Microbial Mysteries—Exploring the Microbiome\'s Impact on Endometriosis: A Review
Journal of South Asian Federation of Obstetrics and Gynaecology,
Год журнала:
2025,
Номер
16(S3), С. S263 - S267
Опубликована: Фев. 3, 2025
Язык: Английский
Dietary index for gut microbiota and its inverse association with female infertility: evidence from NHANES 2013–2018
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 4, 2025
Background
Infertility
has
become
a
global
health
concern,
especially
as
the
aging
population
continues
to
grow.
Previous
studies
suggest
that
gut
microbiota
plays
crucial
role
in
female
reproductive
health.
This
study
aimed
investigate
association
between
Dietary
Index
for
Gut
Microbiota
(DI-GM)
and
infertility.
Methods
We
analyzed
data
from
8,910
participants
aged
20–45
years
NHANES
2013–2018
cycles.
DI-GM
scores
were
calculated
based
on
dietary
recall
interviews,
including
14
foods
nutrients
associated
with
Female
infertility
was
identified
through
questionnaires.
Weighted
logistic
regression
models
used
assess
relationship
infertility,
adjustments
demographic,
lifestyle,
health-related
covariates.
Restricted
cubic
spline
(RCS)
analyses
explored
non-linear
associations,
subgroup
ensured
robustness
of
results.
Results
A
significant
negative
observed
(adjusted
OR
=
0.89,
95%
CI:
0.83–0.95,
p
<
0.001).
Participants
≥6
had
40%
lower
risk
compared
those
0–3
(OR
0.60,
0.44–0.82,
RCS
revealed
an
L-shaped
relationship,
threshold
at
5.
Subgroup
indicated
stronger
associations
women
education
levels
coronary
heart
disease
(
P
interaction
<0.05).
Conclusion
Our
findings
demonstrate
higher
score
is
reduced
suggesting
interventions
targeting
may
offer
cost-effective
strategy
improving
Further
longitudinal
interventional
are
warranted
confirm
causality
elucidate
underlying
mechanisms.
Язык: Английский
Unraveling the relationship between gut microbiota and site-specific endometriosis: a Mendelian randomization analysis
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 4, 2024
Background
Although
numerous
studies
have
illustrated
the
connection
between
gut
microbiota
and
endometriosis,
a
conspicuous
gap
exists
in
research
focusing
on
pathogenesis
of
endometriosis
at
various
sites
its
linkage
with
infertility.
Methods
In
this
study,
we
used
two-sample
Mendelian
randomization
analysis
to
investigate
effect
development
different
regions,
including
uterus,
ovary,
fallopian
tube,
pelvic
peritoneum,
vagina,
rectovaginal
septum,
as
well
intestine.
Additionally,
explored
correlation
endometriosis-induced
Genetic
associations
microbes
were
obtained
from
genome-wide
association
study
(GWAS)
datasets
provided
by
MiBioGen
consortium,
whereas
endometriosis-related
GWAS
data
sourced
FinnGen
dataset.
our
analysis,
single-nucleotide
polymorphisms
instrumental
variables,
primary
estimation
causal
performed
via
inverse
variance
weighting
method.
Our
sensitivity
analyses
incorporated
heterogeneity
tests,
pleiotropy
leave-one-out
Results
We
identified
genus
level
four
bacterial
communities
endometriosis.
Subsequently,
several
subtypes
anatomical
recognized.
Specifically,
three
genera
linked
ovarian
six
associated
tubal
showed
links
peritoneum
five
connected
vaginal
septum
seven
demonstrated
linkages
intestinal
one
was
adenomyosis,
exhibited
Conclusion
elucidates
site-specific
thereby
augmenting
understanding
pathophysiology
Moreover,
findings
pave
way
for
potential
therapeutic
strategies
targeting
individuals
grappling
Язык: Английский
Microbiota, chronic inflammation, and health: The promise of inflammatome and inflammatomics for precision medicine and healthcare
hLife,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
The Multifactorial Pathogenesis of Endometriosis: A Narrative Review Integrating Hormonal, Immune, and Microbiome Aspects
Zaure Datkhayeva,
Ainur Iskakova,
A. Mireeva
и другие.
Medicina,
Год журнала:
2025,
Номер
61(5), С. 811 - 811
Опубликована: Апрель 27, 2025
Endometriosis
(EM)
is
a
common
estrogen-dependent
chronic
inflammatory
disorder
affecting
reproductive-aged
women,
yet
its
pathogenesis
remains
incompletely
understood.
Recent
evidence
suggests
that
the
gut
microbiota
significantly
influence
immune
responses,
estrogen
metabolism,
and
systemic
inflammation,
potentially
contributing
to
EM
progression.
This
narrative
review
explores
relationship
between
EM,
emphasizing
microbial
dysbiosis,
regulation,
potential
microbiome-targeted
therapies.
Studies
published
within
last
30
years
were
included,
focusing
on
composition,
modulation,
therapeutic
interventions
in
EM.
The
selection
criteria
prioritized
peer-reviewed
articles,
clinical
trials,
meta-analyses,
reviews
investigating
microbiota’s
role
pathophysiology
treatment.
