A comprehensive update on the immunoregulatory mechanisms of Akkermansia muciniphila : insights into active ingredients, metabolites, and nutrient-driven modulation DOI

Lihua Mei,

Jiaxin Wang,

Yanling Hao

и другие.

Critical Reviews in Food Science and Nutrition, Год журнала: 2024, Номер unknown, С. 1 - 18

Опубликована: Окт. 16, 2024

Akkermansia muciniphila (A. muciniphila) has gained recognition as a pioneering probiotic, exhibiting considerable potential to enhance immune conditions across both humans and animals. The health benefits of A. are attributed its various components, including outer membrane proteins (PilQ Amuc_1100), secreted (P9 AmTARS), extracellular vesicles, metabolites such SCFAs, ornithine lipids, γ-aminobutyric acid, cobalamin, inosine. dynamic control the mucus layer by plays crucial role in regulating intestinal mucosal immunity. Furthermore, modulates function interacting with macrophages, dendritic cells, T lymphocytes, Paneth cells. Increasing abundance gut through nutritional strategies represents safe effective means augment function. Various polyphenols, oligosaccharides, polysaccharides have been shown elevate levels this bacterium, thereby contributing favorable immunoregulatory outcomes. This paper delves into latest research advancements related probiotic mechanisms provides an overview current understanding how responds nutrients. These insights offer theoretical foundation for utilization immunoregulation.

Язык: Английский

Akkermansia muciniphila: a potential candidate for ameliorating metabolic diseases DOI Creative Commons
Huifang Niu, Minfeng Zhou, Daniel Zogona

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Март 20, 2024

Metabolic diseases are comprehensive disease based on obesity. Numerous cumulative studies have shown a certain correlation between the fluctuating abundance of Akkermansia muciniphila and occurrence metabolic diseases. A. , potential probiotic candidate colonized in human intestinal mucus layer, its derivatives various physiological functions, including treating disorders maintaining health. This review systematically explicates change rules It also details high efficacy specific molecules mechanism obesity, type 2 diabetes mellitus, cardiovascular disease, non-alcoholic fatty liver disease.

Язык: Английский

Процитировано

36

Implications of microbe-derived ɣ-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer’s disease DOI Creative Commons

Kathryn A Conn,

Emily M. Borsom, Emily K. Cope

и другие.

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 15, 2024

The gut microbial ecosystem communicates bidirectionally with the brain in what is known as gut-microbiome-brain axis. Bidirectional signaling occurs through several pathways including via vagus nerve, circulation of metabolites, and immune activation. Alterations microbiota are implicated Alzheimer's disease (AD), a progressive neurodegenerative disease. Perturbations communities may affect within axis altered production metabolites ɣ-aminobutyric acid (GABA), primary inhibitory mammalian neurotransmitter. GABA has been shown to act on integrity modulation mucins tight junction proteins be involved nerve signal inhibition. GABAergic pathway dysregulated AD, responsive interventions. Gut recent interest neurological disorders, AD. Bacteroides Lactic Acid Bacteria (LAB), Lactobacillus, predominant producers GABA. This review highlights how temporal alterations associated AD pathway, intestinal barrier integrity, AD-associated inflammation.

Язык: Английский

Процитировано

21

A new strategy for immunotherapy of microsatellite‐stable (MSS)‐type advanced colorectal cancer: Multi‐pathway combination therapy with PD‐1/PD‐L1 inhibitors DOI Open Access
Lingli Cai, Anqi Chen, Dong Tang

и другие.

