Microbial Mysteries—Exploring the Microbiome\'s Impact on Endometriosis: A Review

Journal of South Asian Federation of Obstetrics and Gynaecology, Journal Year: 2025, Volume and Issue: 16(S3), P. S263 - S267

Published: Feb. 3, 2025

Language: Английский

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Dietary index for gut microbiota and its inverse association with female infertility: evidence from NHANES 2013–2018

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 4, 2025

Background Infertility has become a global health concern, especially as the aging population continues to grow. Previous studies suggest that gut microbiota plays crucial role in female reproductive health. This study aimed investigate association between Dietary Index for Gut Microbiota (DI-GM) and infertility. Methods We analyzed data from 8,910 participants aged 20–45 years NHANES 2013–2018 cycles. DI-GM scores were calculated based on dietary recall interviews, including 14 foods nutrients associated with Female infertility was identified through questionnaires. Weighted logistic regression models used assess relationship infertility, adjustments demographic, lifestyle, health-related covariates. Restricted cubic spline (RCS) analyses explored non-linear associations, subgroup ensured robustness of results. Results A significant negative observed (adjusted OR = 0.89, 95% CI: 0.83–0.95, p < 0.001). Participants ≥6 had 40% lower risk compared those 0–3 (OR 0.60, 0.44–0.82, RCS revealed an L-shaped relationship, threshold at 5. Subgroup indicated stronger associations women education levels coronary heart disease ( P interaction <0.05). Conclusion Our findings demonstrate higher score is reduced suggesting interventions targeting may offer cost-effective strategy improving Further longitudinal interventional are warranted confirm causality elucidate underlying mechanisms.

Language: Английский

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Microbiota, chronic inflammation, and health: The promise of inflammatome and inflammatomics for precision medicine and healthcare

hLife, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Unraveling the relationship between gut microbiota and site-specific endometriosis: a Mendelian randomization analysis

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: July 4, 2024

Background Although numerous studies have illustrated the connection between gut microbiota and endometriosis, a conspicuous gap exists in research focusing on pathogenesis of endometriosis at various sites its linkage with infertility. Methods In this study, we used two-sample Mendelian randomization analysis to investigate effect development different regions, including uterus, ovary, fallopian tube, pelvic peritoneum, vagina, rectovaginal septum, as well intestine. Additionally, explored correlation endometriosis-induced Genetic associations microbes were obtained from genome-wide association study (GWAS) datasets provided by MiBioGen consortium, whereas endometriosis-related GWAS data sourced FinnGen dataset. our analysis, single-nucleotide polymorphisms instrumental variables, primary estimation causal performed via inverse variance weighting method. Our sensitivity analyses incorporated heterogeneity tests, pleiotropy leave-one-out Results We identified genus level four bacterial communities endometriosis. Subsequently, several subtypes anatomical recognized. Specifically, three genera linked ovarian six associated tubal showed links peritoneum five connected vaginal septum seven demonstrated linkages intestinal one was adenomyosis, exhibited Conclusion elucidates site-specific thereby augmenting understanding pathophysiology Moreover, findings pave way for potential therapeutic strategies targeting individuals grappling

Language: Английский

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Dietary and Nutritional Interventions for the Management of Endometriosis

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 3988 - 3988

Published: Nov. 21, 2024

Endometriosis is a chronic, complex, systemic inflammatory condition that impacts approximately 190 million girls and women worldwide, significantly impacting their quality of life. The effective management endometriosis requires multi-disciplinary holistic approach, one includes surgical medical management, such as laparoscopy chronic plan, well dietary, nutritional, lifestyle adjunct interventions, pelvic pain physiotherapy acupuncture. There growing evidence to support the role dietary nutritional interventions in endometriosis-related gastrointestinal symptoms. However, implementation these often not regulated, patients with adopt self-management strategies. Diet nutrition can modulate key players integral pathophysiology endometriosis, as, but limited to, inflammation, estrogen, microbiome. it unclear whether diet plays prevention or onset endometriosis. In this review, we discuss three pathogenesis endometriosis-inflammation, microbiome-and summarize how influence mechanisms, consequently, progression manifestation major need for evidence-based, non-invasive debilitating disease, may be suitable.

