Roles of Oxidative Stress in Synaptic Dysfunction and Neuronal Cell Death in Alzheimer’s Disease

Antioxidants, Год журнала: 2023, Номер 12(8), С. 1628 - 1628

Опубликована: Авг. 17, 2023

Alzheimer’s disease (AD) is a brain disorder that progressively undermines memory and thinking skills by affecting the hippocampus entorhinal cortex. The main histopathological hallmarks of AD are presence abnormal protein aggregates (Aβ tau), synaptic dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA RNA defects, inflammation, neuronal cell death. However, oxidative stress or damage also evident commonly overlooked considered consequence advancement dementia symptoms. control onset linked to activity amyloid-β peptide, which may serve as both antioxidant pro-oxidant molecules. Furthermore, correlated with proteins, nucleic acids, lipids in vulnerable populations, ultimately lead death through different molecular mechanisms. By recognizing an integral feature AD, alternative therapeutic preventive interventions developed tested potential complementary therapies for this devastating neurodegenerative disease.

Язык: Английский

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Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy

Antioxidants, Год журнала: 2023, Номер 12(1), С. 180 - 180

Опубликована: Янв. 12, 2023

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive decline. Although substantial research has been conducted to elucidate the complex pathophysiology of AD, therapeutic approach still limited efficacy in clinical practice. Oxidative stress (OS) established as an early driver several age-related diseases, including neurodegeneration. In increased levels reactive oxygen species mediate neuronal lipid, protein, nucleic acid peroxidation, mitochondrial dysfunction, synaptic damage, inflammation. Thus, identification novel antioxidant molecules capable detecting, preventing, counteracting AD onset progression utmost importance. However, although studies have published, comprehensive up-to-date overviews principal anti-AD agents harboring properties remain scarce. this narrative review, we summarize role vitamins, minerals, flavonoids, non-flavonoids, mitochondria-targeting molecules, organosulfur compounds, carotenoids non-enzymatic antioxidants with diagnostic, preventative, potential, thereby offering insights into relationship between OS

Язык: Английский

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Types of memory, dementia, Alzheimer’s disease, and their various pathological cascades as targets for potential pharmacological drugs

Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102289 - 102289

Опубликована: Апрель 1, 2024

Язык: Английский

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Alzheimer’s Disease as Type 3 Diabetes: Understanding the Link and Implications

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 11955 - 11955

Опубликована: Ноя. 7, 2024

Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two prevalent conditions that present considerable public health issue in aging populations worldwide. Recent research has proposed a novel conceptualization of AD as "type 3 diabetes", highlighting the critical roles insulin resistance impaired glucose metabolism pathogenesis disease. This article examines implications this association, exploring potential new avenues for treatment preventive strategies AD. Key evidence linking to emphasizes metabolic processes contribute neurodegeneration, including inflammation, oxidative stress, alterations signaling pathways. By framing within context, we can enhance our understanding its etiology, which turn may influence early diagnosis, plans, measures. Understanding manifestation opens up possibility employing therapeutic incorporate lifestyle modifications use antidiabetic medications mitigate cognitive decline. integrated approach improve patient outcomes deepen comprehension intricate relationship between neurodegenerative diseases disorders.

Язык: Английский

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A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer’s Disease: A Focus on Probiotic and Vitamin Co-Supplementation

Antioxidants, Год журнала: 2024, Номер 13(2), С. 202 - 202

Опубликована: Фев. 5, 2024

Alzheimer’s disease is a progressive neurodegenerative disorder with complex etiology, and effective interventions to prevent or delay its onset remain global health challenge. In recent years, there has been growing interest in the potential role of probiotic vitamin supplementation as complementary strategies for prevention. This review paper explores current scientific literature on use probiotics vitamins, particularly A, D, E, K, B-complex context prevention management. We delve into mechanisms through which may modulate gut–brain interactions neuroinflammation while vitamins play crucial roles neuronal cognitive function. The also examines collective impact this combinational therapy reducing risk factors associated disease, such oxidative stress, inflammation, gut dysbiosis. By providing comprehensive overview existing evidence mechanisms, aims shed light promise co-supplementation multifaceted approach combat offering insights possible avenues future research clinical application.

Язык: Английский

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The Involvement of Ascorbic Acid in Cancer Treatment

Molecules, Год журнала: 2024, Номер 29(10), С. 2295 - 2295

Опубликована: Май 13, 2024

Vitamin C (VC), also known as ascorbic acid, plays a crucial role water-soluble nutrient within the human body, contributing to variety of metabolic processes. Research findings suggest that increased doses VC demonstrate potential anti-tumor capabilities. This review delves into mechanisms absorption and its implications for cancer management. Building upon these foundational insights, we explore modern delivery systems VC, evaluating use in diverse treatment methods. These include starvation therapy, chemodynamic therapy (CDT), photothermal/photodynamic (PTT/PDT), electrothermal immunotherapy, cellular reprogramming, chemotherapy, radiotherapy, various combination therapies.

