Frontiers in Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 30, 2025
The
interactions
between
macronutrients,
the
human
gut
microbiome,
and
their
metabolites
(short-chain
fatty
acids)
were
comprehensively
investigated
via
an
in
vitro
digestion
fermentation
model
subjected
to
eight
pulse
species.
16S
rRNA
sequencing
taxonomic
analysis
of
digesta
fermented
for
up
24
h
revealed
increase
relative
abundance
health-detrimental
genera
represented
by
Escherichia-Shigella
kidney
bean,
soybean,
cowpea,
chickpea,
black
bean
samples.
In
contrast,
health-positive
genera,
including
Bacteroides
,
Eubacterium
Akkermansia
was
elevated
red
mung
Heunguseul.
At
same
time,
proportion
pathogenic
decreased.
Concurrently,
these
three
species
exhibited
microbial
diversity
as
evidenced
calculation
α
-diversity
(Shannon
index)
β
(Bray-Curtis
distance).
Despite
lower
nutrient
contents
pulses,
carbohydrates,
amino
acids,
network
that
possess
complex
positive
or
negative
correlations
with
a
variety
bacteria,
well
metabolites.
These
more
pronounced
Heunguseul
than
other
pulses.
It
postulated
overall
potential
nourish
environments
due
balance
nutritional
components.
linear
regression
demonstrated
there
association
carbohydrate
acid
Shannon
indices.
Furthermore,
ratio
carbohydrates
acids
displayed
increase.
showed
weak
correlation.
is
noteworthy
diet
comprising
foods
balanced
profile
supports
growth
beneficial
microbes,
thereby
promoting
eubiosis.
Consistent
work
on
different
ingredients
essential
precise
insight
into
interplay
food
microbiome
dietary
patterns.
Nutrients,
Год журнала:
2023,
Номер
15(9), С. 2211 - 2211
Опубликована: Май 6, 2023
Short-chain
fatty
acids
(SCFAs)
play
a
key
role
in
health
and
disease,
as
they
regulate
gut
homeostasis
their
deficiency
is
involved
the
pathogenesis
of
several
disorders,
including
inflammatory
bowel
diseases,
colorectal
cancer,
cardiometabolic
disorders.
SCFAs
are
metabolites
specific
bacterial
taxa
human
microbiota,
production
influenced
by
foods
or
food
supplements,
mainly
prebiotics,
direct
fostering
these
taxa.
This
Review
provides
an
overview
SCFAs’
roles
functions,
SCFA-producing
bacteria,
from
microbiological
characteristics
taxonomy
to
biochemical
process
that
lead
release
SCFAs.
Moreover,
we
will
describe
potential
therapeutic
approaches
boost
levels
treat
different
related
diseases.
Nutrients,
Год журнала:
2023,
Номер
15(20), С. 4466 - 4466
Опубликована: Окт. 21, 2023
The
gut
microbiome
is
a
diverse
bacterial
community
in
the
human
gastrointestinal
tract
that
plays
important
roles
variety
of
biological
processes.
Short-chain
fatty
acids
(SCFA)
are
produced
through
fermentation
dietary
fiber.
Certain
microbes
responsible
for
producing
SCFAs
such
as
acetate,
propionate
and
butyrate.
An
imbalance
diversity
can
lead
to
metabolic
disorders
inflammation-related
diseases.
Changes
SCFA
levels
associated
microbiota
were
observed
IBD,
suggesting
an
association
between
disease.
affect
reactive
oxygen
species
(ROS)
with
IBD.
Gut
closely
related
it
study
them
further.
Nutrients,
Год журнала:
2024,
Номер
16(3), С. 400 - 400
Опубликована: Янв. 30, 2024
The
infant
gut
microbiome
plays
a
key
role
in
the
healthy
development
of
human
organism
and
appears
to
be
influenced
by
dietary
practices
through
multiple
pathways.
First,
maternal
diet
during
pregnancy
nutrition
significantly
influence
microbiota.
Moreover,
breastfeeding
fosters
proliferation
beneficial
bacteria,
while
formula
feeding
increases
microbial
diversity.
timing
introducing
solid
foods
also
influences
microbiota
composition.
In
preterm
infants
is
factors,
including
time
since
birth
intake
breast
milk,
interventions
such
as
probiotics
prebiotics
supplementation
show
promising
results
reducing
morbidity
mortality
this
population.
These
findings
underscore
need
for
future
research
understand
long-term
health
impacts
these
further
strategies
enrich
formula-fed
infants.
Frontiers in Neuroanatomy,
Год журнала:
2025,
Номер
19
Опубликована: Фев. 12, 2025
The
microbiota-gut-brain
axis
(MGBA)
plays
a
significant
role
in
the
maintenance
of
brain
structure
and
function.
MGBA
serves
as
conduit
between
CNS
ENS,
facilitating
communication
emotional
cognitive
centers
via
diverse
pathways.
