Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 1, 2024
The
last
60
years
have
seen
the
emergence
of
several
zoonotic
viruses,
some
which
originate
from
bats.
Among
these
are
Nipah
virus,
Marburg
virus
and
Ebola
high
case
fatality
rates,
pose
significant
public
health
risks.
In
2012,
another
paramyxovirus
bats,
known
as
Sosuga
Virus
(SOSV),
was
discovered
in
a
hospitalized
biologist
who
had
returned
trip
to
Africa.
Given
potential
threats
SOSV,
investigating
its
pathogenesis,
epidemiology
developing
antiviral
strategies
crucial
control
possible
future
outbreaks.
Thus,
this
review,
we
explore
latest
advancements
understanding
SOSV
since
discovery,
focusing
on
animal
models
development
strategies.
By
examining
current
literature,
review
aims
provide
comprehensive
overview
guide
studies
help
efforts
better
mitigating
The Egyptian Journal of Internal Medicine,
Год журнала:
2024,
Номер
36(1)
Опубликована: Янв. 29, 2024
Abstract
The
Nipah
virus,
a
highly
pathogenic
zoonotic
pathogen,
has
once
again
surfaced
in
the
state
of
Kerala,
India,
with
recent
cases
reported
2023.
This
article
delves
into
epidemiological
details
these
cases,
shedding
light
on
two
fatalities
that
occurred
September
2023
and
August
as
well
suspected
have
undergone
testing.
known
for
its
severe
neurological
respiratory
disease
manifestations,
remains
formidable
health
threat
due
to
lack
specific
treatments
or
vaccines.
government’s
response
including
mass
testing
quarantine
measures,
is
discussed,
drawing
lessons
from
past
outbreaks
region.
Kerala
experienced
multiple
virus
since
2018,
prompting
closer
examination
environmental
factors,
such
deforestation
urbanization,
which
increase
risk
transmission.
underscores
global
implications
resurgence
emphasizes
importance
preparedness
vigilance
face
emerging
infectious
diseases.
learned
Kerala’s
experience
provide
valuable
insights
public
professionals
policymakers
worldwide.
Diseases,
Год журнала:
2024,
Номер
12(12), С. 309 - 309
Опубликована: Дек. 2, 2024
Objectives:
Marburg
virus
disease
(MVD)
is
on
the
WHO
list
for
pandemic-prone
pathogens.
The
current
outbreak
in
Rwanda
provides
an
opportunity
to
map
outbreaks
and
generate
information
inform
policymaking,
resource
mobilization,
guide
implementation
of
cost-effective
response
strategies.
Methods:
We
synthesized
available
about
MVD
build
holistic,
up-to-date
evidence
policymakers,
public
health
leaders,
healthcare
services
providers
their
development
preparedness,
prevention,
control
measures.
Results:
have
identified
20
that
occurred
14
countries
between
1967
2024;
these
led
580
confirmed
cases
423
deaths
total.
summarize
main
clinical
signs,
diagnostic
tools,
primary
reservoir,
transmission
dynamics,
case
management
protocol.
also
document
best
practices
prevention
outbreaks,
including
a
multisectoral
One
Health
strategy
incorporates
strict
WASH
infection
measures,
contact
tracing,
isolation
infected
suspected
humans
animals,
enhances
International
Regulations,
particularly
efficient
cross-country
coordination.
Conclusions:
In
absence
licensed
treatment
or
vaccine
MVD,
should
focus
preventive
community
engagement
promote
reduction
reservoirs,
supportive
care
patients,
proper
waste
management.
High
risk
populations
such
as
frontline
responders,
workers,
be
prioritized
so
they
can
access
all
currently
protection
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 25, 2024
Marburg
virus
disease
(MVD)
presents
a
significant
global
health
threat,
lacking
effective
antivirals
and
with
current
supportive
care
offering
limited
therapeutic
options.
This
mini
review
explores
the
emerging
landscape
of
novel
antiviral
strategies
against
MVD,
focusing
on
promising
therapeutics
currently
in
development
pipeline.
We
delve
into
direct-acting
approaches,
including
small
molecule
inhibitors
targeting
viral
entry,
replication,
assembly,
alongside
nucleic
acid
antisense
RNA
interference
strategies.
Host-targeting
are
also
considered,
encompassing
immune
modulators
like
interferons
cytokine/chemokine
modulators,
broad-spectrum
antivirals,
convalescent
plasma
antibody-based
therapies.
The
paper
then
examines
preclinical
clinical
for
therapeutics,
highlighting
vitro
vivo
models
evaluation,
safety
efficacy
assessments,
critical
stages
trials.
Recognizing
challenges
drug
resistance
escape,
underscores
potential
combination
therapy
emphasizes
need
rapid
diagnostic
tools
to
optimize
treatment
initiation.
Finally,
we
discuss
importance
public
preparedness
equitable
access
these
achieving
MVD
control
security.
comprehensive
overview
burgeoning
field
approaches
reshape
future
prevention.
Abstract
Marburg
virus
(MARV)
is
a
highly
contagious
and
virulent
agent
belonging
to
Filoviridae
family.
