DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 31, 2023

Brain glymphatic dysfunction is involved in the pathologic process of acute ischemic stroke (IS). The relationship between brain activity and subacute IS has not been fully elucidated. Diffusion tensor image analysis along perivascular space (DTI-ALPS) index was used this study to explore whether related motor patients.Twenty-six patients with a single lesion left subcortical region 32 healthy controls (HCs) were recruited study. DTI-ALPS DTI metrics (fractional anisotropy, FA, mean diffusivity, MD) compared within groups. Spearman's Pearson's partial correlation analyses performed analyze relationships Fugl-Meyer assessment (FMA) scores corticospinal tract (CST) integrity group, respectively.Six two HCs excluded. group significantly lower than that HC (t = -3.02, p 0.004). In positive simple function score (ρ 0.52, 0.019) significant negative FA (R -0.55, 0.023) MD -0.48, 0.032) values right CST found.Glymphatic IS. could be potential magnetic resonance (MR) biomarker patients. These findings contribute better understanding pathophysiological mechanisms provide new target for alternative treatments

Language: Английский

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Recovery of glymphatic system function in patients with temporal lobe epilepsy after surgery

European Radiology, Journal Year: 2023, Volume and Issue: 33(9), P. 6116 - 6123

Published: April 3, 2023

Language: Английский

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Association between body mass index and glymphatic function using diffusion tensor image-along the perivascular space (DTI-ALPS) in patients with Parkinson’s disease

Quantitative Imaging in Medicine and Surgery, Journal Year: 2024, Volume and Issue: 14(3), P. 2296 - 2308

Published: March 1, 2024

Background: Obesity is considered a risk factor for the development of several neurodegenerative diseases, including Parkinson's disease (PD). Recent studies have revealed that glymphatic function compromised in PD patients. This study aims to investigate impact different body mass index (BMI) statuses on system patients using diffusion tensor image analysis along perivascular space (DTI-ALPS) method.

Language: Английский

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Glymphatic function from diffusion-tensor MRI to predict conversion from mild cognitive impairment to dementia in Parkinson’s disease

Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(8), P. 5598 - 5609

Published: June 24, 2024

Abstract Background Although brain glymphatic dysfunction is a contributing factor to the cognitive deficits in Parkinson’s disease (PD), its role longitudinal progression of remains unknown. Objective To investigate function PD with mild impairment (MCI) that progresses dementia (PDD) and determine predictive value identifying individuals at high risk for developing dementia. Methods We included 64 patients meeting criteria MCI categorized them as either progressed PDD (converters) ( n = 29) or did not progress (nonconverters) 35), depending on whether they developed during follow-up. Meanwhile, 35 age- gender-matched healthy controls (HC) were included. Bilateral diffusion-tensor imaging analysis along perivascular space (DTI-ALPS) indices enlarged spaces (EPVS) volume fraction bilateral centrum semiovale, basal ganglia (BG), midbrain compared among three groups. Correlations DTI-ALPS index EPVS, well performance analyzed. Additionally, we investigated mediation effect EPVS function. Results converters had lower composites scores executive domains than nonconverters P < 0.001). Besides, significantly left hemisphere 0.001) larger BG-PVS 0.03) HC nonconverters. Lower increased associated worse global However, there was no significant mediating effect. Receiver operating characteristic revealed could effectively identify an area under curve (AUC) 0.850. Conclusion The reduction activity, measured by DTI-ALPS, potentially be used non-invasive indicator forecasting conversion before onset patients.

Language: Английский

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Noninvasive neuroimaging provides evidence for deterioration of the glymphatic system in Parkinson's disease relative to essential tremor

Parkinsonism & Related Disorders, Journal Year: 2022, Volume and Issue: 107, P. 105254 - 105254

Published: Dec. 24, 2022

Language: Английский

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