Whole Fruits and Fruit Fiber Emerging Health Effects DOI Open Access

Mark L. Dreher

Nutrients, Год журнала: 2018, Номер 10(12), С. 1833 - 1833

Опубликована: Ноя. 28, 2018

Less than 10% of most Western populations consume adequate levels whole fruits and dietary fiber with typical intake being about half the recommended levels. Evidence beneficial health effects consuming has been steadily growing, especially regarding their bioactive prebiotic role in improved weight control, wellness healthy aging. The primary aim this narrative review article is to examine increasing number benefits which are associated fruits, fruit fiber, throughout human lifecycle. These potential include: protecting colonic gastrointestinal (e.g., constipation, irritable bowel syndrome, inflammatory diseases, diverticular disease); promoting long-term management; reducing risk cardiovascular disease, type 2 diabetes metabolic syndrome; defending against colorectal lung cancers; improving odds successful aging; severity asthma chronic obstructive pulmonary disease; enhancing psychological well-being lowering depression; contributing higher bone mineral density children adults; seborrheic dermatitis; helping attenuate autism spectrum disorder severity. Low represents a potentially more serious global population threat previously recognized, light emerging research on benefits.

Язык: Английский

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases DOI Creative Commons

Daniela Parada Venegas,

Marjorie K. De la Fuente,

Glauben Landskron

и другие.

Frontiers in Immunology, Год журнала: 2019, Номер 10

Опубликована: Март 11, 2019

Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel Diseases (IBD), are caused by a complex interplay between genetic, immunologic, microbial environmental factors. Dysbiosis of the gut microbiome is increasingly considered to be causatively related IBD strongly affected components Western life style. Bacteria that ferment fibers produce short chain fatty acids (SCFAs) typically reduced in mucosa feces patients with IBD, compared healthy individuals. SCFAs, such acetate, propionate butyrate, important metabolites maintaining intestinal homeostasis. Several studies have indeed shown fecal SCFAs levels active IBD. an fuel for epithelial cells strengthen barrier function. Recent findings, however, show particular also immunomodulatory functions. Absorption facilitated substrate transporters like MCT1 SMCT1 promote cellular metabolism. Moreover, may signal through cell surface G-protein coupled receptors (GPCRs), GPR41, GPR43, GPR109A, activate signaling cascades control immune Transgenic mouse models support key role these GPCRs controlling inflammation. Here, we present overview production their effects on specific emphasis relevance discuss therapeutic potential either applied directly or stimulating SCFAs-producing bacteria pre- probiotic approaches.

Язык: Английский

Процитировано

2870
The neuroactive potential of the human gut microbiota in quality of life and depression DOI
Mireia Valles‐Colomer, Gwen Falony, Youssef Darzi

и другие.

Nature Microbiology, Год журнала: 2019, Номер 4(4), С. 623 - 632

Опубликована: Фев. 4, 2019

Язык: Английский

Процитировано

1562
Probiotics and prebiotics in intestinal health and disease: from biology to the clinic DOI
Mary Ellen Sanders, Daniel Merenstein, Gregor Reid

и другие.

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2019, Номер 16(10), С. 605 - 616

Опубликована: Июль 11, 2019

Язык: Английский

Процитировано

1480
Using MicrobiomeAnalyst for comprehensive statistical, functional, and meta-analysis of microbiome data DOI

Jasmine Chong,

Peng Liu,

Guangyan Zhou

и другие.

Nature Protocols, Год журнала: 2020, Номер 15(3), С. 799 - 821

Опубликована: Янв. 15, 2020

Язык: Английский

Процитировано

1425
The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome DOI Open Access
Paulina Markowiak‐Kopeć, Katarzyna Śliżewska

Nutrients, Год журнала: 2020, Номер 12(4), С. 1107 - 1107

Опубликована: Апрель 16, 2020

The relationship between diet and the diversity function of intestinal microbiome its importance for human health is currently subject many studies. type proportion microorganisms found in intestines can determine energy balance host. Intestinal perform important functions, one which participation metabolic processes, e.g., production short-chain fatty acids—SCFAs (also called volatile acids). These acids represent main carbon flow from to host microbiome. Maintaining necessary maintain host's normal prevent diseases. results studies confirm beneficial effect probiotic on produced metabolites, including SCFAs. aim this review summarize what known effects probiotics by gut microbes. In addition, mechanism formation properties these metabolites discussed verified test confirming effectiveness nutrition modulating SCFAs presented.