In
initial
stages
this
review,
we
will
examine
way
how
affects
neurogenesis,
neuronal
dendritic
morphology,
axonal
myelination,
microglia
structure,
blood
barrier
(BBB)
permeability,
synaptic
structure.
Furthermore,
review
potential
mechanistic
pathways
neuroplasticity
through
influence.
short-chain
fatty
acids
(SCFAs)
play
pivotal
MGBA,
where
they
can
modify
BBB.
We
therefore
discuss
SCFAs
influence
microglia,
neuronal,
astrocyte
function,
well
their
disorders
such
Alzheimer’s
disease
(AD),
Parkinson’s
(PD).
Subsequently,
technical
strategies
employed
to
study
interactions,
including
using
germ-free
(GF)
animals,
probiotics,
fecal
microbiota
transplantation
(FMT),
antibiotics-induced
dysbiosis.
Finally,
particular
bacterial
strains
affect
By
gaining
deeper
understanding
it
may
be
possible
facilitate
research
into
microbial-based
pharmacological
interventions
therapeutic
for
neurological
diseases.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 19, 2023
Background
A
growing
number
of
studies
implies
a
strong
association
between
gut
microbiota
and
chronic
obstructive
pulmonary
disease
(COPD).
However,
the
causal
impact
COPD
remains
unclear.
As
result,
we
used
two-sample
Mendelian
randomization
(MR)
method
to
investigate
connection
in
this
study.
Methods
The
largest
available
genome-wide
study
(GWAS)
was
obtained
from
MiBioGen
consortium.
Summary-level
dataset
for
were
FinnGen
main
analysis
determining
link
inverse
variance
weighted
(IVW).
Subsequently,
pleiotropy
heterogeneity
tests
performed
determine
reliability
results.
Results
IVW
identified
9
bacterial
taxa
nominally
associated
with
risk
COPD.
Class
Actinobacteria
(
p
=
0.020),
genus
Allisonella
0.024),
Coprococcus2
0.002)
Oscillospira
0.018)
protective
against
In
addition,
order
Desulfovibrionales
0.011),
family
Desulfovibrionaceae
0.039),
Peptococcaceae
Victivallaceae
0.012)
Marvinbryantia
0.017)
higher
No
or
found.
Conclusion
According
findings
MR
analysis,
relationship
exists
certain
New
insights
into
mechanisms
mediated
by
are
provided.
There
is
mounting
evidence
regarding
the
role
of
gut
microbiota
in
anorexia
nervosa
(AN).
Previous
studies
have
reported
that
patients
with
AN
show
dysbiosis
compared
to
healthy
controls
(HCs);
however,
underlying
mechanisms
are
unclear,
and
data
on
influencing
factors
longitudinal
course
microbiome
changes
scarce.
Here,
we
present
57
adolescent
inpatients
diagnosed
at
up
nine
time
points
(including
a
1-year
follow-up
examination)
compare
these
six
34
HCs.
16S
rRNA
gene
sequencing
was
used
investigate
composition
fecal
samples,
food
intake,
weight
change,
hormonal
recovery
(leptin
levels),
clinical
outcomes
were
recorded.
Differences
HCs
greatest
during
acute
starvation
low-weight
group,
while
diminishing
gain
especially
follow-up.
Illness
duration
prior
loss
strongly
associated
hospital
admission,
whereas
microbial
treatment
kilocalories
consumed,
gain,
recovery.
The
admission
prognostic
for
readmission,
higher
abundance
Sutterella
body
Identifying
clinically
important
further
underlines
potential
relevance
may
help
elucidate
pathophysiology
gut-brain
interactions
AN.
characterization
prognostically
relevant
taxa
could
be
useful
stratify
potentially
identify
candidate
future
supplementation
aimed
improving
treatment.
Nutrients,
Год журнала:
2024,
Номер
16(7), С. 1054 - 1054
Опубликована: Апрель 4, 2024
The
microbiota-gut-brain
(MGB)
axis
is
a
complex
communication
network
linking
the
gut,
microbiota,
and
brain,
influencing
various
aspects
of
health
disease.
Dysbiosis,
disturbance
in
gut
microbiome
equilibrium,
can
significantly
impact
MGB
axis,
leading
to
alterations
microbial
composition
function.
Emerging
evidence
highlights
connection
between
microbiota
neurological
psychiatric
disorders,
including
depression.
This
review
explores
potential
psychobiotics
managing
depressive
emphasizing
their
role
restoring
balance
axis.
Psychobiotics
exhibit
positive
effects
on
intestinal
barrier,
immune
response,
cortisol
levels,
hypothalamic-pituitary-adrenal
(HPA)
Studies
suggest
that
probiotics
may
serve
as
an
adjunct
therapy
for
depression,
especially
treatment-resistant
cases.
discusses
key
findings
from
studies
interventions,
gut-brain
mental
health.
increasing
acceptance
expanded
concept
underscores
importance
microorganisms
well-being.
As
our
understanding
microbiome's
disease
grows,
emerge
promising
agents
addressing
issues,
providing
new
avenues
therapeutic
interventions
disorders.
