International Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown, P. 107371 - 107371
Published: Dec. 1, 2024
Language: Английский
The Egyptian Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 36(1)
Published: Jan. 29, 2024
Abstract The Nipah virus, a highly pathogenic zoonotic pathogen, has once again surfaced in the state of Kerala, India, with recent cases reported 2023. This article delves into epidemiological details these cases, shedding light on two fatalities that occurred September 2023 and August as well suspected have undergone testing. known for its severe neurological respiratory disease manifestations, remains formidable health threat due to lack specific treatments or vaccines. government’s response including mass testing quarantine measures, is discussed, drawing lessons from past outbreaks region. Kerala experienced multiple virus since 2018, prompting closer examination environmental factors, such deforestation urbanization, which increase risk transmission. underscores global implications resurgence emphasizes importance preparedness vigilance face emerging infectious diseases. learned Kerala’s experience provide valuable insights public professionals policymakers worldwide.
Language: Английский
Citations
8
Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: 97, P. 101279 - 101279
Published: May 20, 2024
Language: Английский
Citations
7
Diseases, Journal Year: 2024, Volume and Issue: 12(12), P. 309 - 309
Published: Dec. 2, 2024
Objectives: Marburg virus disease (MVD) is on the WHO list for pandemic-prone pathogens. The current outbreak in Rwanda provides an opportunity to map outbreaks and generate information inform policymaking, resource mobilization, guide implementation of cost-effective response strategies. Methods: We synthesized available about MVD build holistic, up-to-date evidence policymakers, public health leaders, healthcare services providers their development preparedness, prevention, control measures. Results: have identified 20 that occurred 14 countries between 1967 2024; these led 580 confirmed cases 423 deaths total. summarize main clinical signs, diagnostic tools, primary reservoir, transmission dynamics, case management protocol. also document best practices prevention outbreaks, including a multisectoral One Health strategy incorporates strict WASH infection measures, contact tracing, isolation infected suspected humans animals, enhances International Regulations, particularly efficient cross-country coordination. Conclusions: In absence licensed treatment or vaccine MVD, should focus preventive community engagement promote reduction reservoirs, supportive care patients, proper waste management. High risk populations such as frontline responders, workers, be prioritized so they can access all currently protection
Language: Английский
Citations
7
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: April 25, 2024
Marburg virus disease (MVD) presents a significant global health threat, lacking effective antivirals and with current supportive care offering limited therapeutic options. This mini review explores the emerging landscape of novel antiviral strategies against MVD, focusing on promising therapeutics currently in development pipeline. We delve into direct-acting approaches, including small molecule inhibitors targeting viral entry, replication, assembly, alongside nucleic acid antisense RNA interference strategies. Host-targeting are also considered, encompassing immune modulators like interferons cytokine/chemokine modulators, broad-spectrum antivirals, convalescent plasma antibody-based therapies. The paper then examines preclinical clinical for therapeutics, highlighting vitro vivo models evaluation, safety efficacy assessments, critical stages trials. Recognizing challenges drug resistance escape, underscores potential combination therapy emphasizes need rapid diagnostic tools to optimize treatment initiation. Finally, we discuss importance public preparedness equitable access these achieving MVD control security. comprehensive overview burgeoning field approaches reshape future prevention.
Language: Английский
Citations
6
PLoS neglected tropical diseases, Journal Year: 2025, Volume and Issue: 19(1), P. e0012817 - e0012817
Published: Jan. 16, 2025
Background Viral haemorrhagic fevers (VHFs) are identified by international health authorities as priorities for research and development, they pose a threat to global economy. VHFs zoonotic diseases whose acute forms in humans present syndrome shock, with mortality rates of up 90%. This work aims at synthetizing existing knowledge on spatial spatially aggregable determinants that support the emergence maintenance African countries covered tropical moist forest, better identify map areas risk. Methodology/principal findings Using Preferred Reporting Items Systematic reviews Meta-Analyses (PRISMA-ScR) guidelines, extension scoping reviews, we searched PubMed, Embase, CAB Abstracts, Scopus databases. English French peer-reviewed documents were retrieved using Boolean logic keyword search terms. The analysis 79 articles published between 1993 2023 offers comprehensive overview complex interactions among abiotic, biotic, demographic, socio-economic, cultural, political risk factors driving forests. Human-to-human transmission is mainly driven political, demographic factors, whereas spillover determined almost all groups especially those an anthropogenic nature. Conclusions/significance Many questions remain unanswered regarding epidemiology By elucidating relevant which have already been studied, this review seeks advance hotspot predictions, mapping disease surveillance control systems improvement.
Language: Английский
Citations
0
Futuristic Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 02 - 09
Published: March 31, 2025
Marburg viral disease induced by the virus. It is a constituent of Filovirus family, which also encloses Ebola The first came into light in 1967 during episodes virus and Germany. After that, infection caused high CFR Angola, Uganda, Congo. includes sudden outset symptoms, including fever, vomiting, intense headache, abdominal pain, rash. In patients with severe infection, it leads to bleeding, jaundice, organ collapse, eventually death. Fruit bats genus Rousettus are considered be biological pool This destroyed African countries death rates. can transferred from green monkeys or fruit bats. transmitted through human-to-human interactions via blood, body fluids diseased people, contaminated surfaces. MVD diagnosed technical laboratory tests incorporating enzyme-linked immunosorbent assay (ELISA), reverse transcription-polymerase chain reaction (RT-PCR), seclusion. Supportive maintenance has been done demonstrate some efficacy controlling symptoms improving probability survival. Adequate management care have taken prevent unusual spread disease, such as separateness infected suspected individuals, should pertain quarantine measures. Because casualty rate lack certified vaccine any antiviral cure, only way keep check prevention. review briefly overviews virus, diagnosis, pathogenesis, transmission, treatment.
Language: Английский
Citations
0
Advances in virus research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Travel Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: 65, P. 102857 - 102857
Published: April 24, 2025
Citations
0
Current Infectious Disease Reports, Journal Year: 2024, Volume and Issue: 26(2), P. 57 - 67
Published: Jan. 15, 2024
Language: Английский
Citations
3
Environmental Health Insights, Journal Year: 2024, Volume and Issue: 18
Published: Jan. 1, 2024
The World Health Organization (WHO) defined Disease X as an upcoming disease with the potential to cause a pandemic. Pathogen is responsible for X. Marburg virus (MVD) one of diseases from priority list published by WHO. filamentous, negative-sense RNA that belongs same filovirus family lethal Ebola virus. Since first discovery this in 1967, 17 outbreaks occurred sporadically till 2023. Rousettus aegyptiacus acts natural reservoir With average incubation period 5 10 days, its target mononuclear phagocytic system cells. It highly contagious and can be easily transmitted animal human via direct contact blood or body fluid, feces, semen infected host. Although has high case fatality rate close 90%, unfortunately, there no approved vaccines treatments are available. most recent outbreak Equatorial Guinea Tanzania 2023 caused alert global health. However, based on last pandemic COVID-19 sudden re-emerging monkeypox around world, we assume Our modern world depends globalization, which helps transmission among countries. humans fruit bats Pteropodidae family. This causes severe hemorrhagic disease, specific available combat it. Therefore, community engagement early supportive care patients keys successfully controlling MVD.
Language: Английский
Citations
3