Cited by Multi-modal Ca2+ nanogenerator via reversing T cell exhaustion for enhanced chemo-immunotherapy

Metabolic crossroads: unravelling immune cell dynamics in gastrointestinal cancer drug resistance DOI

C. Raman Suri,

Babita Pande,

Lakkakula Suhasini Sahithi

et al.

Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Metabolic reprogramming within the tumor microenvironment (TME) plays a critical role in driving drug resistance gastrointestinal cancers (GI), particularly through pathways of fatty acid oxidation and glycolysis. Cancer cells often rewire their metabolism to sustain growth reshape TME, creating conditions such as nutrient depletion, hypoxia, acidity that impair antitumor immune responses. Immune TME also undergo metabolic alterations, frequently adopting immunosuppressive phenotypes promote progression reduce efficacy therapies. The competition for essential nutrients, glucose, between cancer compromises functions effector cells, T cells. Additionally, by-products like lactate kynurenine further suppress activity populations, including regulatory M2 macrophages. Targeting glycolysis presents new opportunities overcome improve therapeutic outcomes GI cancers. Modulating these key has potential reinvigorate exhausted shift toward phenotypes, enhance effectiveness immunotherapies other treatments. Future strategies will require continued research into metabolism, development novel inhibitors, clinical trials evaluating combination Identifying validating biomarkers be crucial patient stratification treatment monitoring. Insights may have broader implications across multiple types, offering avenues improving treatment.

Language: Английский

Citations

Study on the Mechanism of Jieduquyuziyin prescription Improving the Condition of MRL/lpr Mice by Regulating T Cell Metabolic Reprogramming through the AMPK/mTOR Pathway DOI

Qingmiao Zhu, Yaxue Han, Xiaolong Li

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 345, P. 119584 - 119584

Published: March 3, 2025

Language: Английский

Citations

WWOX attenuates the progression of gallbladder cancer by suppressing cellular glycolysis through the modulation of the P73/HIF-1α signaling pathway DOI

Bo Tang,

Qi-Cai Qu,

Dongyun Cun

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102885 - 102885

Published: April 4, 2025

Language: Английский

Citations

Multi-modal Ca2+ nanogenerator via reversing T cell exhaustion for enhanced chemo-immunotherapy DOI

Jingyi An,

Rong Guo,

Mengyuan Liu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 715 - 727

Published: July 3, 2024

Language: Английский

Citations