Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 18
Опубликована: Окт. 16, 2024
Akkermansia
muciniphila
(A.
muciniphila)
has
gained
recognition
as
a
pioneering
probiotic,
exhibiting
considerable
potential
to
enhance
immune
conditions
across
both
humans
and
animals.
The
health
benefits
of
A.
are
attributed
its
various
components,
including
outer
membrane
proteins
(PilQ
Amuc_1100),
secreted
(P9
AmTARS),
extracellular
vesicles,
metabolites
such
SCFAs,
ornithine
lipids,
γ-aminobutyric
acid,
cobalamin,
inosine.
dynamic
control
the
mucus
layer
by
plays
crucial
role
in
regulating
intestinal
mucosal
immunity.
Furthermore,
modulates
function
interacting
with
macrophages,
dendritic
cells,
T
lymphocytes,
Paneth
cells.
Increasing
abundance
gut
through
nutritional
strategies
represents
safe
effective
means
augment
function.
Various
polyphenols,
oligosaccharides,
polysaccharides
have
been
shown
elevate
levels
this
bacterium,
thereby
contributing
favorable
immunoregulatory
outcomes.
This
paper
delves
into
latest
research
advancements
related
probiotic
mechanisms
provides
an
overview
current
understanding
how
responds
nutrients.
These
insights
offer
theoretical
foundation
for
utilization
immunoregulation.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 20, 2024
Metabolic
diseases
are
comprehensive
disease
based
on
obesity.
Numerous
cumulative
studies
have
shown
a
certain
correlation
between
the
fluctuating
abundance
of
Akkermansia
muciniphila
and
occurrence
metabolic
diseases.
A.
,
potential
probiotic
candidate
colonized
in
human
intestinal
mucus
layer,
its
derivatives
various
physiological
functions,
including
treating
disorders
maintaining
health.
This
review
systematically
explicates
change
rules
It
also
details
high
efficacy
specific
molecules
mechanism
obesity,
type
2
diabetes
mellitus,
cardiovascular
disease,
non-alcoholic
fatty
liver
disease.
The
gut
microbial
ecosystem
communicates
bidirectionally
with
the
brain
in
what
is
known
as
gut-microbiome-brain
axis.
Bidirectional
signaling
occurs
through
several
pathways
including
via
vagus
nerve,
circulation
of
metabolites,
and
immune
activation.
Alterations
microbiota
are
implicated
Alzheimer's
disease
(AD),
a
progressive
neurodegenerative
disease.
Perturbations
communities
may
affect
within
axis
altered
production
metabolites
ɣ-aminobutyric
acid
(GABA),
primary
inhibitory
mammalian
neurotransmitter.
GABA
has
been
shown
to
act
on
integrity
modulation
mucins
tight
junction
proteins
be
involved
nerve
signal
inhibition.
GABAergic
pathway
dysregulated
AD,
responsive
interventions.
Gut
recent
interest
neurological
disorders,
AD.
Bacteroides
Lactic
Acid
Bacteria
(LAB),
Lactobacillus,
predominant
producers
GABA.
This
review
highlights
how
temporal
alterations
associated
AD
pathway,
intestinal
barrier
integrity,
AD-associated
inflammation.
Immunology,
Год журнала:
2024,
Номер
173(2), С. 209 - 226
Опубликована: Март 22, 2024
Abstract
Colorectal
cancer
(CRC)
is
a
frequent
gastrointestinal
malignancy
with
high
rates
of
morbidity
and
mortality;
85%
these
tumours
are
proficient
mismatch
repair
(pMMR)‐microsatellite
instability‐low
(MSI‐L)/microsatellite
stable
(MSS)
CRC
known
as
‘cold’
that
resistant
to
immunosuppressive
drugs.
Monotherapy
programmed
death
1
(PD‐1)/programmed
ligand
(PD‐L1)
inhibitors
ineffective
for
treating
MSS
CRC,
making
immunotherapy
bottleneck.
