Perivascular and parenchymal brain fluid diffusivity in patients with a recent small subcortical infarct

Neuroradiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Язык: Английский

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Glymphatic dysfunction correlates with severity of small vessel disease and cognitive impairment in cerebral amyloid angiopathy

European Journal of Neurology, Год журнала: 2022, Номер 29(10), С. 2895 - 2904

Опубликована: Июнь 17, 2022

Cerebral amyloid angiopathy (CAA) is characterized by β-amyloid deposition in cortical and leptomeningeal arterioles, which might result from glymphatic dysfunction. The aim was to explore function CAA using the non-invasive diffusion tensor image analysis along perivascular space method.Sixty-three patients with were prospectively recruited together seventy age- sex-matched normal controls. Mini-Mental State Examination Montreal Cognitive Assessment applied screen global cognitive status. Magnetic resonance imaging scans conducted calculate index for diffusivity (ALPS index), linear regression models used assess its relationships cerebral small vessel disease (CSVD) markers, status blood biomarkers. Cox proportional hazard role of baseline ALPS recurrence.Patients exhibited a lower than controls globally (p < 0.001). In addition, related more enlarged basal ganglia = 0.026), lacunes 0.001), higher white matter hyperintensity Fazekas score 0.049), elevated total magnetic burden CSVD 0.034) 0.001) as well CAA. During median follow-up 4.1 years, associated recurrence 0.022). also negatively correlated serum soluble intercellular adhesion molecule-1, neurofilament light chitinase-3-like protein 1 CAA.Patients showed impaired function. significantly severity, impairment

Язык: Английский

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The lymphatic drainage systems in the brain: a novel target for ischemic stroke?

Neural Regeneration Research, Год журнала: 2022, Номер 18(3), С. 485 - 485

Опубликована: Авг. 22, 2022

Recent studies have proposed three lymphatic drainage systems in the brain, that is, glymphatic system, intramural periarterial pathway, and meningeal vessels, whose roles various neurological diseases been widely explored. The system is a fluid waste clearance pathway utilizes perivascular space aquaporin-4 protein located astrocyte endfeet to provide for exchange of cerebrospinal interstitial fluid. drives flow through capillary basement membrane arterial tunica media. Meningeal vessels within dura mater are involved removal cerebral macromolecules immune responses. After ischemic stroke, impairment these could lead edema, accumulation toxic factors, activation neuroinflammation, while restoration their normal functions can improve outcomes. In this review, we summarize basic concepts systems, including routes, physiological functions, regulatory mechanisms, detection technologies. We also focus on brain injury after as well recent advances therapeutic strategies targeting systems. These findings information potential novel treatment stroke.

Язык: Английский

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Noninvasive neuroimaging provides evidence for deterioration of the glymphatic system in Parkinson's disease relative to essential tremor

Parkinsonism & Related Disorders, Год журнала: 2022, Номер 107, С. 105254 - 105254

Опубликована: Дек. 24, 2022

Язык: Английский

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Recovery of glymphatic system function in patients with temporal lobe epilepsy after surgery

European Radiology, Год журнала: 2023, Номер 33(9), С. 6116 - 6123

Опубликована: Апрель 3, 2023

Язык: Английский

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