Язык: Английский

Процитировано

832
Estrogen–gut microbiome axis: Physiological and clinical implications DOI Open Access
James Baker, Layla Al‐Nakkash, Melissa M. Herbst‐Kralovetz

и другие.

Maturitas, Год журнала: 2017, Номер 103, С. 45 - 53

Опубликована: Июнь 24, 2017

Язык: Английский

Процитировано

695
Health and disease markers correlate with gut microbiome composition across thousands of people DOI Creative Commons
Ohad Manor, Chengzhen L. Dai, Sergey A. Kornilov

и другие.

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Окт. 15, 2020

Abstract Variation in the human gut microbiome can reflect host lifestyle and behaviors influence disease biomarker levels blood. Understanding relationships between microbes phenotypes are critical for understanding wellness disease. Here, we examine associations microbiota ~150 phenotypic features across ~3,400 individuals. We identify major axes of taxonomic variance a putative diversity maximum along Firmicutes-to-Bacteroidetes axis. Our analyses reveal both known unknown composition clinical markers factors, including host-microbe that composition-specific. These results suggest potential opportunities targeted interventions alter to improve health. By uncovering interrelationships diet blood markers, at population-scale, our serve as roadmap future studies on interactions interventions.

Язык: Английский

Процитировано

636
Gut Microbiota in Patients With Irritable Bowel Syndrome—A Systematic Review DOI Open Access
Rapat Pittayanon,

Jennifer Lau,

Yuhong Yuan

и другие.

Gastroenterology, Год журнала: 2019, Номер 157(1), С. 97 - 108

Опубликована: Март 30, 2019

Язык: Английский

Процитировано

564
Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis DOI Creative Commons
Daniel So, Kevin Whelan,

Megan Rossi

и другие.

American Journal of Clinical Nutrition, Год журнала: 2018, Номер 107(6), С. 965 - 983

Опубликована: Апрель 4, 2018

Язык: Английский

Процитировано

546
Shifts on Gut Microbiota Associated to Mediterranean Diet Adherence and Specific Dietary Intakes on General Adult Population DOI Creative Commons
Izaskun García‐Mantrana, Marta Selma‐Royo, Cristina Alcántara

и другие.

Frontiers in Microbiology, Год журнала: 2018, Номер 9

Опубликована: Май 7, 2018

There is increasing evidence for the interaction between gut microbiome, diet, and health. It known that dysbiosis related to disease most of times this imbalances in microbial populations can be promoted through diet. Western dietary habits, which are characterized by high intakes calories, animal proteins, saturated fats, simple sugars have been linked with higher risk obesity, diabetes, cancer, cardiovascular disease. However, little about impact patterns, components, nutrients on microbiota healthy people. The aim our study determine effect nutrient compounds as well adherence a pattern, Mediterranean diet (MD) microbiome adults. Consequently, composition individuals, may used potential biomarker identify nutritional habits these habits. Dietary information from volunteers (n = 27) was recorded using Food Frequency Questionnaire. Adherence MD measured PREDIMED test. Microbiota diversity were obtained 16S rRNA gene sequencing specific quantitative polymerase chain reaction. Microbial metabolic activity determined quantification short fatty acids (SCFA) performance liquid chromatography (HPLC). results indicated ratio Firmicutes-Bacteroidetes lower MD, greater presence Bacteroidetes associated protein intake. High consumption protein, affected diversity. A significant Christensenellaceae found normal-weight individuals compared those who overweight. This also case adherence. Butyricimonas, Desulfovibrio, Oscillospira genera BMI <25 genus Catenibacterium score. Higher bifidobacterial counts, total SCFA plant-based nutrients, such vegetable proteins polysaccharides. Better significantly levels SCFA. components could affect composition, diversity, activity, an host metabolism diseases.

Язык: Английский

Процитировано

488