Journal of Controlled Release, Год журнала: 2020, Номер 325, С. 25 - 37
Опубликована: Май 28, 2020
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2018, Номер 19(12), С. 4100 - 4100
Опубликована: Дек. 18, 2018
During the last decade, metal nanoparticles (MtNPs) have gained immense popularity due to their characteristic physicochemical properties, as well containing antimicrobial, anti-cancer, catalyzing, optical, electronic and magnetic properties. Primarily, these MtNPs been synthesized through different physical chemical methods. However, conventional methods various drawbacks, such high energy consumption, cost involvement of toxic substances. Microbial flora has provided an alternative platform for biological synthesis in eco-friendly effective way. In this article we focused on microorganisms used MtNPs. We also elaborated intracellular extracellular mechanisms MtNP microorganisms, highlighted advantages along with challenges. Moreover, several over chemically nanoparticles, microbial MtNPs, exclusive dynamic characteristics, can be sectors like agriculture, medicine, cosmetics biotechnology industries near future.
Язык: Английский
Процитировано
379
Frontiers in Aging Neuroscience, Год журнала: 2019, Номер 11
Опубликована: Июнь 26, 2019
Modern research revealed that dietary consumption of flavonoids and flavonoids-rich foods significantly improves cognitive capabilities, inhibits or delays the senescence process related neurological disorders including Alzheimer's disease (AD). The rich such as green tea, cocoa, blue berry other appear to improve states hypofunction, AD dementia-like pathological symptoms in different animal models. mechanism are principally mediated via inhibition cholinesterases (AChE, BChE), beta secretase (BACE1), free radicals modulation signaling pathways implicated neuroprotective performance. Flavonoids interact with several protein like ERK PI3-kinase/Akt modulate their actions, leading effects. Moreover, they enhance vascular blood flow instigate neurogenesis particularly hippocampus area brain models investigated so for. also hamper progression neuro-degenerative neuronal apoptosis induced byneurotoxic substances amyloid proteins (Aβ). All these functions contribute maintenance number, quality neurons synaptic connectivity brain. Thus can thwart age be a potential source for development new drugs effective disabilities disorders.
Язык: Английский
Процитировано
290
Chemico-Biological Interactions, Год журнала: 2019, Номер 308, С. 294 - 303
Опубликована: Май 31, 2019
Язык: Английский
Процитировано
259
Journal of Genetic Engineering and Biotechnology, Год журнала: 2020, Номер 18(1), С. 67 - 67
Опубликована: Окт. 26, 2020
Translating the conventional scientific concepts into a new robust invention is much needed one at present scenario to develop some novel materials with intriguing properties. Particles in nanoscale exhibit superior activity than their bulk counterpart. This unique feature intensively utilized physical, chemical, and biological sectors. Each metal holding optical properties that can be synthesize metallic nanoparticles. At present, versatile nanoparticles were synthesized through chemical methods. Metallic pose numerous merits have promising industrial applications. But concerning pros cons of nanoparticle synthesis methods, researchers elevate drive process utilization plant resources as substitute for use chemicals reagents under theme green chemistry. These antimicrobial, anticancer, larvicidal, leishmaniasis, wound healing, antioxidant, sensor. Therefore, such conceptualized treating infectious environmental applications warranted one. Green chemistry keen prudence method, which bioresources used template this review, we exclusively update context plant-based synthesis, characterization, detailed coverage. Hopefully, our review will modernizing recent trends going on blooming research fraternities.
Язык: Английский
Процитировано
257
Materials, Год журнала: 2022, Номер 15(3), С. 804 - 804
Опубликована: Янв. 21, 2022
The strategies involved in the development of therapeutics for neurodegenerative disorders are very complex and challenging due to existence blood-brain barrier (BBB), a closely spaced network blood vessels endothelial cells that functions prevent entry unwanted substances brain. emergence advancement nanotechnology shows favourable prospects overcome this phenomenon. Engineered nanoparticles conjugated with drug moieties imaging agents have dimensions between 1 100 nm could potentially be used ensure enhanced efficacy, cellular uptake, specific transport, delivery molecules brain, owing their modified physico-chemical features. conjugates medicinal plants, or components known as nano phytomedicine, been gaining significance lately novel neuro-therapeutics natural abundance, promising targeted lesser potential show adverse effects. In present review, application, recent trends combined phytomedicine treatment neurological (ND) compared conventional therapies, addressed. Nanotechnology-based efforts performed bioinformatics early diagnosis well futuristic precision medicine ND also discussed context computational approach.
