Nutrients,
Год журнала:
2018,
Номер
10(12), С. 1833 - 1833
Опубликована: Ноя. 28, 2018
Less
than
10%
of
most
Western
populations
consume
adequate
levels
whole
fruits
and
dietary
fiber
with
typical
intake
being
about
half
the
recommended
levels.
Evidence
beneficial
health
effects
consuming
has
been
steadily
growing,
especially
regarding
their
bioactive
prebiotic
role
in
improved
weight
control,
wellness
healthy
aging.
The
primary
aim
this
narrative
review
article
is
to
examine
increasing
number
benefits
which
are
associated
fruits,
fruit
fiber,
throughout
human
lifecycle.
These
potential
include:
protecting
colonic
gastrointestinal
(e.g.,
constipation,
irritable
bowel
syndrome,
inflammatory
diseases,
diverticular
disease);
promoting
long-term
management;
reducing
risk
cardiovascular
disease,
type
2
diabetes
metabolic
syndrome;
defending
against
colorectal
lung
cancers;
improving
odds
successful
aging;
severity
asthma
chronic
obstructive
pulmonary
disease;
enhancing
psychological
well-being
lowering
depression;
contributing
higher
bone
mineral
density
children
adults;
seborrheic
dermatitis;
helping
attenuate
autism
spectrum
disorder
severity.
Low
represents
a
potentially
more
serious
global
population
threat
previously
recognized,
light
emerging
research
on
benefits.
Frontiers in Immunology,
Год журнала:
2019,
Номер
10
Опубликована: Март 11, 2019
Ulcerative
colitis
(UC)
and
Crohn's
disease
(CD),
collectively
known
as
Inflammatory
Bowel
Diseases
(IBD),
are
caused
by
a
complex
interplay
between
genetic,
immunologic,
microbial
environmental
factors.
Dysbiosis
of
the
gut
microbiome
is
increasingly
considered
to
be
causatively
related
IBD
strongly
affected
components
Western
life
style.
Bacteria
that
ferment
fibers
produce
short
chain
fatty
acids
(SCFAs)
typically
reduced
in
mucosa
feces
patients
with
IBD,
compared
healthy
individuals.
SCFAs,
such
acetate,
propionate
butyrate,
important
metabolites
maintaining
intestinal
homeostasis.
Several
studies
have
indeed
shown
fecal
SCFAs
levels
active
IBD.
an
fuel
for
epithelial
cells
strengthen
barrier
function.
Recent
findings,
however,
show
particular
also
immunomodulatory
functions.
Absorption
facilitated
substrate
transporters
like
MCT1
SMCT1
promote
cellular
metabolism.
Moreover,
may
signal
through
cell
surface
G-protein
coupled
receptors
(GPCRs),
GPR41,
GPR43,
GPR109A,
activate
signaling
cascades
control
immune
Transgenic
mouse
models
support
key
role
these
GPCRs
controlling
inflammation.
Here,
we
present
overview
production
their
effects
on
specific
emphasis
relevance
discuss
therapeutic
potential
either
applied
directly
or
stimulating
SCFAs-producing
bacteria
pre-
probiotic
approaches.
Nutrients,
Год журнала:
2020,
Номер
12(4), С. 1107 - 1107
Опубликована: Апрель 16, 2020
The
relationship
between
diet
and
the
diversity
function
of
intestinal
microbiome
its
importance
for
human
health
is
currently
subject
many
studies.
type
proportion
microorganisms
found
in
intestines
can
determine
energy
balance
host.
Intestinal
perform
important
functions,
one
which
participation
metabolic
processes,
e.g.,
production
short-chain
fatty
acids—SCFAs
(also
called
volatile
acids).
These
acids
represent
main
carbon
flow
from
to
host
microbiome.
Maintaining
necessary
maintain
host's
normal
prevent
diseases.
results
studies
confirm
beneficial
effect
probiotic
on
produced
metabolites,
including
SCFAs.
aim
this
review
summarize
what
known
effects
probiotics
by
gut
microbes.
In
addition,
mechanism
formation
properties
these
metabolites
discussed
verified
test
confirming
effectiveness
nutrition
modulating
SCFAs
presented.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Окт. 15, 2020
Abstract
Variation
in
the
human
gut
microbiome
can
reflect
host
lifestyle
and
behaviors
influence
disease
biomarker
levels
blood.
Understanding
relationships
between
microbes
phenotypes
are
critical
for
understanding
wellness
disease.
Here,
we
examine
associations
microbiota
~150
phenotypic
features
across
~3,400
individuals.
We
identify
major
axes
of
taxonomic
variance
a
putative
diversity
maximum
along
Firmicutes-to-Bacteroidetes
axis.
Our
analyses
reveal
both
known
unknown
composition
clinical
markers
factors,
including
host-microbe
that
composition-specific.
These
results
suggest
potential
opportunities
targeted
interventions
alter
to
improve
health.
By
uncovering
interrelationships
diet
blood
markers,
at
population-scale,
our
serve
as
roadmap
future
studies
on
interactions
interventions.
Frontiers in Microbiology,
Год журнала:
2018,
Номер
9
Опубликована: Май 7, 2018
There
is
increasing
evidence
for
the
interaction
between
gut
microbiome,
diet,
and
health.
It
known
that
dysbiosis
related
to
disease
most
of
times
this
imbalances
in
microbial
populations
can
be
promoted
through
diet.
Western
dietary
habits,
which
are
characterized
by
high
intakes
calories,
animal
proteins,
saturated
fats,
simple
sugars
have
been
linked
with
higher
risk
obesity,
diabetes,
cancer,
cardiovascular
disease.
However,
little
about
impact
patterns,
components,
nutrients
on
microbiota
healthy
people.
The
aim
our
study
determine
effect
nutrient
compounds
as
well
adherence
a
pattern,
Mediterranean
diet
(MD)
microbiome
adults.
Consequently,
composition
individuals,
may
used
potential
biomarker
identify
nutritional
habits
these
habits.
Dietary
information
from
volunteers
(n
=
27)
was
recorded
using
Food
Frequency
Questionnaire.
Adherence
MD
measured
PREDIMED
test.
Microbiota
diversity
were
obtained
16S
rRNA
gene
sequencing
specific
quantitative
polymerase
chain
reaction.
Microbial
metabolic
activity
determined
quantification
short
fatty
acids
(SCFA)
performance
liquid
chromatography
(HPLC).
results
indicated
ratio
Firmicutes-Bacteroidetes
lower
MD,
greater
presence
Bacteroidetes
associated
protein
intake.
High
consumption
protein,
affected
diversity.
A
significant
Christensenellaceae
found
normal-weight
individuals
compared
those
who
overweight.
This
also
case
adherence.
Butyricimonas,
Desulfovibrio,
Oscillospira
genera
BMI
<25
genus
Catenibacterium
score.
Higher
bifidobacterial
counts,
total
SCFA
plant-based
nutrients,
such
vegetable
proteins
polysaccharides.
Better
significantly
levels
SCFA.
components
could
affect
composition,
diversity,
activity,
an
host
metabolism
diseases.