PLoS ONE,
Год журнала:
2025,
Номер
20(4), С. e0319459 - e0319459
Опубликована: Апрель 1, 2025
The
most
common
symptom
reported
by
patients
after
recovery
from
coronavirus
disease
2019
(COVID-19)
is
fatigue.
However,
robust
clinical
evidence
supporting
the
effectiveness
of
treatments
and
interventions
for
fatigue
in
COVID-19
survivors
lacking.
This
pilot
trial
aims
to
assess
safety
efficacy
Kyungok-go,
a
herbal
preparation
targeting
fatigue,
recovering
COVID-19.
study
will
include
100
participants
with
persistent
more
than
12
weeks
recovery.
They
be
randomly
allocated
into
two
groups:
Kyungok-go
group
(n
=
50)
placebo
50).
or
administered
twice
daily
weeks,
assessed
at
4-week
intervals.
primary
outcome
change
Fatigue
Severity
Scale
score.
Secondary
outcomes
cognitive
function,
physical
quality
life,
depression,
sleep
quality,
medication
adherence,
feasibility.
first
attempt
investigate
relieving
related
long
COVID.
results
are
expected
contribute
establishment
knowledge
base
reveal
potential
medicine
prescriptions
managing
sequelae
Trial
registration
number:
KCT0008789
.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6389 - 6389
Опубликована: Июнь 9, 2024
Long
COVID
(LC),
also
referred
to
as
Post
COVID-19
Condition,
Post-Acute
Sequelae
of
SARS-CoV-2
Infection
(PASC),
and
other
terms,
represents
a
complex
multisystem
disease
persisting
after
the
acute
phase
COVID-19.
Characterized
by
myriad
symptoms
across
different
organ
systems,
LC
presents
significant
diagnostic
management
challenges.
Central
disorder
is
role
low-grade
inflammation,
non-classical
inflammatory
response
that
contributes
chronicity
diversity
observed.
This
review
explores
pathophysiological
underpinnings
LC,
emphasizing
importance
inflammation
core
component.
By
delineating
pathogenetic
relationships
clinical
manifestations
this
article
highlights
necessity
for
an
integrated
approach
employs
both
personalized
medicine
standardized
protocols
aimed
at
mitigating
long-term
consequences.
The
insights
gained
not
only
enhance
our
understanding
but
inform
development
therapeutic
strategies
could
be
applicable
chronic
conditions
with
similar
features.
EBioMedicine,
Год журнала:
2024,
Номер
105, С. 105191 - 105191
Опубликована: Июнь 13, 2024
Coronavirus
disease
2019
(COVID-19)
frequently
leads
to
neurological
complications
after
recovery
from
acute
infection,
with
higher
prevalence
in
women.
However,
mechanisms
by
which
SARS-CoV-2
disrupts
brain
function
remain
unclear
and
treatment
strategies
are
lacking.
We
previously
demonstrated
neuroinflammation
the
olfactory
bulb
of
intranasally
infected
hamsters,
followed
alpha-synuclein
tau
accumulation
cortex,
thus
mirroring
pathogenesis
neurodegenerative
diseases
such
as
Parkinson's
or
Alzheimer's
disease.
Myalgic
encephalomyelitis/chronic
fatigue
syndrome
(ME/CFS)
and
long
COVID
are
debilitating
multisystemic
conditions
sharing
similarities
in
immune
dysregulation
cellular
signaling
pathways
contributing
to
the
pathophysiology.
In
this
study,
exhaustion
gene
expression
was
investigated
participants
with
ME/CFS
or
concurrently.
RNA
extracted
from
peripheral
blood
mononuclear
cells
isolated
(n
=
14),
15),
healthy
controls
18).
Participants
were
included
according
Canadian
Consensus
Criteria.
eligible
case
definition
for
"Post
COVID-19
Condition"
published
by
World
Health
Organization.
analyzed
using
NanoString
nCounter
Immune
Exhaustion
panel.
Differential
analysis
revealed
downregulated
IFN
immunoglobulin
genes,
suggested
a
state
of
suppression.
