WWOX attenuates the progression of gallbladder cancer by suppressing cellular glycolysis through the modulation of the P73/HIF-1α signaling pathway DOI Creative Commons
Bo Tang,

Qi-Cai Qu,

Dongyun Cun

и другие.

Tissue and Cell, Год журнала: 2025, Номер 95, С. 102885 - 102885

Опубликована: Апрель 4, 2025

Язык: Английский

Metabolic crossroads: unravelling immune cell dynamics in gastrointestinal cancer drug resistance DOI Open Access

C. Raman Suri,

Babita Pande,

Lakkakula Suhasini Sahithi

и другие.

Cancer Drug Resistance, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Metabolic reprogramming within the tumor microenvironment (TME) plays a critical role in driving drug resistance gastrointestinal cancers (GI), particularly through pathways of fatty acid oxidation and glycolysis. Cancer cells often rewire their metabolism to sustain growth reshape TME, creating conditions such as nutrient depletion, hypoxia, acidity that impair antitumor immune responses. Immune TME also undergo metabolic alterations, frequently adopting immunosuppressive phenotypes promote progression reduce efficacy therapies. The competition for essential nutrients, glucose, between cancer compromises functions effector cells, T cells. Additionally, by-products like lactate kynurenine further suppress activity populations, including regulatory M2 macrophages. Targeting glycolysis presents new opportunities overcome improve therapeutic outcomes GI cancers. Modulating these key has potential reinvigorate exhausted shift toward phenotypes, enhance effectiveness immunotherapies other treatments. Future strategies will require continued research into metabolism, development novel inhibitors, clinical trials evaluating combination Identifying validating biomarkers be crucial patient stratification treatment monitoring. Insights may have broader implications across multiple types, offering avenues improving treatment.

Язык: Английский

Процитировано

1
Multi-modal Ca2+ nanogenerator via reversing T cell exhaustion for enhanced chemo-immunotherapy DOI

Jingyi An,

Rong Guo,

Mengyuan Liu

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 715 - 727

Опубликована: Июль 3, 2024

Язык: Английский

Процитировано

3
Study on the Mechanism of Jieduquyuziyin prescription Improving the Condition of MRL/lpr Mice by Regulating T Cell Metabolic Reprogramming through the AMPK/mTOR Pathway DOI
Qingmiao Zhu, Yaxue Han, Xiaolong Li

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер 345, С. 119584 - 119584

Опубликована: Март 3, 2025

Язык: Английский

Процитировано

0
WWOX attenuates the progression of gallbladder cancer by suppressing cellular glycolysis through the modulation of the P73/HIF-1α signaling pathway DOI Creative Commons
Bo Tang,

Qi-Cai Qu,

Dongyun Cun

и другие.

Tissue and Cell, Год журнала: 2025, Номер 95, С. 102885 - 102885

Опубликована: Апрель 4, 2025

Язык: Английский

Процитировано

0