Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method

Magnetic Resonance in Medical Sciences, Год журнала: 2024, Номер 23(3), С. 268 - 290

Опубликована: Янв. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Язык: Английский

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Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study

Stroke and Vascular Neurology, Год журнала: 2023, Номер 8(5), С. e002191 - e002191

Опубликована: Апрель 12, 2023

This study aims to investigate the associations of glymphatic system with presence, severity and neuroimaging phenotypes cerebral small vessel disease (CSVD) in a community-based population.This report included 2219 community-dwelling people aged 50-75 years who participated PolyvasculaR Evaluation for Cognitive Impairment vaScular Events cohort. The diffusivity along perivascular spaces based on diffusion tensor imaging (DTI-ALPS index) was measured assess pathway. presence CSVD were estimated using score (points from 0 4) modified 4), which driven by 4 features CSVD, including white matter hyperintensity (WMH), enlarged (EPVS), lacunes, microbleeds. Brain atrophy (BA) also evaluated. Binary or ordinal logistic regression analyses carried out relationships DTI-ALPS index CSVD.The mean age 61.3 (SD 6.6) years, 1019 (45.9%) participants men. average 1.67±0.14. Individuals first quartile (Q1) had higher risks (OR 1.77, 95% CI 1.33 2.35, p<0.001), (odds ratio (OR) 1.80, 1.38 2.34, total burden (common OR (cOR) 1.89, 1.43 2.49, p<0.001) (cOR 1.95, 1.51 2.50, compared those fourth (Q4). Additionally, individuals Q1 increased WMH burden, basal ganglia-EPVS BA (all p<0.05).A lower underlay typical markers implying that impairment may interact CSVD-related pathology general ageing population.NCT03178448.

Язык: Английский

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Evaluation of glymphatic system activity by diffusion tensor image analysis along the perivascular space (DTI-ALPS) in dementia patients

British Journal of Radiology, Год журнала: 2023, Номер 96(1146)

Опубликована: Апрель 17, 2023

Objectives: Dementia is a clinical syndrome caused by multiple etiologies, usually manifests with progressive and diffuse brain dysfunction. The activity of the human glymphatic system was evaluated in cases dementia diffusion tensor image analysis along perivascular space (DTI-ALPS). Methods: We recruited 28 healthy subjects 77 patients, including 38 Alzheimer’s disease (AD),18 mild cognitive impairment (MCI), normal controls (NC) 21 vascular (VCI). All participants underwent DTI scanning. Diffusivities X, Y Z axes were obtained lateral ventricle body plane all subjects. assessed diffusivity spaces, as well projection fibers association fibers, respectively, order to acquire an DTI-ALPS-index correlated them mini mental state examination (MMSE) montreal assessment (MOCA) scores using partial correlation which influence age controlled. Results: AD, MCI, VCI patients showed significantly lower (p < 0.001) compared NC. Besides, group had higher than AD = 0.007). There significant positive between MMSE MOCA (the effect controlled), showing that water spaces associated dementia.The Dzassoc led reduced VCI, while Dxassoc contributed decrease AD. Conclusion: evaluation DTI-ALPS demonstrates decreased DTI-ALPS-index. Different from show drainage disorder rather impairment. Advances knowledge: This article comprehensively covers several types performs comparison MCI

Язык: Английский

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Cerebral Small Vessel Disease: a Review of the Pathophysiological Mechanisms

Translational Stroke Research, Год журнала: 2023, Номер 15(6), С. 1050 - 1069

Опубликована: Окт. 21, 2023

Язык: Английский

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The etiology and evolution of magnetic resonance imaging-visible perivascular spaces: Systematic review and meta-analysis

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Март 30, 2023

Perivascular spaces have been involved in neuroinflammatory and neurodegenerative diseases. Upon a certain size, these can become visible on magnetic resonance imaging (MRI), referred to as enlarged perivascular (EPVS) or MRI-visible (MVPVS). However, the lack of systematic evidence etiology temporal dynamics MVPVS hampers their diagnostic utility MRI biomarker. Thus, goal this review was summarize potential etiologies evolution MVPVS.In comprehensive literature search, out 1,488 unique publications, 140 records assessing etiopathogenesis were eligible for qualitative summary. 6 included meta-analysis assess association between brain atrophy.Four overarching partly overlapping proposed: (1) Impairment interstitial fluid circulation, (2) Spiral elongation arteries, (3) Brain atrophy and/or myelin loss, (4) Immune cell accumulation space. The patients with diseases did not support an volume measures [R: -0.15 (95%-CI -0.40-0.11)]. Based few mostly small studies tumefactive vascular diseases, is slow.Collectively, study provides high-grade dynamics. Although several emergence proposed, they are only partially supported by data. Advanced methods should be employed further dissect MVPVS. This benefit implementation biomarker.https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=346564, identifier CRD42022346564.

