Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 12, 2025
The
therapeutic
benefits
of
opioids
are
compromised
by
the
development
analgesic
tolerance,
which
necessitates
higher
dosing
for
pain
management
thereby
increasing
liability
drug
dependence
and
addiction.
Rodent
models
indicate
opposing
roles
gut
microbiota
in
tolerance:
morphine-induced
dysbiosis
exacerbates
whereas
probiotics
ameliorate
tolerance.
Not
all
individuals
develop
could
be
influenced
differences
microbiota,
yet
no
study
design
has
capitalized
upon
this
natural
variation.
We
leveraged
behavioral
variation
a
murine
model
voluntary
oral
morphine
self-administration
to
elucidate
mechanisms
influences
Although
mice
shared
similar
morphine-driven
changes
that
largely
masked
informative
associations
with
variability
our
high-resolution
temporal
analyses
revealed
divergence
progression
best
explained
sustained
antinociception.
Mice
did
not
tolerance
maintained
capacity
production
short-chain
fatty
acid
(SCFA)
butyrate
known
bolster
intestinal
barriers
promote
neuronal
homeostasis.
Both
fecal
microbial
transplantation
(FMT)
from
donor
dietary
supplementation
significantly
reduced
independently
suppression
systemic
inflammation.
These
findings
inform
immediate
therapies
extend
efficacy
opioids.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 20, 2024
Metabolic
diseases
are
comprehensive
disease
based
on
obesity.
Numerous
cumulative
studies
have
shown
a
certain
correlation
between
the
fluctuating
abundance
of
Akkermansia
muciniphila
and
occurrence
metabolic
diseases.
A.
,
potential
probiotic
candidate
colonized
in
human
intestinal
mucus
layer,
its
derivatives
various
physiological
functions,
including
treating
disorders
maintaining
health.
This
review
systematically
explicates
change
rules
It
also
details
high
efficacy
specific
molecules
mechanism
obesity,
type
2
diabetes
mellitus,
cardiovascular
disease,
non-alcoholic
fatty
liver
disease.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: July 15, 2024
The
gut
microbial
ecosystem
communicates
bidirectionally
with
the
brain
in
what
is
known
as
gut-microbiome-brain
axis.
Bidirectional
signaling
occurs
through
several
pathways
including
via
vagus
nerve,
circulation
of
metabolites,
and
immune
activation.
Alterations
microbiota
are
implicated
Alzheimer's
disease
(AD),
a
progressive
neurodegenerative
disease.
Perturbations
communities
may
affect
within
axis
altered
production
metabolites
ɣ-aminobutyric
acid
(GABA),
primary
inhibitory
mammalian
neurotransmitter.
GABA
has
been
shown
to
act
on
integrity
modulation
mucins
tight
junction
proteins
be
involved
nerve
signal
inhibition.
GABAergic
pathway
dysregulated
AD,
responsive
interventions.
Gut
recent
interest
neurological
disorders,
AD.
Bacteroides
Lactic
Acid
Bacteria
(LAB),
Lactobacillus,
predominant
producers
GABA.
This
review
highlights
how
temporal
alterations
associated
AD
pathway,
intestinal
barrier
integrity,
AD-associated
inflammation.
Immunology,
Journal Year:
2024,
Volume and Issue:
173(2), P. 209 - 226
Published: March 22, 2024
Abstract
Colorectal
cancer
(CRC)
is
a
frequent
gastrointestinal
malignancy
with
high
rates
of
morbidity
and
mortality;
85%
these
tumours
are
proficient
mismatch
repair
(pMMR)‐microsatellite
instability‐low
(MSI‐L)/microsatellite
stable
(MSS)
CRC
known
as
‘cold’
that
resistant
to
immunosuppressive
drugs.
Monotherapy
programmed
death
1
(PD‐1)/programmed
ligand
(PD‐L1)
inhibitors
ineffective
for
treating
MSS
CRC,
making
immunotherapy
bottleneck.