Microbial
dysbiosis
characterized
by
reduced
abundance
of
beneficial
bacteria
(Lactobacillus,
Bifidobacterium,
Ruminococcaceae)
an
increased
prevalence
pro-inflammatory
taxa
(Escherichia/Shigella,
Streptococcus,
Bacteroides).
modulate
metabolism
via
estrobolome,
levels
lesion
proliferation.
Additionally,
lipopolysaccharides
(LPS)
from
Gram-negative
activate
TLR4/NF-κB
signaling
pathway,
exacerbating
inflammation
symptoms.
interaction
microbiota,
dysregulation,
critical
pathogenesis.
While
microbiota-targeted
offer
benefits,
further
large-scale,
multi-center
studies
are
needed
validate
biomarkers
optimize
microbiome-based
therapies
for
Integrating
microbiome
research
with
precision
medicine
may
enhance
diagnostic
accuracy
improve
treatment
efficacy.
Язык: Английский
Association between endometriosis and gut microbiota: systematic review and meta-analysis
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Май 7, 2025
Background
Endometriosis,
a
complex
gynecological
disorder,
has
been
increasingly
linked
to
gut
microbiota
dysbiosis,
suggesting
its
potential
role
in
disease
pathogenesis.
Methods
This
systematic
review
and
meta-analysis
explore
the
association
between
endometriosis
by
evaluating
alpha
beta
diversity
measures
across
11
studies
involving
1,727
women,
including
433
diagnosed
with
1,294
controls.
Statistical
analysis
was
performed
utilizing
either
random
effects
models
or
fixed
Revmen5.2
STATA
softwares.
Results
Significant
differences
control
groups
were
observed
using
Shannon
Index
(SMD
=
0.39;
p
<
0.00001),
Subgroup
showed
significant
for
Chinese
0.48;
95%
CI
0.14
0.82;
0.006;
I
2
30%),
Swedish,
0.55;
0.27
0.83;
0.0001;
30%)
Spanish
0.34;
−0.02
0.85;
0.06;
27%),
compared
others
which
highlighting
correlation
different
demographic
groups.
The
Simpson
also
revealed
notable
difference
richness
0.91;
0.03).
However,
no
detected
Chao
0.37;
0.11).
These
findings
underscore
importance
of
understanding
microbiota’s
endometriosis.
Seven
employed
PCoA,
two
used
Bray–Curtis
dissimilarity
index,
one
PCA,
revealing
dissimilarities
composition
Using
Newcastle-Ottawa
Scale,
most
scored
≥7
stars,
indicating
high
quality.
funnel
plot
Egger’s
linear
regression
indicated
publication
bias.
Conclusion
study
highlights
alterations
women
endometriosis,
emphasizing
Future
research
should
focus
on
standardizing
reporting
methods
facilitate
deeper
quantitative
analyses.
Systematic
Review
Registration
PROSPERO
(registration
number
RD42024611701).
Язык: Английский
Dietary and Nutritional Interventions for the Management of Endometriosis
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 3988 - 3988
Опубликована: Ноя. 21, 2024
Endometriosis
is
a
chronic,
complex,
systemic
inflammatory
condition
that
impacts
approximately
190
million
girls
and
women
worldwide,
significantly
impacting
their
quality
of
life.
The
effective
management
endometriosis
requires
multi-disciplinary
holistic
approach,
one
includes
surgical
medical
management,
such
as
laparoscopy
chronic
plan,
well
dietary,
nutritional,
lifestyle
adjunct
interventions,
pelvic
pain
physiotherapy
acupuncture.
There
growing
evidence
to
support
the
role
dietary
nutritional
interventions
in
endometriosis-related
gastrointestinal
symptoms.
However,
implementation
these
often
not
regulated,
patients
with
adopt
self-management
strategies.
Diet
nutrition
can
modulate
key
players
integral
pathophysiology
endometriosis,
as,
but
limited
to,
inflammation,
estrogen,
microbiome.
it
unclear
whether
diet
plays
prevention
or
onset
endometriosis.
In
this
review,
we
discuss
three
pathogenesis
endometriosis-inflammation,
microbiome-and
summarize
how
influence
mechanisms,
consequently,
progression
manifestation
major
need
for
evidence-based,
non-invasive
debilitating
disease,
may
be
suitable.
Язык: Английский
Endometriosis: Future Biological Perspectives for Diagnosis and Treatment
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12242 - 12242
Опубликована: Ноя. 14, 2024
Endometriosis
is
an
oestrogen-dependent
inflammatory
disease
affecting
menstruating
women,
with
varying
levels
of
severity.
Oestrogen
dysregulation
responsible
for
chronic
inflammation,
angiogenesis,
endometrial
lesion
development,
progression,
and
infertility
during
menarche
in
afflicted
women.
The
mediators
associated
this
painful
have
been
established,
research
also
indicating
the
relationship
between
dysbiosis
manifestation.
present
several
comorbidities,
including
cancer,
cardiovascular
disease,
autoimmunity.
lack
specific
sensitive
non-invasive
diagnostic
procedures,
coupled
poor
response
to
current
therapeutic
approaches,
means
that
treatment
needs
remain
unmet.