Immunology, Год журнала: 2024, Номер 173(2), С. 209 - 226

Опубликована: Март 22, 2024

Abstract Colorectal cancer (CRC) is a frequent gastrointestinal malignancy with high rates of morbidity and mortality; 85% these tumours are proficient mismatch repair (pMMR)‐microsatellite instability‐low (MSI‐L)/microsatellite stable (MSS) CRC known as ‘cold’ that resistant to immunosuppressive drugs. Monotherapy programmed death 1 (PD‐1)/programmed ligand (PD‐L1) inhibitors ineffective for treating MSS CRC, making immunotherapy bottleneck. Recent studies have found the multi‐pathway regimens combined PD‐1/PD‐L1 can enhance efficacy anti‐PD‐1/PD‐L1 in by increasing number CD8+ T cells, upregulating PD‐L1 expression improving tumour microenvironment. This paper reviews research progress combination cytotoxic T‐lymphocyte–associated antigen 4 (CTLA‐4) inhibitors, oncolytic virus, intestinal flora, antiangiogenic agents, chemotherapy, radiotherapy epigenetic drugs treatment pMMR‐MSI‐L/MSS CRC.

Язык: Английский

Процитировано

20

Gut microbiota and derived metabolites mediate obstructive sleep apnea induced atherosclerosis DOI Creative Commons

Jin Xue,

Celeste Allaband, Simone Zuffa

и другие.

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Март 2, 2025

Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia/hypercapnia (IHC), affects predominantly obese individuals, and increases atherosclerosis risk. Since we others have implicated gut microbiota metabolites in atherogenesis, dissected their contributions to OSA-induced atherosclerosis. Atherosclerotic lesions were compared between conventionally-reared specific pathogen free (SPF) germ-free (GF) Apoe-/- mice following a high fat cholesterol diet (HFHC), with without IHC conditions. The fecal metabolome profiled using 16S rRNA gene amplicon sequencing untargeted tandem mass spectrometry (LC-MS/MS) respectively. Phenotypic data showed that HFHC significantly increased as regular chow (RC) both aorta pulmonary artery (PA) of SPF mice. exacerbated addition HFHC. Differential abundance analysis identified an enrichment Akkermansiaceae depletion Muribaculaceae (formerly S24-7) family members the HFHC-IHC group. LC-MS/MS dysregulation bile acid profiles taurocholic acid, taurodeoxycholic 12-ketodeoxycholic enriched group, long-chain N-acyl amides, phosphatidylcholines. Interestingly, GF markedly reduced atherosclerotic formation relative under HFHC/IHC In contrast, microbial colonization did not show significant impact on progression PA. summary, this research demonstrated (1) acts cooperatively induce atherosclerosis; (2) modulate induced HFHC/IHC, PA; (3) different analytical methods suggest imbalance bacterial families mediate (4) derived acids, such deoxycholic lithocholic regulate OSA. knowledge obtained provides novel insights into potential therapeutic approaches prevent treat

Язык: Английский

Процитировано

3

The role of Akkermansia muciniphila in colorectal cancer: A double-edged sword of treatment or disease progression? DOI Open Access
Elnaz Faghfuri, Pourya Gholizadeh

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 173, С. 116416 - 116416

Опубликована: Март 11, 2024

Colorectal cancer (CRC) is the second most cancer-related death worldwide. In recent years, probiotics have been used to reduce potential risks of CRC and tumors with various mechanisms. Different bacteria suggested play different roles in progression, prevention, or treatment CRC. Akkermansia muciniphila considered a next-generation probiotic for preventing treating some diseases. Therefore, this review article, we aimed describe discuss mechanisms A. as an intestinal microbiota Some studies that abundance was higher increased patients compared healthy individuals. However, decreased associated severe symptoms CRC, indicating did not role development addition, administration elevates gene expression proliferation-associated molecules such S100A9, Dbf4, Snrpd1, markers cell proliferation. other inflammation tumorigenesis intestine might promoted by muciniphila. Overall, inhibition still unclear controversial. Various methods bacterial supplementation, viability, number, abundance, could all influence colonization effect progression. mucinipila has revealed modulate therapeutic immune checkpoint inhibitors. Preliminary human data propose oral consumption safe, but its efficacy needs be confirmed more clinical studies.