Recent
studies
have
found
the
multi‐pathway
regimens
combined
PD‐1/PD‐L1
can
enhance
efficacy
anti‐PD‐1/PD‐L1
in
by
increasing
number
CD8+
T
cells,
upregulating
PD‐L1
expression
improving
tumour
microenvironment.
This
paper
reviews
research
progress
combination
cytotoxic
T‐lymphocyte–associated
antigen
4
(CTLA‐4)
inhibitors,
oncolytic
virus,
intestinal
flora,
antiangiogenic
agents,
chemotherapy,
radiotherapy
epigenetic
drugs
treatment
pMMR‐MSI‐L/MSS
CRC.
Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: March 2, 2025
Obstructive
sleep
apnea
(OSA)
is
characterized
by
intermittent
hypoxia/hypercapnia
(IHC),
affects
predominantly
obese
individuals,
and
increases
atherosclerosis
risk.
Since
we
others
have
implicated
gut
microbiota
metabolites
in
atherogenesis,
dissected
their
contributions
to
OSA-induced
atherosclerosis.
Atherosclerotic
lesions
were
compared
between
conventionally-reared
specific
pathogen
free
(SPF)
germ-free
(GF)
Apoe-/-
mice
following
a
high
fat
cholesterol
diet
(HFHC),
with
without
IHC
conditions.
The
fecal
metabolome
profiled
using
16S
rRNA
gene
amplicon
sequencing
untargeted
tandem
mass
spectrometry
(LC-MS/MS)
respectively.
Phenotypic
data
showed
that
HFHC
significantly
increased
as
regular
chow
(RC)
both
aorta
pulmonary
artery
(PA)
of
SPF
mice.
exacerbated
addition
HFHC.
Differential
abundance
analysis
identified
an
enrichment
Akkermansiaceae
depletion
Muribaculaceae
(formerly
S24-7)
family
members
the
HFHC-IHC
group.
LC-MS/MS
dysregulation
bile
acid
profiles
taurocholic
acid,
taurodeoxycholic
12-ketodeoxycholic
enriched
group,
long-chain
N-acyl
amides,
phosphatidylcholines.
Interestingly,
GF
markedly
reduced
atherosclerotic
formation
relative
under
HFHC/IHC
In
contrast,
microbial
colonization
did
not
show
significant
impact
on
progression
PA.
summary,
this
research
demonstrated
(1)
acts
cooperatively
induce
atherosclerosis;
(2)
modulate
induced
HFHC/IHC,
PA;
(3)
different
analytical
methods
suggest
imbalance
bacterial
families
mediate
(4)
derived
acids,
such
deoxycholic
lithocholic
regulate
OSA.
knowledge
obtained
provides
novel
insights
into
potential
therapeutic
approaches
prevent
treat
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
173, P. 116416 - 116416
Published: March 11, 2024
Colorectal
cancer
(CRC)
is
the
second
most
cancer-related
death
worldwide.
In
recent
years,
probiotics
have
been
used
to
reduce
potential
risks
of
CRC
and
tumors
with
various
mechanisms.
Different
bacteria
suggested
play
different
roles
in
progression,
prevention,
or
treatment
CRC.
Akkermansia
muciniphila
considered
a
next-generation
probiotic
for
preventing
treating
some
diseases.
Therefore,
this
review
article,
we
aimed
describe
discuss
mechanisms
A.
as
an
intestinal
microbiota
Some
studies
that
abundance
was
higher
increased
patients
compared
healthy
individuals.
However,
decreased
associated
severe
symptoms
CRC,
indicating
did
not
role
development
addition,
administration
elevates
gene
expression
proliferation-associated
molecules
such
S100A9,
Dbf4,
Snrpd1,
markers
cell
proliferation.
other
inflammation
tumorigenesis
intestine
might
promoted
by
muciniphila.
Overall,
inhibition
still
unclear
controversial.