Pathway
implicated
dysregulated
macrophage
activation,
cytokine
production,
immunodeficiency
signaling.
Long
samples
exhibited
genes
regarding
antigen
presentation,
signaling,
activation.
Differentially
expressed
associated
B
cell
development,
This
investigation
elucidates
intricate
role
both
adaptive
innate
underlying
COVID,
emphasizing
potential
importance
disease
progression.
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 751 - 751
Опубликована: Июнь 2, 2024
The
COVID-19
pandemic,
caused
by
SARS-CoV-2,
poses
a
significant
global
health
threat.
spike
glycoprotein
S1
of
the
SARS-CoV-2
virus
is
known
to
induce
production
pro-inflammatory
mediators,
contributing
hyperinflammation
in
patients.
Triphala,
an
ancient
Ayurvedic
remedy
composed
dried
fruits
from
three
plant
species—Emblica
officinalis
(Family
Euphorbiaceae),
Terminalia
bellerica
Combretaceae),
and
chebula
Combretaceae)—shows
promise
addressing
inflammation.
However,
limited
water
solubility
its
ethanolic
extract
impedes
bioavailability.
In
this
study,
we
aimed
develop
nanoparticles
loaded
with
Triphala
extract,
termed
“nanotriphala”,
as
drug
delivery
system.
Additionally,
investigated
vitro
anti-inflammatory
properties
nanotriphala
major
compounds,
namely
gallic
acid,
chebulagic
chebulinic
lung
epithelial
cells
(A549)
induced
CoV2-SP.
formulation
was
prepared
using
solvent
displacement
method.
encapsulation
efficiency
determined
be
87.96
±
2.60%
based
on
total
phenolic
content.
terms
release,
exhibited
biphasic
release
profile
zero-order
kinetics
over
0–8
h.
A549
were
treated
or
active
compounds
then
100
ng/mL
subunit
(CoV2-SP).
results
demonstrate
that
acid
are
nanotriphala,
which
significantly
reduced
cytokine
(IL-6,
IL-1β,
IL-18)
suppressed
expression
inflammatory
genes
IL-18,
NLRP3)
(p
<
0.05).
Mechanistically,
notably
attenuated
inflammasome
machinery
proteins
(NLRP3,
ASC,
Caspase-1)
conclusion,
nanoparticle
enhances
stability
exhibits
against
CoV2-SP-induction.
This
achieved
suppressing
mediators
NLRP3
machinery.
Thus,
holds
supportive
preventive
therapy
for
COVID-19-related
chronic
Life,
Год журнала:
2023,
Номер
13(11), С. 2121 - 2121
Опубликована: Окт. 26, 2023
The
COVID-19
pandemic
has
affected
the
world
unprecedentedly,
with
both
positive
and
negative
impacts.
significantly
impacted
immune
system,
understanding
immunological
consequences
of
is
essential
for
developing
effective
treatment
strategies.
purpose
this
review
to
comprehensively
explore
provide
insights
into
aspects
long
COVID-19,
a
phenomenon
where
individuals
continue
experience
range
symptoms
complications,
even
after
acute
phase
infection
subsided.
system
responds
initial
by
producing
various
cells
molecules,
including
antibodies,
T
cells,
cytokines.
However,
in
some
patients,
response
becomes
dysregulated,
leading
chronic
inflammation
persistent
symptoms.
Long
encompasses
diverse
affecting
multiple
organ
systems,
respiratory,
cardiovascular,
neurological,
gastrointestinal
systems.
In
post-COVID-19
era,
its
impact
on
have
become
significant
concern.
Post-COVID-19
pathology,
autoimmunity
immune-mediated
disorders,
also
been
reported
patients.
This
provides
an
overview
current
relationship
responses,
pathology
patient
outcomes.
Additionally,
addresses
potential
treatments
immunomodulatory
therapies,
rehabilitation
programs,
mental
health
support,
all
which
aim
improve
quality
life
COVID-19.