Язык: Английский

Процитировано

12

Good girl goes bad: Understanding how gut commensals cause disease DOI
Priyankar Dey

Microbial Pathogenesis, Год журнала: 2024, Номер 190, С. 106617 - 106617

Опубликована: Март 16, 2024

Язык: Английский

Процитировано

10

The Anti-inflammatory Potential of a Strain of Probiotic Bifidobacterium pseudocatenulatum G7: In Vitro and In Vivo Evidence DOI
Yukun Sun,

Jiazhi Zhou,

Hengjun Du

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(18), С. 10355 - 10365

Опубликована: Апрель 15, 2024

The genus Bifidobacterium has been widely used in functional foods for health promotion due to its beneficial effects on human health, especially the gastrointestinal tract (GIT). In this study, we characterize anti-inflammatory potential of probiotic strain pseudocatenulatum G7, isolated from a healthy male adult. G7 secretion inhibited inflammatory response lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Moreover, oral administration bacteria alleviated severity colonic inflammation dextran sulfate sodium (DSS)-treated colitis mice, which was evidenced by decreased disease activity index (DAI) and enhanced structural integrity colon. 16S rRNA gene sequencing result illustrated that DSS-induced gut microbiota dysbiosis, accompanied modulated bile acids short-chain fatty acid (SCFA) levels. Overall, our results demonstrated both vitro vivo models, provided solid foundation further development novel probiotic.

Язык: Английский

Процитировано

10

Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer DOI Creative Commons
Rachel C. Fellows, Sung Kook Chun, Natalie Larson

и другие.

Science Advances, Год журнала: 2024, Номер 10(39)

Опубликована: Сен. 27, 2024

Diet is a robust entrainment cue that regulates diurnal rhythms of the gut microbiome. We and others have shown disruption circadian clock drives progression colorectal cancer (CRC). While certain bacterial species been suggested to play driver roles in CRC, it unknown whether intestinal impinges on microbiome accelerate CRC pathogenesis. To address this, genetic clock, an Apc- driven mouse model was used define impact When combined with metagenomic sequencing identified dysregulation many genera including Bacteroides , Helicobacter Megasphaera. identify functional changes microbial pathways dysregulated nucleic acid, amino carbohydrate metabolism, as well barrier function. Our findings suggest microbiota composition permeability may contribute

Язык: Английский

Процитировано

10

The role of Akkermansia muciniphila in maintaining health: a bibliometric study DOI Creative Commons

Fangfang Gao,

Canyu Cheng,

Run‐Wei Li

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Фев. 3, 2025

Background Akkermansia muciniphila , as a probiotic, is negatively linked to IBD, obesity, and T2DM. The aim of this study was comprehensively assess the research status over past decade explore relationships between bacterium various health-related aspects. Methods Tools VOSviewer, Bibliometrix, CiteSpace were used analyze aspects including publication metrics, contributors, institutions, geography, journals, funding, keywords. Results Over decade, on has demonstrated consistent annual growth in number publications, with notable peak 2021. China led totaling 151, whereas United States exhibited higher centrality value. Among 820 institutions involved research, University California (from States) Chinese Academy Sciences China) occupied central positions. Willem M. De Vos ranked at top, 12 publications 1,108 citations. journal GUT, which had 5,125 citations an Impact Factor 23.0 2024, most highly cited. cited articles deepened understanding bacterium’s impact human health, spanning from basic translational medicine. Thirty-nine high-frequency keywords grouped into five clusters, illustrating ’s associations metabolic diseases, chronic kidney disease, gut-brain axis, intestinal inflammation, Bacteroidetes-Firmicutes shifts. Conclusion Given anti-inflammatory gut-barrier-strengthening properties, it holds promise therapeutic for disorders, inflammatory conditions. Therefore, future should its potential further by conducting clinical trials, elucidating mechanisms action, investigating efficacy safety diverse patient populations.

Язык: Английский

Процитировано

2

Modulating the gut microbiota: A novel perspective in colorectal cancer treatment DOI
Xue Bai,

Boyang Liu,

Daiming Fan

и другие.

Cancer Letters, Год журнала: 2025, Номер unknown, С. 217459 - 217459

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1