Journal of Applied Physiology,
Год журнала:
2024,
Номер
137(3), С. 512 - 526
Опубликована: Июль 4, 2024
Alzheimer's
disease
(AD)
is
the
fifth
leading
cause
of
death
in
older
adults,
and
treatment
options
are
severely
lacking.
Recent
findings
demonstrate
a
strong
relationship
between
skeletal
muscle
cognitive
function,
with
evidence
supporting
that
quality
function
positively
correlated
adults.
Conversely,
decreased
associated
threefold
increased
risk
decline.
Based
on
these
observations,
purpose
this
study
was
to
investigate
negative
effects
disuse
[via
model
hindlimb
immobilization
(HLI)]
hippocampal
insulin
sensitivity
mitochondrial
identify
potential
mechanisms
involved.
HLI
for
10
days
4-mo-old
female
Wistar
rats
resulted
following
novel
findings:
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3892 - 3892
Опубликована: Март 31, 2024
The
amyloid
cascade
hypothesis
for
Alzheimer's
disease
is
still
alive,
although
heavily
challenged.
Effective
anti-amyloid
immunotherapy
would
confirm
the
hypothesis'
claim
that
protein
amyloid-beta
cause
of
disease.
Two
antibodies,
aducanumab
and
lecanemab,
have
been
approved
by
U.S.
Food
Drug
Administration,
while
a
third,
donanemab,
under
review.
main
argument
FDA
approvals
presumed
therapy-induced
removal
cerebral
deposits.
Lecanemab
donanemab
are
also
thought
to
some
statistical
delay
in
determination
cognitive
decline.
However,
clinical
efficacy
less
than
with
conventional
treatment,
selection
amyloid-positive
trial
patients
non-specific
amyloid-PET
imaging,
uncertain
amyloids
trials
cast
doubt
on
this
anti-Alzheimer's
antibody
therapy
hence
hypothesis,
calling
more
thorough
investigation
negative
impact
type
brain.
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(11), С. 8715 - 8741
Опубликована: Окт. 16, 2024
Certain
carotene
components,
such
as
lycopene
and
beta-carotene,
are
found
in
tomatoes,
carrots,
sweet
potatoes,
etc.
good
for
human
health.
It
gives
plants
their
distinctive
red
color.
A
class
of
lipid-soluble
natural
pigments
known
carotenoids
is
the
precursor
vitamin
vital
antioxidant
defense
against
peroxides
cells
tissues.
This
review
provides
an
overview
current
state
knowledge
research
on
sources,
structures,
physiochemical
properties,
absorption
metabolism,
functional
advantages,
prevention
many
diseases
associated
with
beta-carotene.
These
antioxidants
have
been
linked
to
a
lower
risk
cardiovascular
disease
cancer,
they
also
help
draw
pollinators
flowers.
Carrots
potatoes
rich
sources
which
strengthens
immune
system
improves
eye
The
vivid
color
reproductive
organs,
including
flowers
fruits,
caused
by
carotenoid,
secondary
metabolite
that
produced
plastids.
other
health
advantages
attributed
lycopene.
When
ingested
through
food
or
supplements,
beta-carotene
manage
prevent
number
diseases,
metabolic,
inflammatory,
cardiovascular,
hepatic,
ophthalmic,
skeletal,
infertility
disorders.
main
point
toxicity
uncommon,
these
generally
accepted
be
safe
at
different
doses.
Including
nutrients
your
diet
can
improve
general
provide
illness
prevention.
Antioxidants,
Год журнала:
2024,
Номер
13(2), С. 191 - 191
Опубликована: Фев. 2, 2024
The
progress
in
understanding
the
pathogenesis
and
treatment
of
Alzheimer’s
disease
(AD)
is
based
on
recognition
primary
causes
disease,
which
can
be
deduced
from
knowledge
risk
factors
biomarkers
measurable
early
stages
disease.