Язык: Английский

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Ascorbate and its transporter SVCT2: The dynamic duo's integrated roles in CNS neurobiology and pathophysiology

Free Radical Biology and Medicine, Год журнала: 2024, Номер 212, С. 448 - 462

Опубликована: Янв. 3, 2024

Ascorbate is a small antioxidant molecule essential for the proper development and function of brain. transported into brain between cells via Sodium vitamin C co-transporter 2 (SVCT2). This review provides an in-depth analysis ascorbate's physiology, including how ascorbate absorbed from food CNS, emphasizing cellular mechanisms recycling release in different CNS compartments. Additionally, delves various functions its impact on epigenetic modulation, synaptic plasticity, neurotransmission. It also emphasizes role neuromodulation involvement neurodevelopmental processes disorders. Furthermore, it analyzes relationship duo ascorbate/SVCT2 neuroinflammation, particularly effects microglial activation, cytokine release, oxidative stress responses, highlighting association with neurodegenerative diseases, such as Alzheimer's disease (AD). Overall, this crucial dynamic physiology pathology need further research to fully comprehend significance neurobiological context potential therapeutic applications.

Язык: Английский

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Serum vitamin C levels and their correlation with chronic kidney disease in adults: a nationwide study

Renal Failure, Год журнала: 2024, Номер 46(1)

Опубликована: Янв. 8, 2024

Introduction Inflammation and oxidative stress play significant roles in the development of chronic kidney disease (CKD). Given recognized antioxidant properties vitamin C, our study aimed to explore correlation between CKD serum C levels.

Язык: Английский

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Restoring Impaired Neurogenesis and Alleviating Oxidative Stress by Cyanidin against Bisphenol A-induced Neurotoxicity: In Vivo and In Vitro Evidence

Current Drug Discovery Technologies, Год журнала: 2024, Номер 21(2)

Опубликована: Янв. 26, 2024

Background: Bisphenol A (BPA) is a known neurotoxic compound with potentially harmful effects on the nervous system. Cyanidin (CYN) has shown promise as neuroprotective agent. Objective: The current study aims to determine efficacy of CYN against BPA-induced neuropathology. Methods: In vitro experiments utilized PC12 cells were pre-treated gradient doses and further stimulated 10ng/ml BPA. DPPH radical scavenging activity, catalase total ROS nitric oxide activity done. vivo assessments employed doublecortin immunohistochemistry brain in BPA-exposed Sprague-Dawley rats. Further, silico molecular docking all proteins involved canonical Wnt signaling was performed using Autodock v4.2 tool BIOVIA Discovery Studio Visualizer. Results: IC50 values ascorbic acid determined dose-response curves, it found be 24.68 ± 0.563µg/ml 20.69 1.591µg/ml, respectively. BPA-stimulated pretreated showed comparable (p=0.0287). reactive species production by CYN-treated significantly decreased compared (p<0.0001). Moreover, inhibited BPA control vivo, positively affected immature neuron quantity, correlating dosage. During analysis, exhibited binding affinity > -7Kcal/mol key associated Wnt/β-catenin cascade. Conclusion: Conclusively, our finding suggests that counteracting BPAinduced oxidative stress, improving compromised neurogenesis hippocampal cortical regions, displaying notable interactions proteins. Thereby, could render its potential neuropathology

Язык: Английский

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Unlocking the Vitamin Puzzle: Investigating Levels in People With Alzheimer's Disease Versus Healthy Controls Through Systematic Review and Network Meta‐Analysis

Journal of Human Nutrition and Dietetics, Год журнала: 2025, Номер 38(1)

Опубликована: Янв. 6, 2025

ABSTRACT The progression of Alzheimer's disease (AD) is intricately tied to the impairment neurons, crucial for neurological functions. Despite extensive research, precise mechanism underlying AD development remains elusive due its multifaceted aetiology. Vitamin deficiency has emerged as a notable contributor onset and progression, exerting significant influence on brain function. To explore this link, we conducted thorough review using PubMed, Web Science MEDLINE databases gather literature average vitamin concentrations in people with healthy controls. Applying frequentist network meta‐analysis techniques, calculated standardised mean differences (SMDs) between control groups, both directly indirectly. Our analysis, based 67 articles, revealed statistically findings various vitamins. Notably, C displayed most substantial difference concentration supported by high p ‐score 0.92. Other vitamins that showed included D, folate, E, A B12. Moreover, considering alternative reference groups vitamins, derived indirect estimates, which further emphasised role pathology. ranking their discrepancy underscored importance C, followed In conclusion, our comprehensive analysis highlights potential significance levels understanding This underscores avenues research therapeutic interventions targeting deficiencies AD, potentially offering new strategies managing disease. Trial Registration: CRD42023447203

Язык: Английский

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