Medical Hypotheses, Год журнала: 2023, Номер 172, С. 111032 - 111032
Опубликована: Фев. 20, 2023
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4898 - 4898
Опубликована: Апрель 30, 2024
Extracellular vesicles (EVs) are tools for intercellular communication, mediating molecular transport processes. Emerging studies have revealed that EVs significantly involved in immune processes, including sepsis. Sepsis, a dysregulated response to infection, triggers systemic inflammation and multi-organ dysfunction, posing life-threatening condition. Although extensive research has been conducted on animals, the complex inflammatory mechanisms cause sepsis-induced organ failure humans still not fully understood. Recent focused secreted exosomes, which small extracellular from various body cells, shed light their involvement pathophysiology of During sepsis, exosomes undergo changes content, concentration, function, affect metabolism endothelia, cardiovascular functions, coagulation. Investigating role exosome content pathogenesis sepsis shows promise understanding basis human This review explores contributions activated cells diverse cells' vital dysfunction providing insights into potential biomarkers predicting septic shock.
Язык: Английский
Процитировано
1
Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)
Опубликована: Июнь 27, 2024
Abstract Due to the advanced studies on stem cells in developmental biology, roles of body and their phenotypes related diseases have not been covered clearly. Meanwhile, with intensive research mechanisms regulating various diseases, cell therapy is increasingly being attention because its effectiveness safety. As one most widely used therapies, hematopoietic transplantation shows huge advantage treatment leukemia other blood-malignant diseases. Besides, due effect anti-inflammatory immunomodulatory, mesenchymal could be a potential therapeutic strategy for variety infectious In this review, we summarized effects Staphylococcus aureus ( S. ) components different types adult downstream signaling pathways. Also, reviewed kinds disease models caused by , providing new insights applying treat
Язык: Английский
Процитировано
1
Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17
Опубликована: Авг. 7, 2024
Objective This study aims to systematically evaluate the efficacy of bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exo) in improving spinal cord injury (SCI) mitigate risk translational discrepancies from animal experiments clinical applications. Methods We conducted a comprehensive literature search up March 2024 using PubMed, Embase, Web Science, and Scopus databases. Two researchers independently screened literature, extracted data, assessed quality studies. Data analysis was performed STATA16 software. Results A total 30 studies were included. The results indicated that BMSCs-Exo significantly improved BBB score SCI rats (WMD = 3.47, 95% CI [3.31, 3.63]), inhibited expression pro-inflammatory cytokine TNF- α (SMD -3.12, [−3.57, −2.67]), promoted anti-inflammatory cytokines IL-10 2.76, [1.88, 3.63]) TGF- β 3.89, [3.02, 4.76]). Additionally, reduced apoptosis levels −4.52, [−5.14, −3.89]), axonal regeneration markers NeuN cells/field 3.54, [2.65, 4.42]), NF200 4.88, [3.70, 6.05]), number Nissl bodies 1.89, [1.13, 2.65]), decreased astrogliosis marker GFAP −5.15, [−6.47, −3.82]). heterogeneity among primarily due variations transplantation doses, with increasing higher doses. Conclusion motor function by modulating inflammatory responses, reducing apoptosis, inhibiting astrogliosis, promoting regeneration. However, presence selection, performance, detection biases current may undermine evidence this study.
Язык: Английский
Процитировано
1
Seminars in Cell and Developmental Biology, Год журнала: 2022, Номер 144, С. 31 - 40
Опубликована: Ноя. 18, 2022
Язык: Английский
Процитировано
7
Veterinary Sciences, Год журнала: 2022, Номер 9(11), С. 610 - 610
Опубликована: Ноя. 4, 2022
Antimicrobial resistance and biofilm formation both present challenges to treatment of bacterial infections with conventional antibiotic therapy serve as the impetus for development improved therapeutic approaches. Mesenchymal stromal cell (MSC) exerts an antimicrobial effect demonstrated in multiple acute infection models. This can be enhanced by pre-conditioning MSC Toll or Nod-like receptor stimulation, termed activated cellular (ACT). The purpose this review is summarize current literature on mechanisms activity emphasis effects through agonism, data supporting use ACT veterinary species including dogs, cats, horses implications further applications. will advance field's understanding treat infection, action potential
Язык: Английский
Процитировано
6
Biomedical Journal of Scientific & Technical Research, Год журнала: 2023, Номер 51(3)
Опубликована: Июль 12, 2023
Antibacterial properties of the stem cells and human- plant- derived microvesicles are attracting increasing attention research community. Awareness publications pointing out to pronounced anti-bacterial isolated from supernatants different human origin prompted us test corresponding supernatant using simplified protocol. Extensive with more than 100 laboratory strains hospital isolates Gram-positive Gram- negative bacteria point a activity cultures actively dividing cells.
Язык: Английский
Процитировано
2
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 185 - 201
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 339 - 362
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0
Nano Express, Год журнала: 2024, Номер 5(4), С. 045009 - 045009
Опубликована: Ноя. 14, 2024
Abstract Microbial diseases represent a significant challenge to global health, highlighting the importance of developing novel alternative antibacterial agents. The widely used spice and traditional medicinal plant Zingiber officinale its derivatives have been demonstrated possess promising properties. aim present study was assess efficacy -derived exosome-like nanoparticles (ZODENs) against model bacterium, Escherichia coli ( E. ). ZODENs were isolated from rhizome subjected morphological, size distribution, zeta potential characterization. bacterial growth curve assays colony formation that remarkably inhibited following incubation with ZODENs. observed be internalized by bacteria incubation, subsequently remarkable killing effects. Furthermore, ZODEN-derived lipids, rather than remaining fractions, capacity inhibit cells, indicating activity at least partially attributable lipid content. These findings paved way for development ZODEN-based agents will facilitate future clinical translation plant-derived nanomedicines.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Дек. 12, 2024
Outer membrane vesicles (OMVs) and exosomes are essential mediators of host-pathogen interactions. Elucidating their mechanisms action offers valuable insights into diagnosing treating infectious diseases cancers. However, the specific interactions Helicobacter pylori ( H. ) with host cells via OMVs in modulating immune responses have not been thoroughly investigated. This review explores how these elicit inflammatory immunosuppressive environment, facilitate pathogen invasion cells, enable evasion defenses, thereby contributing to progression gastric extra-gastric disseminated through bloodstream. Furthermore, discusses challenges future directions for investigating exosomes, underscoring potential as therapeutic targets -associated diseases.
Язык: Английский
Процитировано
0