Progress in Materials Science, Год журнала: 2024, Номер unknown, С. 101384 - 101384
Опубликована: Окт. 1, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 5253 - 5253
Опубликована: Май 8, 2022
Being one of the leading causes death and disability worldwide, cancer represents an ongoing interdisciplinary challenge for scientific community. As currently used treatments may face limitations in terms both efficiency adverse effects, continuous research has been directed towards overcoming existing challenges finding safer specific alternatives. In particular, increasing interest gathered around integrating nanotechnology management subsequentially developing various tumor-targeting nanoparticles applications. this respect, present paper briefly describes most clinical practice to set a reference framework recent findings, further focusing on novel developments field. More specifically, review elaborates top studies concerning nanomaterials (i.e., carbon-based, metal-based, liposomes, cubosomes, lipid-based, polymer-based, micelles, virus-based, exosomes, cell membrane-coated nanomaterials) that show promising potential different
Язык: Английский
Процитировано
70
FlatChem, Год журнала: 2023, Номер 38, С. 100484 - 100484
Опубликована: Фев. 13, 2023
Язык: Английский
Процитировано
69
Advanced Materials, Год журнала: 2024, Номер 36(24)
Опубликована: Март 6, 2024
Abstract The quest for effective and reliable methods of delivering medications, with the aim improving delivery therapeutic agent to intended location, has presented a demanding yet captivating field in biomedical research. concept smart drug systems is an evolving approach, serving as model directing drugs specific targets or sites. These have been developed specifically target regulate administration substances diverse array chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel rheumatoid arthritis, different cancers. Nevertheless, numerous comprehensive clinical trials are still required ascertain both immediate enduring impacts such nanosystems on human subjects. This review delves into benefits vehicles, aiming enhance comprehension their applicability addressing present medical requirements. Additionally, it touches upon current applications these stimuli‐reactive biomedicine outlines future development prospects.
Язык: Английский
Процитировано
22
Advanced Materials, Год журнала: 2024, Номер 36(24)
Опубликована: Март 19, 2024
Abstract The introduction of glucose oxidase, exhibiting characteristics consumption and H 2 O production, represents an emerging antineoplastic therapeutic approach that disrupts nutrient supply promotes efficient generation reactive oxygen species (ROS). However, the instability natural enzymes their low efficacy significantly impede broader application. In this context, 2D Ca Mn 8 16 nanosheets (CMO NSs) designed engineered to serve as a high‐performance nanozyme, enhancing enzyodynamic effect for ferroptosis–apoptosis synergistic tumor therapy, are presented. addition mimicking activities glutathione peroxidase, catalase, CMO NSs exhibit oxidase‐mimicking activities. This feature contributes antitumor performance through cascade catalytic reactions, involving disruption supply, self‐supply , subsequent ROS generation. exogenous 2+ released from NSs, along with endogenous enrichment induced by peroxidase‐ collectively mediate overload, leading apoptosis. Importantly, ferroptosis process is triggered synchronously output consumption. application ultrasound stimulation further enhances efficiency treatment. work underscores crucial role in therapy against tumors.
Язык: Английский
Процитировано
22
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 7, 2025
Nanocarriers are transport and encapsulation systems that primarily serve to protect improve the dispersibility of predominantly hydrophobic active ingredients but also enable their targeted delivery controlled release at site action. mainly made either organic or inorganic materials, various combinations materials in complex structures under development. Most nanocarriers represent entities rationally designed meet functional requirements a specific application. They can therefore be understood as Advanced Materials. Nanocarrier already being used medicine, cosmetics, agriculture, food, household products. variety products, ideally safe sustainable, may need registered before they placed on market. Inspired by medical research, increasingly for precision farming (nano-agrochemicals) such air fresheners lithium-ion batteries, could thus released into environment large quantities. To identification critical subsequent investigations, comprehensive literature review broad heterogeneous research field is provided, well an approach categorization based origin chemical composition constituent materials. A definition size (1–1000 nm) function proposed risk assessment.
Язык: Английский
Процитировано
2
ACS Applied Nano Materials, Год журнала: 2021, Номер 4(5), С. 4284 - 4306
Опубликована: Май 3, 2021
Over the past few years, engineered inorganic nanoparticles have been studied, researched, and applied extensively in biomedical field because resultant platforms increase usage of for particular theranostic applications. The innovation such nanosystems has potential to develop a mode that integrates both diagnosis treatment diseases system via combinatorial approaches imaging, targeting, therapy accomplish personalized tailored medicine. manipulation magnetic (MNPs) as agents attained growing consideration materials science owing their exclusive capability resonance chemotherapy, hyperthermia, bioseparation, gene therapy, enzyme immobilization, controlled release drug. To intensify diagnostic therapeutic efficacy, MNPs ornamented or functionalized with range enhance biocompatibility, stability, carrying payloads encapsulating imaging agents. Preferentially synthetic natural polymers exploited coatings ensure colloidal stability good dispersibility biological fluids. Stimuli-responsive also used functionalize establish approach can significantly effectiveness including real-time monitoring specific cells tissues. present review highlights progress emphasizing functionalization using diverse organic biomaterials. Furthermore, it provides soundproof concept on counterparts, which offer attractive possibilities Finally, main challenges limitations use advanced applications critically provided.
Язык: Английский
Процитировано
102
Bioactive Materials, Год журнала: 2022, Номер 23, С. 471 - 507
Опубликована: Дек. 5, 2022
Remarkable progress in phototherapy has been made recent decades, due to its non-invasiveness and instant therapeutic efficacy. In addition, with the rapid development of nanoscience nanotechnology, systems based on nanoparticles or nanocomposites also evolved as an emerging hotspot nanomedicine research, especially cancer. this review, first we briefly introduce history phototherapy, mechanisms cancer treatment. Then, summarize representative over past three five years nanoparticle-based highlight design innovative thereof. Finally, discuss feasibility potential clinical anticancer applications, aiming predict future research directions field. Our review is a tutorial work, at providing useful insights researchers field
Язык: Английский
Процитировано
64
Journal of Controlled Release, Год журнала: 2022, Номер 346, С. 43 - 70
Опубликована: Апрель 9, 2022
Язык: Английский
Процитировано
46
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 195, С. 114730 - 114730
Опубликована: Фев. 14, 2023
Язык: Английский
Процитировано
39
Bioengineering & Translational Medicine, Год журнала: 2022, Номер 8(2)
Опубликована: Июль 26, 2022
Abstract Tissue engineering (TE) is currently considered a cutting‐edge discipline that offers the potential for developing treatments health conditions negatively affect quality of life. This interdisciplinary field typically involves combination cells, scaffolds, and appropriate induction factors regeneration repair damaged tissue. Cell fate decisions, such as survival, proliferation, or differentiation, critically depend on various biochemical biophysical provided by extracellular environment during developmental, physiological, pathological processes. Therefore, understanding mechanisms action these critical to accurately mimic complex architecture living tissues improve efficiency TE approaches. In this review, we recapitulate effects have aspects cell fate. While role factors, growth small molecules, matrix (ECM) components, cytokines, has been extensively studied in context applications, it only recently begun understand signals surface topography, mechanical, electrical signals. These cues could provide more robust set stimuli manipulate signaling pathways formation engineered Furthermore, simultaneous application different types appears elicit synergistic responses are likely functional outcomes, which help translate results into successful clinical therapies future.
Язык: Английский
Процитировано
38