Язык: Английский

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Association of Cognition and Brain Reserve in Aging and Glymphatic Function Using Diffusion Tensor Image-along the Perivascular Space (DTI-ALPS)

Neuroscience, Год журнала: 2023, Номер 524, С. 11 - 20

Опубликована: Апрель 6, 2023

Язык: Английский

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Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies

Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)

Опубликована: Май 27, 2024

Abstract The brain’s network of perivascular channels for clearance excess fluids and waste plays a critical role in the pathogenesis several neurodegenerative diseases including cerebral amyloid angiopathy (CAA). CAA is main cause hemorrhagic stroke elderly, most common vascular comorbidity Alzheimer’s disease also implicated adverse events related to anti-amyloid immunotherapy. Remarkably, mechanisms governing soluble β—a key culprit CAA—from brain draining lymphatics systemic circulation remains poorly understood. This knowledge gap critically important bridge understanding pathophysiology accelerate development targeted therapeutics. authors this review recently converged their diverse expertise field physiology specifically address problem within framework Leducq Foundation Transatlantic Network Excellence on Brain Clearance. discusses overarching goal consortium explores evidence supporting or refuting impaired with focus translating observations from rodents humans. We discuss anatomical features as well biophysical characteristics fluid solute transport.

Язык: Английский

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The glymphatic system and cerebral small vessel disease

Journal of Stroke and Cerebrovascular Diseases, Год журнала: 2024, Номер 33(3), С. 107557 - 107557

Опубликована: Янв. 9, 2024

Cerebral small vessel disease is a group of pathologies in which alterations the brain's blood vessels contribute to stroke and neurocognitive changes. Recently, neurotoxic waste clearance system composed perivascular spaces abutting vessels, termed glymphatic system, has been identified as key player brain homeostasis. Given that share anatomical structures, this review aims reexamine context highlight novel aspects physiology.

Язык: Английский

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Intracranial Atherosclerotic Disease and Incident Dementia: The ARIC Study (Atherosclerosis Risk in Communities)

Circulation, Год журнала: 2024, Номер 150(11), С. 838 - 847

Опубликована: Авг. 1, 2024

BACKGROUND: Studies of the neurovascular contribution to dementia have largely focused on cerebral small vessel disease (CSVD), but role intracranial atherosclerotic (ICAD) remains unknown in general population. The objective this study was determine risk incident from ICAD after adjusting for CSVD and cardiovascular factors a US community-based cohort. METHODS: We acquired brain magnetic resonance imaging examinations 2011 through 2013 1980 Black White participants ARIC (Atherosclerosis Risk Communities), prospective cohort conducted 4 communities. Magnetic included high-resolution wall angiography identify ICAD. Of these participants, 1590 without dementia, missing covariates, with adequate image quality were followed 2019 dementia. Associations between assessed using Cox proportional hazard ratios adjusted (characterized by white matter hyperintensities, lacunar infarctions, microhemorrhages), APOE4 genotype (apolipoprotein E gene ε4), factors. RESULTS: mean age (SD) 77.4 (5.2) years. detected 34.6% participants. After median follow-up 5.6 years, 286 developed Compared ICAD, fully (95% CIs) any only causing stenosis ≤50%, >50% ≥1 1.57 (1.17–2.11), 1.41 (1.02–1.95), 1.94 (1.32–2.84), respectively. associated even among low hyperintensities burden, marker CSVD. CONCLUSIONS: an increased independent CSVD, genotype, evident group less likely be affected vascular low-grade stenosis. Our results suggest that may partially mediate effect leading Both must considered understand contributions cognitive decline.

Язык: Английский

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Blood–Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights

Journal of Magnetic Resonance Imaging, Год журнала: 2023, Номер 59(2), С. 397 - 411

Опубликована: Сен. 1, 2023

Perivascular spaces (PVS) and blood-brain barrier (BBB) disruption are two key features of cerebral small vessel disease (cSVD) neurodegenerative diseases that have been linked to cognitive impairment involved in the waste clearance system. Magnetic resonance imaging (MRI) offers possibility study these pathophysiological processes noninvasively vivo. This educational review provides an overview MRI techniques used assess PVS functionality BBB disruption. MRI-visible can be scored on structural images by either (subjectively) counting or (automatically) delineating PVS. We highlight emerging (diffusion) measure proxies perivascular fluid its movement, which may provide a more comprehensive understanding role diseases. For measurement disruption, we explain most commonly technique, dynamic contrast-enhanced (DCE) MRI, as well recently developed technique based arterial spin labeling (ASL). DCE ASL thought complementary characteristics BBB. Furthermore, describe clinical studies utilized cSVD diseases, particularly Alzheimer's (AD). These demonstrate dysfunction insight into large overlap, but also differences between AD. Overall, valuable insights mechanisms underlying potential markers for progression treatment response. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY: Stage 2.

Язык: Английский

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