Understanding
complex
interplay
between
crucial
targeted
therapeutic
strategies
providing
optimal
care
era.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Сен. 17, 2023
Abstract
Both
myalgic
encephalomyelitis
or
chronic
fatigue
syndrome
(ME/CFS)
and
long
COVID
(LC)
are
characterized
by
similar
immunological
alterations,
persistence
of
viral
infection,
autoimmunity,
inflammatory
state,
reactivation,
hypocortisolism,
microclot
formation.
They
also
present
with
symptoms
such
as
asthenia,
exercise
intolerance,
sleep
disorders,
cognitive
dysfunction,
neurological
gastrointestinal
complaints.
In
addition,
both
pathologies
Epstein–Barr
virus
(EBV)
indicating
the
possibility
this
being
link
between
pathologies.
Therefore,
we
propose
that
latency
recurrent
EBV
reactivation
could
generate
an
acquired
immunodeficiency
in
three
steps:
first,
develops
individuals
“weak”
HLA-II
haplotypes,
which
prevents
control
I
cells.
Second,
ectopic
lymphoid
structures
form
different
tissues
(including
CNS),
promoting
responses
further
impairment
cell-mediated
immunity.
Finally,
immune
exhaustion
occurs
due
to
exposure
antigens,
consolidation
disease.
case
LC,
prior
first
step,
there
is
previous
SARS-CoV-2
infection
haplotypes
against
and/or
EBV.
Dementia & Neuropsychologia,
Год журнала:
2024,
Номер
18
Опубликована: Янв. 1, 2024
ABSTRACT.
Infection
with
the
SARS-CoV-2
virus
can
lead
to
neurological
symptoms
in
acute
phase
and
Long
COVID
phase.
These
usually
involve
cognition,
sleep,
smell
disorders,
psychiatric
manifestations,
headache
others.
This
condition
is
more
commonly
described
young
adults
women.
symptomatology
follow
severe
or
mild
cases
of
disease.
The
importance
this
issue
resides
high
prevalence
phase,
which
entails
significant
morbidity
population.
In
addition,
such
a
associated
health
care
costs,
some
estimates
hovering
around
3.7
trillion
US
dollars.
review,
we
will
sequentially
describe
current
knowledge
about
most
prevalent
COVID,
as
well
their
pathophysiology
possible
biomarkers.
Eastern Ukrainian Medical Journal,
Год журнала:
2024,
Номер
12(2), С. 422 - 430
Опубликована: Янв. 1, 2024
Introduction:
Despite
the
fact
that
entire
scientific
world
is
concerned
about
COVID-19,
65
million
people
are
living
with
Long
COVID,
suffering
from
general
weakness,
fatigue,
cognitive
dysfunction,
and
shortness
of
breath.
This
problem
global
for
humanity
because
decrease
in
ability
to
work
mental
activity
population,
which
leads
economic
losses.
The
remains
open
requires
further
research.
Materials
Methods:
a
total
108
patients
were
examined
divided
into
three
groups:
group
A
–
31
confirmed
B
35
C
42
practically
healthy
individuals.
Hematologic
nonspecific
immunologic
changes
studied.
Statistical
data
processing
was
performed
using
STATA
software
by
StataCorp
(Texas,
USA)
calculation
parametric
non-parametric
criteria.
Results:
middle-aged
women
predominated
study
groups.
Among
hematologic
parameters,
an
increase
leukocytes,
erythrocytes,
ESR
observed
COVID-19
group.
Patients
had
2.5
times
more
rods
neutrophils
than
2.3
C.
In
integrative
indicators
endogenous
intoxication
exceeded
corresponding
compared
COVID
(p<0.05).
there
tendency
(p=0.055
0.588)
increased
(the
index
2.6
higher
(p<0.05))
indices
reactivity
(resistance
coefficient,
lymphocyte
index,
eosinophil
ratio
allergy
index)
lower
inflammation
(total
Krebs
leukocyte/
individuals
Conclusions:
characterized
leftward
shift
leukocyte
formula,
intoxication,
pronounced
inflammatory
process,
activation
tissue
breakdown.
For
slight
low
degree
