Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Nature Reviews Endocrinology, Год журнала: 2018, Номер 14(10), С. 576 - 590

Опубликована: Июль 25, 2018

Язык: Английский

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The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(9), С. 4642 - 4642

Опубликована: Апрель 28, 2021

Living species are continuously subjected to all extrinsic forms of reactive oxidants and others that produced endogenously. There is extensive literature on the generation effects oxygen (ROS) in biological processes, both terms alteration their role cellular signaling regulatory pathways. Cells produce ROS as a controlled physiological process, but increasing becomes pathological leads oxidative stress disease. The induction an imbalance between production radical antioxidant defense systems, which can cause damage biomolecules, including lipids, proteins DNA. Cellular biochemical experiments have been complemented various ways explain chemistry oxidants. However, it often unclear how this translates into chemical reactions involving redox changes. This review addresses question includes robust mechanistic explanation stress.

Язык: Английский

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International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines

The journal of nutrition health & aging, Год журнала: 2021, Номер 25(7), С. 824 - 853

Опубликована: Июль 1, 2021

The human ageing process is universal, ubiquitous and inevitable. Every physiological function being continuously diminished. There a range between two distinct phenotypes of ageing, shaped by patterns living - experiences behaviours, in particular the presence or absence physical activity (PA) structured exercise (i.e., sedentary lifestyle). Ageing lifestyle are associated with declines muscle cardiorespiratory fitness, resulting an impaired capacity to perform daily activities maintain independent functioning. However, adequate exercise/PA these changes muscular aerobic age substantially attenuated. Additionally, both overall PA play important roles as preventive strategies for many chronic diseases, including cardiovascular disease, stroke, diabetes, osteoporosis, obesity; improvement mobility, mental health, quality life; reduction mortality, among other benefits. Notably, intervention programmes improve hallmarks frailty (low body mass, strength, level, energy) cognition, thus optimising functional during ageing. In pathological conditions used therapeutic agent follows precepts identifying cause disease then using evidence-based dose eliminate moderate disease. Prescription PA/structured should therefore be based on intended outcome (e.g., primary prevention, fitness status treatment), individualised, adjusted controlled like any medical treatment. addition, line agents, shows dose-response effect can individualised different modalities, volumes and/or intensities appropriate health state condition. Importantly, therapy often directed at several systems simultaneously, rather than targeted single generally case pharmacological approaches management. diseases which alternative treatment (such depression), contributing goal deprescribing potentially inappropriate medications (PIMS). where no effective drug currently available sarcopenia dementia), it may serve role prevention Therefore, this consensus statement provides rationale promotion older adults. Exercise prescription discussed terms specific modalities doses that have been studied randomised trials their effectiveness attenuating adults disability. Recommendations proposed bridge gaps current literature optimise use preventative medicine agent.

Язык: Английский

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Undulating changes in human plasma proteome profiles across the lifespan

Nature Medicine, Год журнала: 2019, Номер 25(12), С. 1843 - 1850

Опубликована: Дек. 1, 2019

Язык: Английский

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Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Ageing Research Reviews, Год журнала: 2021, Номер 71, С. 101422 - 101422

Опубликована: Авг. 13, 2021

Язык: Английский

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Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

mBio, Год журнала: 2019, Номер 10(3)

Опубликована: Май 6, 2019

Studies of the intestinal microbiome and AD have demonstrated associations with composition at genus level among matched cohorts. We move this body literature forward by more deeply investigating via metagenomics comparing patients against those without dementia other types. also exploit machine learning approaches that combine both metagenomic clinical data. Finally, our functional studies using stool samples from elders demonstrate how c can affect health dysregulation P-glycoprotein pathway. contributes directly to inflammatory disorders intestine. Since has been long thought be linked chronic bacterial infections as a possible etiology, findings therefore fill gap in knowledge field research identifying nexus between microbiome, loss homeostasis, inflammation may underlie neurodegenerative disorder.

Язык: Английский

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Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

Frontiers in Genetics, Год журнала: 2021, Номер 11

Опубликована: Янв. 21, 2021

Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate telomere attrition also common feature age-related diseases. Therefore, length (TL) has been recognized for long time as one the best biomarkers Recent research findings, however, indicate that TL per se can only allow rough estimate aging hardly be regarded clinically important risk marker pathologies mortality. Evidence obtained other indicators such certain immune parameters, indices epigenetic age, etc., could stronger predictors health status chronic disease. However, despite these issues limitations, remains to very informative in accessing biological age when used along with markers homeostatic dysregulation, frailty index, clock, etc. This review article aimed at describing current state art field discussing recent findings divergent viewpoints regarding usefulness leukocyte estimating human age.

Язык: Английский

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Airway Remodeling in Asthma

Frontiers in Medicine, Год журнала: 2020, Номер 7

Опубликована: Май 21, 2020

Asthma is an inflammatory disease of the airways that may result from exposure to allergens or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness breath. The structural changes associated with asthma, broadly referred as airway remodeling, a pathological feature chronic asthma contributes clinical manifestations disease. Airway remodeling constitutes cellular extracellular matrix large small airways, epithelial cell apoptosis, smooth muscle proliferation fibroblast activation. These are orchestrated by crosstalk different types within wall submucosa. Environmental exposures dust, chemicals cigarette smoke can initiate cascade pro-inflammatory responses trigger through paracrine signaling mechanostimulatory cues drive remodeling. In this review, we explore three integrated dynamic processes remodeling: (1) initiation cells; (2) amplification immune (3) mesenchymal effector functions. Furthermore, role inflammaging dysregulated persistent response perpetuates elderly asthmatics.

Язык: Английский

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Sex differences in biological aging with a focus on human studies

eLife, Год журнала: 2021, Номер 10

Опубликована: Май 13, 2021

Aging is a complex biological process characterized by hallmark features accumulating over the life course, shaping individual's aging trajectory and subsequent disease risks. There substantial individual variability in between men women. In general, women live longer than men, consistent with lower ages as assessed molecular biomarkers, but there paradox. Women are frailer have worse health at end of life, while still perform better physical function examinations. Moreover, many age-related diseases show sex-specific patterns. this review, we aim to summarize current knowledge on sexual dimorphism human studies, support from animal research, illnesses. We also attempt place it context theories aging, well discuss explanations for sex differences, example, sex-chromosome linked mechanisms hormonally driven differences.

Язык: Английский

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The integration of inflammaging in age-related diseases

Seminars in Immunology, Год журнала: 2018, Номер 40, С. 17 - 35

Опубликована: Окт. 2, 2018

Язык: Английский

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