Language: Английский

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Cardio‐Metabolic Risk Profile of Women With Endometriosis: A Population‐Based Study

Endocrinology Diabetes & Metabolism, Journal Year: 2024, Volume and Issue: 7(6)

Published: Oct. 13, 2024

ABSTRACT Aims Endometriosis (EM) and metabolic disorders are frequent health problems among reproductive‐aged women worldwide. Cardio‐metabolic risk profile of with EM is not well understood. We aimed to investigate the cardio‐metabolic Iranian EM. Methods This study included 976 female participants aged 20–45 years Tehran Lipid Glucose Study. was diagnosed based on participants' self‐reported previous diagnosis EM, which confirmed by reviewing relevant medical documentation. All biochemical measures (low‐density lipoprotein cholesterol [LDL], high‐density [HDL], triglycerides [TG], fasting blood glucose concentrations [FBG]) measurement systolic pressure (SBP) diastolic (DBP) anthropometric parameters were performed according standard protocol TLGS. Logistic regression analysis estimate odds ratio disease. Results Of participants, 161 individuals (16.5%) had a endometriosis. There no significant differences in median without endometriosis ( p > 0.05). The prevalence syndrome significantly higher group compared non‐EM (21.9% vs. 14.9%). presence associated an increased (adjusted 1.99 [95% CI 1.20–3.30]; = 0.007). And low HDL 2.07 (1.02–4.20); after adjustment, it still remained 0.03). also high waist circumstance (1.58 [1.06–2.37]; 0.02). Conclusions Women may be at developing syndrome, their counterparts condition. Given potential implications, healthcare providers should consider assessing

Language: Английский

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Endometriosis: Future Biological Perspectives for Diagnosis and Treatment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12242 - 12242

Published: Nov. 14, 2024

Endometriosis is an oestrogen-dependent inflammatory disease affecting menstruating women, with varying levels of severity. Oestrogen dysregulation responsible for chronic inflammation, angiogenesis, endometrial lesion development, progression, and infertility during menarche in afflicted women. The mediators associated this painful have been established, research also indicating the relationship between dysbiosis manifestation. present several comorbidities, including cancer, cardiovascular disease, autoimmunity. lack specific sensitive non-invasive diagnostic procedures, coupled poor response to current therapeutic approaches, means that treatment needs remain unmet. Surgical procedures are performed remove endometriosis ectopic lesions, which recurrence rate up 50%, certain patients exhibiting no alleviation symptoms. This review aims outline aetiology endometriosis, detailing novel approaches potential namely advanced medical products (ATMPs), stem cell therapy clustered regularly interspaced short palindromic repeats (CRISPR) gene editing. timely provides insights into important recent modalities may be applied diagnosis biomarkers, microfluidic platforms, organoid systems. Undoubtedly, reliable, reproducible, sensitive, models humans urgently needed investigate detail debilitating disease.

Language: Английский

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ENDOMETRIOSE: REVISÃO SISTEMÁTICA SOBRE A FISIOPATOLOGIA, COMPLICAÇÕES E ABORDAGENS TERAPÊUTICAS PARA UMA DOENÇA CRÔNICA COMPLEXA

LUMEN ET VIRTUS, Journal Year: 2024, Volume and Issue: 15(42), P. 7245 - 7258

Published: Nov. 20, 2024

Objetivo: O objetivo geral deste estudo é analisar a produção científica sobre Endometriose, identificando as principais complicações e tratamentos dessa patologia. Metodologia: Esta uma revisão sistemática focada em compreender os aspectos essenciais da Endometriose. A pesquisa foi guiada pela pergunta: "Quais são para Endometriose?". Para encontrar respostas, foram realizadas buscas na base de dados PubMed utilizando cinco descritores combinados com o termo booleano "AND": (Infertility) AND (Endometriosis) (Endometrial diseases) (Female infertility) diseases). Isso resultou um total 23 artigos, dos quais selecionados análise detalhada. Resultados: As identificadas incluem dor pélvica crônica, infertilidade variedade problemas relacionados à inflamação presença tecido endometriótico fora do útero. Tratamentos hormonais, como progestinas agonistas GnRH, mais comumente utilizados, embora novas terapias estejam sendo investigadas, inibidores aromatase moduladores seletivos receptores hormonais. Além disso, abordagens cirúrgicas frequentemente necessárias casos graves ou resistentes médicos. também destaca importância diagnóstico precoce manejo multidisciplinar melhorar resultados pacientes. Conclusão: Conclui-se que Endometriose condição complexa requer abordagem multifacetada seu manejo. caracterização das desenvolvimento estratégias tratamento eficazes fundamentais qualidade vida combinação cirúrgicos oferece esperança controle eficaz doença.

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