaches for osteosarcoma DOI
Hye In Ka, Se Hwan Mun,

Sora Han

и другие.

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Год журнала: 2024, Номер 33(3), С. 519 - 531

Опубликована: Ноя. 6, 2024

Osteosarcoma is a bone malignancy characterized by strong invasiveness and rapid disease progression. The tumor microenvironment of osteosarcoma contains various types immune cells, including myeloid-derived suppressor macrophages, T B cells. Imbalances these cells can promote the proliferation metastasis osteosarcoma. Recent studies have indicated substantial increase in levels an cell associated with immunosuppressive pro-cancer effects, peripheral blood patients Moreover, pro-inflammatory cytokine interleukin 18 are positively correlated those animal models In this review, we explore function based on clinical diagnoses discuss future therapeutic approaches for targeting Targeting represents promising approach to improving prognosis survival rates

Язык: Английский

Процитировано

0
Delineating the nexus between gut-intratumoral microbiome and osteo-immune system in bone metastases DOI Creative Commons

Shreya Kapoor,

Muskan Gupta,

Leena Sapra

и другие.

Bone Reports, Год журнала: 2024, Номер 23, С. 101809 - 101809

Опубликована: Окт. 11, 2024

Emerging insights in osteoimmunology have enabled researchers to explore depth the role of immune modulation regulating bone health. Bone is one common sites metastasis notably case breast cancer, prostate cancer and several other types. High calcium ion concentration presence factors within mineralized matrix including TGF-β, BMP etc., aid tumor growth proliferation. Accumulating evidence has substantiated gut-microbiota (GM) tumorigenesis, further providing a strong impetus for growing "immune-cancer-gut microbiota" relationship. Recent advancements research highlight importance intra-tumor microbiota conjunction with GM metastasis. Intratumoral owing their ability cause genetic instability, mutations, epigenetic modifications microenvironment, been recognized affect cell physiology. The host system crosstalk shapes innate adaptive arms system, which key player progression. In this review, we aim decipher microorganisms mediating by shedding light on immuno-onco-microbiome (IOM) axis. We discussed feasible therapeutic interventions based microbiome-immune axis includes prebiotics, probiotics, postbiotics. Here, leverage conceptual framework published articles microbiota-based therapies target metastases. Understanding complicated nexus will provide into fundamental governing metastases subsequently help managing malignancy better efficacy.

Язык: Английский

Процитировано

0
Breast cancer cells promote osteoclast differentiation in an MRTF-dependent paracrine manner DOI Open Access
Pooja A. Chawla, Ishani Sharma, David Gau

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 8, 2023

ABSTRACT Bone is a frequent site for breast cancer metastasis. The vast majority of cancer-associated metastasis osteolytic in nature, and RANKL (receptor activator nuclear factor κB)-induced differentiation bone marrow-derived macrophages (BMDMs) to osteoclasts (OCLs) key requirement metastatic growth cells. In this study, we demonstrate that Myocardin-related transcription (MRTF) cells plays an important role paracrine modulation RANKL-induced osteoclast differentiation. This partly attributed MRTF’s critical maintaining the basal cellular expression connective tissue (CTGF), findings align with strong positive correlation between CTGF MRTF-A gene signature human disease context. Luminex analyses reveal MRTF depletion has broad impact on OCL-regulatory cell-secreted factors extend beyond CTGF. Experimental studies diminishes OCL abundance colonization vivo , suggesting inhibition could be effective strategy diminish formation skeletal involvement cancer. summary, study highlights novel tumor-extrinsic function relevant SIGNIFICANCE STATEMENT MRTF, transcriptional coactivator SRF, known promote progression through its tumor-cell-intrinsic function. Whether how activity tumor modulates other types microenvironment are not clearly understood. uncovers tumor-cell-extrinsic promoting regulation, further demonstrates vivo. Our suggest

Язык: Английский

Процитировано

0