Brain Behavior and Immunity, Год журнала: 2024, Номер 124, С. 365 - 375
Опубликована: Дек. 15, 2024
Язык: Английский
Life Sciences, Год журнала: 2024, Номер 351, С. 122815 - 122815
Опубликована: Июнь 11, 2024
Язык: Английский
Процитировано
20
Phytomedicine, Год журнала: 2024, Номер 126, С. 155422 - 155422
Опубликована: Фев. 5, 2024
Язык: Английский
Процитировано
7
BMC Psychiatry, Год журнала: 2024, Номер 24(1)
Опубликована: Май 27, 2024
Abstract Background There are many articles reporting that the component of intestinal microbiota implies a link to anxiety disorders (AD), and brain-gut axis is also hot topic in current research. However, specific relevance between gut AD uncertain. We aimed investigate causal relationship by using bidirectional Mendelian randomization (MR). Methods Genetic instrumental variable (IV) for were obtained from genome-wide association study (GWAS) involving 18,340 participants. Summary data derived GWAS included 158,565 cases 300,995 controls. applied inverse variance weighted (IVW) method as main analysis. Cochran’s Q values was computed evaluate heterogeneity among IVs. Sensitivity analyses including intercept MR-Egger MR-PRESSO analysis used test horizontal pleiotropy. Result discovered 9 potential connections bacterial traits on genus level AD. Utilizing IVW method, we identified 5 genera exhibited direct correlation with risk AD: Eubacteriumbrachygroup , Coprococcus3 Enterorhabdus Oxalobacter Ruminiclostridium6 . Additionally, found 4 negative Blautia Butyricicoccus Erysipelotrichaceae-UCG003 Parasutterella The associations confirmed sensitivity analyses. Conclusion Our relation parts Further randomized controlled trials crucial elucidate positive effects probiotics their particular protection systems.
Язык: Английский
Процитировано
6
BMC Psychiatry, Год журнала: 2024, Номер 24(1)
Опубликована: Май 2, 2024
Abstract Background This study aimed to explore the gut microbiota and inflammatory factor characteristics in major depressive disorder (MDD) patients with anorexia analyze correlation between factors, anorexia, HAMD scores. Methods 46 MDD healthy controls (HC) were included study. The divided into two groups according whether they had anorexia:20 without (MDA0 group) 26 (MDA1 group). We used Hamilton Depression Scale-24 (HAMD-24) evaluate depression status of all participants 16 S ribosomal RNA (16 rRNA)sequencing composition microbiota. Inflammatory factors peripheral blood such as C-reactive protein (CRP) detected using enzyme-linked immunosorbent assay (ELISA). Spearman’s analysis was scores, anorexia. Results 1). CRP significantly higher MDA0, MDA1, than HC. 2). An α-diversity shows: Simpson Pielou indices HC group are MDA1 ( P < 0.05). 3). β-diversity shows differences microbial communities group. 4). A showed that Blautia positively correlated level, whereas Faecalibacterium, Bacteroides, Roseburia, Parabacteroides negatively level. 5). receiver operating characteristic (ROC) curve drawn differential bacterial genera or biomarkers identify accompanied its area under (AUC) 0.85. ROC diagnose AUC 0.97. Conclusion suggested a distinct compared individuals, level CRP. more abundant CRP, might have influenced through
Язык: Английский
Процитировано
5
Heliyon, Год журнала: 2024, Номер 10(3), С. e24899 - e24899
Опубликована: Янв. 23, 2024
Emerging evidence has demonstrated the impact of psychological stress on intestinal microbiota, however, precise mechanisms are not fully understood. Enteric glia, a unique type peripheral glia found within enteric nervous system (ENS), play an active role in neural circuits and have profound effects gut functions. In present study, we tested hypothesis that involved alterations microflora barrier induced by chronic water-avoidance (WAS) gut.
Язык: Английский
Процитировано
4
Antioxidants, Год журнала: 2025, Номер 14(2), С. 195 - 195
Опубликована: Фев. 9, 2025
Chronic stress poses threats to the physical and psychological well-being of dogs. Resveratrol (Res) is a polyphenol with antidepressant properties has rarely been studied in This study aimed investigate stress-relieving effects underlying mechanism Res Dogs were fed basal diet supplemented for 35 days. The fecal microbiota dogs was cultured vitro. results show that improved stress-related behaviors increased serum levels 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF), immunoglobulin A, antioxidant capacity downregulated hormones hypothalamic–pituitary–adrenal axis. abundance butyric-producing bacteria, like Blautia, increased, while growth Fusobacterium related gut inflammation inhibited group. A higher content butyric acid observed metabolome indicated tryptophan (Trp) decreased consumption Trp by microorganisms. chronic unpredictable mild mouse model established, administered ameliorated behavior 5-HT whole brains mice. relative mRNA expression genes associated tight junction protein, aryl hydrocarbon receptor, transporters colon upregulated. In conclusion, could ameliorate canine increasing 5-HT, BDNF, improving immune function response, which attributed role restructuring modulation metabolism.