Recent
studies
have
found
the
multi‐pathway
regimens
combined
PD‐1/PD‐L1
can
enhance
efficacy
anti‐PD‐1/PD‐L1
in
by
increasing
number
CD8+
T
cells,
upregulating
PD‐L1
expression
improving
tumour
microenvironment.
This
paper
reviews
research
progress
combination
cytotoxic
T‐lymphocyte–associated
antigen
4
(CTLA‐4)
inhibitors,
oncolytic
virus,
intestinal
flora,
antiangiogenic
agents,
chemotherapy,
radiotherapy
epigenetic
drugs
treatment
pMMR‐MSI‐L/MSS
CRC.
Obstructive
sleep
apnea
(OSA)
is
characterized
by
intermittent
hypoxia/hypercapnia
(IHC),
affects
predominantly
obese
individuals,
and
increases
atherosclerosis
risk.
Since
we
others
have
implicated
gut
microbiota
metabolites
in
atherogenesis,
dissected
their
contributions
to
OSA-induced
atherosclerosis.
Atherosclerotic
lesions
were
compared
between
conventionally-reared
specific
pathogen
free
(SPF)
germ-free
(GF)
Apoe-/-
mice
following
a
high
fat
cholesterol
diet
(HFHC),
with
without
IHC
conditions.
The
fecal
metabolome
profiled
using
16S
rRNA
gene
amplicon
sequencing
untargeted
tandem
mass
spectrometry
(LC-MS/MS)
respectively.
Phenotypic
data
showed
that
HFHC
significantly
increased
as
regular
chow
(RC)
both
aorta
pulmonary
artery
(PA)
of
SPF
mice.
exacerbated
addition
HFHC.
Differential
abundance
analysis
identified
an
enrichment
Akkermansiaceae
depletion
Muribaculaceae
(formerly
S24-7)
family
members
the
HFHC-IHC
group.
LC-MS/MS
dysregulation
bile
acid
profiles
taurocholic
acid,
taurodeoxycholic
12-ketodeoxycholic
enriched
group,
long-chain
N-acyl
amides,
phosphatidylcholines.
Interestingly,
GF
markedly
reduced
atherosclerotic
formation
relative
under
HFHC/IHC
In
contrast,
microbial
colonization
did
not
show
significant
impact
on
progression
PA.
summary,
this
research
demonstrated
(1)
acts
cooperatively
induce
atherosclerosis;
(2)
modulate
induced
HFHC/IHC,
PA;
(3)
different
analytical
methods
suggest
imbalance
bacterial
families
mediate
(4)
derived
acids,
such
deoxycholic
lithocholic
regulate
OSA.
knowledge
obtained
provides
novel
insights
into
potential
therapeutic
approaches
prevent
treat
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
173, С. 116416 - 116416
Опубликована: Март 11, 2024
Colorectal
cancer
(CRC)
is
the
second
most
cancer-related
death
worldwide.
In
recent
years,
probiotics
have
been
used
to
reduce
potential
risks
of
CRC
and
tumors
with
various
mechanisms.
Different
bacteria
suggested
play
different
roles
in
progression,
prevention,
or
treatment
CRC.
Akkermansia
muciniphila
considered
a
next-generation
probiotic
for
preventing
treating
some
diseases.
Therefore,
this
review
article,
we
aimed
describe
discuss
mechanisms
A.
as
an
intestinal
microbiota
Some
studies
that
abundance
was
higher
increased
patients
compared
healthy
individuals.
However,
decreased
associated
severe
symptoms
CRC,
indicating
did
not
role
development
addition,
administration
elevates
gene
expression
proliferation-associated
molecules
such
S100A9,
Dbf4,
Snrpd1,
markers
cell
proliferation.
other
inflammation
tumorigenesis
intestine
might
promoted
by
muciniphila.
Overall,
inhibition
still
unclear
controversial.
Various
methods
bacterial
supplementation,
viability,
number,
abundance,
could
all
influence
colonization
effect
progression.
mucinipila
has
revealed
modulate
therapeutic
immune
checkpoint
inhibitors.