Insights
into
time
course
biomarker
abnormalities
point
to
a
role
for
connection
amyloid
beta
(Aβ)
pathology,
tau
mitochondrial
dysfunction,
oxidative
stress
onset
development
AD.
Coenzyme
Q10
(CoQ10)
lipid
antioxidant
electron
transporter
transport
system.
availability
activity
CoQ10
crucial
proper
function
cellular
bioenergetics.
Based
hypothesis
AD
stress,
regulation
efficiency
phosphorylation
system
by
means
considered
promising
restoring
impaired
AD,
or
preventing
dysfunction
pathology
This
review
summarizes
pathophysiology
may
play
significant
role,
with
aim
evaluating
perspective
pharmacotherapy
its
analogues.
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1462 - 1462
Опубликована: Ноя. 28, 2024
Upregulation
of
reactive
oxygen
species
(ROS)
levels
is
a
principal
feature
observed
in
the
brains
neurodegenerative
diseases
such
as
Parkinson’s
disease
(PD)
and
Alzheimer’s
(AD).
In
these
diseases,
oxidative
stress
can
disrupt
blood–brain
barrier
(BBB).
This
disruption
allows
neurotoxic
plasma
components,
blood
cells,
pathogens
to
enter
brain,
leading
increased
ROS
production,
mitochondrial
dysfunction,
inflammation.
Collectively,
factors
result
protein
modification,
lipid
peroxidation,
DNA
damage,
and,
ultimately,
neural
cell
damage.
this
review
article,
we
present
mechanisms
by
which
damage
leads
BBB
breakdown
brain
diseases.
Additionally,
summarize
potential
therapeutic
approaches
aimed
at
reducing
that
contributes
ACS Omega,
Год журнала:
2024,
Номер
9(10), С. 11321 - 11338
Опубликована: Фев. 29, 2024
Nanoparticle
(NP)
systems
have
attracted
the
attention
of
researchers
in
recent
years
due
to
their
advantages,
such
as
modified
release
features,
increased
therapeutic
efficacy,
and
reduced
side
effects.
Ferulic
acid
(FA)
has
effects
anti-inflammatory,
anti-Alzheimer's,
antioxidant,
antimicrobial,
anticancer,
antihyperlipidemic,
antidiabetic.
In
this
study,
FA-loaded
PLGA-based
NPs
were
prepared
by
a
nanoprecipitation
method
effect
varying
concentrations
Poloxamer
188
Span
60
on
NP
properties
was
investigated.
A-FA
coded
formulation
chosen
optimum.
High
encapsulation
efficiency
been
achieved
low
affinity
FA
water
phase
and,
therefore,
its
lipophilic
nature,
which
tends
migrate
organic
phase.
It
determined
that
from
slower
than
pure
prolonged
24
h.
Antioxidant
anti-Alzheimer's
investigated
biological
activity
studies.
showed
strong
DPPH
free
radical
scavenging,
ABTS
cation
decolorizing,
reducing
antioxidant
activity.
Since
it
both
AChE
inhibitor
according
results
anti-Alzheimer
activity,
concluded
study
shows
promise
treatment
oxidative
stress-related
diseases
Alzheimer's.
Progress
in
understanding
the
pathogenesis
and
treatment
of
Alzheimer's
disease
(AD)
is
based
on
recognition
primary
causes
disease,
which
can
be
deduced
from
knowledge
risk
factors
biomarkers
measurable
early
stages
disease.
Insights
into
time
course
biomarker
abnormalities
point
to
a
role
for
mitochondrial
dysfunction
oxidative
stress
onset
development
AD.
Coenzyme
Q10
(CoQ10)
lipid
antioxidant
electron
transporter
transport
system.
The
availability
activity
CoQ10
crucial
proper
function
cellular
bioenergetics.
Based
hypothesis
AD
stress,
regulation
efficiency
phosphorylation
system
by
means
considered
promising
restoring
impaired
AD,
or
preventing
amyloid
tau
pathology
