Опубликована: Янв. 1, 2024
Язык: Английский
Microorganisms, Год журнала: 2024, Номер 12(4), С. 697 - 697
Опубликована: Март 29, 2024
The ocean is the habitat of a great number organisms with different characteristics. Compared to terrestrial microorganisms, marine microorganisms also represent vast and largely unexplored reservoir bioactive compounds diverse industrial applications like microorganisms. This review examines properties potential products derived from including bacteriocins, enzymes, exopolysaccharides, pigments, juxtaposing them in some cases against their counterparts. We discuss distinct characteristics that set marine-derived apart, enhanced stability unique structural features such as amount uronic acid sulfate groups exopolysaccharides. Further, we explore uses these across various industries, ranging food pharmaceuticals cosmetics biotechnology. presents broad description biotechnologically important produced by bacteria isolated environments, qualities compared
Язык: Английский
Процитировано
7
International Journal of Translational Medicine, Год журнала: 2024, Номер 4(4), С. 740 - 781
Опубликована: Дек. 6, 2024
The increase in cancer incidence recent years necessitates urgent exploration of novel and alternative sources natural bioactives for targeted therapy. Approximately 75% the Earth’s surface is covered by oceans, which are thought to harbor untapped physiologically active compounds with potential efficacy against cancer. Recently, a growing focus has been on isolating investigating bioactive derived from marine sources. Bioactive metabolites diverse chemical structures, isolated various species such as algae, mollusks, actinomycetes, demonstrate wide range cancers. To our knowledge, this one articles that reviewed papers application marine-derived This study aims showcase some most current developments therapy have identified
Язык: Английский
Процитировано
7
Bioresource Technology, Год журнала: 2025, Номер 427, С. 132424 - 132424
Опубликована: Март 22, 2025
Язык: Английский
Процитировано
1
Biocatalysis and Agricultural Biotechnology, Год журнала: 2024, Номер 58, С. 103150 - 103150
Опубликована: Апрель 6, 2024
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135823 - 135823
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
5
Marine Drugs, Год журнала: 2024, Номер 22(7), С. 327 - 327
Опубликована: Июль 22, 2024
The marine kingdom is an important source of a huge variety scaffolds inspiring the design new drugs. complex molecules found in oceans present great challenge to organic and medicinal chemists. However, wide biological activities they can display worth effort. In this article, we overview different seaweeds as potential sources bioactive pigments with activity against neurodegenerative diseases, especially due their neuroprotective effects. Along broad introduction seaweed pigments, review focused on astaxanthin fucoxanthin and/or anti-neurodegenerative agents. PubMed SciFinder were used main search select most relevant scientific articles within field.
Язык: Английский
Процитировано
3
Marine Drugs, Год журнала: 2024, Номер 22(8), С. 373 - 373
Опубликована: Авг. 17, 2024
Soluble epoxide hydrolase (sEH) is essential for converting epoxy fatty acids, such as epoxyeicosatrienoic acids (EETs), into their dihydroxy forms. EETs play a crucial role in regulating blood pressure, mediating anti-inflammatory responses, and modulating pain, making sEH key target therapeutic interventions. Current research increasingly focused on identifying inhibitors from natural sources, particularly marine environments, which are rich bioactive compounds due to unique metabolic adaptations. In this study, the inhibitory activities of ten cembranoid diterpenes (1–10) isolated soft coral Sinularia maxima were evaluated. Among them, 3 9 exhibited considerable inhibition, with IC50 values 70.68 μM 78.83 μM, respectively. Enzyme kinetics analysis revealed that these two active inhibit through non-competitive mode. Additionally, silico approaches, including molecular docking dynamics simulations, confirmed stability interactions sEH, highlighting potential agents managing cardiovascular inflammatory diseases.
Язык: Английский
Процитировано
3
Frontiers in Microbiology, Год журнала: 2025, Номер 16
Опубликована: Янв. 28, 2025
Three new sorbicillinoid derivatives, citrinsorbicillinol A-C ( 1 – 3 ), along with three known compounds, such as trichosorbicillin G 4 dibutyl phthalate 5 and 3-(4-methoxyphenyl) propanoic acid 6 were isolated from the endophyte Trichoderma citrinoviride of Coptis chinensis . Their structures elucidated through extensive analyses spectroscopic data, computer-assisted structure elucidation (ACD/Structure Elucidator), density functional theory (DFT) calculations nuclear magnetic resonance (NMR) spectra, electronic circular dichroism (ECD). Biologically, compounds exhibited potential antioxidant activity, assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, IC 50 values ranging 27.8 to 89.6 μM. In particular, 2 demonstrated radical scavenging activity comparable that positive control, ascorbic acid, 31.2 μM, respectively. Moreover, compound anti-inflammatory by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages, an value 52.7 These findings underscore therapeutic derivatives for applications.
Язык: Английский
Процитировано
0
Pest Management Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Abstract BACKGROUND Rice blast, caused by Pyricularia oryzae , is a devastating fungal disease threatening global rice production. Overreliance on chemical fungicides has raised environmental concerns and led to resistant strains, necessitating the development of sustainable alternatives. This study integrated marine microbiology natural antifungal compounds create eco‐friendly alternatives for management. RESULTS We identified Pseudomonas aeruginosa R64 with broad‐spectrum antimicrobial activity from mangrove soil in Mai Po Nature Reserve. The fermentation extract (RFE) exhibited multifaceted inhibition P. suppressing mycelial growth, conidiation, conidial germination appressorial formation, while disturbing cell wall membrane function. It also attenuated virulence impairing penetration invasive growth. Further analysis phenazines quinolines as primary RFE, corroborated PCR detection corresponding phenazine biosynthetic gene clusters. Comparative bioassays two main bioactive components phenazine‐1‐carboxamide (PCN) phenazine‐1‐carboxylic acid (PCA), against implicated PCN principal effector. RFE had higher efficacy than tricyclazole growth inhibition, but were less effective isoprothiolane. Furthermore, displayed lower acute ecotoxicity an indicator organism isoprothiolane, suggesting their potential biopesticides blast CONCLUSION Natural products bacterium inhibited key developmental infection processes effectively reducing development. promising low mangrove‐associated bacteria highlight untapped innovative, fungicide mining agriculture. © 2025 Author(s). Pest Management Science published John Wiley & Sons Ltd behalf Society Chemical Industry.
Язык: Английский
Процитировано
0
Scientific Data, Год журнала: 2025, Номер 12(1)
Опубликована: Март 4, 2025
The coastal ocean is the dynamic interface where terrestrial, atmospheric, and marine systems converge, acting as a hotspot for microbial activity, which underpins intricate web of carbon nitrogen cycling. Dapeng Bay, typical semi-enclosed bay along southern coastline China, strongly influenced by monsoon climates human activities. Despite its ecological importance, long-term observations investigations into community structure in this region are notably lacking. To address gap, we conducted two-year continuous sampling from May 2021 to June 2023 explore shifts nearshore surface communities assess effects environmental stressors. This study presents comprehensive amplicon, metagenomic, metatranscriptomic information. We identified 3,600 amplicon sequence variants recovered 1,216 high-quality metagenome-assembled MAGs, representing 17 bacterial 3 archaeal phyla. Additionally, 587 MAGs were correlated with transcriptional comprising 539 48 populations. dataset anticipated provide multi-dimensional perspective, enhancing our understanding complexity, dynamics, adaptability environments.
Язык: Английский
Процитировано
0