MARV
causes
severe
hemorrhagic
fever
in
humans
non-human
primates.
Owing
its
nature,
preventive
approaches
are
promising
for
control.
There
currently
no
approved
drug
or
vaccine
against
MARV,
management
mainly
involves
supportive
care
treat
symptoms
prevent
complications.
Our
aim
was
design
novel
multi-epitope
(MEV)
using
immunoinformatics
studies.
In
this
study,
various
proteins
(VP35,
VP40
glycoprotein
precursor)
were
used
potential
epitopes
selected.
CTL
HTL
covered
79.44%
70.55%
of
the
global
population,
respectively.
The
designed
MEV
construct
stable
expressed
Escherichia
coli
(E.
coli)
host.
physicochemical
properties
also
acceptable.
candidate
could
predict
comprehensive
immune
responses
such
as
those
humoral
cellular
silico.
Additionally,
efficient
interaction
toll-like
receptor
3
(TLR3)
agonist
(β-defensin)
predicted.
need
validation
these
results
further
vitro
vivo
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
The
ongoing
outbreak
of
Marburg
virus
disease
(MVD)
in
Rwanda
marks
the
third
largest
historically,
though
it
has
exhibited
lowest
fatality
rate.
Genomic
analysis
identified
a
lineage
with
limited
internal
diversity
most
closely
related
to
genome
sequence
from
sporadic
case
sampled
2014
Uganda,
lineages
have
diverged
common
ancestor
that
was
circulating
for
decades
animal
reservoir.
Notably,
data
also
provide
evidence
resulted
single
zoonotic
transmission
event
human-to-human
transmission,
rather
than
multiple
independent
events.
Rwandan
MVD
prompted
thorough
investigation
included
contact
tracing,
clinical
assessment,
travel
history,
sequencing,
and
serology
testing,
trace
virus’s
origin.
Results
investigations
linked
index
mining
cave
inhabited
by
Rousettus
aegyptiacus
(the
Egyptian
fruit
bat),
where
three
individuals
tested
seropositive
IgG
IgM,
further
supporting
origin
through
human-animal
interactions.
Hygiene,
Год журнала:
2025,
Номер
5(2), С. 18 - 18
Опубликована: Май 2, 2025
In
recent
decades,
the
world
has
observed
emergence
and
re-emergence
of
a
multitude
previously
non-existent
or
re-emerging
infectious
diseases,
for
which
there
is
paucity
timely
effective
preventative
measures.
The
WHO
published
catalogue
priority
pathogens
that
are
likely
to
trigger
future
epidemics,
with
objective
designing
prophylactic
therapeutic
interventions.
rationale
behind
these
interventions
rooted
in
comprehensive
understanding
aetiology,
epidemiology,
pathogenesis
target
diseases.
While
it
imperative
acknowledge
pivotal
role
evolutionary
changes
play,
equally
important
recognise
influence
multifaceted
interplay
factors
on
These
include
human
populations,
vectors
reservoirs
exposure,
environmental
changes.
This
review
summarises
ten
as
well
those
high
epidemic
potential
already
focus
specific
control
programme
initiatives,
such
HIV/AIDS,
tuberculosis,
malaria
Furthermore,
this
concentrated
means
addressing
infections
through
public
health
surveillance
response
systems.
Such
systems
must
be
designed
rapidly
detect
unusual
unexpected
disease
patterns,
track
share
information
real
time,
mobilise
global
responses,
most
ways
effectively
contain
transmission.
Environmental Health Insights,
Год журнала:
2024,
Номер
18
Опубликована: Янв. 1, 2024
The
World
Health
Organization
(WHO)
defined
Disease
X
as
an
upcoming
disease
with
the
potential
to
cause
a
pandemic.
Pathogen
is
responsible
for
X.
Marburg
virus
(MVD)
one
of
diseases
from
priority
list
published
by
WHO.
filamentous,
negative-sense
RNA
that
belongs
same
filovirus
family
lethal
Ebola
virus.
Since
first
discovery
this
in
1967,
17
outbreaks
occurred
sporadically
till
2023.
Rousettus
aegyptiacus
acts
natural
reservoir
With
average
incubation
period
5
10
days,
its
target
mononuclear
phagocytic
system
cells.
It
highly
contagious
and
can
be
easily
transmitted
animal
human
via
direct
contact
blood
or
body
fluid,
feces,
semen
infected
host.
Although
has
high
case
fatality
rate
close
90%,
unfortunately,
there
no
approved
vaccines
treatments
are
available.
most
recent
outbreak
Equatorial
Guinea
Tanzania
2023
caused
alert
global
health.
However,
based
on
last
pandemic
COVID-19
sudden
re-emerging
monkeypox
around
world,
we
assume
Our
modern
world
depends
globalization,
which
helps
transmission
among
countries.
humans
fruit
bats
Pteropodidae
family.
This
causes
severe
hemorrhagic
disease,
specific
available
combat
it.
Therefore,
community
engagement
early
supportive
care
patients
keys
successfully
controlling
MVD.