Язык: Английский
Процитировано
188
Evidence-based Complementary and Alternative Medicine, Год журнала: 2020, Номер 2020(1)
Опубликована: Янв. 1, 2020
In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored studied for therapeutic potentials various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s Parkinson’s amyotrophic lateral sclerosis are characterized by the progressive dysfunction loss of neuronal structure function that resulted in cell death. Since multifactorial pathological mechanisms associated neurodegeneration, targeting multiple actions neuroprotection approach, involves preventing death restoring to damaged neurons, could be promising strategies prevention Natural products emerged potential neuroprotective agents treatment This review focused on exert a effect pathologies
Язык: Английский
Процитировано
160
Cells, Год журнала: 2021, Номер 10(6), С. 1309 - 1309
Опубликована: Май 25, 2021
Alzheimer's disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in research community pharmaceutical industry their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of from origins been evaluated preclinically clinically preventing attenuating multifactorial pathologies This review mainly focuses on possible that may be beneficial product mixtures or extracts sources demonstrated activity preclinical and/or clinical studies. It believed containing multiple bioactive compounds can work additively synergistically exhibit might an effective approach drug discovery.
Язык: Английский
Процитировано
152
Molecules, Год журнала: 2021, Номер 26(17), С. 5327 - 5327
Опубликована: Сен. 2, 2021
Natural products derived from plants, as well their bioactive compounds, have been extensively studied in recent years for therapeutic potential a variety of neurodegenerative diseases (NDs), including Alzheimer’s (AD), Huntington’s (HD), and Parkinson’s (PD) disease. These are characterized by progressive dysfunction loss neuronal structure function. There has little progress designing efficient treatments, despite impressive breakthroughs our understanding NDs. In the prevention therapy NDs, use natural may provide great opportunities; however, many clinical issues emerged regarding use, primarily based on lack scientific support or proof effectiveness patient safety. Since neurodegeneration is associated with myriad pathological processes, targeting multi-mechanisms action neuroprotection approaches that include preventing cell death restoring function damaged neurons should be employed. treatment AD PD, neuroprotective agents. This current review will highlight numerous compounds thatexert effects pathologies
Язык: Английский
Процитировано
105
Frontiers in Pharmacology, Год журнала: 2021, Номер 12
Опубликована: Окт. 4, 2021
In recent years, with the development of nanomaterials, research drug delivery systems has become a new field cancer therapy. Compared conventional antitumor drugs, such as nanoparticles (NPs) are expected to have more advantages in antineoplastic effects, including easy preparation, high efficiency, low toxicity, especially active tumor-targeting ability. Drug usually composed carriers, and even target molecules. At present, there few comprehensive reports on summary applied for tumor This review introduces characteristics, applications several common carriers expounds mechanism different drugs detail which provides theoretical basis clinical application personalized nanomedicine future.
Язык: Английский
Процитировано
96
Biosystems Diversity, Год журнала: 2020, Номер 28(1), С. 9 - 17
Опубликована: Март 2, 2020
In recent decades, the attention of scientists has been drawn towards nanoparticles (NPs) metals and metalloids. Traditional methods for manufacturing NPs are now being extensively studied. However, disadvantages such as use toxic agents high energy consumption associated with chemical physical processes impede their continued in various fields. this article, we analyse relevance living systems components development "green" synthesis nano-objects exceptional properties a wide range applications. The nano-biotechnological potential large-scale application commercial potential. Bacteria an extremely convenient target green nanoparticle due to variety ability adapt different environmental conditions. Synthesis by microorganisms can occur both intracellularly extracellularly. It is known that individual bacteria able bind concentrate dissolved metal ions metalloids, thereby detoxifying environment. There cellular enzymes, proteins, peptides, pigments, which involved formation nanoparticles. Bio-intensive environmentally friendly inexpensive requires low consumption. Some biosynthetic used heterogeneous catalysts restoration, exhibiting higher catalytic efficiency stability increased biocompatibility. nanofactories provide new approach removal or metalloid production materials unique properties. Although have synthetic mechanisms proposed, some these not detail. This review focuses on applications obtained using bacteria. Known bioreduction prospects discussed.
Язык: Английский
Процитировано
92