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(7), С. 1637 - 1637
Опубликована: Апрель 7, 2025
Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder that significantly impacts learning, daily functioning, and personal development. Astaxanthin (ASTA), naturally occurring antioxidant, has garnered interest as potential therapeutic agent for various diseases, particularly in mitigating oxidative stress. This study explores novel application of ASTA the context ADHD, aiming to investigate its effects underlying mechanisms. Spontaneously hypertensive rats (SHRs), widely used ADHD model animals, were treated with (50/100 mg/kg/day) three weeks, 5 mg/kg/day atomoxetine (ATO) positive, Wistar Kyoto (WKY) control. Behavioral improvements assessed using open field test (OFT) Morris water maze (MWM). Biochemical analyses conducted evaluate changes levels neurotrophic factors, while histological examinations performed assess neuroprotective effects. Additionally, role brain–gut axis was investigated. The behavioral symptoms hyperactivity, anxiety, impaired spatial memory animals mitigated by ASTA. improvement primarily attributed restoration neurotransmitter levels, dopamine (DA), achieved through modulation several critical components within system, including receptor 1 (DR1), transporter (DAT), tyrosine hydroxylase (TH), synaptic-associated protein 25 (SNAP-25). regulating serotonin (SERT) glial cell-derived factor (GDNF) supports recovery facilitates optimal brain Furthermore, cerebellar cells protected, structure intestinal microbiota regulated. can mitigate SHR dopaminergic multiple neurotransmitters, neuro-intestinal environment, which establishes promising nutraceutical candidate adjunctive therapy pediatric ADHD.
Язык: Английский
Процитировано
0
Microbiome, Год журнала: 2025, Номер 13(1)
Опубликована: Апрель 15, 2025
Fecal microbial transplantation (FMT) is an important technology for treating diarrhea and enteritis. Additionally, FMT has been applied to improve productivity, alter abnormal behavior, relieve stress, reduce burdens. However, some previous studies have reported that may cause stress in acceptor animals. Inulin, a prebiotic, can promote growth, enhance immunity, balance the gut microbiota. Currently, there are limited reports on effects of combining with inulin early growth performance chicks. In this study, total 90 1-day-old chicks were randomly divided into control group (CON), group, (INU). The CON was fed basic diet, whereas INU groups received fecal microbiota treatment, respectively. Compared groups, presented significantly greater average daily gain (ADG) feed intake (ADFI) values (P < 0.05). organ indices did not change > ratio villi crypts ileum differed at 21 35 days addition, cecum concentrations acetic acid butyric increased inflammation serum decreased immune factors after supplementation. Firmicutes Bacteroidetes dominant phyla, more than 90% all sequences being identified as originating from these two phyla. Inulin supplementation during mother-sourced abundance Rikenella, Butyricicoccus, [Ruminococcus], which contributed positively promotion intestinal health facilitated results study suggest maternal effectively probiotic colonization, favors Video Abstract.
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106746 - 106746
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Microorganisms, Год журнала: 2024, Номер 12(9), С. 1750 - 1750
Опубликована: Авг. 23, 2024
The microbiome is a complex ecosystem of microorganisms that inhabit specific environment. It plays significant role in human health, from food digestion to immune system strengthening. “Novel Foods” refer foods or ingredients have not been consumed by humans the European Union before 1997. Currently, there growing interest understanding how affect and health. aim this review was assess effects on gut microbiome. Research conducted using scientific databases, focusing literature published since 2000, with an emphasis past decade. In general, benefits derived type diet are due interaction between polyphenols, oligosaccharides, prebiotics, probiotics, fibre content, microbiome, which selectively promotes microbial species increases diversity. More research being consumption novel demonstrate they and, thus, Consumption health-promoting properties should be further explored maintain diversity functionality as potential tool prevent onset progression chronic diseases.
Язык: Английский
Процитировано
2