Surgical
procedures
are
performed
remove
endometriosis
ectopic
lesions,
which
recurrence
rate
up
50%,
certain
patients
exhibiting
no
alleviation
symptoms.
This
review
aims
outline
aetiology
endometriosis,
detailing
novel
approaches
potential
namely
advanced
medical
products
(ATMPs),
stem
cell
therapy
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)
gene
editing.
timely
provides
insights
into
important
recent
modalities
may
be
applied
diagnosis
biomarkers,
microfluidic
platforms,
organoid
systems.
Undoubtedly,
reliable,
reproducible,
sensitive,
models
humans
urgently
needed
investigate
detail
debilitating
disease.
Язык: Английский
ENDOMETRIOSE: REVISÃO SISTEMÁTICA SOBRE A FISIOPATOLOGIA, COMPLICAÇÕES E ABORDAGENS TERAPÊUTICAS PARA UMA DOENÇA CRÔNICA COMPLEXA
M. C. O. do Nascimento,
Silvia Gomes Paranhos,
Lorena Kellen Silva Guilherme
и другие.
LUMEN ET VIRTUS,
Год журнала:
2024,
Номер
15(42), С. 7245 - 7258
Опубликована: Ноя. 20, 2024
Objetivo:
O
objetivo
geral
deste
estudo
é
analisar
a
produção
científica
sobre
Endometriose,
identificando
as
principais
complicações
e
tratamentos
dessa
patologia.
Metodologia:
Esta
uma
revisão
sistemática
focada
em
compreender
os
aspectos
essenciais
da
Endometriose.
A
pesquisa
foi
guiada
pela
pergunta:
"Quais
são
para
Endometriose?".
Para
encontrar
respostas,
foram
realizadas
buscas
na
base
de
dados
PubMed
utilizando
cinco
descritores
combinados
com
o
termo
booleano
"AND":
(Infertility)
AND
(Endometriosis)
(Endometrial
diseases)
(Female
infertility)
diseases).
Isso
resultou
um
total
23
artigos,
dos
quais
selecionados
análise
detalhada.
Resultados:
As
identificadas
incluem
dor
pélvica
crônica,
infertilidade
variedade
problemas
relacionados
à
inflamação
presença
tecido
endometriótico
fora
do
útero.
Tratamentos
hormonais,
como
progestinas
agonistas
GnRH,
mais
comumente
utilizados,
embora
novas
terapias
estejam
sendo
investigadas,
inibidores
aromatase
moduladores
seletivos
receptores
hormonais.
Além
disso,
abordagens
cirúrgicas
frequentemente
necessárias
casos
graves
ou
resistentes
médicos.
também
destaca
importância
diagnóstico
precoce
manejo
multidisciplinar
melhorar
resultados
pacientes.
Conclusão:
Conclui-se
que
Endometriose
condição
complexa
requer
abordagem
multifacetada
seu
manejo.
caracterização
das
desenvolvimento
estratégias
tratamento
eficazes
fundamentais
qualidade
vida
combinação
cirúrgicos
oferece
esperança
controle
eficaz
doença.
Cardio‐Metabolic Risk Profile of Women With Endometriosis: A Population‐Based Study
Endocrinology Diabetes & Metabolism,
Год журнала:
2024,
Номер
7(6)
Опубликована: Окт. 13, 2024
ABSTRACT
Aims
Endometriosis
(EM)
and
metabolic
disorders
are
frequent
health
problems
among
reproductive‐aged
women
worldwide.
Cardio‐metabolic
risk
profile
of
with
EM
is
not
well
understood.
We
aimed
to
investigate
the
cardio‐metabolic
Iranian
EM.
Methods
This
study
included
976
female
participants
aged
20–45
years
Tehran
Lipid
Glucose
Study.
was
diagnosed
based
on
participants'
self‐reported
previous
diagnosis
EM,
which
confirmed
by
reviewing
relevant
medical
documentation.
All
biochemical
measures
(low‐density
lipoprotein
cholesterol
[LDL],
high‐density
[HDL],
triglycerides
[TG],
fasting
blood
glucose
concentrations
[FBG])
measurement
systolic
pressure
(SBP)
diastolic
(DBP)
anthropometric
parameters
were
performed
according
standard
protocol
TLGS.
Logistic
regression
analysis
estimate
odds
ratio
disease.
Results
Of
participants,
161
individuals
(16.5%)
had
a
endometriosis.
There
no
significant
differences
in
median
without
endometriosis
(
p
>
0.05).
The
prevalence
syndrome
significantly
higher
group
compared
non‐EM
(21.9%
vs.
14.9%).
presence
associated
an
increased
(adjusted
1.99
[95%
CI
1.20–3.30];
=
0.007).
And
low
HDL
2.07
(1.02–4.20);
after
adjustment,
it
still
remained
0.03).
also
high
waist
circumstance
(1.58
[1.06–2.37];
0.02).
Conclusions
Women
may
be
at
developing
syndrome,
their
counterparts
condition.
Given
potential
implications,
healthcare
providers
should
consider
assessing
Язык: Английский