Various
methods
bacterial
supplementation,
viability,
number,
abundance,
could
all
influence
colonization
effect
progression.
mucinipila
has
revealed
modulate
therapeutic
immune
checkpoint
inhibitors.
Preliminary
human
data
propose
oral
consumption
safe,
but
its
efficacy
needs
be
confirmed
more
clinical
studies.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(18), P. 10355 - 10365
Published: April 15, 2024
The
genus
Bifidobacterium
has
been
widely
used
in
functional
foods
for
health
promotion
due
to
its
beneficial
effects
on
human
health,
especially
the
gastrointestinal
tract
(GIT).
In
this
study,
we
characterize
anti-inflammatory
potential
of
probiotic
strain
pseudocatenulatum
G7,
isolated
from
a
healthy
male
adult.
G7
secretion
inhibited
inflammatory
response
lipopolysaccharide
(LPS)-stimulated
RAW
264.7
macrophages.
Moreover,
oral
administration
bacteria
alleviated
severity
colonic
inflammation
dextran
sulfate
sodium
(DSS)-treated
colitis
mice,
which
was
evidenced
by
decreased
disease
activity
index
(DAI)
and
enhanced
structural
integrity
colon.
16S
rRNA
gene
sequencing
result
illustrated
that
DSS-induced
gut
microbiota
dysbiosis,
accompanied
modulated
bile
acids
short-chain
fatty
acid
(SCFA)
levels.
Overall,
our
results
demonstrated
both
vitro
vivo
models,
provided
solid
foundation
further
development
novel
probiotic.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(39)
Published: Sept. 27, 2024
Diet
is
a
robust
entrainment
cue
that
regulates
diurnal
rhythms
of
the
gut
microbiome.
We
and
others
have
shown
disruption
circadian
clock
drives
progression
colorectal
cancer
(CRC).
While
certain
bacterial
species
been
suggested
to
play
driver
roles
in
CRC,
it
unknown
whether
intestinal
impinges
on
microbiome
accelerate
CRC
pathogenesis.
To
address
this,
genetic
clock,
an
Apc-
driven
mouse
model
was
used
define
impact
When
combined
with
metagenomic
sequencing
identified
dysregulation
many
genera
including
Bacteroides
,
Helicobacter
Megasphaera.
identify
functional
changes
microbial
pathways
dysregulated
nucleic
acid,
amino
carbohydrate
metabolism,
as
well
barrier
function.
Our
findings
suggest
microbiota
composition
permeability
may
contribute
The FASEB Journal,
Journal Year:
2024,
Volume and Issue:
38(8)
Published: April 22, 2024
Recent
evidence
suggests
that
chronic
exposure
to
opioid
analgesics
such
as
morphine
disrupts
the
intestinal
epithelial
layer
and
causes
dysbiosis.
Depleting
gut
bacteria
can
preclude
development
of
tolerance
opioid-induced
antinociception,
suggesting
an
important
role
gut-brain
axis
in
mediating
effects.
The
mechanism
underlying
dysbiosis,
however,
remains
unclear.
Host-produced
antimicrobial
peptides
(AMPs)
are
critical
for
integrity
barrier
they
prevent
pathogenesis
enteric
microbiota.
Here,
we
report
or
fentanyl
reduces
activity
ileum,
resulting
changes
composition
bacteria.
Fecal
samples
from
morphine-treated
mice
had
increased
levels
Akkermansia
muciniphila
with
a
shift
abundance
ratio
Firmicutes
Bacteroidetes.
microbial
transplant
(FMT)
morphine-naïve
oral
supplementation
butyrate
restored
(a)
activity,
(b)
expression
peptide,
Reg3γ,
(c)
prevented
increase
permeability
(d)
antinociceptive
morphine-dependent
mice.
Improved
function
FMT
enrichment
mucin-degrading
A.
These
data
implicate
impairment
epithelium
by
which
opioids
disrupt
microbiota-gut-brain
axis.
