World Journal of Psychiatry,
Год журнала:
2025,
Номер
15(3)
Опубликована: Фев. 26, 2025
Cognitive
impairment
is
one
of
the
common
clinical
manifestations
depression,
causing
negative
distress
to
patients.
Elevated
homocysteine
(Hcy)
concentrations
and
gut
microbiome
dysfunction
may
be
observed
in
patients
with
depression.
To
investigate
relationship
between
Hcy,
microbiome,
cognition
depressive
We
recruited
67
major
disorder
(MDD)
(MDD
group)
94
healthy
controls
(HCs)
individuals
(HCs
group).
Serum
Hcy
levels
were
determined
using
enzyme
circulation
method.
16s
rRNA
sequencing
was
used
classify
identify
fecal
bacteria.
17
Hamilton
depression
rating
scale
MATRICS
consensus
cognitive
battery
evaluate
mood
states
MDD.
Correlation
analysis
performed
explore
correlation
flora,
function.
serum
seen
MDD
compared
individuals.
Patients
indicated
significant
decreases
scores
(P
<
0.001)
six
modules:
Speed
processing,
working
memory,
visual
learning,
reasoning
problem-solving,
social
cognition,
total
scores.
showed
a
processing
speed,
0.05).
also
significantly
negatively
correlated
Alistipes,
Ruminococcae,
Tenericides,
Porphyromonas
Our
results
highlight
that
This
interaction
related
physiological
pathological
mechanisms
underlying
deficits
Frontiers in Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 15, 2024
Background
Numerous
pertinent
investigations
have
demonstrated
a
correlation
between
gut
microflora
(GM)
and
the
occurrence
of
dementia.
However,
causal
connection
GM
dementia
its
subtypes
has
not
yet
been
clarified.
Objective
To
explore
association
dementia,
including
subtypes,
two-sample
Mendelian
randomization
(TSMR)
analysis
was
used.
Methods
Our
data
comes
from
Genome-Wide
Association
Study
(GWAS).
The
principal
approach
employed
for
study
inverse-variance
weighted
method,
supplemented
by
four
methods:
MR-Egger,
median,
simple
mode,
mode.
This
followed
Cochrane’s
Q
test,
MR-Egger
intercept
MR-PRESSO
global
leave-one-out
as
sensitivity
validation.
Results
Twenty-one
GMs
associated
with
any
Alzheimer’s
disease,
vascular
Lewy
body
Parkinson’s
under
other
disease
classifications
were
derived
analysis,
21
passed
tests.
Conclusion
We
confirmed
relationship
specific
flora
increased
or
decreased
risk
provided
new
ideas
preventive,
diagnostic,
therapeutic
interventions
mediated
microbiota.
One Health,
Год журнала:
2024,
Номер
18, С. 100734 - 100734
Опубликована: Апрель 20, 2024
Non-communicable
diseases
(NCDs)
pose
a
global
health
challenge,
leading
to
substantial
morbidity,
mortality,
and
economic
strain.
Our
review
underscores
the
escalating
incidence
of
NCDs
worldwide
highlights
potential
regenerative
agriculture
(RA)
products
in
mitigating
these
diseases.
We
also
explore
efficacy
dietary
interventions
NCD
management
prevention,
emphasizing
superiority
plant-based
diets
over
those
high
processed
foods
red
meat.
Examining
role
gut
microbiome
various
diseases,
including
liver
disorders,
allergies,
metabolic
syndrome,
inflammatory
bowel
disease,
colon
cancer,
we
find
compelling
evidence
implicating
its
influence
on
disease
development.
Notably,
modifications
can
positively
affect
microbiome,
fostering
symbiotic
relationship
with
host
making
this
critical
strategy
prevention
treatment.
Investigating
agricultural
practices,
identify
parallels
between
soil/plant
human
studies,
suggesting
crucial
link
soil
health,
plant-
animal-derived
food
quality,
well-being.
Conventional/Industrial
(IA)
characterized
part
by
use
chemical
inputs,
have
adverse
effects
diversity,
ecosystems.
In
contrast,
RA
prioritizes
through
natural
processes,
includes
avoiding
synthetic
crop
rotation,
integrating
livestock.
Emerging
suggests
that
from
systems
surpasses
IA-produced
quality
nutritional
value.
Recognizing
interconnection
human,
plant,
microbiomes,
promoting
RA-produced
emerges
as
improve
environmental
sustainability.
By
climate
change
impacts
carbon
sequestration
water
cycling,
offers
dual
benefits
for
planetary
Emphasizing
pivotal
diet
practices
combating
addressing
concerns,
adoption
regional
becomes
imperative.
Increasing
integration
into
local
enhance
availability,
affordability
while
safeguarding
planet's
future.
World Journal of Psychiatry,
Год журнала:
2025,
Номер
15(3)
Опубликована: Фев. 26, 2025
Cognitive
impairment
is
one
of
the
common
clinical
manifestations
depression,
causing
negative
distress
to
patients.
Elevated
homocysteine
(Hcy)
concentrations
and
gut
microbiome
dysfunction
may
be
observed
in
patients
with
depression.
To
investigate
relationship
between
Hcy,
microbiome,
cognition
depressive
We
recruited
67
major
disorder
(MDD)
(MDD
group)
94
healthy
controls
(HCs)
individuals
(HCs
group).
Serum
Hcy
levels
were
determined
using
enzyme
circulation
method.
16s
rRNA
sequencing
was
used
classify
identify
fecal
bacteria.
17
Hamilton
depression
rating
scale
MATRICS
consensus
cognitive
battery
evaluate
mood
states
MDD.
Correlation
analysis
performed
explore
correlation
flora,
function.
serum
seen
MDD
compared
individuals.
Patients
indicated
significant
decreases
scores
(P
<
0.001)
six
modules:
Speed
processing,
working
memory,
visual
learning,
reasoning
problem-solving,
social
cognition,
total
scores.
showed
a
processing
speed,
0.05).
also
significantly
negatively
correlated
Alistipes,
Ruminococcae,
Tenericides,
Porphyromonas
Our
results
highlight
that
This
interaction
related
physiological
pathological
mechanisms
underlying
deficits