Preliminary
human
data
propose
oral
consumption
safe,
but
its
efficacy
needs
be
confirmed
more
clinical
studies.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(18), С. 10355 - 10365
Опубликована: Апрель 15, 2024
The
genus
Bifidobacterium
has
been
widely
used
in
functional
foods
for
health
promotion
due
to
its
beneficial
effects
on
human
health,
especially
the
gastrointestinal
tract
(GIT).
In
this
study,
we
characterize
anti-inflammatory
potential
of
probiotic
strain
pseudocatenulatum
G7,
isolated
from
a
healthy
male
adult.
G7
secretion
inhibited
inflammatory
response
lipopolysaccharide
(LPS)-stimulated
RAW
264.7
macrophages.
Moreover,
oral
administration
bacteria
alleviated
severity
colonic
inflammation
dextran
sulfate
sodium
(DSS)-treated
colitis
mice,
which
was
evidenced
by
decreased
disease
activity
index
(DAI)
and
enhanced
structural
integrity
colon.
16S
rRNA
gene
sequencing
result
illustrated
that
DSS-induced
gut
microbiota
dysbiosis,
accompanied
modulated
bile
acids
short-chain
fatty
acid
(SCFA)
levels.
Overall,
our
results
demonstrated
both
vitro
vivo
models,
provided
solid
foundation
further
development
novel
probiotic.
Diet
is
a
robust
entrainment
cue
that
regulates
diurnal
rhythms
of
the
gut
microbiome.
We
and
others
have
shown
disruption
circadian
clock
drives
progression
colorectal
cancer
(CRC).
While
certain
bacterial
species
been
suggested
to
play
driver
roles
in
CRC,
it
unknown
whether
intestinal
impinges
on
microbiome
accelerate
CRC
pathogenesis.
To
address
this,
genetic
clock,
an
Apc-
driven
mouse
model
was
used
define
impact
When
combined
with
metagenomic
sequencing
identified
dysregulation
many
genera
including
Bacteroides
,
Helicobacter
Megasphaera.
identify
functional
changes
microbial
pathways
dysregulated
nucleic
acid,
amino
carbohydrate
metabolism,
as
well
barrier
function.
Our
findings
suggest
microbiota
composition
permeability
may
contribute
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 3, 2025
Background
Akkermansia
muciniphila
,
as
a
probiotic,
is
negatively
linked
to
IBD,
obesity,
and
T2DM.
The
aim
of
this
study
was
comprehensively
assess
the
research
status
over
past
decade
explore
relationships
between
bacterium
various
health-related
aspects.
Methods
Tools
VOSviewer,
Bibliometrix,
CiteSpace
were
used
analyze
aspects
including
publication
metrics,
contributors,
institutions,
geography,
journals,
funding,
keywords.
Results
Over
decade,
on
has
demonstrated
consistent
annual
growth
in
number
publications,
with
notable
peak
2021.
China
led
totaling
151,
whereas
United
States
exhibited
higher
centrality
value.
Among
820
institutions
involved
research,
University
California
(from
States)
Chinese
Academy
Sciences
China)
occupied
central
positions.
Willem
M.
De
Vos
ranked
at
top,
12
publications
1,108
citations.
journal
GUT,
which
had
5,125
citations
an
Impact
Factor
23.0
2024,
most
highly
cited.
cited
articles
deepened
understanding
bacterium’s
impact
human
health,
spanning
from
basic
translational
medicine.
Thirty-nine
high-frequency
keywords
grouped
into
five
clusters,
illustrating
’s
associations
metabolic
diseases,
chronic
kidney
disease,
gut-brain
axis,
intestinal
inflammation,
Bacteroidetes-Firmicutes
shifts.
Conclusion
Given
anti-inflammatory
gut-barrier-strengthening
properties,
it
holds
promise
therapeutic
for
disorders,
inflammatory
conditions.
Therefore,
future
should
its
potential
further
by
conducting
clinical
trials,
elucidating
mechanisms
action,
investigating
efficacy
safety
diverse
patient
populations.
